Details for: PLEKHM2
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.38
Marker Score: 80,994 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.77
Marker Score: 7,402 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.69
Marker Score: 1,779 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.54
Marker Score: 94,902 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.42
Marker Score: 13,375 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 1.42
Marker Score: 31,723 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.37
Marker Score: 12,998 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.34
Marker Score: 11,479 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.34
Marker Score: 1,476 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.31
Marker Score: 26,112 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.31
Marker Score: 549 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.3
Marker Score: 48,139 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.3
Marker Score: 2,754 - Cell Name: neuron (CL0000540)
Fold Change: 1.3
Marker Score: 5,281 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.27
Marker Score: 1,958 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.27
Marker Score: 13,085 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 1.23
Marker Score: 4,369 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.23
Marker Score: 4,750 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.21
Marker Score: 18,050 - Cell Name: fibroblast of breast (CL4006000)
Fold Change: 1.21
Marker Score: 688 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.2
Marker Score: 18,759 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.19
Marker Score: 9,086 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 1.15
Marker Score: 786 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.15
Marker Score: 24,489 - Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 1.13
Marker Score: 5,568 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.13
Marker Score: 4,664 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.12
Marker Score: 42,388 - Cell Name: endocrine cell (CL0000163)
Fold Change: 1.11
Marker Score: 572 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.11
Marker Score: 644 - Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.1
Marker Score: 693 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.04
Marker Score: 2,614 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.04
Marker Score: 2,459 - Cell Name: elicited macrophage (CL0000861)
Fold Change: 1.04
Marker Score: 6,321 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.03
Marker Score: 1,095 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.01
Marker Score: 1,159 - Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 1
Marker Score: 1,205 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,705 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47,930 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.99
Marker Score: 314 - Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 0.98
Marker Score: 547 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,393 - Cell Name: keratocyte (CL0002363)
Fold Change: 0.97
Marker Score: 224 - Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.96
Marker Score: 3,721 - Cell Name: IgG memory B cell (CL0000979)
Fold Change: 0.96
Marker Score: 578 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.94
Marker Score: 466 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2,396 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.94
Marker Score: 2,315 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.93
Marker Score: 480 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.93
Marker Score: 2,043 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.92
Marker Score: 435 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.91
Marker Score: 442 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.9
Marker Score: 2,703 - Cell Name: keratinocyte (CL0000312)
Fold Change: 0.9
Marker Score: 750 - Cell Name: mesangial cell (CL0000650)
Fold Change: 0.89
Marker Score: 1,069 - Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.88
Marker Score: 3,253 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,294 - Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.87
Marker Score: 309 - Cell Name: fat cell (CL0000136)
Fold Change: 0.87
Marker Score: 484 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.87
Marker Score: 7,601 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.86
Marker Score: 236 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.86
Marker Score: 309 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.86
Marker Score: 1,649 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.85
Marker Score: 4,851 - Cell Name: cardiac neuron (CL0010022)
Fold Change: 0.85
Marker Score: 1,054 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.84
Marker Score: 1,371 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 0.83
Marker Score: 3,820 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.82
Marker Score: 478 - Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 0.82
Marker Score: 1,185 - Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 0.81
Marker Score: 296 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.8
Marker Score: 1,634 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.8
Marker Score: 801 - Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.8
Marker Score: 398 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.8
Marker Score: 532 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.8
Marker Score: 438 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.78
Marker Score: 599 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.78
Marker Score: 313 - Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 0.77
Marker Score: 761 - Cell Name: ependymal cell (CL0000065)
Fold Change: 0.77
Marker Score: 269 - Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.77
Marker Score: 273 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.77
Marker Score: 486 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.76
Marker Score: 660 - Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 0.76
Marker Score: 316 - Cell Name: alveolar macrophage (CL0000583)
Fold Change: 0.75
Marker Score: 19,298 - Cell Name: lung macrophage (CL1001603)
Fold Change: 0.75
Marker Score: 858 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.75
Marker Score: 805 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.74
Marker Score: 251 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.74
Marker Score: 766 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.73
Marker Score: 3,063 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.72
Marker Score: 373 - Cell Name: astrocyte (CL0000127)
Fold Change: 0.72
Marker Score: 624 - Cell Name: proerythroblast (CL0000547)
Fold Change: 0.72
Marker Score: 486 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.72
Marker Score: 810 - Cell Name: podocyte (CL0000653)
Fold Change: 0.71
Marker Score: 264 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.71
Marker Score: 39,712 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.7
Marker Score: 1,034 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.7
Marker Score: 4,201 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.69
Marker Score: 202 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.69
Marker Score: 221 - Cell Name: PP cell (CL0000696)
Fold Change: 0.68
Marker Score: 154 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.68
Marker Score: 10,936
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3387786293
Symbol: PKHM2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10048485
Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 10048485
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15905402
Title: The intracellular fate of Salmonella depends on the recruitment of kinesin.
