Details for: RRS1

Gene ID: 23212

Symbol: RRS1

Ensembl ID: ENSG00000179041

Description: ribosome biogenesis regulator 1 homolog

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 3.17
    Marker Score: 12,259
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.41
    Marker Score: 2,977
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.29
    Marker Score: 878
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.18
    Marker Score: 1,259
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.12
    Marker Score: 999
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,733
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,957
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,401
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.95
    Marker Score: 932
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,401
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.94
    Marker Score: 2,296
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 480
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.93
    Marker Score: 294
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 437
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.91
    Marker Score: 4,464
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,711
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5,162
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,251
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.86
    Marker Score: 13,441
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.84
    Marker Score: 569
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,264
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.76
    Marker Score: 753
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.75
    Marker Score: 255
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.75
    Marker Score: 1,264
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.74
    Marker Score: 771
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 292
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.72
    Marker Score: 259
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 374
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 552
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.71
    Marker Score: 2,916
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.7
    Marker Score: 442
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.7
    Marker Score: 525
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7
    Marker Score: 1,027
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.69
    Marker Score: 2,895
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 627
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2,858
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.66
    Marker Score: 1,577
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.65
    Marker Score: 372
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.64
    Marker Score: 2,777
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.63
    Marker Score: 497
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.63
    Marker Score: 662
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.62
    Marker Score: 775
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6
    Marker Score: 2,361
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.59
    Marker Score: 2,293
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.56
    Marker Score: 114
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.56
    Marker Score: 1,329
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.56
    Marker Score: 370
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.56
    Marker Score: 180
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.55
    Marker Score: 882
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.55
    Marker Score: 229
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.55
    Marker Score: 1,039
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.55
    Marker Score: 574
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.54
    Marker Score: 143
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 429
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.53
    Marker Score: 569
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.53
    Marker Score: 263
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.53
    Marker Score: 158
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.52
    Marker Score: 261
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.52
    Marker Score: 485
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.52
    Marker Score: 829
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.51
    Marker Score: 130
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.51
    Marker Score: 5,716
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.51
    Marker Score: 338
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.5
    Marker Score: 868
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.49
    Marker Score: 524
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.49
    Marker Score: 141
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.49
    Marker Score: 319
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.48
    Marker Score: 307
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.48
    Marker Score: 149
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.48
    Marker Score: 113
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.47
    Marker Score: 512
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.47
    Marker Score: 147
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.47
    Marker Score: 198
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.47
    Marker Score: 184
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.47
    Marker Score: 4,079
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.47
    Marker Score: 877
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.46
    Marker Score: 118
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.46
    Marker Score: 942
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.46
    Marker Score: 660
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.46
    Marker Score: 957
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.45
    Marker Score: 907
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.45
    Marker Score: 457
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.45
    Marker Score: 110
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.44
    Marker Score: 113
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.44
    Marker Score: 117
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.44
    Marker Score: 125
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.44
    Marker Score: 999
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.44
    Marker Score: 131
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.44
    Marker Score: 1,033
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.44
    Marker Score: 621
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.44
    Marker Score: 96
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.43
    Marker Score: 97
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.43
    Marker Score: 103
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.43
    Marker Score: 11,014
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.43
    Marker Score: 555
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.43
    Marker Score: 14,561
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.43
    Marker Score: 161
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.43
    Marker Score: 197

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Ribosome biogenesis regulator**: RRS1 is a key regulator of ribosome biogenesis, a process essential for protein synthesis. It is involved in the assembly of ribosomal subunits and the regulation of gene expression. 2. **High expression in various cell types**: RRS1 is highly expressed in neural progenitor cells, pancreatic acinar cells, proerythroblast, skeletal muscle satellite stem cells, extravillous trophoblasts, and other cell types. 3. **Regulation of signal transduction by p53 class mediators**: RRS1 interacts with p53 class mediators, suggesting its role in regulating signal transduction pathways in response to cellular stress. 4. **Involvement in hematopoietic progenitor cell differentiation**: RRS1 is expressed in hematopoietic progenitor cells, indicating its potential role in the development of blood cells. **Pathways and Functions:** 1. **Ribosomal large subunit assembly**: RRS1 is involved in the assembly of the ribosomal large subunit, a critical step in ribosome biogenesis. 2. **Endonucleolytic cleavage**: RRS1 is required for the endonucleolytic cleavage of the tricistronic transcript, which separates the SSU-RNA, 5.8S-RNA, and LSU-RNA. 3. **Condensed nuclear chromosome**: RRS1 is involved in the regulation of the condensed nuclear chromosome, which is essential for the proper assembly of ribosomes. 4. **Protein binding and localization**: RRS1 interacts with various proteins and localizes to the nucleolus, where ribosome biogenesis occurs. **Clinical Significance:** 1. **Cancer research**: RRS1 may play a role in cancer development and progression, as its dysregulation can lead to uncontrolled cell growth and tumor formation. 2. **Neurological disorders**: RRS1's involvement in neural progenitor cell development suggests its potential role in neurological disorders, such as neurodegenerative diseases. 3. **Hematological disorders**: RRS1's expression in hematopoietic progenitor cells indicates its potential role in hematological disorders, such as leukemia and lymphoma. 4. **Ribosomal biogenesis disorders**: RRS1's involvement in ribosome biogenesis suggests its potential role in disorders related to ribosomal dysfunction, such as ribosomal dysgenesis. In conclusion, RRS1 is a critical regulator of ribosome biogenesis, and its dysregulation can have significant implications for various cellular processes, including signal transduction, hematopoiesis, and cancer development. Further research is needed to fully understand the role of RRS1 in human diseases and to explore its potential as a therapeutic target.

Genular Protein ID: 831083135

Symbol: RRS1_HUMAN

Name: Ribosome biogenesis regulatory protein homolog

UniProtKB Accession Codes:

Q15050 Q9BUX8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 EMDB 13 EPD 1 Ensembl 1 GO 14 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 13 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SMR 1 STRING 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7788527

Title: Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 7788527

DOI: 10.1093/dnares/2.1.37

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12429849

Title: Functional proteomic analysis of human nucleolus.

PubMed ID: 12429849

DOI: 10.1091/mbc.e02-05-0271

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24120868

Title: The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress.

PubMed ID: 24120868

DOI: 10.1016/j.celrep.2013.08.049

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 365
  • Mass: 41193
  • Checksum: 061C3A6174C2E7C2
  • Sequence:
    • MEGQSVEELL AKAEQDEAEK LQRITVHKEL ELQFDLGNLL ASDRNPPTGL RCAGPTPEAE 
LQALARDNTQ LLINQLWQLP TERVEEAIVA RLPEPTTRLP REKPLPRPRP LTRWQQFARL 
KGIRPKKKTN LVWDEVSGQW RRRWGYQRAR DDTKEWLIEV PGNADPLEDQ FAKRIQAKKE 
RVAKNELNRL RNLARAHKMQ LPSAAGLHPT GHQSKEELGR AMQVAKVSTA SVGRFQERLP 
KEKVPRGSGK KRKFQPLFGD FAAEKKNQLE LLRVMNSKKP QLDVTRATNK QMREEDQEEA 
AKRRKMSQKG KRKGGRQGPG GKRKGGPPSQ GGKRKGGLGG KMNSGPPGLG GKRKGGQRPG 
GKRRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.