Details for: SULF1

Gene ID: 23213

Symbol: SULF1

Ensembl ID: ENSG00000137573

Description: sulfatase 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 3.33
    Marker Score: 4,481
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.89
    Marker Score: 929
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.8
    Marker Score: 3,390
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.73
    Marker Score: 3,752
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.3
    Marker Score: 1,341
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.96
    Marker Score: 6,559
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.82
    Marker Score: 883
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.69
    Marker Score: 833
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.67
    Marker Score: 61,741
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.67
    Marker Score: 15,864
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.53
    Marker Score: 397
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,357
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.46
    Marker Score: 1,458
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.45
    Marker Score: 2,785
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.38
    Marker Score: 1,911
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 860
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.23
    Marker Score: 494
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.17
    Marker Score: 850
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.15
    Marker Score: 478
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.15
    Marker Score: 264
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4,783
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.11
    Marker Score: 410
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.05
    Marker Score: 897
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.04
    Marker Score: 258
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.04
    Marker Score: 265
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,788
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,011
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,405
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.97
    Marker Score: 9,770
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 500
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,409
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.95
    Marker Score: 268
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 367
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.91
    Marker Score: 1,860
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,737
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.89
    Marker Score: 5,332
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5,009
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.88
    Marker Score: 2,292
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.87
    Marker Score: 400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,273
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.8
    Marker Score: 1,237
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.78
    Marker Score: 12,274
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 599
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.78
    Marker Score: 326
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.78
    Marker Score: 246
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.78
    Marker Score: 175
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.77
    Marker Score: 512
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,250
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 691
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 389
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.75
    Marker Score: 191
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.74
    Marker Score: 490
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.73
    Marker Score: 704
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.72
    Marker Score: 375
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.69
    Marker Score: 330
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.68
    Marker Score: 386
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.64
    Marker Score: 386
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.64
    Marker Score: 1,197
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.62
    Marker Score: 225
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.61
    Marker Score: 251
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.6
    Marker Score: 518
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.58
    Marker Score: 374
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.58
    Marker Score: 406
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 240
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.57
    Marker Score: 647
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.57
    Marker Score: 331
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.55
    Marker Score: 308
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.55
    Marker Score: 206
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.54
    Marker Score: 518
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.54
    Marker Score: 120
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.53
    Marker Score: 335
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.52
    Marker Score: 162
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.51
    Marker Score: 2,089
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.51
    Marker Score: 2,121
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.51
    Marker Score: 244
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.51
    Marker Score: 453
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.5
    Marker Score: 733
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.5
    Marker Score: 4,326
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.49
    Marker Score: 273
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.49
    Marker Score: 126
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.49
    Marker Score: 329
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.48
    Marker Score: 118
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.47
    Marker Score: 591
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.47
    Marker Score: 118
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.47
    Marker Score: 118
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.47
    Marker Score: 252
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.47
    Marker Score: 1,022
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.44
    Marker Score: 4,969
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.44
    Marker Score: 245
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.44
    Marker Score: 332
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.43
    Marker Score: 1,023
  • Cell Name: adipose microvascular endothelial cell (CL2000072)
    Fold Change: 0.43
    Marker Score: 129
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.43
    Marker Score: 381
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.42
    Marker Score: 120

