Details for: PLEKHM2

Gene ID: 23207

Symbol: PLEKHM2

Ensembl ID: ENSG00000116786

Description: pleckstrin homology and RUN domain containing M2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.38
    Marker Score: 80,994
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.77
    Marker Score: 7,402
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.69
    Marker Score: 1,779
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.54
    Marker Score: 94,902
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.42
    Marker Score: 13,375
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.42
    Marker Score: 31,723
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.37
    Marker Score: 12,998
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.34
    Marker Score: 11,479
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.34
    Marker Score: 1,476
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.31
    Marker Score: 26,112
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.31
    Marker Score: 549
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.3
    Marker Score: 48,139
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.3
    Marker Score: 2,754
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.3
    Marker Score: 5,281
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.27
    Marker Score: 1,958
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.27
    Marker Score: 13,085
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.23
    Marker Score: 4,369
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.23
    Marker Score: 4,750
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.21
    Marker Score: 18,050
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.21
    Marker Score: 688
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.2
    Marker Score: 18,759
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.19
    Marker Score: 9,086
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.15
    Marker Score: 786
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.15
    Marker Score: 24,489
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.13
    Marker Score: 5,568
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.13
    Marker Score: 4,664
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.12
    Marker Score: 42,388
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.11
    Marker Score: 572
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.11
    Marker Score: 644
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.1
    Marker Score: 693
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.04
    Marker Score: 2,614
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.04
    Marker Score: 2,459
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.04
    Marker Score: 6,321
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.03
    Marker Score: 1,095
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.01
    Marker Score: 1,159
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1
    Marker Score: 1,205
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,705
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,930
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.99
    Marker Score: 314
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.98
    Marker Score: 547
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,393
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.97
    Marker Score: 224
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.96
    Marker Score: 3,721
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.96
    Marker Score: 578
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.94
    Marker Score: 466
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,396
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.94
    Marker Score: 2,315
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 480
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.93
    Marker Score: 2,043
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.91
    Marker Score: 442
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,703
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.9
    Marker Score: 750
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.89
    Marker Score: 1,069
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.88
    Marker Score: 3,253
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,294
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.87
    Marker Score: 309
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.87
    Marker Score: 484
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.87
    Marker Score: 7,601
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.86
    Marker Score: 236
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.86
    Marker Score: 1,649
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4,851
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.85
    Marker Score: 1,054
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.84
    Marker Score: 1,371
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.83
    Marker Score: 3,820
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.82
    Marker Score: 478
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.82
    Marker Score: 1,185
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.81
    Marker Score: 296
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.8
    Marker Score: 1,634
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.8
    Marker Score: 801
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.8
    Marker Score: 398
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.8
    Marker Score: 532
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.8
    Marker Score: 438
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 599
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 313
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.77
    Marker Score: 761
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.77
    Marker Score: 269
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.77
    Marker Score: 273
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.77
    Marker Score: 486
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.76
    Marker Score: 660
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.76
    Marker Score: 316
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.75
    Marker Score: 19,298
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.75
    Marker Score: 858
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.75
    Marker Score: 805
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.74
    Marker Score: 251
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.74
    Marker Score: 766
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3,063
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 373
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.72
    Marker Score: 624
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.72
    Marker Score: 486
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.72
    Marker Score: 810
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.71
    Marker Score: 264
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.71
    Marker Score: 39,712
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7
    Marker Score: 1,034
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.7
    Marker Score: 4,201
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.69
    Marker Score: 202
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.69
    Marker Score: 221
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.68
    Marker Score: 154
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.68
    Marker Score: 10,936

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PLEKHM2 is a relatively understudied gene, with limited information available in the literature. However, based on the available data, we can infer the following characteristics: 1. **Cell type specificity:** PLEKHM2 is predominantly expressed in specific cell types, including fibroblasts of the mammary gland, pigmented epithelial cells, conjunctival epithelial cells, and various types of neurons. 2. **Protein binding:** PLEKHM2 interacts with multiple proteins, including those involved in endosome membrane organization, Golgi function, and lysosomal membrane regulation. 3. **Regulation of protein localization:** PLEKHM2 plays a crucial role in regulating the localization of proteins within cells, which is essential for maintaining cellular homeostasis and function. **Pathways and Functions:** PLEKHM2 is involved in several signaling pathways, including: 1. **Endosome membrane organization:** PLEKHM2 regulates the organization of endosomes, which is essential for maintaining cellular homeostasis and function. 2. **Golgi organization:** PLEKHM2 interacts with Golgi proteins, ensuring proper Golgi function and protein trafficking. 3. **Kinesin binding:** PLEKHM2 binds to kinesin proteins, which are involved in motor transport within cells. 4. **Lysosomal membrane regulation:** PLEKHM2 regulates the organization of lysosomal membranes, which is essential for maintaining cellular homeostasis and function. 5. **Natural killer cell mediated cytotoxicity:** PLEKHM2 is involved in regulating the function of natural killer cells, which play a crucial role in immune surveillance. **Clinical Significance:** While PLEKHM2 is not well-studied, its involvement in various cellular processes suggests potential implications in immunological disorders. Some possible clinical implications of PLEKHM2 dysfunction include: 1. **Autoimmune diseases:** Dysregulation of PLEKHM2 could contribute to autoimmune diseases, such as rheumatoid arthritis or lupus, by disrupting normal cellular homeostasis. 2. **Neurological disorders:** PLEKHM2's role in regulating protein localization and lysosomal membrane organization suggests potential implications in neurological disorders, such as Alzheimer's disease or Parkinson's disease. 3. **Cancer:** PLEKHM2's involvement in regulating endosome membrane organization and Golgi function suggests potential implications in cancer development and progression. In conclusion, PLEKHM2 is a multifunctional gene with significant implications in various cellular processes. Further research is needed to fully elucidate the role of PLEKHM2 in immunological disorders and its potential therapeutic applications.

