Details for: ATG4B
Associated with
Other Information
Genular Protein ID: 3322643845
Symbol: ATG4B_HUMAN
Name: AUT-like 1 cysteine endopeptidase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 12446702
Title: Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy.
PubMed ID: 12446702
PubMed ID: 30808002
PubMed ID: 15169837
Title: LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation.
PubMed ID: 15169837
DOI: 10.1242/jcs.01131
PubMed ID: 10231032
Title: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 10231032
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15187094
Title: HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates.
PubMed ID: 15187094
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 17347651
Title: Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4.
PubMed ID: 17347651
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20818167
Title: Synthetic substrates for measuring activity of autophagy proteases: autophagins (Atg4).
PubMed ID: 20818167
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21177865
Title: Kinetics comparisons of mammalian Atg4 homologues indicate selective preferences toward diverse Atg8 substrates.
PubMed ID: 21177865
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22302004
Title: A high-throughput FRET-based assay for determination of Atg4 activity.
PubMed ID: 22302004
DOI: 10.4161/auto.18777
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 23093945
Title: Regulation of ATG4B stability by RNF5 limits basal levels of autophagy and influences susceptibility to bacterial infection.
PubMed ID: 23093945
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 26378241
Title: ATG4B (Autophagin-1) phosphorylation modulates autophagy.
PubMed ID: 26378241
PubMed ID: 27527864
Title: O-GlcNAcylation of ATG4B positively regulates autophagy by increasing its hydroxylase activity.
PubMed ID: 27527864
PubMed ID: 28633005
Title: Autophagy impairment mediated by S-nitrosation of ATG4B leads to neurotoxicity in response to hyperglycemia.
PubMed ID: 28633005
PubMed ID: 29232556
Title: MST4 phosphorylation of ATG4B regulates autophagic activity, tumorigenicity, and radioresistance in glioblastoma.
PubMed ID: 29232556
PubMed ID: 28821708
Title: A reversible phospho-switch mediated by ULK1 regulates the activity of autophagy protease ATG4B.
PubMed ID: 28821708
PubMed ID: 29165041
Title: AKT-mediated phosphorylation of ATG4B impairs mitochondrial activity and enhances the Warburg effect in hepatocellular carcinoma cells.
PubMed ID: 29165041
PubMed ID: 29458288
Title: Delipidation of mammalian Atg8-family proteins by each of the four ATG4 proteases.
PubMed ID: 29458288
PubMed ID: 30443548
Title: Identification of kinases and phosphatases that regulate ATG4B activity by siRNA and small molecule screening in cells.
PubMed ID: 30443548
PubMed ID: 30076329
Title: A new quinoline-based chemical probe inhibits the autophagy-related cysteine protease ATG4B.
PubMed ID: 30076329
PubMed ID: 30661429
Title: Redundancy of human ATG4 protease isoforms in autophagy and LC3/GABARAP processing revealed in cells.
PubMed ID: 30661429
PubMed ID: 31315929
Title: Human ATG4 autophagy proteases counteract attachment of ubiquitin-like LC3/GABARAP proteins to other cellular proteins.
PubMed ID: 31315929
PubMed ID: 31880198
Title: The protease activity of human ATG4B is regulated by reversible oxidative modification.
PubMed ID: 31880198
PubMed ID: 32686895
Title: Distinct mechanisms for processing autophagy protein LC3-PE by RavZ and ATG4B.
PubMed ID: 32686895
PubMed ID: 33607258
Title: PFKP facilitates ATG4B phosphorylation during amino acid deprivation-induced autophagy.
PubMed ID: 33607258
PubMed ID: 33773106
Title: ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system.
PubMed ID: 33773106
PubMed ID: 33909989
Title: Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine.
PubMed ID: 33909989
PubMed ID: 16183633
Title: Structural basis for the specificity and catalysis of human Atg4B responsible for mammalian autophagy.
PubMed ID: 16183633
PubMed ID: 16325851
Title: The crystal structure of human Atg4b, a processing and de-conjugating enzyme for autophagosome-forming modifiers.
PubMed ID: 16325851
PubMed ID: 19322194
Title: The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy.
PubMed ID: 19322194
PubMed ID: 28287329
Title: ATG4B contains a C-terminal LIR motif important for binding and efficient cleavage of mammalian orthologs of yeast Atg8.
PubMed ID: 28287329
Sequence Information:
- Length: 393
- Mass: 44294
- Checksum: F4ADB3192176E0E5
- Sequence:
MDAATLTYDT LRFAEFEDFP ETSEPVWILG RKYSIFTEKD EILSDVASRL WFTYRKNFPA IGGTGPTSDT GWGCMLRCGQ MIFAQALVCR HLGRDWRWTQ RKRQPDSYFS VLNAFIDRKD SYYSIHQIAQ MGVGEGKSIG QWYGPNTVAQ VLKKLAVFDT WSSLAVHIAM DNTVVMEEIR RLCRTSVPCA GATAFPADSD RHCNGFPAGA EVTNRPSPWR PLVLLIPLRL GLTDINEAYV ETLKHCFMMP QSLGVIGGKP NSAHYFIGYV GEELIYLDPH TTQPAVEPTD GCFIPDESFH CQHPPCRMSI AELDPSIAVG FFCKTEDDFN DWCQQVKKLS LLGGALPMFE LVELQPSHLA CPDVLNLSLD SSDVERLERF FDSEDEDFEI LSL
Genular Protein ID: 1128436402
Symbol: B3KVU2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 146
- Mass: 16221
- Checksum: 0A3C1A20A98CCF4B
- Sequence:
MRPPLSLSSA GSATHLPTCL ILPGEELIYL DPHTTQPAVE PTDGCFIPDE SFHCQHPPCR MSIAELDPSI AVGFFCKTED DFNDWCQQVK KLSLLGGALP MFELVELQPS HLACPDVLNL SLDSSDVERL ERFFDSEDED FEILSL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.