CYFIP1 | ENSG00000273749 | NCBI 23191

Details for: CYFIP1

Gene ID: 23191

Symbol: CYFIP1

Ensembl ID: ENSG00000273749

Description: cytoplasmic FMR1 interacting protein 1

Associated with

Disease
(R-HSA-1643685)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania phagocytosis
(R-HSA-9664417)
Neutrophil degranulation
(R-HSA-6798695)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Rac1 gtpase cycle
(R-HSA-9013149)
Rac2 gtpase cycle
(R-HSA-9013404)
Rac3 gtpase cycle
(R-HSA-9013423)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Rhog gtpase cycle
(R-HSA-9013408)
Rho gtpase cycle
(R-HSA-9012999)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate wasps and waves
(R-HSA-5663213)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by vegf
(R-HSA-194138)
Signal transduction
(R-HSA-162582)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Actin filament binding
(GO:0051015)
Axonal growth cone
(GO:0044295)
Axon extension
(GO:0048675)
Axon guidance
(GO:0007411)
Cell morphogenesis
(GO:0000902)
Cellular response to insulin stimulus
(GO:0032869)
Central region of growth cone
(GO:0090724)
Cognition
(GO:0050890)
Cytosol
(GO:0005829)
Dendrite extension
(GO:0097484)
Dendritic growth cone
(GO:0044294)
Dendritic spine
(GO:0043197)
Excitatory synapse
(GO:0060076)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Filopodium tip
(GO:0032433)
Focal adhesion
(GO:0005925)
Lamellipodium
(GO:0030027)
Lamellipodium assembly
(GO:0030032)
Modification of synaptic structure
(GO:0099563)
Negative regulation of synaptic vesicle recycling
(GO:1903422)
Neuronal cell body
(GO:0043025)
Neuron projection
(GO:0043005)
Perinuclear region of cytoplasm
(GO:0048471)
Peripheral region of growth cone
(GO:0090725)
Positive regulation of arp2/3 complex-mediated actin nucleation
(GO:2000601)
Positive regulation of axon extension
(GO:0045773)
Positive regulation of dendrite development
(GO:1900006)
Positive regulation of lamellipodium assembly
(GO:0010592)
Positive regulation of neurotrophin trk receptor signaling pathway
(GO:0051388)
Positive regulation of ruffle assembly
(GO:1900029)
Protein binding
(GO:0005515)
Rac protein signal transduction
(GO:0016601)
Regulation of actin filament polymerization
(GO:0030833)
Regulation of cell shape
(GO:0008360)
Regulation of modification of postsynaptic actin cytoskeleton
(GO:1905274)
Regulation of myelination
(GO:0031641)
Regulation of translation
(GO:0006417)
Regulation of translation at postsynapse, modulating synaptic transmission
(GO:0099578)
Response to electrical stimulus
(GO:0051602)
Rna 7-methylguanosine cap binding
(GO:0000340)
Ruffle
(GO:0001726)
Ruffle organization
(GO:0031529)
Scar complex
(GO:0031209)
Secretory granule lumen
(GO:0034774)
Small gtpase binding
(GO:0031267)
Specific granule lumen
(GO:0035580)
Synapse
(GO:0045202)
Terminal bouton
(GO:0043195)
Tertiary granule lumen
(GO:1904724)

Other Information

Proteins

Cytoplasmic FMR1-interacting protein 1

Genular Protein ID: 2470596072

Symbol: CYFP1_HUMAN

Name: Cytoplasmic FMR1-interacting protein 1

UniProtKB Accession Codes:

Q7L576 A8K6D9 Q14467 Q5IED0 Q6ZSX1 Q9BSD9 Q9BVC7

Database IDs:

Citations:

PubMed ID: 7584044

Title: Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 7584044

DOI: 10.1093/dnares/1.5.223

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9417078

Title: p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase.

PubMed ID: 9417078

DOI: 10.1074/jbc.273.1.291

PubMed ID: 16260607

Title: CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation.

PubMed ID: 16260607

DOI: 10.1128/mcb.25.22.9920-9935.2005

PubMed ID: 16417406

Title: Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis.

