Details for: ACSBG1

Gene ID: 23205

Symbol: ACSBG1

Ensembl ID: ENSG00000103740

Description: acyl-CoA synthetase bubblegum family member 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.92
    Marker Score: 62,427
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 2.85
    Marker Score: 5,902
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.26
    Marker Score: 1,487
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.76
    Marker Score: 1,529
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1,169
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.46
    Marker Score: 1,097
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 855
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.19
    Marker Score: 18,655
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,826
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,051
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,330
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.92
    Marker Score: 1,734
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,739
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.91
    Marker Score: 377
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.89
    Marker Score: 2,089
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,288
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.84
    Marker Score: 385
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 606
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,263
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.74
    Marker Score: 1,295
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.72
    Marker Score: 288
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.72
    Marker Score: 207
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2,970
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.64
    Marker Score: 196
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.63
    Marker Score: 2,159
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.61
    Marker Score: 274
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.61
    Marker Score: 5,271
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.56
    Marker Score: 358
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.53
    Marker Score: 1,086
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.52
    Marker Score: 167
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.52
    Marker Score: 311
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.5
    Marker Score: 717
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.48
    Marker Score: 153
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.46
    Marker Score: 204
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.44
    Marker Score: 1,061
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.42
    Marker Score: 1,608
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.41
    Marker Score: 102
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.41
    Marker Score: 559
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.39
    Marker Score: 407
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.38
    Marker Score: 259
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.37
    Marker Score: 175
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.31
    Marker Score: 126
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.3
    Marker Score: 576
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.29
    Marker Score: 75
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.28
    Marker Score: 119
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.27
    Marker Score: 86
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.27
    Marker Score: 486
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.26
    Marker Score: 122
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.24
    Marker Score: 4,337
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.24
    Marker Score: 63
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.23
    Marker Score: 103
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.22
    Marker Score: 66
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.21
    Marker Score: 94
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.21
    Marker Score: 255
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.19
    Marker Score: 235
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.18
    Marker Score: 112
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.18
    Marker Score: 89
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.17
    Marker Score: 60
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.17
    Marker Score: 116
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.17
    Marker Score: 59
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.16
    Marker Score: 119
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.15
    Marker Score: 80
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.15
    Marker Score: 75
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.15
    Marker Score: 53
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.14
    Marker Score: 53
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.14
    Marker Score: 91
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.13
    Marker Score: 193
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.13
    Marker Score: 88
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.12
    Marker Score: 70
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.12
    Marker Score: 153
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.12
    Marker Score: 203
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.12
    Marker Score: 124
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.12
    Marker Score: 183
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.12
    Marker Score: 49
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.12
    Marker Score: 53
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.11
    Marker Score: 466
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.11
    Marker Score: 49
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.11
    Marker Score: 67
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.11
    Marker Score: 60
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.11
    Marker Score: 1,143
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.11
    Marker Score: 24
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.11
    Marker Score: 72
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.11
    Marker Score: 63
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.11
    Marker Score: 44
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.11
    Marker Score: 178
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.1
    Marker Score: 96
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.1
    Marker Score: 92

