Details for: SYT11

Gene ID: 23208

Symbol: SYT11

Ensembl ID: ENSG00000132718

Description: synaptotagmin 11

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 3.52
    Marker Score: 4,955
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.79
    Marker Score: 14,617
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.52
    Marker Score: 6,026
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.23
    Marker Score: 10,295
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.13
    Marker Score: 42,381
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.09
    Marker Score: 79,556
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.06
    Marker Score: 15,772
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.01
    Marker Score: 7,772
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.99
    Marker Score: 42,475
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.99
    Marker Score: 29,746
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.96
    Marker Score: 1,957
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.94
    Marker Score: 8,041
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.84
    Marker Score: 113,136
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.8
    Marker Score: 18,613
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.79
    Marker Score: 2,013
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.78
    Marker Score: 15,305
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.78
    Marker Score: 16,896
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.77
    Marker Score: 65,296
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.74
    Marker Score: 16,381
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.73
    Marker Score: 2,394
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.7
    Marker Score: 57,530
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.68
    Marker Score: 566
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.61
    Marker Score: 5,413
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.57
    Marker Score: 8,435
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.57
    Marker Score: 1,139
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.56
    Marker Score: 6,349
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.53
    Marker Score: 3,509
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.52
    Marker Score: 2,339
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.51
    Marker Score: 11,372
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.45
    Marker Score: 2,937
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.36
    Marker Score: 795
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.35
    Marker Score: 1,672
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.27
    Marker Score: 418
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.2
    Marker Score: 1,043
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.19
    Marker Score: 783
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.17
    Marker Score: 472
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.17
    Marker Score: 551
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.16
    Marker Score: 688
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4,767
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.09
    Marker Score: 1,312
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.01
    Marker Score: 373
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1
    Marker Score: 1,684
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,769
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,994
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.99
    Marker Score: 938
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,403
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.96
    Marker Score: 217
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.96
    Marker Score: 501
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.96
    Marker Score: 1,947
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 490
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 444
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,304
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.92
    Marker Score: 374
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.92
    Marker Score: 380
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.92
    Marker Score: 1,054
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,727
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.91
    Marker Score: 470
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9
    Marker Score: 360
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.9
    Marker Score: 2,555
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.87
    Marker Score: 13,633
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 313
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,266
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.86
    Marker Score: 951
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.86
    Marker Score: 921
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.85
    Marker Score: 479
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.85
    Marker Score: 392
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.85
    Marker Score: 5,047
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.85
    Marker Score: 505
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.79
    Marker Score: 743
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.78
    Marker Score: 491
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1,238
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 580
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 688
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.75
    Marker Score: 938
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 381
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.73
    Marker Score: 548
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.71
    Marker Score: 214
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.69
    Marker Score: 287
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.68
    Marker Score: 304
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.68
    Marker Score: 325
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.67
    Marker Score: 215
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.65
    Marker Score: 376
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.63
    Marker Score: 243
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.62
    Marker Score: 375
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 0.62
    Marker Score: 182
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.61
    Marker Score: 1,152
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.6
    Marker Score: 1,419
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.59
    Marker Score: 263
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.57
    Marker Score: 330
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.57
    Marker Score: 3,442
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.57
    Marker Score: 156
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.56
    Marker Score: 677
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.56
    Marker Score: 3,550
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.55
    Marker Score: 2,281
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 436
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.55
    Marker Score: 171
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.54
    Marker Score: 260
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.54
    Marker Score: 1,719

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SYT11 is a calcium-binding protein that interacts with various signaling molecules, including synaptophysin, SNAP-25, and SNAP-29, to regulate neurotransmitter release. It is also involved in the regulation of vesicle fusion and exocytosis, which are essential for synaptic transmission. The protein has a unique structure, consisting of a calcium-binding domain, a transmembrane domain, and a cytoplasmic domain. SYT11 is highly conserved across species, suggesting its importance in neural function and development. **Pathways and Functions** SYT11 is involved in several key pathways, including: 1. **Calcium-dependent exocytosis**: SYT11 interacts with calcium channels to regulate neurotransmitter release from synaptic vesicles. 2. **Autophagy**: SYT11 is involved in the regulation of autophagy, a process by which cells recycle damaged or dysfunctional organelles and proteins. 3. **Membrane trafficking**: SYT11 regulates the movement of vesicles and organelles within the cell, including endocytosis and exocytosis. 4. **Neurotransmitter release**: SYT11 is involved in the regulation of neurotransmitter release, including dopamine and GABA. **Clinical Significance** Dysregulation of SYT11 has been implicated in various neurological disorders, including: 1. **Neurodegenerative diseases**: SYT11 has been linked to neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. 2. **Schizophrenia**: SYT11 has been implicated in schizophrenia, a psychiatric disorder characterized by cognitive and emotional disturbances. 3. **Depression**: SYT11 has been linked to depression, a mood disorder characterized by persistent feelings of sadness and loss of interest. 4. **Cerebral ischemia**: SYT11 has been implicated in cerebral ischemia, a condition characterized by reduced blood flow to the brain. In conclusion, SYT11 is a critical protein involved in regulating neurotransmitter release, synaptic transmission, and cellular processes. Dysregulation of SYT11 has been implicated in various neurological disorders, highlighting its importance in understanding the molecular mechanisms underlying these conditions. Further research is needed to elucidate the role of SYT11 in human health and disease.

Genular Protein ID: 3684136100

Symbol: SYT11_HUMAN

Name: Synaptotagmin XI

UniProtKB Accession Codes:

Q9BT88 Q14998 Q5W0D4 Q68CT5 Q8IXU3 Q96SU2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 8 Ensembl 1 GO 57 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7584044

Title: Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 7584044

DOI: 10.1093/dnares/1.5.223

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12925569

Title: The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI.

PubMed ID: 12925569

DOI: 10.1093/hmg/ddg269

PubMed ID: 27278822

Title: The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway.

PubMed ID: 27278822

DOI: 10.1038/ncomms11803

Sequence Information:

  • Length: 431
  • Mass: 48297
  • Checksum: 5C8667D2C23D758E
  • Sequence:
    • MAEITNIRPS FDVSPVVAGL IGASVLVVCV SVTVFVWSCC HQQAEKKQKN PPYKFIHMLK 
GISIYPETLS NKKKIIKVRR DKDGPGREGG RRNLLVDAAE AGLLSRDKDP RGPSSGSCID 
QLPIKMDYGE ELRSPITSLT PGESKTTSPS SPEEDVMLGS LTFSVDYNFP KKALVVTIQE 
AHGLPVMDDQ TQGSDPYIKM TILPDKRHRV KTRVLRKTLD PVFDETFTFY GIPYSQLQDL 
VLHFLVLSFD RFSRDDVIGE VMVPLAGVDP STGKVQLTRD IIKRNIQKCI SRGELQVSLS 
YQPVAQRMTV VVLKARHLPK MDITGLSGNP YVKVNVYYGR KRIAKKKTHV KKCTLNPIFN 
ESFIYDIPTD LLPDISIEFL VIDFDRTTKN EVVGRLILGA HSVTASGAEH WREVCESPRK 
PVAKWHSLSE Y

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.