Details for: ZC3H4

Gene ID: 23211

Symbol: ZC3H4

Ensembl ID: ENSG00000130749

Description: zinc finger CCCH-type containing 4

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.14
    Marker Score: 1,045
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.14
    Marker Score: 17,792
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.05
    Marker Score: 337
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.04
    Marker Score: 624
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.01
    Marker Score: 1,065
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1
    Marker Score: 2,354
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,718
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,942
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,395
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.95
    Marker Score: 296
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,398
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 475
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 431
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,705
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,292
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4,935
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.86
    Marker Score: 1,323
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 305
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.83
    Marker Score: 50,936
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.82
    Marker Score: 7,775
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.81
    Marker Score: 6,997
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.81
    Marker Score: 8,411
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.81
    Marker Score: 4,879
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,262
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 579
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.74
    Marker Score: 815
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.74
    Marker Score: 3,001
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 295
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.73
    Marker Score: 500
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.73
    Marker Score: 346
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.71
    Marker Score: 370
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.71
    Marker Score: 15,119
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.71
    Marker Score: 691
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7
    Marker Score: 2,703
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.69
    Marker Score: 26,135
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2,858
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.67
    Marker Score: 234
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.67
    Marker Score: 1,687
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.66
    Marker Score: 601
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.65
    Marker Score: 433
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.65
    Marker Score: 23,837
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.64
    Marker Score: 167
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.64
    Marker Score: 861
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.64
    Marker Score: 5,980
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.63
    Marker Score: 676
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.62
    Marker Score: 4,740
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.61
    Marker Score: 9,191
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.61
    Marker Score: 634
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.61
    Marker Score: 405
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.6
    Marker Score: 572
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.6
    Marker Score: 148
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.59
    Marker Score: 711
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.59
    Marker Score: 399
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.58
    Marker Score: 373
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.58
    Marker Score: 168
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.58
    Marker Score: 1,427
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.58
    Marker Score: 668
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.58
    Marker Score: 620
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.57
    Marker Score: 11,331
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.57
    Marker Score: 639
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.56
    Marker Score: 352
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.55
    Marker Score: 477
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.55
    Marker Score: 807
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.54
    Marker Score: 701
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.54
    Marker Score: 226
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.54
    Marker Score: 577
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.54
    Marker Score: 302
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 429
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.54
    Marker Score: 231
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.53
    Marker Score: 236
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.53
    Marker Score: 311
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.53
    Marker Score: 537
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.53
    Marker Score: 140
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.53
    Marker Score: 2,188
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.52
    Marker Score: 194
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.52
    Marker Score: 298
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.52
    Marker Score: 860
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.52
    Marker Score: 550
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.52
    Marker Score: 1,174
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.51
    Marker Score: 159
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.51
    Marker Score: 715
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.5
    Marker Score: 114
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5
    Marker Score: 150
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.5
    Marker Score: 472
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.5
    Marker Score: 503
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.5
    Marker Score: 115
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.5
    Marker Score: 120
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.5
    Marker Score: 340
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.5
    Marker Score: 1,332
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.5
    Marker Score: 111
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.5
    Marker Score: 2,072
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.49
    Marker Score: 864
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.49
    Marker Score: 118
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.49
    Marker Score: 121
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.48
    Marker Score: 182
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.48
    Marker Score: 197
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.48
    Marker Score: 145
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.48
    Marker Score: 241
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.48
    Marker Score: 121

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZC3H4 is a zinc finger protein that belongs to the CCCH-type family of transcriptional regulators. Its expression has been identified in a wide range of tissues, including the choroid plexus epithelial cell, cardiac muscle myoblast, mononuclear cell, lymphoid lineage restricted progenitor cell, conjunctival epithelial cell, kidney proximal straight tubule epithelial cell, cerebral cortex GABAergic interneuron, forebrain radial glial cell, absorptive cell, and kidney capillary endothelial cell. This widespread expression suggests that ZC3H4 plays a crucial role in regulating gene expression in various cell types. **Pathways and Functions:** ZC3H4 has been implicated in multiple cellular pathways, including: 1. **Negative regulation of DNA-templated transcription**: ZC3H4 acts as a transcriptional regulator by binding to specific DNA sequences and inhibiting the recruitment of transcriptional machinery, thereby controlling the expression of target genes. 2. **LncRNA catabolic process**: ZC3H4 has been shown to regulate the degradation of long non-coding RNAs (lncRNAs), which are essential for various cellular processes, including gene expression and chromatin structure. 3. **Metal ion binding**: ZC3H4 contains a metal ion-binding motif, which suggests that it may interact with metal ions and influence gene expression. 4. **Nuclear RNA surveillance**: ZC3H4 has been implicated in the regulation of nuclear RNA metabolism, including the surveillance of aberrant RNA molecules. **Clinical Significance:** The clinical significance of ZC3H4 remains to be fully elucidated, but its involvement in various cellular pathways suggests that dysregulation of ZC3H4 may contribute to the development of diseases. For example: 1. **Neurological disorders**: Aberrant expression of ZC3H4 in the cerebral cortex may contribute to the development of neurological disorders, such as epilepsy and Alzheimer's disease. 2. **Cancer**: ZC3H4 has been implicated in the regulation of lncRNA expression, which is often dysregulated in cancer. Therefore, ZC3H4 may play a role in the development and progression of cancer. 3. **Cardiovascular disease**: ZC3H4 has been shown to regulate gene expression in cardiac muscle cells, suggesting that its dysregulation may contribute to the development of cardiovascular disease. In conclusion, ZC3H4 is a multifunctional gene that plays a crucial role in regulating gene expression in various human tissues. Further research is needed to fully elucidate the clinical significance of ZC3H4 and its potential role in human disease.

