Details for: ARL6IP1

Gene ID: 23204

Symbol: ARL6IP1

Ensembl ID: ENSG00000170540

Description: ADP ribosylation factor like GTPase 6 interacting protein 1

Associated with

  • Apoptotic process
    (GO:0006915)
  • Cotranslational protein targeting to membrane
    (GO:0006613)
  • Cytosol
    (GO:0005829)
  • Endoplasmic reticulum
    (GO:0005783)
  • Endoplasmic reticulum membrane
    (GO:0005789)
  • Endoplasmic reticulum tubular network
    (GO:0071782)
  • Endoplasmic reticulum tubular network formation
    (GO:0071787)
  • Endoplasmic reticulum tubular network membrane organization
    (GO:1990809)
  • Identical protein binding
    (GO:0042802)
  • Membrane
    (GO:0016020)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043154)
  • Positive regulation of l-glutamate import across plasma membrane
    (GO:0002038)
  • Protein binding
    (GO:0005515)
  • Regulation of endoplasmic reticulum tubular network organization
    (GO:1903371)
  • Sec61 translocon complex
    (GO:0005784)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.84
    Marker Score: 3,006
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 3.28
    Marker Score: 13,686
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 3.16
    Marker Score: 2,229
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.05
    Marker Score: 3,687
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.05
    Marker Score: 8,698
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.04
    Marker Score: 6,187
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 3.01
    Marker Score: 1,828
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.92
    Marker Score: 18,653
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.87
    Marker Score: 2,446
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.83
    Marker Score: 2,668
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.79
    Marker Score: 6,811
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.66
    Marker Score: 16,184
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 2.66
    Marker Score: 2,256
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.62
    Marker Score: 781
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.52
    Marker Score: 1,989
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.5
    Marker Score: 63,949
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 2.47
    Marker Score: 2,417
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.42
    Marker Score: 9,335
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 2.41
    Marker Score: 5,914
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.36
    Marker Score: 80,292
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.36
    Marker Score: 1,691
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.33
    Marker Score: 972
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.3
    Marker Score: 793
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.3
    Marker Score: 2,299
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.29
    Marker Score: 5,191
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.27
    Marker Score: 4,744
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.25
    Marker Score: 3,314
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.25
    Marker Score: 6,304
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.19
    Marker Score: 4,374
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.19
    Marker Score: 21,643
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.18
    Marker Score: 3,362
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 2.18
    Marker Score: 9,061
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.18
    Marker Score: 737
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 2.15
    Marker Score: 793
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.15
    Marker Score: 5,412
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2.12
    Marker Score: 8,197
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.11
    Marker Score: 1,981
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.09
    Marker Score: 1,797
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.08
    Marker Score: 9,996
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.07
    Marker Score: 3,526
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.06
    Marker Score: 1,377
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.06
    Marker Score: 13,169
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.06
    Marker Score: 2,312
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.04
    Marker Score: 8,002
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.02
    Marker Score: 2,140
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.02
    Marker Score: 824
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.01
    Marker Score: 69,771
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.01
    Marker Score: 3,397
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.99
    Marker Score: 1,745
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.98
    Marker Score: 2,912
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.97
    Marker Score: 2,070
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.97
    Marker Score: 5,267
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.96
    Marker Score: 2,780
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.96
    Marker Score: 1,984
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.94
    Marker Score: 34,387
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.93
    Marker Score: 3,427
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.92
    Marker Score: 1,204
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.92
    Marker Score: 387
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.91
    Marker Score: 1,101
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.9
    Marker Score: 1,979
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.89
    Marker Score: 1,374
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.88
    Marker Score: 3,117
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.88
    Marker Score: 1,173
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.88
    Marker Score: 3,418
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.87
    Marker Score: 1,945
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 1.86
    Marker Score: 994
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.85
    Marker Score: 10,982
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.85
    Marker Score: 2,116
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.84
    Marker Score: 1,333
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.84
    Marker Score: 539
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.83
    Marker Score: 1,008
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.82
    Marker Score: 434
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.82
    Marker Score: 8,921
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.8
    Marker Score: 423
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.8
    Marker Score: 604
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.79
    Marker Score: 7,735
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.79
    Marker Score: 2,099
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.79
    Marker Score: 778
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.79
    Marker Score: 15,415
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.79
    Marker Score: 1,122
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.78
    Marker Score: 1,112
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.78
    Marker Score: 59,985
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.77
    Marker Score: 4,214
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.77
    Marker Score: 4,898
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.77
    Marker Score: 2,495
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.77
    Marker Score: 835
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.75
    Marker Score: 5,510
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.74
    Marker Score: 1,187
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.74
    Marker Score: 65,934
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.74
    Marker Score: 432
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.73
    Marker Score: 23,298
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.73
    Marker Score: 896
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.73
    Marker Score: 339
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.73
    Marker Score: 1,656
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.72
    Marker Score: 432
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.72
    Marker Score: 5,015
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.72
    Marker Score: 1,444
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.71
    Marker Score: 998
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.69
    Marker Score: 1,510
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.69
    Marker Score: 445

