Details for: GSE1

Gene ID: 23199

Symbol: GSE1

Ensembl ID: ENSG00000131149

Description: Gse1 coiled-coil protein

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.84
    Marker Score: 1,577
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.6
    Marker Score: 5,008
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.33
    Marker Score: 17,823
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 2.2
    Marker Score: 690
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.19
    Marker Score: 32,788
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.12
    Marker Score: 80,658
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 2.12
    Marker Score: 1,598
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.02
    Marker Score: 1,127
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.98
    Marker Score: 1,045
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.97
    Marker Score: 8,180
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.93
    Marker Score: 41,222
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.89
    Marker Score: 7,323
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.88
    Marker Score: 69,314
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.87
    Marker Score: 1,050
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.86
    Marker Score: 2,244
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.81
    Marker Score: 935
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.8
    Marker Score: 15,487
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.8
    Marker Score: 1,051
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.71
    Marker Score: 1,367
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.7
    Marker Score: 4,007
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.69
    Marker Score: 982
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.66
    Marker Score: 1,830
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.63
    Marker Score: 6,038
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.63
    Marker Score: 36,424
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.62
    Marker Score: 99,394
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.57
    Marker Score: 575
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.56
    Marker Score: 2,274
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.55
    Marker Score: 5,519
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.54
    Marker Score: 3,382
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.53
    Marker Score: 6,391
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.51
    Marker Score: 2,330
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.5
    Marker Score: 729
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.47
    Marker Score: 3,607
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,546
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.46
    Marker Score: 426
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.46
    Marker Score: 1,813
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.46
    Marker Score: 23,367
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.44
    Marker Score: 378
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.39
    Marker Score: 440
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.39
    Marker Score: 1,499
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.38
    Marker Score: 1,315
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.38
    Marker Score: 8,179
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.37
    Marker Score: 394
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.34
    Marker Score: 2,341
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.33
    Marker Score: 1,495
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.32
    Marker Score: 20,689
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.32
    Marker Score: 1,422
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.29
    Marker Score: 5,399
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.28
    Marker Score: 517
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.26
    Marker Score: 659
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.26
    Marker Score: 855
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.24
    Marker Score: 467
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.24
    Marker Score: 24,640
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.24
    Marker Score: 12,455
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.24
    Marker Score: 2,814
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.23
    Marker Score: 591
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.22
    Marker Score: 1,480
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.22
    Marker Score: 1,713
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.21
    Marker Score: 360
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.21
    Marker Score: 992
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.21
    Marker Score: 725
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.2
    Marker Score: 1,280
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.17
    Marker Score: 1,189
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.16
    Marker Score: 4,830
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.15
    Marker Score: 4,515
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.11
    Marker Score: 2,260
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.08
    Marker Score: 3,849
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.08
    Marker Score: 11,151
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.05
    Marker Score: 1,007
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.04
    Marker Score: 574
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.04
    Marker Score: 734
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.03
    Marker Score: 327
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.03
    Marker Score: 6,598
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 1.01
    Marker Score: 263
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.01
    Marker Score: 777
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.01
    Marker Score: 598
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.01
    Marker Score: 375
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1
    Marker Score: 869
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1
    Marker Score: 320
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,680
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1
    Marker Score: 339
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,905
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.99
    Marker Score: 1,666
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,386
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.98
    Marker Score: 465
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.98
    Marker Score: 584
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.97
    Marker Score: 470
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.96
    Marker Score: 9,133
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.96
    Marker Score: 5,045
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.96
    Marker Score: 1,236
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.96
    Marker Score: 1,353
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.95
    Marker Score: 262
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,392
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.94
    Marker Score: 486
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.94
    Marker Score: 9,490
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 481
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.93
    Marker Score: 8,146
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.92
    Marker Score: 1,114
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.92
    Marker Score: 3,990
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 436