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ACSBG1 is a member of the acyl-CoA synthetase bubblegum family, a group of enzymes responsible for catalyzing the transfer of acyl groups to CoA molecules. The ACSBG1 protein is a cytosolic enzyme that exhibits a high degree of specificity for long-chain fatty acids, with a preference for palmitoyl-CoA and stearoyl-CoA. This specificity is crucial for maintaining the delicate balance of fatty acid metabolism in cells. **Pathways and Functions:** ACSBG1 plays a pivotal role in various cellular pathways, including: 1. **Fatty Acid Metabolism:** ACSBG1 is involved in the synthesis and degradation of long-chain fatty acids, which are essential for energy production, membrane biogenesis, and signaling pathways. 2. **Myelination:** ACSBG1 has been implicated in the regulation of myelin sheath formation, a critical process in the development of the nervous system. 3. **Glucocorticoid Response:** ACSBG1 is responsive to glucocorticoids, which are steroid hormones that regulate a wide range of physiological processes, including metabolism, immune response, and stress response. 4. **Endoplasmic Reticulum Stress Response:** ACSBG1 has been shown to play a role in the regulation of endoplasmic reticulum (ER) stress response, a critical mechanism for maintaining cellular homeostasis. **Clinical Significance:** The dysregulation of ACSBG1 has been implicated in various diseases, including: 1. **Metabolic Disorders:** Abnormalities in fatty acid metabolism have been linked to metabolic disorders, such as obesity, type 2 diabetes, and dyslipidemia. 2. **Neurological Disorders:** Dysregulation of myelination and ER stress response has been implicated in neurological disorders, such as multiple sclerosis, Parkinson's disease, and Alzheimer's disease. 3. **Cancer:** ACSBG1 has been shown to play a role in cancer cell metabolism, with implications for the development of novel therapeutic strategies. In conclusion, ACSBG1 is a multifunctional gene that plays a critical role in maintaining cellular homeostasis and regulating various cellular processes, including fatty acid metabolism, myelination, and glucocorticoid response. Further research is needed to fully elucidate the mechanisms underlying ACSBG1's function and to explore its potential as a therapeutic target for various diseases. **Recommendations:** 1. Further studies are needed to elucidate the mechanisms underlying ACSBG1's function in fatty acid metabolism and myelination. 2. The role of ACSBG1 in glucocorticoid response and ER stress response requires further investigation. 3. The potential of ACSBG1 as a therapeutic target for metabolic disorders, neurological disorders, and cancer warrants further exploration. By advancing our understanding of ACSBG1's function and its implications in disease pathogenesis, we can unlock new avenues for therapeutic innovation and improve our ability to diagnose and treat a range of diseases.

Genular Protein ID: 1469530056

Symbol: ACBG1_HUMAN

Name: Acyl-CoA synthetase bubblegum family member 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10954726

Title: Very long-chain acyl-CoA synthetases. Human 'bubblegum' represents a new family of proteins capable of activating very long-chain fatty acids.

PubMed ID: 10954726

DOI: 10.1074/jbc.m006403200

PubMed ID: 9734811

Title: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9734811

DOI: 10.1093/dnares/5.3.169

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12975357

Title: The acyl-CoA synthetase 'bubblegum' (lipidosin): further characterization and role in neuronal fatty acid beta-oxidation.

PubMed ID: 12975357

DOI: 10.1074/jbc.m310075200

PubMed ID: 24269233

Title: Identification of acyl-CoA synthetases involved in the mammalian sphingosine 1-phosphate metabolic pathway.

PubMed ID: 24269233

DOI: 10.1016/j.bbrc.2013.11.036

Sequence Information:

  • Length: 724
  • Mass: 81290
  • Checksum: 2C27BA65CE95CE17
  • Sequence:
  • MPRNSGAGYG CPHGDPSMLD SRETPQESRQ DMIVRTTQEK LKTSSLTDRQ PLSKESLNHA 
    LELSVPEKVN NAQWDAPEEA LWTTRADGRV RLRIDPSCPQ LPYTVHRMFY EALDKYGDLI 
    ALGFKRQDKW EHISYSQYYL LARRAAKGFL KLGLKQAHSV AILGFNSPEW FFSAVGTVFA 
    GGIVTGIYTT SSPEACQYIA YDCCANVIMV DTQKQLEKIL KIWKQLPHLK AVVIYKEPPP 
    NKMANVYTME EFMELGNEVP EEALDAIIDT QQPNQCCVLV YTSGTTGNPK GVMLSQDNIT 
    WTARYGSQAG DIRPAEVQQE VVVSYLPLSH IAAQIYDLWT GIQWGAQVCF AEPDALKGSL 
    VNTLREVEPT SHMGVPRVWE KIMERIQEVA AQSGFIRRKM LLWAMSVTLE QNLTCPGSDL 
    KPFTTRLADY LVLAKVRQAL GFAKCQKNFY GAAPMMAETQ HFFLGLNIRL YAGYGLSETS 
    GPHFMSSPYN YRLYSSGKLV PGCRVKLVNQ DAEGIGEICL WGRTIFMGYL NMEDKTCEAI 
    DEEGWLHTGD AGRLDADGFL YITGRLKELI ITAGGENVPP VPIEEAVKME LPIISNAMLI 
    GDQRKFLSML LTLKCTLDPD TSDQTDNLTE QAMEFCQRVG SRATTVSEII EKKDEAVYQA 
    IEEGIRRVNM NAAARPYHIQ KWAILERDFS ISGGELGPTM KLKRLTVLEK YKGIIDSFYQ 
    EQKM

