Details for: ARL6IP1

Gene ID: 23204

Symbol: ARL6IP1

Ensembl ID: ENSG00000170540

Description: ADP ribosylation factor like GTPase 6 interacting protein 1

Associated with

  • Apoptotic process
    (GO:0006915)
  • Cotranslational protein targeting to membrane
    (GO:0006613)
  • Cytosol
    (GO:0005829)
  • Endoplasmic reticulum
    (GO:0005783)
  • Endoplasmic reticulum membrane
    (GO:0005789)
  • Endoplasmic reticulum tubular network
    (GO:0071782)
  • Endoplasmic reticulum tubular network formation
    (GO:0071787)
  • Endoplasmic reticulum tubular network membrane organization
    (GO:1990809)
  • Identical protein binding
    (GO:0042802)
  • Membrane
    (GO:0016020)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043154)
  • Positive regulation of l-glutamate import across plasma membrane
    (GO:0002038)
  • Protein binding
    (GO:0005515)
  • Regulation of endoplasmic reticulum tubular network organization
    (GO:1903371)
  • Sec61 translocon complex
    (GO:0005784)

Other Information

Genular Protein ID: 1817620222

Symbol: AR6P1_HUMAN

Name: ADP-ribosylation factor-like protein 6-interacting protein 1

UniProtKB Accession Codes:

Q15041 B7Z6S5 B7Z791 F5GXP4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 15 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7584044

Title: Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 7584044

DOI: 10.1093/dnares/1.5.223

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10995579

Title: Characterization, chromosomal localization, and expression during hematopoietic differentiation of the gene encoding Arl6ip, ADP-ribosylation-like factor-6 interacting protein (ARL6).

PubMed ID: 10995579

DOI: 10.1006/geno.2000.6278

PubMed ID: 12754298

Title: ARMER, apoptotic regulator in the membrane of the endoplasmic reticulum, a novel inhibitor of apoptosis.

PubMed ID: 12754298

PubMed ID: 24076029

Title: Determination of topological structure of ARL6ip1 in cells: identification of the essential binding region of ARL6ip1 for conophylline.

PubMed ID: 24076029

DOI: 10.1016/j.febslet.2013.09.017

PubMed ID: 24262037

Title: Arl6IP1 has the ability to shape the mammalian ER membrane in a reticulon-like fashion.

PubMed ID: 24262037

DOI: 10.1042/bj20131186

PubMed ID: 25612671

Title: Identification and characterization of TMEM33 as a reticulon-binding protein.

PubMed ID: 25612671

PubMed ID: 24482476

Title: Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders.

PubMed ID: 24482476

DOI: 10.1126/science.1247363

PubMed ID: 30237576

Title: Autozygome and high throughput confirmation of disease genes candidacy.

PubMed ID: 30237576

DOI: 10.1038/s41436-018-0138-x

Sequence Information:

  • Length: 203
  • Mass: 23363
  • Checksum: CE914D8FC9609FC6
  • Sequence:
    • MAEGDNRSTN LLAAETASLE EQLQGWGEVM LMADKVLRWE RAWFPPAIMG VVSLVFLIIY 
YLDPSVLSGV SCFVMFLCLA DYLVPILAPR IFGSNKWTTE QQQRFHEICS NLVKTRRRAV 
GWWKRLFTLK EEKPKMYFMT MIVSLAAVAW VGQQVHNLLL TYLIVTSLLL LPGLNQHGII 
LKYIGMAKRE INKLLKQKEK KNE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.