Details for: PRRC2C

Gene ID: 23215

Symbol: PRRC2C

Ensembl ID: ENSG00000117523

Description: proline rich coiled-coil 2C

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.56
    Marker Score: 121,089
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 3.32
    Marker Score: 2,512
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.31
    Marker Score: 3,258
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 3.24
    Marker Score: 171,237
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.22
    Marker Score: 28,243
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.15
    Marker Score: 8,833
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.14
    Marker Score: 9,894
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 3.13
    Marker Score: 6,555
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.04
    Marker Score: 30,116
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.03
    Marker Score: 2,379
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 3.02
    Marker Score: 2,020
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.96
    Marker Score: 708
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.95
    Marker Score: 6,473
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.94
    Marker Score: 3,135
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.87
    Marker Score: 3,468
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.86
    Marker Score: 2,438
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.83
    Marker Score: 1,222
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.82
    Marker Score: 3,895
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.79
    Marker Score: 96,534
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 2.78
    Marker Score: 1,128
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.77
    Marker Score: 32,237
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.77
    Marker Score: 797
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.76
    Marker Score: 2,904
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.75
    Marker Score: 2,573
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 2.75
    Marker Score: 1,120
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.74
    Marker Score: 1,649
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.73
    Marker Score: 1,362
  • Cell Name: podocyte (CL0000653)
    Fold Change: 2.71
    Marker Score: 1,001
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 2.7
    Marker Score: 941
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.67
    Marker Score: 6,532
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.67
    Marker Score: 4,774
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 2.67
    Marker Score: 930
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.66
    Marker Score: 2,242
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.64
    Marker Score: 2,875
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.63
    Marker Score: 6,421
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.63
    Marker Score: 26,676
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.6
    Marker Score: 921
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.6
    Marker Score: 3,357
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 2.6
    Marker Score: 1,673
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 2.6
    Marker Score: 779
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.59
    Marker Score: 11,127
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.59
    Marker Score: 1,163
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.59
    Marker Score: 1,962
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.57
    Marker Score: 1,427
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.56
    Marker Score: 2,215
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.56
    Marker Score: 4,929
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.56
    Marker Score: 12,580
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 2.56
    Marker Score: 888
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.56
    Marker Score: 1,065
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.56
    Marker Score: 3,440
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.55
    Marker Score: 10,686
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.53
    Marker Score: 834
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 2.53
    Marker Score: 2,069
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.52
    Marker Score: 780
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.51
    Marker Score: 10,475
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 2.5
    Marker Score: 1,562
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.5
    Marker Score: 1,968
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.49
    Marker Score: 1,808
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.48
    Marker Score: 1,417
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 2.48
    Marker Score: 569
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 2.48
    Marker Score: 543
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 2.48
    Marker Score: 1,273
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 2.48
    Marker Score: 2,389
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.46
    Marker Score: 1,790
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.45
    Marker Score: 700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.45
    Marker Score: 2,965
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 2.44
    Marker Score: 1,720
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 2.43
    Marker Score: 1,127
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.43
    Marker Score: 135,863
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 2.43
    Marker Score: 1,634
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.42
    Marker Score: 3,557
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 2.41
    Marker Score: 672
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 2.41
    Marker Score: 2,598
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 2.41
    Marker Score: 2,043
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 2.4
    Marker Score: 598
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.4
    Marker Score: 3,529
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.39
    Marker Score: 2,101
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.38
    Marker Score: 31,994
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.37
    Marker Score: 2,128
  • Cell Name: interneuron (CL0000099)
    Fold Change: 2.37
    Marker Score: 1,084
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 2.37
    Marker Score: 669
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 2.37
    Marker Score: 628
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.37
    Marker Score: 3,437
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.36
    Marker Score: 8,130
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.35
    Marker Score: 26,510
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 2.35
    Marker Score: 1,606
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.34
    Marker Score: 46,518
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.34
    Marker Score: 1,153
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.33
    Marker Score: 1,159
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 2.33
    Marker Score: 617
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 2.33
    Marker Score: 707
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.33
    Marker Score: 17,326
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 2.33
    Marker Score: 2,137
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.33
    Marker Score: 4,056
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.32
    Marker Score: 2,184
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.32
    Marker Score: 2,214
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 2.32
    Marker Score: 570
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 2.32
    Marker Score: 2,069
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 2.31
    Marker Score: 503
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 2.31
    Marker Score: 2,316

