Details for: FAM168A

Gene ID: 23201

Symbol: FAM168A

Ensembl ID: ENSG00000054965

Description: family with sequence similarity 168 member A

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.33
    Marker Score: 112,502
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.81
    Marker Score: 59,989
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 2.65
    Marker Score: 1,997
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.6
    Marker Score: 6,502
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.57
    Marker Score: 38,362
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.52
    Marker Score: 13,533
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.47
    Marker Score: 18,969
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.46
    Marker Score: 10,216
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.45
    Marker Score: 48,686
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.39
    Marker Score: 90,830
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.39
    Marker Score: 11,057
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.38
    Marker Score: 12,464
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.35
    Marker Score: 2,850
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.25
    Marker Score: 1,318
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 2.23
    Marker Score: 7,465
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.22
    Marker Score: 8,567
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.2
    Marker Score: 81,082
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.16
    Marker Score: 907
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.09
    Marker Score: 5,015
  • Cell Name: granule cell (CL0000120)
    Fold Change: 2.07
    Marker Score: 15,605
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.05
    Marker Score: 19,294
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.05
    Marker Score: 4,714
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.02
    Marker Score: 1,330
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.02
    Marker Score: 124,182
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.98
    Marker Score: 5,635
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.96
    Marker Score: 43,706
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.95
    Marker Score: 20,164
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.94
    Marker Score: 965
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.93
    Marker Score: 7,854
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.89
    Marker Score: 2,538
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.88
    Marker Score: 17,908
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.87
    Marker Score: 676
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.85
    Marker Score: 15,929
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.85
    Marker Score: 588
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.83
    Marker Score: 703
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.81
    Marker Score: 1,049
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.77
    Marker Score: 916
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.77
    Marker Score: 2,971
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.76
    Marker Score: 3,864
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.76
    Marker Score: 1,517
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.75
    Marker Score: 579
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.7
    Marker Score: 464
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.68
    Marker Score: 1,932
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.63
    Marker Score: 912
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.61
    Marker Score: 2,481
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.58
    Marker Score: 3,048
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.56
    Marker Score: 1,933
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.54
    Marker Score: 2,167
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.53
    Marker Score: 737
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.51
    Marker Score: 1,674
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.49
    Marker Score: 736
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.47
    Marker Score: 797
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,780
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.46
    Marker Score: 849
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.42
    Marker Score: 5,935
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.41
    Marker Score: 1,222
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.4
    Marker Score: 1,742
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.38
    Marker Score: 4,900
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.37
    Marker Score: 1,058
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.37
    Marker Score: 1,303
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.33
    Marker Score: 3,129
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.32
    Marker Score: 424
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.31
    Marker Score: 414
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.3
    Marker Score: 1,476
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.3
    Marker Score: 5,453
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.26
    Marker Score: 19,728
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.21
    Marker Score: 842
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.2
    Marker Score: 2,443
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.2
    Marker Score: 1,493
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.17
    Marker Score: 342
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.17
    Marker Score: 20,741
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.16
    Marker Score: 693
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.13
    Marker Score: 1,218
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.06
    Marker Score: 1,545
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.06
    Marker Score: 936
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.05
    Marker Score: 585
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.03
    Marker Score: 350
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.02
    Marker Score: 1,780
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.01
    Marker Score: 563
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 1
    Marker Score: 302
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,738
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1
    Marker Score: 525
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,966
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.98
    Marker Score: 364
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,399
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.98
    Marker Score: 1,179
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 493
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.95
    Marker Score: 3,116
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,406
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 447
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.94
    Marker Score: 240
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.93
    Marker Score: 352
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.93
    Marker Score: 292
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.93
    Marker Score: 14,964
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.92
    Marker Score: 1,297
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,723
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.89
    Marker Score: 532
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 315
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4,968

