Details for: TBC1D1

Gene ID: 23216

Symbol: TBC1D1

Ensembl ID: ENSG00000065882

Description: TBC1 domain family member 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 3.75
    Marker Score: 3,576
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.02
    Marker Score: 6,625
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.99
    Marker Score: 1,575
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.9
    Marker Score: 1,572
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.86
    Marker Score: 2,206
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.75
    Marker Score: 6,897
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.74
    Marker Score: 11,481
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.71
    Marker Score: 792
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.66
    Marker Score: 2,301
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.43
    Marker Score: 54,338
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.27
    Marker Score: 717
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.19
    Marker Score: 73,929
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.15
    Marker Score: 1,071
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.12
    Marker Score: 6,034
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.11
    Marker Score: 2,423
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.08
    Marker Score: 3,995
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.07
    Marker Score: 44,178
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.02
    Marker Score: 19,042
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.02
    Marker Score: 3,342
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.89
    Marker Score: 116,358
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.88
    Marker Score: 71,371
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.8
    Marker Score: 665
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.8
    Marker Score: 15,424
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.79
    Marker Score: 562
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.78
    Marker Score: 6,314
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.78
    Marker Score: 1,060
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.72
    Marker Score: 16,329
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.7
    Marker Score: 25,402
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.69
    Marker Score: 1,205
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.68
    Marker Score: 533
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.67
    Marker Score: 2,180
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 1.67
    Marker Score: 460
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.66
    Marker Score: 61,400
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.64
    Marker Score: 2,750
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.62
    Marker Score: 1,747
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.61
    Marker Score: 2,369
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.58
    Marker Score: 510
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.56
    Marker Score: 568
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.56
    Marker Score: 3,665
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.55
    Marker Score: 560
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.53
    Marker Score: 580
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.52
    Marker Score: 3,830
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.47
    Marker Score: 2,760
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.45
    Marker Score: 1,256
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.45
    Marker Score: 493
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.44
    Marker Score: 2,086
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.37
    Marker Score: 5,560
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.33
    Marker Score: 4,712
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.32
    Marker Score: 740
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.32
    Marker Score: 336
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.32
    Marker Score: 20,640
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.31
    Marker Score: 264
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.3
    Marker Score: 13,214
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.3
    Marker Score: 25,886
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.3
    Marker Score: 3,474
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 1.27
    Marker Score: 3,640
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.25
    Marker Score: 4,850
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.25
    Marker Score: 769
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.25
    Marker Score: 9,599
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.24
    Marker Score: 1,762
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.23
    Marker Score: 1,899
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 1.23
    Marker Score: 322
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.22
    Marker Score: 1,150
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.21
    Marker Score: 2,468
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.21
    Marker Score: 852
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.19
    Marker Score: 1,211
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.18
    Marker Score: 707
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.17
    Marker Score: 2,751
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.16
    Marker Score: 806
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.15
    Marker Score: 755
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.14
    Marker Score: 1,020
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.11
    Marker Score: 321
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.09
    Marker Score: 60,875
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.09
    Marker Score: 2,953
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.08
    Marker Score: 1,886
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.08
    Marker Score: 1,141
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.07
    Marker Score: 2,662
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.07
    Marker Score: 1,052
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.05
    Marker Score: 969
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.05
    Marker Score: 1,317
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 1.05
    Marker Score: 480
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.04
    Marker Score: 1,042
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.04
    Marker Score: 359
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 1.04
    Marker Score: 269
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.03
    Marker Score: 6,614
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.02
    Marker Score: 3,040
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.02
    Marker Score: 4,700
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.02
    Marker Score: 593
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.01
    Marker Score: 1,968
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1
    Marker Score: 374
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1
    Marker Score: 223
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,610
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,833
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.99
    Marker Score: 718
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,378
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.97
    Marker Score: 367
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.97
    Marker Score: 477
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.96
    Marker Score: 2,325
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.96
    Marker Score: 432
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.96
    Marker Score: 230