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PRRC2C is a coiled-coil protein that exhibits a unique structural arrangement, comprising two proline-rich coiled-coil domains. This specific architecture enables PRRC2C to interact with a diverse range of proteins, including other coiled-coil proteins, RNA-binding proteins, and cytoskeletal components. Notably, PRRC2C is predominantly expressed in hematopoietic cells, including T cells, B cells, and natural killer (NK) cells, where it plays a critical role in cell differentiation, survival, and function. **Pathways and Functions:** PRRC2C is involved in several key signaling pathways, including: 1. **Stress Granule Assembly:** PRRC2C interacts with RNA-binding proteins, such as TIA-1 and TRIST, to form stress granules, which are essential for regulating mRNA translation and stability in response to cellular stress. 2. **Cytoskeletal Organization:** PRRC2C interacts with cytoskeletal proteins, such as actin and tubulin, to regulate cytoskeletal dynamics and cell migration. 3. **Protein Binding:** PRRC2C binds to a wide range of proteins, including other coiled-coil proteins, kinases, and phosphatases, to regulate protein-protein interactions and signaling cascades. **Clinical Significance:** PRRC2C has been implicated in various immunological disorders, including: 1. **Autoimmune Diseases:** PRRC2C has been shown to be overexpressed in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where it may contribute to the pathogenesis of these conditions. 2. **Cancer:** PRRC2C has been found to be overexpressed in certain types of cancer, including T-cell acute lymphoblastic leukemia (T-ALL) and diffuse large B-cell lymphoma (DLBCL), where it may contribute to tumorigenesis and progression. 3. **Infectious Diseases:** PRRC2C has been implicated in the regulation of immune responses to viral infections, such as HIV and influenza, where it may play a role in modulating the host immune response. In conclusion, PRRC2C is a multifunctional protein that plays a critical role in various cellular processes, including stress granule assembly, cytoskeletal organization, and protein-protein interactions. Its involvement in immunological disorders highlights the importance of PRRC2C as a potential therapeutic target for the treatment of autoimmune diseases, cancer, and infectious diseases. Further research is necessary to fully elucidate the mechanisms by which PRRC2C regulates immune responses and to explore its potential as a therapeutic agent.

Genular Protein ID: 347329770

Symbol: PRC2C_HUMAN

Name: Protein PRRC2C

UniProtKB Accession Codes:

Q9Y520 Q05DM8 Q49A39 Q6PD54 Q9H2N2 Q9HA05 Q9NSM8 Q9NXL3 Q9UF29 Q9UPQ6

Database IDs:

AGR 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 6 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PIR 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 7 Pumba 1 RNAct 1 RefSeq 3 SAM 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10470851

Title: Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10470851

DOI: 10.1093/dnares/6.3.197

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12443540

Title: KIAA1096, a gene on chromosome 1q, is amplified and overexpressed in bladder cancer.

PubMed ID: 12443540

DOI: 10.1089/104454902760599681

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 29395067

Title: High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies.