Genular Protein ID: 3198488529

Symbol: ZC3H4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9UPT8 Q9Y420

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10470851

Title: Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10470851

DOI: 10.1093/dnares/6.3.197

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 33913806

Title: ZC3H4 restricts non-coding transcription in human cells.

PubMed ID: 33913806

DOI: 10.7554/elife.67305

PubMed ID: 33767452

Title: A first exon termination checkpoint preferentially suppresses extragenic transcription.

PubMed ID: 33767452

DOI: 10.1038/s41594-021-00572-y

Sequence Information:

  • Length: 1303
  • Mass: 140257
  • Checksum: A6DAE368F543FF4D
  • Sequence:
    • MEAAPGTPPP PPSESPPPPS PPPPSTPSPP PCSPDARPAT PHLLHHRLPL PDDREDGELE 
EGELEDDGAE ETQDTSGGPE RSRKEKGEKH HSDSDEEKSH RRLKRKRKKE REKEKRRSKK 
RRKSKHKRHA SSSDDFSDFS DDSDFSPSEK GHRKYREYSP PYAPSHQQYP PSHATPLPKK 
AYSKMDSKSY GMYEDYENEQ YGEYEGDEEE DMGKEDYDDF TKELNQYRRA KEGSSRGRGS 
RGRGRGYRGR GSRGGSRGRG MGRGSRGRGR GSMGGDHPED EEDFYEEEMD YGESEEPMGD 
DDYDEYSKEL NQYRRSKDSR GRGLSRGRGR GSRGRGKGMG RGRGRGGSRG GMNKGGMNDD 
EDFYDEDMGD GGGGSYRSRD HDKPHQQSDK KGKVICKYFV EGRCTWGDHC NFSHDIELPK 
KRELCKFYIT GFCARAENCP YMHGDFPCKL YHTTGNCING DDCMFSHDPL TEETRELLDK 
MLADDAEAGA EDEKEVEELK KQGINPLPKP PPGVGLLPTP PRPPGPQAPT SPNGRPMQGG 
PPPPPPPPPP PPGPPQMPMP VHEPLSPQQL QQQDMYNKKI PSLFEIVVRP TGQLAEKLGV 
RFPGPGGPPG PMGPGPNMGP PGPMGGPMHP DMHPDMHPDM HPDMHADMHA DMPMGPGMNP 
GPPMGPGGPP MMPYGPGDSP HSGMMPPIPP AQNFYENFYQ QQEGMEMEPG LLGDAEDYGH 
YEELPGEPGE HLFPEHPLEP DSFSEGGPPG RPKPGAGVPD FLPSAQRALY LRIQQKQQEE 
EERARRLAES SKQDRENEEG DTGNWYSSDE DEGGSSVTSI LKTLRQQTSS RPPASVGELS 
SSGLGDPRLQ KGHPTGSRLA DPRLSRDPRL TRHVEASGGS GPGDSGPSDP RLARALPTSK 
PEGSLHSSPV GPSSSKGSGP PPTEEEEGER ALREKAVNIP LDPLPGHPLR DPRSQLQQFS 
HIKKDVTLSK PSFARTVLWN PEDLIPLPIP KQDAVPPVPA ALQSMPTLDP RLHRAATAGP 
PNARQRPGAS TDSSTQGANL PDFELLSRIL KTVNATGSSA APGSSDKPSD PRVRKAPTDP 
RLQKPTDSTA SSRAAKPGPA EAPSPTASPS GDASPPATAP YDPRVLAAGG LGQGGGGGQS 
SVLSGISLYD PRTPNAGGKA TEPAADTGAQ PKGAEGNGKS SASKAKEPPF VRKSALEQPE 
TGKAGADGGT PTDRYNSYNR PRPKAAAAPA ATTATPPPEG APPQPGVHNL PVPTLFGTVK 
QTPKTGSGSP FAGNSPAREG EQDAASLKDV FKGFDPTASP FCQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.