Genular Protein ID: 3787208836

Symbol: B3KNS7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 724
  • Mass: 81318
  • Checksum: BB99AA6B08A2CE13
  • Sequence:
  • MPRNSGAGYG CPHGDPSMLD SRETPQESRQ DMIVRTTQEK LKTSSLTDRQ PLSKESLNHA 
    LELSVPEKVN NAQWDAPEEA LWTTRADGRV RLRIDPSCPQ LPYTVHRMFY EALDKYGDLI 
    ALGFKRQDKW EHISYSQYYL LARRAAKGFL KLGLKQAHSV AILGFNSPEW FFSAVGTVFA 
    GGIVTGIYTT SSPEACQYIA YDCCANVIMV DTQKQLEKIL KIWKQLPHLK AVVIYKEPPP 
    NKMANVYTME EFMELGNEVP EEALDAIIDT QQPNQCCVLV YTSGTTGNPK GVMLSQDNIT 
    WTARYGSQAG DIRPAEVQQE VVVSYLPLSH IAAQIYDLWT GIQWGAQVCF AEPDALKGSL 
    VNTLREVEPT SHMGVPRVWE KIMERIQEVA AQSGFIRRKM LLWAMSVTLE QNLTCPGSDL 
    KPFTTRLADY LVLAKVRQAL GFAKCQKNFY GAVPMMAETQ HFFLGLNIRL YAGYGLSETS 
    GPHFMSSPYN YRLYSSGKLV PGCRVKLVNQ DAEGIGEICL WGRTIFMGYL NMEDKTCEAI 
    DEEGWLHTGD AGRLDADGFL YITGRLKELI ITAGGENVPP VPIEEAVKME LPIISNAMLI 
    GDQRKFLSML LTLKCTLDPD TSDQTDNLTE QAMEFCQRVG SRATTVSEII EKKDEAVYQA 
    IEEGIRRVNM NAAARPYHIQ KWAILERDFS ISGGELGPTM KLKRLTVLEK YKGIIDSFYQ 
    EQKM

Genular Protein ID: 2590849556

Symbol: B7Z2Y6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 720
  • Mass: 80817
  • Checksum: 4CC560F276F5AEC4
  • Sequence:
  • MPRNSGAGYG CPHGDPSMLD SRETPQESRQ DMIVRTTQEK LKTSSLTDRQ PLSKESLNHA 
    LELSVPEKVN NAQWDAPEEA LWTTRADGRV RLRIDPSCPQ LPYTVHRMFY EALDKYGDLI 
    ALGFKRQDKW EHISYSQYYL LARRAAKGFL KQAHSVAILG FNSPEWFFSA VGTVFAGGIV 
    TGIYTTSSPE ACQYIAYDCC ANVIMVDTQK QLEKILKIWK QLPHLKAVVI YKEPPPNKMA 
    NVYTMEEFME LGNEVPEEAL DAIIDTQQPN QCCVLVYTSG TTGNPKGVML SQDNITWTAR 
    YGSQAGDIRP AEVQQEVVVS YLPLSHIAAQ IYDLWTGIQW GAQVCFAEPD ALKGSLVNTL 
    REVEPTSHMG VPRVWVKIME RIQEVAAQSG FIRRKMLLWA MSVTLEQNLT CPGSDLKPFT 
    TRLADYLVLA KVRQALGFAK CQKNFYGAAP MMAETQHFFL GLNIRLYAGY GLSETSGPHF 
    MSSPYNYRLY SSGKLVPGCR VKLVNQDAEG IGEICLWGRT IFMGYLNMED KTCEAIDEEG 
    WLHTGDAGRL DADGFLYITG RLKELIITAG GENVPPVPIE EAVKMELPII SNAMLIGDQR 
    KFLSMLLTLK CTLDPDTSDQ TDNLTEQAVE FCQRVGSRAT TVSEIIEKKD EAVYQAIEEG 
    IRRVNMNAAA RPYHIQKWAI LERDFSISGG ELGPTMKLKR LTVLEKYKGI IDSFYQEQKM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.