PubMed ID: 16417406

DOI: 10.1371/journal.pbio.0040038

PubMed ID: 19524508

Title: Cyfip1 is a putative invasion suppressor in epithelial cancers.

PubMed ID: 19524508

DOI: 10.1016/j.cell.2009.04.013

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 21107423

Title: Structure and control of the actin regulatory WAVE complex.

PubMed ID: 21107423

DOI: 10.1038/nature09623

Sequence Information:

Length: 1253
Mass: 145182
Checksum: D8F45E13207BEF16
Sequence:

MAAQVTLEDA LSNVDLLEEL PLPDQQPCIE PPPSSLLYQP NFNTNFEDRN AFVTGIARYI 
EQATVHSSMN EMLEEGQEYA VMLYTWRSCS RAIPQVKCNE QPNRVEIYEK TVEVLEPEVT 
KLMNFMYFQR NAIERFCGEV RRLCHAERRK DFVSEAYLIT LGKFINMFAV LDELKNMKCS 
VKNDHSAYKR AAQFLRKMAD PQSIQESQNL SMFLANHNKI TQSLQQQLEV ISGYEELLAD 
IVNLCVDYYE NRMYLTPSEK HMLLKVMGFG LYLMDGSVSN IYKLDAKKRI NLSKIDKYFK 
QLQVVPLFGD MQIELARYIK TSAHYEENKS RWTCTSSGSS PQYNICEQMI QIREDHMRFI 
SELARYSNSE VVTGSGRQEA QKTDAEYRKL FDLALQGLQL LSQWSAHVME VYSWKLVHPT 
DKYSNKDCPD SAEEYERATR YNYTSEEKFA LVEVIAMIKG LQVLMGRMES VFNHAIRHTV 
YAALQDFSQV TLREPLRQAI KKKKNVIQSV LQAIRKTVCD WETGHEPFND PALRGEKDPK 
SGFDIKVPRR AVGPSSTQLY MVRTMLESLI ADKSGSKKTL RSSLEGPTIL DIEKFHRESF 
FYTHLINFSE TLQQCCDLSQ LWFREFFLEL TMGRRIQFPI EMSMPWILTD HILETKEASM 
MEYVLYSLDL YNDSAHYALT RFNKQFLYDE IEAEVNLCFD QFVYKLADQI FAYYKVMAGS 
LLLDKRLRSE CKNQGATIHL PPSNRYETLL KQRHVQLLGR SIDLNRLITQ RVSAAMYKSL 
ELAIGRFESE DLTSIVELDG LLEINRMTHK LLSRYLTLDG FDAMFREANH NVSAPYGRIT 
LHVFWELNYD FLPNYCYNGS TNRFVRTVLP FSQEFQRDKQ PNAQPQYLHG SKALNLAYSS 
IYGSYRNFVG PPHFQVICRL LGYQGIAVVM EELLKVVKSL LQGTILQYVK TLMEVMPKIC 
RLPRHEYGSP GILEFFHHQL KDIVEYAELK TVCFQNLREV GNAILFCLLI EQSLSLEEVC 
DLLHAAPFQN ILPRVHVKEG ERLDAKMKRL ESKYAPLHLV PLIERLGTPQ QIAIAREGDL 
LTKERLCCGL SMFEVILTRI RSFLDDPIWR GPLPSNGVMH VDECVEFHRL WSAMQFVYCI 
PVGTHEFTVE QCFGDGLHWA GCMIIVLLGQ QRRFAVLDFC YHLLKVQKHD GKDEIIKNVP 
LKKMVERIRK FQILNDEIIT ILDKYLKSGD GEGTPVEHVR CFQPPIHQSL ASS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CYFIP1

Associated with

Other Information

Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. PubMed ID: 7584044

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase. PubMed ID: 9417078

CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation. PubMed ID: 16260607

Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. PubMed ID: 16417406

Cyfip1 is a putative invasion suppressor in epithelial cancers. PubMed ID: 19524508

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Structure and control of the actin regulatory WAVE complex. PubMed ID: 21107423