Details for: FAF2

Gene ID: 23197

Symbol: FAF2

Ensembl ID: ENSG00000113194

Description: Fas associated factor family member 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.59
    Marker Score: 6,664
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.47
    Marker Score: 15,141
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.46
    Marker Score: 53,784
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.44
    Marker Score: 88,634
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.42
    Marker Score: 25,136
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.41
    Marker Score: 13,384
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.39
    Marker Score: 29,743
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.39
    Marker Score: 5,653
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.38
    Marker Score: 20,632
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.38
    Marker Score: 807
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.36
    Marker Score: 12,771
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.36
    Marker Score: 11,648
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.35
    Marker Score: 1,496
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.35
    Marker Score: 51,346
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.34
    Marker Score: 2,951
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.33
    Marker Score: 5,140
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.32
    Marker Score: 1,600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.31
    Marker Score: 26,122
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.3
    Marker Score: 9,972
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.3
    Marker Score: 2,004
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.27
    Marker Score: 5,280
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.23
    Marker Score: 1,652
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.22
    Marker Score: 4,708
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.21
    Marker Score: 1,784
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.21
    Marker Score: 4,475
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.19
    Marker Score: 692
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.18
    Marker Score: 1,475
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.16
    Marker Score: 487
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.15
    Marker Score: 1,324
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.14
    Marker Score: 630
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.11
    Marker Score: 1,591
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.1
    Marker Score: 743
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.09
    Marker Score: 1,175
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.07
    Marker Score: 2,058
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.07
    Marker Score: 924
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.07
    Marker Score: 312
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.06
    Marker Score: 1,415
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.06
    Marker Score: 23,723
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.06
    Marker Score: 427
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.04
    Marker Score: 329
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.04
    Marker Score: 2,368
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.04
    Marker Score: 11,696
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.04
    Marker Score: 504
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.03
    Marker Score: 1,083
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.03
    Marker Score: 1,325
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.01
    Marker Score: 562
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1
    Marker Score: 571
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,652
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,876
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.98
    Marker Score: 4,100
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.98
    Marker Score: 1,059
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,381
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.97
    Marker Score: 4,063
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.97
    Marker Score: 265
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.97
    Marker Score: 1,170
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.97
    Marker Score: 3,433
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.96
    Marker Score: 15,054
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.95
    Marker Score: 270
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.95
    Marker Score: 1,011
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,389
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.94
    Marker Score: 860
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.93
    Marker Score: 719
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.93
    Marker Score: 485
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.93
    Marker Score: 14,894
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 477
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.92
    Marker Score: 292
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 433
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.92
    Marker Score: 482
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.91
    Marker Score: 224
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.91
    Marker Score: 941
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.91
    Marker Score: 1,471
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,710
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9
    Marker Score: 3,554
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.9
    Marker Score: 207
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.9
    Marker Score: 259
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9
    Marker Score: 31,104
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5,105
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.89
    Marker Score: 2,428
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.89
    Marker Score: 609
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.89
    Marker Score: 256
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.88
    Marker Score: 1,031
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.88
    Marker Score: 326
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.88
    Marker Score: 1,828
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.87
    Marker Score: 758
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.87
    Marker Score: 552
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,293
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.87
    Marker Score: 4,018
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.86
    Marker Score: 5,558
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.86
    Marker Score: 322
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.86
    Marker Score: 1,561
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.85
    Marker Score: 1,209
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.85
    Marker Score: 346
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.85
    Marker Score: 8,557
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.85
    Marker Score: 565
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.84
    Marker Score: 506
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.84
    Marker Score: 414
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.84
    Marker Score: 523
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.83
    Marker Score: 5,428
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.83
    Marker Score: 3,592

