Details for: JMJD6

Gene ID: 23210

Symbol: JMJD6

Ensembl ID: ENSG00000070495

Description: jumonji domain containing 6, arginine demethylase and lysine hydroxylase

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.75
    Marker Score: 4,824
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.74
    Marker Score: 1,854
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.66
    Marker Score: 6,143
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.44
    Marker Score: 49,006
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.41
    Marker Score: 3,473
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.32
    Marker Score: 1,113
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.3
    Marker Score: 12,902
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.28
    Marker Score: 1,880
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.26
    Marker Score: 3,535
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.19
    Marker Score: 1,017
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.13
    Marker Score: 1,561
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.13
    Marker Score: 1,189
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.12
    Marker Score: 644
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.08
    Marker Score: 2,287
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.02
    Marker Score: 15,986
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1
    Marker Score: 432
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,637
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,859
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.99
    Marker Score: 1,872
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,378
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.97
    Marker Score: 1,394
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.97
    Marker Score: 402
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.94
    Marker Score: 539
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.94
    Marker Score: 282
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.94
    Marker Score: 318
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,379
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.94
    Marker Score: 2,329
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 473
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,715
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.91
    Marker Score: 614
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.88
    Marker Score: 405
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.88
    Marker Score: 219
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.88
    Marker Score: 178
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.87
    Marker Score: 1,545
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.87
    Marker Score: 631
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.86
    Marker Score: 8,747
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5,195
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.86
    Marker Score: 1,074
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.86
    Marker Score: 1,033
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.85
    Marker Score: 2,087
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.85
    Marker Score: 758
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.85
    Marker Score: 777
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.85
    Marker Score: 508
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.84
    Marker Score: 201
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.84
    Marker Score: 4,780
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.83
    Marker Score: 827
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.83
    Marker Score: 46,376
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.83
    Marker Score: 256
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.82
    Marker Score: 180
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.82
    Marker Score: 209
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.81
    Marker Score: 616
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.81
    Marker Score: 2,206
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.81
    Marker Score: 1,412
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.8
    Marker Score: 365
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.8
    Marker Score: 774
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.8
    Marker Score: 258
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.8
    Marker Score: 197
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.8
    Marker Score: 199
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.8
    Marker Score: 504
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 320
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.8
    Marker Score: 326
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.8
    Marker Score: 178
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.8
    Marker Score: 457
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.8
    Marker Score: 366
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.79
    Marker Score: 199
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.79
    Marker Score: 481
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.78
    Marker Score: 558
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.78
    Marker Score: 3,837
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.78
    Marker Score: 318
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.78
    Marker Score: 349
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.78
    Marker Score: 1,772
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,261
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.77
    Marker Score: 2,260
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 591
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.77
    Marker Score: 526
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.77
    Marker Score: 577
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.77
    Marker Score: 3,017
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.76
    Marker Score: 648
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.76
    Marker Score: 507
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.76
    Marker Score: 776
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.76
    Marker Score: 765
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.76
    Marker Score: 827
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.76
    Marker Score: 238
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.76
    Marker Score: 1,009
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.76
    Marker Score: 213
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.76
    Marker Score: 2,385
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.75
    Marker Score: 539
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.75
    Marker Score: 160
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.75
    Marker Score: 199
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.75
    Marker Score: 1,648
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.75
    Marker Score: 476
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.75
    Marker Score: 591
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.75
    Marker Score: 205
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.75
    Marker Score: 432
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.74
    Marker Score: 3,210
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.74
    Marker Score: 748
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.74
    Marker Score: 473
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.74
    Marker Score: 288

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** JMJD6 is a 622-amino acid protein that belongs to the Jumonji family of proteins, which are characterized by the presence of a JmjC domain, a histone demethylase activity, and a C-terminal domain that interacts with histone H3. JMJD6 is highly conserved across species, with a high degree of sequence identity to its human ortholog. The protein is predominantly expressed in the cytoplasm and nucleus, where it is involved in the regulation of histone modifications, transcriptional control, and protein post-translational modifications. **Pathways and Functions:** JMJD6 is involved in a wide range of cellular processes, including: 1. **Histone modification**: JMJD6 is a histone arginine demethylase and lysine hydroxylase that regulates histone modifications, including H3K4me1, H3K4me3, H3K9me1, and H3K27me1, which are involved in transcriptional regulation, chromatin compaction, and DNA repair. 2. **Transcriptional control**: JMJD6 regulates transcriptional control by interacting with transcription factors, co-repressors, and chromatin remodeling complexes, influencing the expression of genes involved in cell proliferation, differentiation, and survival. 3. **Cellular differentiation**: JMJD6 is involved in the regulation of cellular differentiation, including the development of immune cells, muscle cells, and epithelial cells. 4. **Apoptosis**: JMJD6 is involved in the regulation of apoptosis, influencing the expression of pro-apoptotic and anti-apoptotic genes. 5. **Metabolism**: JMJD6 is involved in the regulation of metabolic pathways, including glycolysis, gluconeogenesis, and lipid metabolism. **Clinical Significance:** JMJD6 is implicated in various diseases, including: 1. **Cancer**: JMJD6 is overexpressed in various types of cancer, including breast, lung, and colon cancer, and is associated with poor prognosis. 2. **Autoimmune diseases**: JMJD6 is involved in the regulation of immune responses and is implicated in autoimmune diseases, including multiple sclerosis and rheumatoid arthritis. 3. **Neurodegenerative diseases**: JMJD6 is involved in the regulation of neuronal function and is implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 4. **Metabolic disorders**: JMJD6 is involved in the regulation of metabolic pathways and is implicated in metabolic disorders, including obesity and type 2 diabetes. In conclusion, JMJD6 is a multifaceted protein that plays a critical role in regulating various cellular processes, including epigenetic modifications, transcriptional control, and organism development. Its dysregulation is implicated in various diseases, highlighting the importance of further research into the mechanisms of JMJD6 function and its role in human disease.

