Details for: MLC1
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.75
Marker Score: 37,446 - Cell Name: mature astrocyte (CL0002627)
Fold Change: 1.52
Marker Score: 999 - Cell Name: goblet cell (CL0000160)
Fold Change: 1.13
Marker Score: 7,518 - Cell Name: astrocyte (CL0000127)
Fold Change: 1.04
Marker Score: 901 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,816 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,040 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,408 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.97
Marker Score: 2,469 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5,334 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.93
Marker Score: 1,753 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2,741 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.91
Marker Score: 579 - Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 0.9
Marker Score: 290 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,286 - Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.83
Marker Score: 408 - Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.79
Marker Score: 595 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1,258 - Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 704 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 393 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.75
Marker Score: 570 - Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.71
Marker Score: 288 - Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 0.69
Marker Score: 500 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 176 - Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.65
Marker Score: 2,519 - Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 0.61
Marker Score: 415 - Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.59
Marker Score: 286 - Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 0.58
Marker Score: 192 - Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 0.58
Marker Score: 251 - Cell Name: promyelocyte (CL0000836)
Fold Change: 0.57
Marker Score: 284 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.57
Marker Score: 8,986 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.57
Marker Score: 1,158 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444 - Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 0.55
Marker Score: 4,690 - Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 0.55
Marker Score: 467 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.55
Marker Score: 287 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.54
Marker Score: 5,450 - Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.53
Marker Score: 141 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.52
Marker Score: 313 - Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 0.52
Marker Score: 1,518 - Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.52
Marker Score: 182 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.5
Marker Score: 507 - Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 0.49
Marker Score: 368 - Cell Name: osteoblast (CL0000062)
Fold Change: 0.46
Marker Score: 247 - Cell Name: pro-T cell (CL0000827)
Fold Change: 0.45
Marker Score: 1,838 - Cell Name: ILC1, human (CL0001077)
Fold Change: 0.45
Marker Score: 113 - Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 0.42
Marker Score: 346 - Cell Name: Unknown (CL0000548)
Fold Change: 0.4
Marker Score: 293 - Cell Name: mature B cell (CL0000785)
Fold Change: 0.4
Marker Score: 294 - Cell Name: preosteoblast (CL0007010)
Fold Change: 0.39
Marker Score: 111 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.38
Marker Score: 3,857 - Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.36
Marker Score: 207 - Cell Name: proerythroblast (CL0000547)
Fold Change: 0.36
Marker Score: 242 - Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 0.36
Marker Score: 372 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.35
Marker Score: 234 - Cell Name: megakaryocyte progenitor cell (CL0000553)
Fold Change: 0.35
Marker Score: 97 - Cell Name: lymphocyte (CL0000542)
Fold Change: 0.34
Marker Score: 173 - Cell Name: natural killer cell (CL0000623)
Fold Change: 0.34
Marker Score: 442 - Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.33
Marker Score: 1,976 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.33
Marker Score: 139 - Cell Name: pro-B cell (CL0000826)
Fold Change: 0.32
Marker Score: 307 - Cell Name: myelocyte (CL0002193)
Fold Change: 0.3
Marker Score: 131 - Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.29
Marker Score: 602 - Cell Name: erythroid lineage cell (CL0000764)
Fold Change: 0.29
Marker Score: 143 - Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.28
Marker Score: 69 - Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.27
Marker Score: 211 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.26
Marker Score: 123 - Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.25
Marker Score: 87 - Cell Name: erythroblast (CL0000765)