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SULF1 is a sulfatase enzyme that catalyzes the removal of sulfate groups from heparan sulfate proteoglycans (HSPGs). This process is essential for regulating the activity of various growth factors, cytokines, and cell surface receptors. SULF1 is characterized by its ability to modulate the activity of multiple signaling pathways, including the Wnt, BMP, and VEGF pathways. **Pathways and Functions:** SULF1 plays a pivotal role in regulating cell signaling, development, and tissue homeostasis through its involvement in various pathways, including: 1. **Apoptotic process:** SULF1 modulates the activity of pro-apoptotic and anti-apoptotic proteins, influencing cell survival and death. 2. **Arylsulfatase activity:** SULF1 catalyzes the removal of sulfate groups from HSPGs, regulating the activity of growth factors and cell surface receptors. 3. **Bone development:** SULF1 is involved in the regulation of osteoblast and osteoclast activity, influencing bone formation and resorption. 4. **Cartilage development:** SULF1 modulates the activity of chondrocytes, influencing cartilage formation and maintenance. 5. **Cell surface:** SULF1 regulates the activity of cell surface receptors, including those involved in immune responses and cell migration. **Clinical Significance:** Dysregulation of SULF1 has been implicated in various diseases, including: 1. **Cancer:** SULF1 expression is altered in several types of cancer, including breast, lung, and colon cancer, suggesting its potential as a biomarker or therapeutic target. 2. **Neurological disorders:** SULF1 has been linked to neurodevelopmental disorders, such as autism and schizophrenia, and neurodegenerative diseases, such as Alzheimer's and Parkinson's. 3. **Cardiovascular disease:** SULF1 is involved in the regulation of vascular endothelial growth factor (VEGF) production, which is critical in the development of cardiovascular disease. 4. **Immunological disorders:** SULF1 modulates the activity of immune cells, including T cells and B cells, influencing immune responses and autoimmunity. In conclusion, SULF1 is a multifaceted enzyme involved in various biological processes, including cell signaling, development, and tissue homeostasis. Its dysregulation has been implicated in several diseases, highlighting the need for further research into the mechanisms underlying SULF1 function and its potential as a therapeutic target.

Genular Protein ID: 1812813888

Symbol: SULF1_HUMAN

Name: Extracellular sulfatase Sulf-1

UniProtKB Accession Codes:

Q8IWU6 Q86YV8 Q8NCA2 Q9UPS5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 11 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 4 Ensembl 4 ExpressionAtlas 1 GO 33 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 4 Rhea 1 SAM 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12368295

Title: Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans.

PubMed ID: 12368295

DOI: 10.1074/jbc.m205131200

PubMed ID: 12686563

Title: Loss of HSulf-1 up-regulates heparin-binding growth factor signaling in cancer.

PubMed ID: 12686563

DOI: 10.1074/jbc.m302203200

PubMed ID: 10470851

Title: Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10470851

DOI: 10.1093/dnares/6.3.197

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

Sequence Information:

  • Length: 871
  • Mass: 101027
  • Checksum: 9A90ADB280304364
  • Sequence:
    • MKYSCCALVL AVLGTELLGS LCSTVRSPRF RGRIQQERKN IRPNIILVLT DDQDVELGSL 
QVMNKTRKIM EHGGATFINA FVTTPMCCPS RSSMLTGKYV HNHNVYTNNE NCSSPSWQAM 
HEPRTFAVYL NNTGYRTAFF GKYLNEYNGS YIPPGWREWL GLIKNSRFYN YTVCRNGIKE 
KHGFDYAKDY FTDLITNESI NYFKMSKRMY PHRPVMMVIS HAAPHGPEDS APQFSKLYPN 
ASQHITPSYN YAPNMDKHWI MQYTGPMLPI HMEFTNILQR KRLQTLMSVD DSVERLYNML 
VETGELENTY IIYTADHGYH IGQFGLVKGK SMPYDFDIRV PFFIRGPSVE PGSIVPQIVL 
NIDLAPTILD IAGLDTPPDV DGKSVLKLLD PEKPGNRFRT NKKAKIWRDT FLVERGKFLR 
KKEESSKNIQ QSNHLPKYER VKELCQQARY QTACEQPGQK WQCIEDTSGK LRIHKCKGPS 
DLLTVRQSTR NLYARGFHDK DKECSCRESG YRASRSQRKS QRQFLRNQGT PKYKPRFVHT 
RQTRSLSVEF EGEIYDINLE EEEELQVLQP RNIAKRHDEG HKGPRDLQAS SGGNRGRMLA 
DSSNAVGPPT TVRVTHKCFI LPNDSIHCER ELYQSARAWK DHKAYIDKEI EALQDKIKNL 
REVRGHLKRR KPEECSCSKQ SYYNKEKGVK KQEKLKSHLH PFKEAAQEVD SKLQLFKENN 
RRRKKERKEK RRQRKGEECS LPGLTCFTHD NNHWQTAPFW NLGSFCACTS SNNNTYWCLR 
TVNETHNFLF CEFATGFLEY FDMNTDPYQL TNTVHTVERG ILNQLHVQLM ELRSCQGYKQ 
CNPRPKNLDV GNKDGGSYDL HRGQLWDGWE G

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.