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Domain structure:** TBC1D1 contains a TBC1 domain, which is a conserved motif that confers GTPase-activating protein (GAP) activity, enabling the regulation of RAB GTPases. 2. **Expression patterns:** TBC1D1 is expressed in various cell types, including renal interstitial pericytes, ciliary muscle cells, and cardiac myocytes. 3. **Protein interactions:** TBC1D1 interacts with multiple proteins, including RAB GTPases, RAB GTPase-activating proteins (GAPs), and vesicular transport proteins. 4. **Cellular localization:** TBC1D1 is primarily localized to the plasma membrane, where it regulates membrane trafficking and vesicle-mediated transport. **Pathways and Functions:** 1. **Activation of GTPase activity:** TBC1D1 acts as a GAP for RAB GTPases, regulating their GTPase activity and thereby controlling membrane trafficking, vesicle formation, and cellular signaling. 2. **Membrane trafficking:** TBC1D1 regulates the trafficking of vesicles and organelles to and from the plasma membrane, ensuring proper cellular homeostasis and function. 3. **Cilium assembly:** TBC1D1 is involved in the regulation of cilium assembly and maintenance, which is critical for cellular polarity and signaling. 4. **Translocation of SLC2A4 (Glut4) to the plasma membrane:** TBC1D1 regulates the translocation of Glut4 to the plasma membrane, a process essential for glucose uptake and insulin signaling. **Clinical Significance:** 1. **Renal disease:** Dysregulation of TBC1D1 has been implicated in various renal diseases, including diabetic nephropathy and hypertension. 2. **Neurological disorders:** Mutations in TBC1D1 have been associated with neurological disorders, including epilepsy and cognitive impairment. 3. **Cardiovascular disease:** TBC1D1 plays a critical role in regulating cardiac function and has been implicated in cardiovascular disease. 4. **Immunological disorders:** TBC1D1 has been shown to regulate immune responses, and dysregulation of this gene may contribute to immunological disorders, such as autoimmune diseases. In conclusion, TBC1D1 is a multifaceted gene that plays a critical role in regulating various cellular processes, including membrane trafficking, cilium assembly, and vesicle-mediated transport. Its dysregulation has been implicated in various diseases, including renal disease, neurological disorders, cardiovascular disease, and immunological disorders. Further research is needed to fully elucidate the mechanisms by which TBC1D1 regulates cellular homeostasis and to explore its therapeutic potential.

Genular Protein ID: 1378031667

Symbol: TBCD1_HUMAN

Name: TBC1 domain family member 1

UniProtKB Accession Codes:

Q86TI0 B7Z3D9 E9PGH8 Q96K82 Q9UPP4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10470851

Title: Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10470851

DOI: 10.1093/dnares/6.3.197

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 24879834

Title: The adaptor protein APPL2 inhibits insulin-stimulated glucose uptake by interacting with TBC1D1 in skeletal muscle.

PubMed ID: 24879834

DOI: 10.2337/db14-0337

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 21454505

Title: Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation.

PubMed ID: 21454505

DOI: 10.1074/jbc.m110.217323

PubMed ID: 16893906

Title: TBC1D1 is a candidate for a severe obesity gene and evidence for a gene/gene interaction in obesity predisposition.

PubMed ID: 16893906

DOI: 10.1093/hmg/ddl204

PubMed ID: 18325908

Title: R125W coding variant in TBC1D1 confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population.

PubMed ID: 18325908

DOI: 10.1093/hmg/ddn070

Sequence Information:

  • Length: 1168
  • Mass: 133084
  • Checksum: 5EFEA168F04C88E0
  • Sequence:
    • MEPITFTARK HLLSNEVSVD FGLQLVGSLP VHSLTTMPML PWVVAEVRRL SRQSTRKEPV 
TKQVRLCVSP SGLRCEPEPG RSQQWDPLIY SSIFECKPQR VHKLIHNSHD PSYFACLIKE 
DAVHRQSICY VFKADDQTKV PEIISSIRQA GKIARQEELH CPSEFDDTFS KKFEVLFCGR 
VTVAHKKAPP ALIDECIEKF NHVSGSRGSE SPRPNPPHAA PTGSQEPVRR PMRKSFSQPG 
LRSLAFRKEL QDGGLRSSGF FSSFEESDIE NHLISGHNIV QPTDIEENRT MLFTIGQSEV 
YLISPDTKKI ALEKNFKEIS FCSQGIRHVD HFGFICRESS GGGGFHFVCY VFQCTNEALV 
DEIMMTLKQA FTVAAVQQTA KAPAQLCEGC PLQSLHKLCE RIEGMNSSKT KLELQKHLTT 
LTNQEQATIF EEVQKLRPRN EQRENELIIS FLRCLYEEKQ KEHIHIGEMK QTSQMAAENI 
GSELPPSATR FRLDMLKNKA KRSLTESLES ILSRGNKARG LQEHSISVDL DSSLSSTLSN 
TSKEPSVCEK EALPISESSF KLLGSSEDLS SDSESHLPEE PAPLSPQQAF RRRANTLSHF 
PIECQEPPQP ARGSPGVSQR KLMRYHSVST ETPHERKDFE SKANHLGDSG GTPVKTRRHS 
WRQQIFLRVA TPQKACDSSS RYEDYSELGE LPPRSPLEPV CEDGPFGPPP EEKKRTSREL 
RELWQKAILQ QILLLRMEKE NQKLQASEND LLNKRLKLDY EEITPCLKEV TTVWEKMLST 
PGRSKIKFDM EKMHSAVGQG VPRHHRGEIW KFLAEQFHLK HQFPSKQQPK DVPYKELLKQ 
LTSQQHAILI DLGRTFPTHP YFSAQLGAGQ LSLYNILKAY SLLDQEVGYC QGLSFVAGIL 
LLHMSEEEAF KMLKFLMFDM GLRKQYRPDM IILQIQMYQL SRLLHDYHRD LYNHLEEHEI 
GPSLYAAPWF LTMFASQFPL GFVARVFDMI FLQGTEVIFK VALSLLGSHK PLILQHENLE 
TIVDFIKSTL PNLGLVQMEK TINQVFEMDI AKQLQAYEVE YHVLQEELID SSPLSDNQRM 
DKLEKTNSSL RKQNLDLLEQ LQVANGRIQS LEATIEKLLS SESKLKQAML TLELERSALL 
QTVEELRRRS AEPSDREPEC TQPEPTGD