PubMed ID: 15905402
PubMed ID: 18220336
Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
PubMed ID: 18220336
DOI: 10.1021/pr0705441
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 22172677
Title: Arl8 and SKIP act together to link lysosomes to kinesin-1.
PubMed ID: 22172677
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24088571
Title: Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity.
PubMed ID: 24088571
PubMed ID: 25898167
Title: BORC, a multisubunit complex that regulates lysosome positioning.
PubMed ID: 25898167
PubMed ID: 28325809
Title: The Rab7 effector PLEKHM1 binds Arl8b to promote cargo traffic to lysosomes.
PubMed ID: 28325809
PubMed ID: 18996344
Title: Structure and function of Salmonella SifA indicate that its interactions with SKIP, SseJ, and RhoA family GTPases induce endosomal tubulation.
PubMed ID: 18996344
Sequence Information:
- Length: 1019
- Mass: 112780
- Checksum: FFD857F4C11BC0DB
- Sequence:
MEPGEVKDRI LENISLSVKK LQSYFAACED EIPAIRNHDK VLQRLCEHLD HALLYGLQDL SSGYWVLVVH FTRREAIKQI EVLQHVATNL GRSRAWLYLA LNENSLESYL RLFQENLGLL HKYYVKNALV CSHDHLTLFL TLVSGLEFIR FELDLDAPYL DLAPYMPDYY KPQYLLDFED RLPSSVHGSD SLSLNSFNSV TSTNLEWDDS AIAPSSEDYD FGDVFPAVPS VPSTDWEDGD LTDTVSGPRS TASDLTSSKA STRSPTQRQN PFNEEPAETV SSSDTTPVHT TSQEKEEAQA LDPPDACTEL EVIRVTKKKK IGKKKKSRSD EEASPLHPAC SQKKCAKQGD GDSRNGSPSL GRDSPDTMLA SPQEEGEGPS STTESSERSE PGLLIPEMKD TSMERLGQPL SKVIDQLNGQ LDPSTWCSRA EPPDQSFRTG SPGDAPERPP LCDFSEGLSA PMDFYRFTVE SPSTVTSGGG HHDPAGLGQP LHVPSSPEAA GQEEEGGGGE GQTPRPLEDT TREAQELEAQ LSLVREGPVS EPEPGTQEVL CQLKRDQPSP CLSSAEDSGV DEGQGSPSEM VHSSEFRVDN NHLLLLMIHV FRENEEQLFK MIRMSTGHME GNLQLLYVLL TDCYVYLLRK GATEKPYLVE EAVSYNELDY VSVGLDQQTV KLVCTNRRKQ FLLDTADVAL AEFFLASLKS AMIKGCREPP YPSILTDATM EKLALAKFVA QESKCEASAV TVRFYGLVHW EDPTDESLGP TPCHCSPPEG TITKEGMLHY KAGTSYLGKE HWKTCFVVLS NGILYQYPDR TDVIPLLSVN MGGEQCGGCR RANTTDRPHA FQVILSDRPC LELSAESEAE MAEWMQHLCQ AVSKGVIPQG VAPSPCIPCC LVLTDDRLFT CHEDCQTSFF RSLGTAKLGD ISAVSTEPGK EYCVLEFSQD SQQLLPPWVI YLSCTSELDR LLSALNSGWK TIYQVDLPHT AIQEASNKKK FEDALSLIHS AWQRSDSLCR GRASRDPWC
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.