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ARL6IP1 is a protein-coding gene that interacts with ADP-ribosylation factor-like GTPase 6 (ARL6), a crucial component in the regulation of cellular processes such as apoptosis, endoplasmic reticulum (ER) tubular network organization, and protein targeting to the membrane. The protein's ability to regulate these processes highlights its vital role in maintaining cellular homeostasis. **Pathways and Functions:** ARL6IP1 is implicated in several critical pathways, including: 1. **Apoptotic Process:** ARL6IP1 negatively regulates the apoptotic process, thereby preventing excessive cell death and maintaining tissue homeostasis. 2. **Cotranslational Protein Targeting to Membrane:** ARL6IP1 facilitates the targeting of proteins to the membrane, ensuring proper protein localization and function. 3. **Endoplasmic Reticulum Tubular Network Organization:** ARL6IP1 regulates the formation and organization of ER tubular networks, which are essential for protein folding, lipid synthesis, and calcium storage. 4. **Regulation of Endoplasmic Reticulum Tubular Network Membrane Organization:** ARL6IP1 ensures the proper membrane organization of ER tubular networks, which is critical for maintaining cellular function. **Clinical Significance:** The dysregulation of ARL6IP1 has been implicated in various diseases, including: 1. **Immunological Disorders:** ARL6IP1's role in regulating the apoptotic process and protein targeting to the membrane makes it a potential target for the treatment of immunological disorders, such as autoimmune diseases and cancer. 2. **Neurological Disorders:** The involvement of ARL6IP1 in the regulation of ER tubular networks and protein targeting to the membrane may contribute to its role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer:** ARL6IP1's negative regulation of the apoptotic process and its involvement in protein targeting to the membrane make it a potential target for cancer therapy. **Significantly Expressed Cells:** ARL6IP1 is expressed in various cell types, including: 1. **Thyroid Follicular Cells:** ARL6IP1 is expressed in thyroid follicular cells, where it regulates the apoptotic process and protein targeting to the membrane. 2. **GABAergic Neurons:** ARL6IP1 is expressed in GABAergic neurons, where it regulates the regulation of ER tubular networks and protein targeting to the membrane. 3. **Monocytes:** ARL6IP1 is expressed in monocytes, where it regulates the apoptotic process and protein targeting to the membrane. In conclusion, ARL6IP1 is a gene of growing interest in immunology, with a complex involvement in various cellular processes. Its dysregulation has been implicated in various diseases, highlighting its potential as a therapeutic target. Further research is necessary to fully elucidate the functions and clinical significance of ARL6IP1.

Genular Protein ID: 1817620222

Symbol: AR6P1_HUMAN

Name: ADP-ribosylation factor-like protein 6-interacting protein 1

UniProtKB Accession Codes:

Q15041 B7Z6S5 B7Z791 F5GXP4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 15 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7584044

Title: Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 7584044

DOI: 10.1093/dnares/1.5.223

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10995579

Title: Characterization, chromosomal localization, and expression during hematopoietic differentiation of the gene encoding Arl6ip, ADP-ribosylation-like factor-6 interacting protein (ARL6).

PubMed ID: 10995579

DOI: 10.1006/geno.2000.6278

PubMed ID: 12754298

Title: ARMER, apoptotic regulator in the membrane of the endoplasmic reticulum, a novel inhibitor of apoptosis.

PubMed ID: 12754298

PubMed ID: 24076029

Title: Determination of topological structure of ARL6ip1 in cells: identification of the essential binding region of ARL6ip1 for conophylline.

PubMed ID: 24076029

DOI: 10.1016/j.febslet.2013.09.017

PubMed ID: 24262037

Title: Arl6IP1 has the ability to shape the mammalian ER membrane in a reticulon-like fashion.

PubMed ID: 24262037

DOI: 10.1042/bj20131186

PubMed ID: 25612671

Title: Identification and characterization of TMEM33 as a reticulon-binding protein.

PubMed ID: 25612671

PubMed ID: 24482476

Title: Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders.

PubMed ID: 24482476

DOI: 10.1126/science.1247363

PubMed ID: 30237576

Title: Autozygome and high throughput confirmation of disease genes candidacy.

PubMed ID: 30237576

DOI: 10.1038/s41436-018-0138-x

Sequence Information:

  • Length: 203
  • Mass: 23363
  • Checksum: CE914D8FC9609FC6
  • Sequence:
    • MAEGDNRSTN LLAAETASLE EQLQGWGEVM LMADKVLRWE RAWFPPAIMG VVSLVFLIIY 
YLDPSVLSGV SCFVMFLCLA DYLVPILAPR IFGSNKWTTE QQQRFHEICS NLVKTRRRAV 
GWWKRLFTLK EEKPKMYFMT MIVSLAAVAW VGQQVHNLLL TYLIVTSLLL LPGLNQHGII 
LKYIGMAKRE INKLLKQKEK KNE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.