Details for: ZFR2

Gene ID: 23217

Symbol: ZFR2

Ensembl ID: ENSG00000105278

Description: zinc finger RNA binding protein 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.99
    Marker Score: 75,693
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.95
    Marker Score: 38,785
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.91
    Marker Score: 7,780
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.9
    Marker Score: 17,886
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.86
    Marker Score: 27,789
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.83
    Marker Score: 14,060
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.83
    Marker Score: 767
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.82
    Marker Score: 7,044
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.74
    Marker Score: 106,962
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.74
    Marker Score: 16,517
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.74
    Marker Score: 7,200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.71
    Marker Score: 17,692
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.66
    Marker Score: 14,251
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.62
    Marker Score: 514
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1,170
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.6
    Marker Score: 58,942
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.54
    Marker Score: 2,377
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5
    Marker Score: 1,497
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 870
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.33
    Marker Score: 364
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.32
    Marker Score: 2,213
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 855
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.21
    Marker Score: 2,301
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.19
    Marker Score: 2,413
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,815
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 503
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 796
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.03
    Marker Score: 1,248
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,824
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,048
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.99
    Marker Score: 33,416
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.97
    Marker Score: 912
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,328
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.93
    Marker Score: 1,619
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.93
    Marker Score: 384
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.92
    Marker Score: 4,269
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.89
    Marker Score: 3,438
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.89
    Marker Score: 3,693
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,288
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,262
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.77
    Marker Score: 465
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.77
    Marker Score: 2,199
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 703
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.75
    Marker Score: 217
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.75
    Marker Score: 235
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 461
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.68
    Marker Score: 1,389
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.66
    Marker Score: 743
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.66
    Marker Score: 221
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.64
    Marker Score: 373
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.64
    Marker Score: 246
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.64
    Marker Score: 158
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.59
    Marker Score: 393
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.59
    Marker Score: 1,226
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.59
    Marker Score: 849
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.59
    Marker Score: 175
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.57
    Marker Score: 262
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.56
    Marker Score: 295
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.55
    Marker Score: 1,558
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.53
    Marker Score: 8,291
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.51
    Marker Score: 3,420
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.49
    Marker Score: 1,137
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.45
    Marker Score: 148
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.43
    Marker Score: 3,276
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.39
    Marker Score: 482
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.38
    Marker Score: 3,777
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.37
    Marker Score: 99
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.37
    Marker Score: 215
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.36
    Marker Score: 115
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.36
    Marker Score: 1,501
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.35
    Marker Score: 113
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.34
    Marker Score: 169
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.33
    Marker Score: 329
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.3
    Marker Score: 103
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.29
    Marker Score: 312
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.29
    Marker Score: 116
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.29
    Marker Score: 138
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.28
    Marker Score: 116
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.27
    Marker Score: 263
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.27
    Marker Score: 162
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.27
    Marker Score: 652
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.26
    Marker Score: 126
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.25
    Marker Score: 70
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.24
    Marker Score: 2,437
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.24
    Marker Score: 261
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.24
    Marker Score: 119
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.24
    Marker Score: 1,264
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.23
    Marker Score: 852
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.23
    Marker Score: 626