PubMed ID: 29395067

DOI: 10.1016/j.molcel.2017.12.020

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 2896
  • Mass: 316911
  • Checksum: F0E037C36F04CDF9
  • Sequence:
    • MSEKSGQSTK AKDGKKYATL SLFNTYKGKS LETQKTTARH GLQSLGKVGI SRRMPPPANL 
PSLKAENKGN DPNVNIVPKD GTGWASKQEQ HEEEKTPEVP PAQPKPGVAA PPEVAPAPKS 
WASNKQGGQG DGIQVNSQFQ QEFPSLQAAG DQEKKEKETN DDNYGPGPSL RPPNVACWRD 
GGKAAGSPSS SDQDEKLPGQ DESTAGTSEQ NDILKVVEKR IACGPPQAKL NGQQAALASQ 
YRAMMPPYMF QQYPRMTYPP LHGPMRFPPS LSETNKGLRG RGPPPSWASE PERPSILSAS 
ELKELDKFDN LDAEADEGWA GAQMEVDYTE QLNFSDDDEQ GSNSPKENNS EDQGSKASEN 
NENKKETDEV SNTKSSSQIP AQPSVAKVPY GKGPSFNQER GTSSHLPPPP KLLAQQHPPP 
DRQAVPGRPG PFPSKQQVAD EDEIWKQRRR QQSEISAAVE RARKRREEEE RRMEEQRKAA 
CAEKLKRLDE KLGILEKQPS PEEIRERERE KEREREKELE KEQEQEREKE REKDRERQQE 
KEKELEKEQE KQREMEKERK QEKEKELERQ KEKEKELQKM KEQEKECELE KEREKLEEKI 
EPREPNLEPM VEKQESENSC NKEEEPVFTR QDSNRSEKEA TPVVHETEPE SGSQPRPAVL 
SGYFKQFQKS LPPRFQRQQE QMKQQQWQQQ QQQGVLPQTV PSQPSSSTVP PPPHRPLYQP 
MQPHPQHLAS MGFDPRWLMM QSYMDPRMMS GRPAMDIPPI HPGMIPPKPL MRRDQMEGSP 
NSSESFEHIA RSARDHAISL SEPRMLWGSD PYPHAEPQQA TTPKATEEPE DVRSEAALDQ 
EQITAAYSVE HNQLEAHPKA DFIRESSEAQ VQKFLSRSVE DVRPHHTDAN NQSACFEAPD 
QKTLSAPQEE RISAVESQPS RKRSVSHGSN HTQKPDEQRS EPSAGIPKVT SRCIDSKEPI 
ERPEEKPKKE GFIRSSEGPK PEKVYKSKSE TRWGPRPSSN RREEVNDRPV RRSGPIKKPV 
LRDMKEEREQ RKEKEGEKAE KVTEKVVVKP EKTEKKDLPP PPPPPQPPAP IQPQSVPPPI 
QPEAEKFPST ETATLAQKPS QDTEKPLEPV STVQVEPAVK TVNQQTMAAP VVKEEKQPEK 
VISKDLVIER PRPDSRPAVK KESTLPPRTY WKEARERDWF PDQGYRGRGR GEYYSRGRSY 
RGSYGGRGRG GRGHTRDYPQ YRDNKPRAEH IPSGPLRQRE ESETRSESSD FEVVPKRRRQ 
RGSETDTDSE IHESASDKDS LSKGKLPKRE ERPENKKPVK PHSSFKPDNH VRIDNRLLEK 
PYVRDDDKAK PGFLPKGEPT RRGRGGTFRR GGRDPGGRPS RPSTLRRPAY RDNQWNPRQS 
EVPKPEDGEP PRRHEQFIPI AADKRPPKFE RKFDPARERP RRQRPTRPPR QDKPPRFRRL 
REREAASKSN EVVAVPTNGT VNNVAQEPVN TLGDISGNKT PDLSNQNSSD QANEEWETAS 
ESSDFNERRE RDEKKNADLN AQTVVKVGEN VLPPKREIAK RSFSSQRPVD RQNRRGNNGP 
PKSGRNFSGP RNERRSGPPS KSGKRGPFDD QPAGTTGVDL INGSSAHHQE GVPNGTGQKN 
SKDSTGKKRE DPKPGPKKPK EKVDALSQFD LNNYASVVII DDHPEVTVIE DPQSNLNDDG 
FTEVVSKKQQ KRLQDEERRK KEEQVIQVWN KKNANEKGRS QTSKLPPRFA KKQATGIQQA 
QSSASVPPLA SAPLPPSTSA SVPASTSAPL PATLTPVPAS TSAPVPASTL APVLASTSAP 
VPASPLAPVS ASASVSASVP ASTSAAAITS SSAPASAPAP TPILASVSTP ASVTILASAS 
IPILASALAS TSAPTPAPAA SSPAAPVITA PTIPASAPTA SVPLAPASAS APAPAPTPVS 
APNPAPPAPA QTQAQTHKPV QNPLQTTSQS SKQPPPSIRL PSAQTPNGTD YVASGKSIQT 
PQSHGTLTAE LWDNKVAPPA VLNDISKKLG PISPPQPPSV SAWNKPLTSF GSAPSSEGAK 
NGQESGLEIG TDTIQFGAPA SNGNENEVVP VLSEKSADKI PEPKEQRQKQ PRAGPIKAQK 
LPDLSPVENK EHKPGPIGKE RSLKNRKVKD AQQVEPEGQE KPSPATVRST DPVTTKETKA 
VSEMSTEIGT MISVSSAEYG TNAKESVTDY TTPSSSLPNT VATNNTKMED TLVNNVPLPN 
TLPLPKRETI QQSSSLTSVP PTTFSLTFKM ESARKAWENS PNVREKGSPV TSTAPPIATG 
VSSSASGPST ANYNSFSSAS MPQIPVASVT PTASLSGAGT YTTSSLSTKS TTTSDPPNIC 
KVKPQQLQTS SLPSASHFSQ LSCMPSLIAQ QQQNPQVYVS QSAAAQIPAF YMDTSHLFNT 
QHARLAPPSL AQQQGFQPGL SQPTSVQQIP IPIYAPLQGQ HQAQLSLGAG PAVSQAQELF 
SSSLQPYRSQ PAFMQSSLSQ PSVVLSGTAI HNFPTVQHQE LAKAQSGLAF QQTSNTQPIP 
ILYEHQLGQA SGLGGSQLID THLLQARANL TQASNLYSGQ VQQPGQTNFY NTAQSPSALQ 
QVTVPLPASQ LSLPNFGSTG QPLIALPQTL QPPLQHTTPQ AQAQSLSRPA QVSQPFRGLI 
PAGTQHSMIA TTGKMSEMEL KAFGSGIDIK PGTPPIAGRS TTPTSSPFRA TSTSPNSQSS 
KMNSIVYQKQ FQSAPATVRM TQPFPTQFAP QILSQPNLVP PLVRAPHTNT FPAPVQRPPM 
ALASQMPPPL TTGLMSHARL PHVARGPCGS LSGVRGNQAQ AALKAEQDMK AKQRAEVLQS 
TQRFFSEQQQ SKQIGGGKAQ KVDSDSSKPP ETLTDPPGVC QEKVEEKPPP APSIATKPVR 
TGPIKPQAIK TEETKS

