FAF2 | ENSG00000113194 | NCBI 23197

Details for: FAF2

Gene ID: 23197

Symbol: FAF2

Ensembl ID: ENSG00000113194

Description: Fas associated factor family member 2

Associated with

Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Neutrophil degranulation
(R-HSA-6798695)
Rhoa gtpase cycle
(R-HSA-8980692)
Rho gtpase cycle
(R-HSA-9012999)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Azurophil granule lumen
(GO:0035578)
Endoplasmic reticulum
(GO:0005783)
Erad pathway
(GO:0036503)
Extracellular region
(GO:0005576)
Lipase binding
(GO:0035473)
Lipase inhibitor activity
(GO:0055102)
Lipid droplet
(GO:0005811)
Lipid droplet organization
(GO:0034389)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Response to unfolded protein
(GO:0006986)
Retrograde protein transport, er to cytosol
(GO:0030970)
Stress granule disassembly
(GO:0035617)
Ubiquitin binding
(GO:0043130)
Ubiquitin protein ligase binding
(GO:0031625)
Vcp-npl4-ufd1 aaa atpase complex
(GO:0034098)

Other Information

Proteins

FAS-associated factor 2

Genular Protein ID: 3427392295

Symbol: FAF2_HUMAN

Name: FAS-associated factor 2

UniProtKB Accession Codes:

Q96CS3 O94963 Q8IUF2 Q9BRP2 Q9BVM7

Database IDs:

Citations:

PubMed ID: 12372427

Title: Cloning and characterization of the highly expressed ETEA gene from blood cells of atopic dermatitis patients.

PubMed ID: 12372427

DOI: 10.1016/s0006-291x(02)02380-x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 18711132

Title: SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins.

PubMed ID: 18711132

DOI: 10.1073/pnas.0805371105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19773358

Title: Targeting sequences of UBXD8 and AAM-B reveal that the ER has a direct role in the emergence and regression of lipid droplets.

PubMed ID: 19773358

DOI: 10.1242/jcs.054700

PubMed ID: 19818707

Title: The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER.

PubMed ID: 19818707

DOI: 10.1016/j.molcel.2009.09.016

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23297223

Title: Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover.

PubMed ID: 23297223

DOI: 10.1073/pnas.1213738110

PubMed ID: 24160817

Title: Signal-peptide-mediated translocation is regulated by a p97-AIRAPL complex.

PubMed ID: 24160817

DOI: 10.1042/bj20130710

PubMed ID: 24215460

Title: Pathogenic mutation of UBQLN2 impairs its interaction with UBXD8 and disrupts endoplasmic reticulum-associated protein degradation.

PubMed ID: 24215460

DOI: 10.1111/jnc.12606

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26692333

Title: Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling.

PubMed ID: 26692333

DOI: 10.1038/nm.4013

PubMed ID: 31073040

Title: LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling.

PubMed ID: 31073040

DOI: 10.1126/science.aau0812

PubMed ID: 34739333

Title: Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner.

PubMed ID: 34739333

DOI: 10.1126/science.abf6548

Sequence Information:

Length: 445
Mass: 52623
Checksum: D5510BCB0623096B
Sequence:

MAAPEERDLT QEQTEKLLQF QDLTGIESMD QCRHTLEQHN WNIEAAVQDR LNEQEGVPSV 
FNPPPSRPLQ VNTADHRIYS YVVSRPQPRG LLGWGYYLIM LPFRFTYYTI LDIFRFALRF 
IRPDPRSRVT DPVGDIVSFM HSFEEKYGRA HPVFYQGTYS QALNDAKREL RFLLVYLHGD 
DHQDSDEFCR NTLCAPEVIS LINTRMLFWA CSTNKPEGYR VSQALRENTY PFLAMIMLKD 
RRMTVVGRLE GLIQPDDLIN QLTFIMDANQ TYLVSERLER EERNQTQVLR QQQDEAYLAS 
LRADQEKERK KREERERKRR KEEEVQQQKL AEERRRQNLQ EEKERKLECL PPEPSPDDPE 
SVKIIFKLPN DSRVERRFHF SQSLTVIHDF LFSLKESPEK FQIEANFPRR VLPCIPSEEW 
PNPPTLQEAG LSHTEVLFVQ DLTDE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: FAF2

Associated with

Other Information

Cloning and characterization of the highly expressed ETEA gene from blood cells of atopic dermatitis patients. PubMed ID: 12372427

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 10048485

SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins. PubMed ID: 18711132

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Targeting sequences of UBXD8 and AAM-B reveal that the ER has a direct role in the emergence and regression of lipid droplets. PubMed ID: 19773358

The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER. PubMed ID: 19818707

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover. PubMed ID: 23297223

Signal-peptide-mediated translocation is regulated by a p97-AIRAPL complex. PubMed ID: 24160817

Pathogenic mutation of UBQLN2 impairs its interaction with UBXD8 and disrupts endoplasmic reticulum-associated protein degradation. PubMed ID: 24215460

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling. PubMed ID: 26692333

LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling. PubMed ID: 31073040

Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner. PubMed ID: 34739333