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GSE1 is a coiled-coil protein, characterized by its unique structural features, which may contribute to its interactions with other proteins and regulation of cellular processes. The coiled-coil domain is a common structural motif found in many proteins, often involved in protein-protein interactions and dimerization. The broad tissue expression profile of GSE1 suggests that it may play a role in maintaining tissue homeostasis and regulating cellular processes in various organs. **Pathways and Functions:** While the exact mechanisms of action of GSE1 are still unclear, several pathways and functions have been implicated. GSE1 has been associated with protein binding, which may suggest its role in regulating protein-protein interactions and modulating signaling pathways. The coiled-coil domain of GSE1 may facilitate dimerization with other coiled-coil proteins, leading to the formation of complexes that regulate cellular processes. Additionally, GSE1 has been found to interact with various signaling molecules, including GABAergic cortical interneurons, suggesting its involvement in neurotransmission and neuronal function. **Functions:** Several potential functions of GSE1 have been proposed based on its tissue expression profile and interactions with other proteins. GSE1 may play a role in maintaining tissue homeostasis by regulating cellular processes in various organs, including the lung, kidney, and retina. Additionally, GSE1 may be involved in regulating neurotransmission and neuronal function, particularly in the context of GABAergic cortical interneurons. The protein's interactions with photoreceptor cells and fat cells may also suggest its role in regulating energy metabolism and visual function. **Clinical Significance:** While the clinical significance of GSE1 is still unclear, its widespread tissue expression profile and interactions with various signaling molecules suggest potential implications for human disease. Mutations in the GSE1 gene may contribute to the development of various diseases, including neurological disorders and metabolic disorders. Furthermore, GSE1 may serve as a potential therapeutic target for diseases characterized by disrupted tissue homeostasis and cellular function. Ongoing research aimed at elucidating the mechanisms of action and clinical significance of GSE1 will be essential for uncovering its potential therapeutic applications. In conclusion, GSE1 is a coiled-coil protein with a broad tissue expression profile and potential implications for human disease. Further research is necessary to fully understand its mechanisms of action and clinical significance, but its unique structural features and interactions with various signaling molecules make it an intriguing candidate for investigation.

Genular Protein ID: 1445544543

Symbol: GSE1_HUMAN

Name: Genetic suppressor element 1

UniProtKB Accession Codes:

Q14687 D3DUM4 Q8IY61 Q96GA4 Q9BW09

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 3 ExpressionAtlas 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 3 SAM 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8724849

Title: Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 8724849

DOI: 10.1093/dnares/3.1.17

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12493763

Title: A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes.

PubMed ID: 12493763

DOI: 10.1074/jbc.m208992200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 26828271

Title: GSE1 negative regulation by miR-489-5p promotes breast cancer cell proliferation and invasion.

PubMed ID: 26828271

DOI: 10.1016/j.bbrc.2016.01.168

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 1217
  • Mass: 136164
  • Checksum: 4291FBE301B70F36
  • Sequence:
    • MKGMSHEPKS PSLGMLSTAT RTTATVNPLT PSPLNGALVP SGSPATSSAL SAQAAPSSSF 
AAALRKLAKQ AEEPRGSSLS SESSPVSSPA TNHSSPASTP KRVPMGPIIV PPGGHSVPST 
PPVVTIAPTK TVNGVWRSES RQDAGSRSSS GGRERLIVEP PLPQEKAGGP AIPSHLLSTP 
YPFGLSPSSV VQDSRFPPLN LQRPVHHVVP PSTVTEDYLR SFRPYHTTDD LRMSSLPPLG 
LDPATAAAYY HPSYLAPHPF PHPAFRMDDS YCLSALRSPF YPIPTPGSLP PLHPSAMHLH 
LSGVRYPPEL SHSSLAALHS ERMSGLSAER LQMDEELRRE RERERERERE READREREKE 
REREREKERE QEKEREREKE RERELERQRE QRAREKELLA AKALEPSFLP VAELHGLRGH 
ATEERGKPSE QLTPTRAEKL KDAGLQAPKP VQHPLHPVPT PHHTVPSLIS NHGIFSLPSS 
SAATALLIQR TNEEEKWLAR QRRLRQEKED RQSQVSEFRQ QVLEQHLDMG RPPVPAEAEH 
RPESTTRPGP NRHEPGGRDP PQHFGGPPPL ISPKPQLHAA PTALWNPVSL MDNTLETRRA 
ESHSLHSHPA AFEPSRQAAV PLVKVERVFC PEKAEEGPRK REPAPLDKYQ PPPPPPREGG 
SLEHQPFLPG PGPFLAELEK STQTILGQQR ASLPQAATFG ELSGPLKPGS PYRPPVPRAP 
DPAYIYDEFL QQRRRLVSKL DLEERRRREA QEKGYYYDLD DSYDESDEEE VRAHLRCVAE 
QPPLKLDTSS EKLEFLQLFG LTTQQQKEEL VAQKRRKRRR MLRERSPSPP TIQSKRQTPS 
PRLALSTRYS PDEMNNSPNF EEKKKFLTIF NLTHISAEKR KDKERLVEML RAMKQKALSA 
AVADSLTNSP RDSPAVSLSE PATQQASLDV EKPVGVAASL SDIPKAAEPG KLEQVRPQEL 
SRVQELAPAS GEKARLSEAP GGKKSLSMLH YIRGAAPKDI PVPLSHSTNG KSKPWEPFVA 
EEFAHQFHES VLQSTQKALQ KHKGSVAVLS AEQNHKVDTS VHYNIPELQS SSRAPPPQHN 
GQQEPPTARK GPPTQELDRD SEEEEEEDDE DGEDEEEVPK RKWQGIEAVF EAYQEHIEEQ 
NLERQVLQTQ CRRLEARHYS LSLTAEQLSH SVAELRSQKQ KMVSERERLQ AELDHLRKCL 
ALPAMHWPRG YLKGYPR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.