Genular Protein ID: 3387786293

Symbol: PKHM2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8IWE5 O94928 Q5VT65 Q5VVD7 Q6NUH9 Q7L8G1 Q8IVT7 Q8N2T4 Q96AY0 Q9NTF7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 11 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 3 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15905402

Title: The intracellular fate of Salmonella depends on the recruitment of kinesin.

PubMed ID: 15905402

DOI: 10.1126/science.1110225

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 22172677

Title: Arl8 and SKIP act together to link lysosomes to kinesin-1.

PubMed ID: 22172677

DOI: 10.1016/j.devcel.2011.10.007

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24088571

Title: Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity.

PubMed ID: 24088571

DOI: 10.1091/mbc.e13-05-0259

PubMed ID: 25898167

Title: BORC, a multisubunit complex that regulates lysosome positioning.

PubMed ID: 25898167

DOI: 10.1016/j.devcel.2015.02.011

PubMed ID: 28325809

Title: The Rab7 effector PLEKHM1 binds Arl8b to promote cargo traffic to lysosomes.

PubMed ID: 28325809

DOI: 10.1083/jcb.201607085

PubMed ID: 18996344

Title: Structure and function of Salmonella SifA indicate that its interactions with SKIP, SseJ, and RhoA family GTPases induce endosomal tubulation.

PubMed ID: 18996344

DOI: 10.1016/j.chom.2008.08.012

Sequence Information:

  • Length: 1019
  • Mass: 112780
  • Checksum: FFD857F4C11BC0DB
  • Sequence:
    • MEPGEVKDRI LENISLSVKK LQSYFAACED EIPAIRNHDK VLQRLCEHLD HALLYGLQDL 
SSGYWVLVVH FTRREAIKQI EVLQHVATNL GRSRAWLYLA LNENSLESYL RLFQENLGLL 
HKYYVKNALV CSHDHLTLFL TLVSGLEFIR FELDLDAPYL DLAPYMPDYY KPQYLLDFED 
RLPSSVHGSD SLSLNSFNSV TSTNLEWDDS AIAPSSEDYD FGDVFPAVPS VPSTDWEDGD 
LTDTVSGPRS TASDLTSSKA STRSPTQRQN PFNEEPAETV SSSDTTPVHT TSQEKEEAQA 
LDPPDACTEL EVIRVTKKKK IGKKKKSRSD EEASPLHPAC SQKKCAKQGD GDSRNGSPSL 
GRDSPDTMLA SPQEEGEGPS STTESSERSE PGLLIPEMKD TSMERLGQPL SKVIDQLNGQ 
LDPSTWCSRA EPPDQSFRTG SPGDAPERPP LCDFSEGLSA PMDFYRFTVE SPSTVTSGGG 
HHDPAGLGQP LHVPSSPEAA GQEEEGGGGE GQTPRPLEDT TREAQELEAQ LSLVREGPVS 
EPEPGTQEVL CQLKRDQPSP CLSSAEDSGV DEGQGSPSEM VHSSEFRVDN NHLLLLMIHV 
FRENEEQLFK MIRMSTGHME GNLQLLYVLL TDCYVYLLRK GATEKPYLVE EAVSYNELDY 
VSVGLDQQTV KLVCTNRRKQ FLLDTADVAL AEFFLASLKS AMIKGCREPP YPSILTDATM 
EKLALAKFVA QESKCEASAV TVRFYGLVHW EDPTDESLGP TPCHCSPPEG TITKEGMLHY 
KAGTSYLGKE HWKTCFVVLS NGILYQYPDR TDVIPLLSVN MGGEQCGGCR RANTTDRPHA 
FQVILSDRPC LELSAESEAE MAEWMQHLCQ AVSKGVIPQG VAPSPCIPCC LVLTDDRLFT 
CHEDCQTSFF RSLGTAKLGD ISAVSTEPGK EYCVLEFSQD SQQLLPPWVI YLSCTSELDR 
LLSALNSGWK TIYQVDLPHT AIQEASNKKK FEDALSLIHS AWQRSDSLCR GRASRDPWC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.