Genular Protein ID: 302083204

Symbol: JMJD6_HUMAN

Name: Histone arginine demethylase JMJD6

UniProtKB Accession Codes:

Q6NYC1 B3KMN8 B4DGX1 Q86VY0 Q8IUM5 Q9Y4E2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 34 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 42 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 6 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 12 SABIO-RK 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9628581

Title: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9628581

DOI: 10.1093/dnares/5.1.31

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14729065

Title: Nuclear localization of the phosphatidylserine receptor protein via multiple nuclear localization signals.

PubMed ID: 14729065

DOI: 10.1016/j.yexcr.2003.09.023

PubMed ID: 15072554

Title: Phosphatidylserine receptor cooperates with high-density lipoprotein receptor in recognition of apoptotic cells by thymic nurse cells.

PubMed ID: 15072554

DOI: 10.1677/jme.0.0320497

PubMed ID: 15622002

Title: Phosphatidylserine receptor in chronic pancreatitis: evidence for a macrophage independent role.

PubMed ID: 15622002

DOI: 10.1097/01.sla.0000149304.89456.5a

PubMed ID: 17947579

Title: JMJD6 is a histone arginine demethylase.

PubMed ID: 17947579

DOI: 10.1126/science.1145801

PubMed ID: 19574390

Title: Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing.

PubMed ID: 19574390

DOI: 10.1126/science.1175865

PubMed ID: 21060799

Title: Analysis of Jmjd6 cellular localization and testing for its involvement in histone demethylation.

PubMed ID: 21060799

DOI: 10.1371/journal.pone.0013769

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21555454

Title: The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.

PubMed ID: 21555454

DOI: 10.1128/mcb.01341-10

PubMed ID: 22189873

Title: The hydroxylation activity of Jmjd6 is required for its homo-oligomerization.

PubMed ID: 22189873

DOI: 10.1002/jcb.24035

PubMed ID: 24360279

Title: Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release.

PubMed ID: 24360279

DOI: 10.1016/j.cell.2013.10.056

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24498420

Title: JMJD6 regulates ERalpha methylation on arginine.

PubMed ID: 24498420

DOI: 10.1371/journal.pone.0087982

PubMed ID: 20684070

Title: Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6.

PubMed ID: 20684070

DOI: 10.1016/j.jmb.2010.05.054

PubMed ID: 20679243

Title: Interaction of JMJD6 with single-stranded RNA.

PubMed ID: 20679243

DOI: 10.1073/pnas.1008832107

PubMed ID: 29176719

Title: Structural Mechanism of the Oxygenase JMJD6 Recognition by the Extraterminal (ET) Domain of BRD4.

PubMed ID: 29176719

DOI: 10.1038/s41598-017-16588-8

Sequence Information:

  • Length: 403
  • Mass: 46462
  • Checksum: 9C9AADA98B24B035
  • Sequence:
    • MNHKSKKRIR EAKRSARPEL KDSLDWTRHN YYESFSLSPA AVADNVERAD ALQLSVEEFV 
ERYERPYKPV VLLNAQEGWS AQEKWTLERL KRKYRNQKFK CGEDNDGYSV KMKMKYYIEY 
MESTRDDSPL YIFDSSYGEH PKRRKLLEDY KVPKFFTDDL FQYAGEKRRP PYRWFVMGPP 
RSGTGIHIDP LGTSAWNALV QGHKRWCLFP TSTPRELIKV TRDEGGNQQD EAITWFNVIY 
PRTQLPTWPP EFKPLEILQK PGETVFVPGG WWHVVLNLDT TIAITQNFAS STNFPVVWHK 
TVRGRPKLSR KWYRILKQEH PELAVLADSV DLQESTGIAS DSSSDSSSSS SSSSSDSDSE 
CESGSEGDGT VHRRKKRRTC SMVGNGDTTS QDDCVSKERS SSR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.