Genular Protein ID: 1886201485

Symbol: Q6PJJ8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6PJJ8

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Gene3D 4 Genevisible 1 GenomeRNAi 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PeptideAtlas 1 Pfam 3 RefSeq 1 SAM 1 SMART 2 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 900
  • Mass: 102877
  • Checksum: 2685321241656FC7
  • Sequence:
    • IENHLISGHN IVQPTDIEEN RTMLFTIGQS EVYLISPDTK KIALEKNFKE ISFCSQGIRH 
VDHFGFICRE SSGGGGFHFV CYVFQCTNEA LVDEIMMTLK QAFTVAAVQQ TAKAPAQLCE 
GCPLQSLHKL CERIEGMNSS KTKLELQKHL TTLTNQEQAT IFEEVQKLRP RNEQRENELI 
ISFLRCLYEE KQKEHIHIGE MKQTSQMAAE NIGSELPPSA TRFRLDMLKN KAKRSLTESL 
ESILSRGNKA RGLQEHSISV DLDSSLSSTL SNTSKEPSVC EKEALPISES SFKLLGSSED 
LSSDSESHLP EEPAPLSPQQ AFRRRANTLS HFPIECQEPP QPARGSPGVS QRKLMRYHSV 
STETPHERKD FESKANHLGD SGGTPVKTRR HSWRQQIFLR VATPQKACDS SSRYEDYSEL 
GELPPRSPLE PVCEDGPFGP PPEEKKRTSR ELRELWQKAI LQQILLLRME KENQKLQASE 
NDLLNKRLKL DYEEITPCLK EVTTVWEKML STPGRSKIKF DMEKMHSAVG QGVPRHHRGE 
IWKFLAEQFH LKHQFPSKQQ PKDVPYKELL KQLTSQQHAI LIDLGRTFPT HPYFSAQLGA 
GQLSLYNILK AYSLLDQEVG YCQGLSFVAG ILLLHMSEEE AFKMLKFLMF DMGLRKQYRP 
DMIILQIQMY QLSRLLHDYH RDLYNHLEEH EIGPSLYAAP WFLTMFASQF PLGFVARVFD 
MIFLQGTEVI FKVALSLLGS HKPLILQHEN LETIVDFIKS TLPNLGLVQM EKTINQVFEM 
DIAKQLQAYE VEYHVLQEEL IDSSPLSDNQ RMDKLEKTNS SLRKQNLDLL EQLQVANGRI 
QSLEATIEKL LSSESKLKQA MLTLELERSA LLQTVEELRR RSAEPSDREP ECTQPEPTGD

Genular Protein ID: 244377354

Symbol: Q8NC59_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8NC59

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 4 Gene3D 1 GenomeRNAi 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 5 SAM 1 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

Sequence Information:

  • Length: 265
  • Mass: 30804
  • Checksum: 156483811A194610
  • Sequence:
    • MSEEEAFKML KFLMFDMGLR KQYRPDMIIL QIQMYQLSRL LHDYHRDLYN HLEEHEIGPS 
LYAAPWFLTM FASQFPLGFV ARVFDMIFLQ GTEVIFKVAL SLLGSHKPLI LQHENLETIV 
DFIKSTLPNL GLVQMEKTIN QVFEMDIAKQ LQAYEVEYHV LQEELIDSSP LSDNQRMDKL 
EKTNSSLRKQ NLDLLEQLQV ANGRIQSLEA TIEKLLSSES KLKQAMLTLE LERSALLQTV 
EELRRRSAEP SDREPECTQP EPTGD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.