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** FAM168A is expressed in a limited set of cell types, including Purkinje cells, astrocytes, photoreceptor cells, skeletal muscle fibers, and specific types of GABAergic cortical interneurons. This restricted expression pattern suggests a specialized function within these cell types. 2. **Pathways and Functions:** FAM168A is involved in the positive regulation of base-excision repair, a crucial process for maintaining genetic integrity. Additionally, its protein binding capabilities suggest a role in modulating protein-protein interactions, potentially influencing cellular signaling pathways. 3. **Cellular Localization:** The expression of FAM168A in specific cell types, particularly in the CNS, implies a role in maintaining neural function and homeostasis. **Pathways and Functions:** 1. **Base-Excision Repair (BER):** FAM168A is involved in the positive regulation of BER, a critical pathway for repairing damaged DNA. This process is essential for maintaining genetic stability and preventing mutations that can lead to cellular dysfunction or disease. 2. **Protein Binding:** FAM168A's protein binding capabilities suggest a role in modulating protein-protein interactions, potentially influencing cellular signaling pathways. This could involve interactions with other proteins involved in transcriptional regulation, protein degradation, or cell survival. 3. **Cellular Homeostasis:** The expression of FAM168A in specific cell types, particularly in the CNS, implies a role in maintaining neural function and homeostasis. This could involve regulating cellular processes such as proliferation, differentiation, or survival. **Clinical Significance:** 1. **Neurodegenerative Diseases:** The involvement of FAM168A in base-excision repair and protein binding pathways suggests a potential role in neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, or Huntington's disease. Dysregulation of FAM168A may contribute to disease progression. 2. **CNS Disorders:** The expression of FAM168A in specific cell types within the CNS implies a role in maintaining neural function and homeostasis. Dysregulation of FAM168A may contribute to CNS disorders, such as epilepsy, multiple sclerosis, or stroke. 3. **Cancer:** The involvement of FAM168A in base-excision repair pathways suggests a potential role in cancer development and progression. Dysregulation of FAM168A may contribute to cancer development or progression. In conclusion, FAM168A is a gene with significant implications in neuroprotection, cellular homeostasis, and cellular signaling pathways. Further research is necessary to fully understand its functions and clinical significance, particularly in the context of neurodegenerative diseases, CNS disorders, and cancer.

Genular Protein ID: 3001215773

Symbol: F168A_HUMAN

Name: Protein FAM168A

UniProtKB Accession Codes:

Q92567 A2ICY2 A2ID81 Q86UG2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 3 GO 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 3 SAM 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9039502

Title: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.

PubMed ID: 9039502

DOI: 10.1093/dnares/3.5.321

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21334329

Title: Cloning and functional characterization of TCRP1, a novel gene mediating resistance to cisplatin in an oral squamous cell carcinoma cell line.

PubMed ID: 21334329

DOI: 10.1016/j.febslet.2010.12.045

PubMed ID: 21603883

Title: TCRP1 promotes radioresistance of oral squamous cell carcinoma cells via Akt signal pathway.

PubMed ID: 21603883

DOI: 10.1007/s11010-011-0880-8

PubMed ID: 22771904

Title: Characterizing the neurite outgrowth inhibitory effect of Mani.

PubMed ID: 22771904

DOI: 10.1016/j.febslet.2012.06.043

PubMed ID: 23251525

Title: Microarray-assisted pathway analysis identifies MT1X & NFkappaB as mediators of TCRP1-associated resistance to cisplatin in oral squamous cell carcinoma.

PubMed ID: 23251525

DOI: 10.1371/journal.pone.0051413

PubMed ID: 25260657

Title: TCRP1 contributes to cisplatin resistance by preventing Pol beta degradation in lung cancer cells.

PubMed ID: 25260657

DOI: 10.1007/s11010-014-2217-x

Sequence Information:

  • Length: 244
  • Mass: 26184
  • Checksum: 60E3E9621665D30C
  • Sequence:
    • MNPVYSPVQP GAPYGNPKNM AYTGYPTAYP AAAPAYNPSL YPTNSPSYAP EFQFLHSAYA 
TLLMKQAWPQ NSSSCGTEGT FHLPVDTGTE NRTYQASSAA FRYTAGTPYK VPPTQSNTAP 
PPYSPSPNPY QTAMYPIRSA YPQQNLYAQG AYYTQPVYAA QPHVIHHTTV VQPNSIPSAI 
YPAPVAAPRT NGVAMGMVAG TTMAMSAGTL LTTPQHTAIG AHPVSMPTYR AQGTPAYSYV 
PPHW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.