Fold Change: 0.25
Marker Score: 156 - Cell Name: granulocyte (CL0000094)
Fold Change: 0.24
Marker Score: 108 - Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 0.24
Marker Score: 208 - Cell Name: respiratory basal cell (CL0002633)
Fold Change: 0.22
Marker Score: 315 - Cell Name: pre-conventional dendritic cell (CL0002010)
Fold Change: 0.22
Marker Score: 64 - Cell Name: ependymal cell (CL0000065)
Fold Change: 0.21
Marker Score: 73 - Cell Name: retina horizontal cell (CL0000745)
Fold Change: 0.2
Marker Score: 196 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.2
Marker Score: 494 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.19
Marker Score: 114 - Cell Name: early promyelocyte (CL0002154)
Fold Change: 0.18
Marker Score: 144 - Cell Name: T cell (CL0000084)
Fold Change: 0.18
Marker Score: 310 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.18
Marker Score: 94 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.17
Marker Score: 114 - Cell Name: leukocyte (CL0000738)
Fold Change: 0.17
Marker Score: 98 - Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.17
Marker Score: 155 - Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 0.17
Marker Score: 202 - Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.17
Marker Score: 49 - Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.16
Marker Score: 74 - Cell Name: IgG memory B cell (CL0000979)
Fold Change: 0.16
Marker Score: 94 - Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 0.15
Marker Score: 228 - Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.15
Marker Score: 69 - Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.15
Marker Score: 68 - Cell Name: promonocyte (CL0000559)
Fold Change: 0.15
Marker Score: 98 - Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.15
Marker Score: 209 - Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
Fold Change: 0.15
Marker Score: 33 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.15
Marker Score: 51 - Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.15
Marker Score: 47 - Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: 0.15
Marker Score: 62 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.15
Marker Score: 147 - Cell Name: blood cell (CL0000081)
Fold Change: 0.15
Marker Score: 1,694 - Cell Name: eosinophil (CL0000771)
Fold Change: 0.14
Marker Score: 47 - Cell Name: plasmablast (CL0000980)
Fold Change: 0.14
Marker Score: 191 - Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.14
Marker Score: 95
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1216626852
Symbol: MLC1_HUMAN
Name: Membrane protein MLC1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11326298
Title: A missense mutation in a novel gene encoding a putative cation channel is associated with catatonic schizophrenia in a large pedigree.
PubMed ID: 11326298
PubMed ID: 7584026
Title: Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.
PubMed ID: 7584026
PubMed ID: 12168954
Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
PubMed ID: 12168954
PubMed ID: 15461802
Title: A genome annotation-driven approach to cloning the human ORFeome.
PubMed ID: 15461802
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 10591208
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12665801
Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
PubMed ID: 12665801
DOI: 10.1038/nbt810
PubMed ID: 22328087
Title: Megalencephalic leukoencephalopathy with subcortical cysts protein 1 functionally cooperates with the TRPV4 cation channel to activate the response of astrocytes to osmotic stress: dysregulation by pathological mutations.
PubMed ID: 22328087
DOI: 10.1093/hmg/dds032
PubMed ID: 11254442
Title: Mutations of MLC1 (KIAA0027), encoding a putative membrane protein, cause megalencephalic leukoencephalopathy with subcortical cysts.
PubMed ID: 11254442
DOI: 10.1086/319519
PubMed ID: 11935341
Title: Identification of novel mutations in MLC1 responsible for megalencephalic leukoencephalopathy with subcortical cysts.
PubMed ID: 11935341
PubMed ID: 12189496
Title: Megalencephalic leukoencephalopathy with subcortical cysts; a founder effect in Israeli patients and a higher than expected carrier rate among Libyan Jews.
PubMed ID: 12189496
PubMed ID: 16652334
Title: Megalencephalic leukoencephalopathy with subcortical cysts: an update and extended mutation analysis of MLC1.
PubMed ID: 16652334
DOI: 10.1002/humu.20332
Sequence Information:
- Length: 377
- Mass: 41141
- Checksum: 9AF70B87D979F459
- Sequence:
MTQEPFREEL AYDRMPTLER GRQDPASYAP DAKPSDLQLS KRLPPCFSHK TWVFSVLMGS CLLVTSGFSL YLGNVFPAEM DYLRCAAGSC IPSAIVSFTV SRRNANVIPN FQILFVSTFA VTTTCLIWFG CKLVLNPSAI NINFNLILLL LLELLMAATV IIAARSSEED CKKKKGSMSD SANILDEVPF PARVLKSYSV VEVIAGISAV LGGIIALNVD DSVSGPHLSV TFFWILVACF PSAIASHVAA ECPSKCLVEV LIAISSLTSP LLFTASGYLS FSIMRIVEMF KDYPPAIKPS YDVLLLLLLL VLLLQAGLNT GTAIQCVRFK VSARLQGASW DTQNGPQERL AGEVARSPLK EFDKEKAWRA VVVQMAQ
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.