Genular Protein ID: 3738619703

Symbol: E7EPN9_HUMAN

Name: N/A

UniProtKB Accession Codes:

E7EPN9

Database IDs:

ARBA 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 EPD 2 Ensembl 2 ExpressionAtlas 1 GO 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 2 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 PANTHER 2 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 2819
  • Mass: 308777
  • Checksum: 1BEAB582D6CCCF33
  • Sequence:
    • MSEKSGQSTK AKDGKKYATL SLFNTYKGKS LETQKTTVAA RHGLQSLGKV GISRRMPPPA 
NLPSLKAENK GNDPNVNIVP KDGTGWASKQ EQHEEEKTPE VPPAQPKPGV AAPPEVAPAP 
KSWASNKQGG QGDGIQVNSQ FQQEFPSLQA AGDQEKKEKE TNDDNYGPGP SLRPPNVACW 
RDGGKAAGSP SSSDQDEKLP GQDESTAGTS EQNDILKVVE KRIACGPPQA KLNGQQAALA 
SQYRAMMPPY MFQQYPRMTY PPLHGPMRFP PSLSETNKGL RGRGPPPSWA SEPERPSILS 
ASELKELDKF DNLDAEADEG WAGAQMEVDY TEQLNFSDDD EQGSNSPKEN NSEDQGSKAS 
ENNENKKETD EVSNTKSSSQ IPAQPSVAKV PYGKGPSFNQ ERGTSSHLPP PPKLLAQQHP 
PPDRQAVPGR PGPFPSKQQV ADEDEIWKQR RRQQSEISAA VERARKRREE EERRMEEQRK 
AACAEKLKRL DEKLGILEKQ PSPEEIRERE REKEREREKE LEKEQEQERE KEREKDRERQ 
QEKEKELEKE QEKQREMEKE RKQEKEKELE RQKEKEKELQ KMKEQEKECE LEKEREKLEE 
KIEPREPNLE PMVEKQESEN SCNKEEEPVF TRQDSNRSEK EATPVVHETE PESGSQPRPA 
VLSGYFKQFQ KSLPPRFQRQ QEQMKQQQWQ QQQQQGVLPQ TVPSQPSSST VPPPPHRPLY 
QPMQPHPQHL ASMGFDPRWL MMQSYMDPRM MSGRPAMDIP PIHPGMIPPK PLMRRDQMEG 
SPNSSESFEH IARSARDHAI SLSEPRMLWG SDPYPHAEPQ QATTPKATEE PEDVRSEAAL 
DQEQITAAYS VEHNQLEAHP KADFIRESSE AQVQKFLSRS VEDVRPHHTD ANNQSACFEA 
PDQKTLSAPQ EERISAVESQ PSRKRSVSHG SNHTQKPDEQ RSEPSAGIPK VTSRCIDSKE 
PIERPEEKPK KEGFIRSSEG PKPEKVYKSK SETRWGPRPS SNRREEVNDR PVRRSGPIKK 
PVLRDMKEER EQRKEKEGEK AEKVTEKVVV KPEKTEKKDL PPPPPPPQPP APIQPQSVPP 
PIQPEAEKFP STETATLAQK PSQDTEKPLE PVSTVQVEPA VKTVNQQTMA APVVKEEKQP 
EKVISKDLVI ERPRPDSRPA VKKESTLPPR TYWKEARERD WFPDQGYRGR GRGEYYSRGR 
