JMJD6 | ENSG00000070495 | NCBI 23210

Details for: JMJD6

Gene ID: 23210

Symbol: JMJD6

Ensembl ID: ENSG00000070495

Description: jumonji domain containing 6, arginine demethylase and lysine hydroxylase

Associated with

Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
(R-HSA-163841)
Hdms demethylate histones
(R-HSA-3214842)
Metabolism of proteins
(R-HSA-392499)
Post-translational protein modification
(R-HSA-597592)
Protein hydroxylation
(R-HSA-9629569)
Cell surface receptor signaling pathway
(GO:0007166)
Chromatin remodeling
(GO:0006338)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Erythrocyte development
(GO:0048821)
Heart development
(GO:0007507)
Histone demethylase activity
(GO:0032452)
Histone h3r2 demethylase activity
(GO:0033746)
Histone h4r3 demethylase activity
(GO:0033749)
Identical protein binding
(GO:0042802)
Iron ion binding
(GO:0005506)
Kidney development
(GO:0001822)
Lung development
(GO:0030324)
Macrophage activation
(GO:0042116)
Mrna processing
(GO:0006397)
Negative regulation of protein homooligomerization
(GO:0032463)
Non-membrane-bounded organelle assembly
(GO:0140694)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Oxidative rna demethylase activity
(GO:0035515)
Oxidative rna demethylation
(GO:0035513)
P-tefb complex binding
(GO:0106140)
Peptidyl-lysine 5-dioxygenase activity
(GO:0070815)
Peptidyl-lysine hydroxylation to 5-hydroxy-l-lysine
(GO:0018395)
Phagocytosis
(GO:0006909)
Plasma membrane
(GO:0005886)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein demethylase activity
(GO:0140457)
Protein homooligomerization
(GO:0051260)
Recognition of apoptotic cell
(GO:0043654)
Regulation of mrna splicing, via spliceosome
(GO:0048024)
Retina development in camera-type eye
(GO:0060041)
Ribonucleoprotein complex
(GO:1990904)
Rna binding
(GO:0003723)
Rna splicing
(GO:0008380)
Signaling receptor activity
(GO:0038023)
Single-stranded rna binding
(GO:0003727)
Sprouting angiogenesis
(GO:0002040)
T cell differentiation in thymus
(GO:0033077)
Transcription regulator activator activity
(GO:0140537)

Other Information

Proteins

Histone arginine demethylase JMJD6

Genular Protein ID: 302083204

Symbol: JMJD6_HUMAN

Name: Histone arginine demethylase JMJD6

UniProtKB Accession Codes:

Q6NYC1 B3KMN8 B4DGX1 Q86VY0 Q8IUM5 Q9Y4E2

Database IDs:

Citations:

PubMed ID: 9628581

Title: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9628581

DOI: 10.1093/dnares/5.1.31

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14729065

Title: Nuclear localization of the phosphatidylserine receptor protein via multiple nuclear localization signals.

PubMed ID: 14729065

DOI: 10.1016/j.yexcr.2003.09.023

PubMed ID: 15072554

Title: Phosphatidylserine receptor cooperates with high-density lipoprotein receptor in recognition of apoptotic cells by thymic nurse cells.

PubMed ID: 15072554

DOI: 10.1677/jme.0.0320497

PubMed ID: 15622002

Title: Phosphatidylserine receptor in chronic pancreatitis: evidence for a macrophage independent role.

PubMed ID: 15622002

DOI: 10.1097/01.sla.0000149304.89456.5a

PubMed ID: 17947579

Title: JMJD6 is a histone arginine demethylase.

PubMed ID: 17947579

DOI: 10.1126/science.1145801

PubMed ID: 19574390

Title: Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing.

PubMed ID: 19574390

DOI: 10.1126/science.1175865

PubMed ID: 21060799

Title: Analysis of Jmjd6 cellular localization and testing for its involvement in histone demethylation.

PubMed ID: 21060799

DOI: 10.1371/journal.pone.0013769

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21555454

Title: The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.

PubMed ID: 21555454

DOI: 10.1128/mcb.01341-10

PubMed ID: 22189873

Title: The hydroxylation activity of Jmjd6 is required for its homo-oligomerization.

PubMed ID: 22189873

DOI: 10.1002/jcb.24035

PubMed ID: 24360279

Title: Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release.

PubMed ID: 24360279

DOI: 10.1016/j.cell.2013.10.056

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24498420

Title: JMJD6 regulates ERalpha methylation on arginine.

PubMed ID: 24498420

DOI: 10.1371/journal.pone.0087982

PubMed ID: 20684070

Title: Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6.

PubMed ID: 20684070

DOI: 10.1016/j.jmb.2010.05.054

PubMed ID: 20679243

Title: Interaction of JMJD6 with single-stranded RNA.

PubMed ID: 20679243

DOI: 10.1073/pnas.1008832107

PubMed ID: 29176719

Title: Structural Mechanism of the Oxygenase JMJD6 Recognition by the Extraterminal (ET) Domain of BRD4.

PubMed ID: 29176719

DOI: 10.1038/s41598-017-16588-8

Sequence Information:

Length: 403
Mass: 46462
Checksum: 9C9AADA98B24B035
Sequence:

MNHKSKKRIR EAKRSARPEL KDSLDWTRHN YYESFSLSPA AVADNVERAD ALQLSVEEFV 
ERYERPYKPV VLLNAQEGWS AQEKWTLERL KRKYRNQKFK CGEDNDGYSV KMKMKYYIEY 
MESTRDDSPL YIFDSSYGEH PKRRKLLEDY KVPKFFTDDL FQYAGEKRRP PYRWFVMGPP 
RSGTGIHIDP LGTSAWNALV QGHKRWCLFP TSTPRELIKV TRDEGGNQQD EAITWFNVIY 
PRTQLPTWPP EFKPLEILQK PGETVFVPGG WWHVVLNLDT TIAITQNFAS STNFPVVWHK 
TVRGRPKLSR KWYRILKQEH PELAVLADSV DLQESTGIAS DSSSDSSSSS SSSSSDSDSE 
CESGSEGDGT VHRRKKRRTC SMVGNGDTTS QDDCVSKERS SSR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: JMJD6

Associated with

Other Information

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. PubMed ID: 9628581

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Nuclear localization of the phosphatidylserine receptor protein via multiple nuclear localization signals. PubMed ID: 14729065

Phosphatidylserine receptor cooperates with high-density lipoprotein receptor in recognition of apoptotic cells by thymic nurse cells. PubMed ID: 15072554

Phosphatidylserine receptor in chronic pancreatitis: evidence for a macrophage independent role. PubMed ID: 15622002

JMJD6 is a histone arginine demethylase. PubMed ID: 17947579

Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing. PubMed ID: 19574390

Analysis of Jmjd6 cellular localization and testing for its involvement in histone demethylation. PubMed ID: 21060799

Initial characterization of the human central proteome. PubMed ID: 21269460

The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3. PubMed ID: 21555454

The hydroxylation activity of Jmjd6 is required for its homo-oligomerization. PubMed ID: 22189873

Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release. PubMed ID: 24360279

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

JMJD6 regulates ERalpha methylation on arginine. PubMed ID: 24498420

Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6. PubMed ID: 20684070

Interaction of JMJD6 with single-stranded RNA. PubMed ID: 20679243

Structural Mechanism of the Oxygenase JMJD6 Recognition by the Extraterminal (ET) Domain of BRD4. PubMed ID: 29176719