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FAF2 is a member of the Fas-associated factor family, which consists of proteins that interact with the Fas receptor, a key component of the immune system. FAF2 is primarily expressed in various cell types, including pigmented epithelial cells, dopaminergic neurons, and neurons, highlighting its widespread distribution across the nervous system and other tissues. The gene's expression is tightly regulated, suggesting its involvement in specific cellular processes. **Pathways and Functions:** FAF2 is implicated in several signaling pathways, including: 1. **Immune system:** FAF2 interacts with the Fas receptor, modulating the immune response and preventing excessive inflammation. 2. **Neurotransmission:** FAF2 is expressed in neurons, where it may play a role in regulating neurotransmitter release and synaptic plasticity. 3. **Protein organization:** FAF2 has been shown to interact with various proteins, including lipases, and influence their localization and activity. 4. **Stress response:** FAF2 may contribute to the unfolded protein response, a cellular mechanism that helps mitigate protein misfolding and aggregation. **Clinical Significance:** The dysregulation of FAF2 has been linked to various diseases, including: 1. **Neurological disorders:** Altered FAF2 expression has been observed in neurodegenerative diseases, such as Alzheimer's and Parkinson's, suggesting its potential role in disease pathology. 2. **Immune disorders:** FAF2's involvement in immune regulation implies its potential contribution to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer:** FAF2's expression in cancer cells may influence tumor growth, metastasis, and treatment resistance. In conclusion, FAF2 is a multifaceted gene that plays a crucial role in regulating immune responses, cellular signaling, and protein organization. Further research is necessary to fully elucidate the mechanisms underlying FAF2's functions and its clinical significance, but its potential implications in human health and disease are undeniable. **Future Directions:** 1. **Investigating FAF2's role in specific diseases:** Elucidating FAF2's involvement in specific neurological and immune disorders will provide valuable insights into its therapeutic potential. 2. **Exploring FAF2's interactions with other proteins:** Further studies on FAF2's protein interactions will reveal its complex regulatory network and shed light on its mechanisms of action. 3. **Developing FAF2-targeted therapies:** Understanding FAF2's functions and dysregulation will pave the way for the development of novel therapeutic strategies targeting this gene. By continuing to unravel the mysteries of FAF2, we can uncover new avenues for treating a range of diseases and improve our understanding of the intricate relationships between genes, proteins, and cellular processes.

Genular Protein ID: 3427392295

Symbol: FAF2_HUMAN

Name: FAS-associated factor 2

UniProtKB Accession Codes:

Q96CS3 O94963 Q8IUF2 Q9BRP2 Q9BVM7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12372427

Title: Cloning and characterization of the highly expressed ETEA gene from blood cells of atopic dermatitis patients.

PubMed ID: 12372427

DOI: 10.1016/s0006-291x(02)02380-x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 18711132

Title: SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins.

PubMed ID: 18711132

DOI: 10.1073/pnas.0805371105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19773358

Title: Targeting sequences of UBXD8 and AAM-B reveal that the ER has a direct role in the emergence and regression of lipid droplets.

PubMed ID: 19773358

DOI: 10.1242/jcs.054700

PubMed ID: 19818707

Title: The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER.

PubMed ID: 19818707

DOI: 10.1016/j.molcel.2009.09.016

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23297223

Title: Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover.

PubMed ID: 23297223

DOI: 10.1073/pnas.1213738110

PubMed ID: 24160817

Title: Signal-peptide-mediated translocation is regulated by a p97-AIRAPL complex.

PubMed ID: 24160817

DOI: 10.1042/bj20130710

PubMed ID: 24215460

Title: Pathogenic mutation of UBQLN2 impairs its interaction with UBXD8 and disrupts endoplasmic reticulum-associated protein degradation.

PubMed ID: 24215460

DOI: 10.1111/jnc.12606

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26692333

Title: Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling.

PubMed ID: 26692333

DOI: 10.1038/nm.4013

PubMed ID: 31073040

Title: LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling.

PubMed ID: 31073040

DOI: 10.1126/science.aau0812

PubMed ID: 34739333

Title: Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner.

PubMed ID: 34739333

DOI: 10.1126/science.abf6548

Sequence Information:

  • Length: 445
  • Mass: 52623
  • Checksum: D5510BCB0623096B
  • Sequence:
    • MAAPEERDLT QEQTEKLLQF QDLTGIESMD QCRHTLEQHN WNIEAAVQDR LNEQEGVPSV 
FNPPPSRPLQ VNTADHRIYS YVVSRPQPRG LLGWGYYLIM LPFRFTYYTI LDIFRFALRF 
IRPDPRSRVT DPVGDIVSFM HSFEEKYGRA HPVFYQGTYS QALNDAKREL RFLLVYLHGD 
DHQDSDEFCR NTLCAPEVIS LINTRMLFWA CSTNKPEGYR VSQALRENTY PFLAMIMLKD 
RRMTVVGRLE GLIQPDDLIN QLTFIMDANQ TYLVSERLER EERNQTQVLR QQQDEAYLAS 
LRADQEKERK KREERERKRR KEEEVQQQKL AEERRRQNLQ EEKERKLECL PPEPSPDDPE 
SVKIIFKLPN DSRVERRFHF SQSLTVIHDF LFSLKESPEK FQIEANFPRR VLPCIPSEEW 
PNPPTLQEAG LSHTEVLFVQ DLTDE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.