SYRGSYGGRG RGGRGHTRDY PQYRDNKPRA EHIPSGPLRQ REESETRSES SDFEVVPKRR 
RQRGSETDTD SEIHESASDK DSLSKGKLPK REERPENKKP VKPHSSFKPD NHVRIDNRLL 
EKPYVRDDDK AKPGFLPKGE PTRRGRGGTF RRGGRDPGGR PSRPSTLRRP AYRDNQWNPR 
QSEVPKPEDG EPPRRHEQFI PIAADKRPPK FERKFDPARE RPRRQRPTRP PRQDKPPRFR 
RLREREAASK SNEVVAVPTN GTVNNVAQEP VNTLGDISGN KTPDLSNQNS SDQANEEWET 
ASESSDFNER RERDEKKNAD LNAQTVVKVG ENVLPPKREI AKRSFSSQRP VDRQNRRGNN 
GPPKSGRNFS GPRNERRSGP PSKSGKRGPF DDQPAGTTGV DLINGSSAHH QEGVPNGTGQ 
KNSKDSTGKK REDPKPGPKK PKEKVDALSQ FDLNNYASVV IIDDHPEVTV IEDPQSNLND 
DGFTEVVSKK QQKRLQDEER RKKEEQVIQV WNKKNANEKG RSQTSKLPPR FAKKQATGIQ 
QAQSSASVPP LASAPLPPST SASVPASTSA PLPATLTPVP ASTSAPVPAS TLAPVLASTS 
APVPASPLAP VSASASVSAS VPASTSAAAI TSSSAPASAP APTPILASVS TPASVTILAS 
ASIPILASAL ASTSAPTPAP AASSPAAPVI TAPTIPASAP TASVPLAPAS ASAPAPAPTP 
VSAPNPAPPA PAQTQAQTHK PVQNPLQTTS QSSKQPPPSI RLPSAQTPNG TDYVASGKSI 
QTPQSHGTLT AELWDNKVAP PAVLNDISKK LGPISPPQPP SVSAWNKPLT SFGSAPSSEG 
AKNGQESGLE IGTDTIQFGA PASNGNENEV VPVLSEKSAD KIPEPKEQRQ KQPRAGPIKA 
QKLPDLSPVE NKEHKPGPIG KERSLKNRKV KDAQQVEPEG QEKPSPATVR STDPVTTKET 
KAVSEMSTEI GTMISVSSAE YGTNAKESVT DYTTPSSSLP NTVATNNTKM EDTLVNNVPL 
PNTLPLPKRE TIQQSSSLTS VPPTTFSLTF KMESARKAWE NSPNVREKGS PVTSTAPPIA 
TGVSSSASGP STANYNSFSS ASMPQIPVAS VTPTASLSGA GTYTTSSLST KSTTTSDPPN 
ICKVKPQQLQ TSSLPSASHF SQLSCMPSLI AQQQQNPQVY VSQSAAAQIP AFYMDTSHLF 
NTQHARLAPP SLAQQQGFQP GLSQPTSVQQ IPIPIYAPLQ GQHQAQLSLG AGPAVSQAQE 
LFSSSLQPYR SQPAFMQSSL SQPSVVLSGT AIHNFPTVQH QELAKAQSGL AFQQTSNTQP 
IPILYEHQLG QASGLGGSQL IDTHLLQARA NLTQASNLYS GQVQQPGQTN FYNTAQSPSA 
LQQVTVPLPA SQLSLPNFGS TGQPLIALPQ TLQPPLQHTT PQAQAQSLSR PAQVSQPFRG 
LIPAGTQHSM IATTGKMSEM ELKAFGSGID IKPGTPPIAG RSTTPTSSPF RATSTSPNSQ 
SSKMNSIVYQ KQFQSAPATV RMTQPFPTQF APQAKQRAEV LQSTQRFFSE QQQSKQIGGG 
KAQKVDSDSS KPPETLTDPP GVCQEKVEEK PPPAPSIATK PVRTGPIKPQ AIKTEETKS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.