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **RNA-binding protein:** ZFR2 is a member of the zinc finger RNA binding protein family, which are known for their ability to recognize and bind to specific RNA sequences, thereby regulating gene expression. 2. **Specific expression pattern:** ZFR2 is expressed in a variety of neuronal populations, including GABAergic interneurons, glutamatergic neurons, and retinal ganglion cells, suggesting a specialized role in these cells. 3. **Zinc finger motif:** The protein contains a zinc finger motif, which is a conserved structural motif that allows for the recognition and binding of specific DNA or RNA sequences. 4. **Conserved sequence:** ZFR2 shares high sequence similarity with other zinc finger RNA binding proteins, indicating a conserved evolutionary function. **Pathways and Functions:** 1. **RNA stability and splicing regulation:** ZFR2 may regulate RNA stability and splicing by binding to specific RNA sequences, thereby modulating the expression of target genes. 2. **Translation regulation:** ZFR2 may also regulate translation by binding to specific mRNA sequences, thereby controlling the levels of protein expression. 3. **Neuronal excitability modulation:** ZFR2 may modulate neuronal excitability by regulating the expression of genes involved in synaptic transmission and neuronal plasticity. 4. **Synaptic transmission regulation:** ZFR2 may also regulate synaptic transmission by modulating the expression of genes involved in neurotransmitter release and receptor function. **Clinical Significance:** 1. **Neurodevelopmental disorders:** Abnormal expression or function of ZFR2 may contribute to neurodevelopmental disorders, such as autism spectrum disorder, schizophrenia, and intellectual disability. 2. **Neurodegenerative diseases:** ZFR2 may also play a role in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, by regulating gene expression and neuronal function. 3. **Cancer:** ZFR2 has been implicated in cancer, particularly in the regulation of gene expression and cell growth. 4. **Therapeutic potential:** Understanding the function and regulation of ZFR2 may lead to the development of novel therapeutic strategies for treating neurodevelopmental and neurodegenerative disorders. In conclusion, ZFR2 is a multifunctional protein that plays a critical role in regulating gene expression and neuronal function in the nervous system. Further research is needed to fully elucidate the function and significance of ZFR2 in the context of neural development, function, and disease.

Genular Protein ID: 499032288

Symbol: ZFR2_HUMAN

Name: Zinc finger RNA-binding protein 2

UniProtKB Accession Codes:

Q9UPR6 B4DHD0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 3 ExpressionAtlas 1 GO 3 Gene3D 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SAM 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10470851

Title: Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10470851

DOI: 10.1093/dnares/6.3.197

Sequence Information:

  • Length: 939
  • Mass: 101330
  • Checksum: 94E63C2C1C13C845
  • Sequence:
    • MATSQYFDFA QGGGPQYSAQ PPTLPLPTVG ASYTAQPTPG MDPAVNPAFP PAAPAGYGGY 
QPHSGQDFAY GSRPQEPVPT ATTMATYQDS YSYGQSAAAR SYEDRPYFQS AALQSGRMTA 
ADSGQPGTQE ACGQPSPHGS HSHAQPPQQA PIVESGQPAS TLSSGYTYPT ATGVQPESSA 
SIVTSYPPPS YNPTCTAYTA PSYPNYDASV YSAASPFYPP AQPPPPPGPP QQLPPPPAPA 
GSGSSPRADS KPPLPSKLPR PKAGPRQLQL HYCDICKISC AGPQTYREHL GGQKHRKKEA 
AQKTGVQPNG SPRGVQAQLH CDLCAVSCTG ADAYAAHIRG SKHQKVFKLH AKLGKPIPTL 
EPALATESPP GAEAKPTSPT GPSVCASSRP ALAKRPVASK ALCEGPPEPQ AAGCRPQWGK 
PAQPKLEGPG APTQGGSKEA PAGCSDAQPV GPEYVEEVFS DEGRVLRFHC KLCECSFNDL 
NAKDLHVRGR RHRLQYRKKV NPDLPIATEP SSRARKVLEE RMRKQRHLAE ERLEQLRRWH 
AERRRLEEEP PQDVPPHAPP DWAQPLLMGR PESPASAPLQ PGRRPASSDD RHVMCKHATI 
YPTEQELLAV QRAVSHAERA LKLVSDTLAE EDRGRREEEG DKRSSVAPQT RVLKGVMRVG 
ILAKGLLLRG DRNVRLALLC SEKPTHSLLR RIAQQLPRQL QMVTEDEYEV SSDPEANIVI 
SSCEEPRMQV TISVTSPLMR EDPSTDPGVE EPQADAGDVL SPKKCLESLA ALRHARWFQA 
RASGLQPCVI VIRVLRDLCR RVPTWGALPA WAMELLVEKA VSSAAGPLGP GDAVRRVLEC 
VATGTLLTDG PGLQDPCERD QTDALEPMTL QEREDVTASA QHALRMLAFR QTHKVLGMDL 
LPPRHRLGAR FRKRQRGPGE GEEGAGEKKR GRRGGEGLV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.