Details for: FBXO28

Gene ID: 23219

Symbol: FBXO28

Ensembl ID: ENSG00000143756

Description: F-box protein 28

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuron (CL0000540)
    Fold Change: 1.71
    Marker Score: 6,951
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.68
    Marker Score: 103,203
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.61
    Marker Score: 15,334
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.55
    Marker Score: 14,602
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.55
    Marker Score: 13,318
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.51
    Marker Score: 15,553
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.48
    Marker Score: 54,639
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,990
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.46
    Marker Score: 5,631
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.46
    Marker Score: 21,763
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.45
    Marker Score: 55,104
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.45
    Marker Score: 28,849
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.4
    Marker Score: 2,160
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.39
    Marker Score: 10,654
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.27
    Marker Score: 5,283
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.12
    Marker Score: 23,913
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.11
    Marker Score: 1,282
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.09
    Marker Score: 318
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.08
    Marker Score: 1,359
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.08
    Marker Score: 5,010
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.02
    Marker Score: 4,418
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.01
    Marker Score: 1,949
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.01
    Marker Score: 1,262
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,703
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,928
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,394
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.98
    Marker Score: 1,055
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.96
    Marker Score: 1,085
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.96
    Marker Score: 535
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.95
    Marker Score: 6,132
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,398
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 481
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 437
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.92
    Marker Score: 3,831
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.91
    Marker Score: 1,989
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.9
    Marker Score: 998
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,706
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.9
    Marker Score: 1,460
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.9
    Marker Score: 4,818
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.89
    Marker Score: 793
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.87
    Marker Score: 522
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.87
    Marker Score: 19,389
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.86
    Marker Score: 312
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.86
    Marker Score: 418
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4,860
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.83
    Marker Score: 12,924
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.82
    Marker Score: 237
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.82
    Marker Score: 3,021
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.81
    Marker Score: 565
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.81
    Marker Score: 404
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.81
    Marker Score: 425
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.8
    Marker Score: 1,972
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.8
    Marker Score: 300
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.8
    Marker Score: 296
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.8
    Marker Score: 689
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.79
    Marker Score: 2,823
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.79
    Marker Score: 784
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.79
    Marker Score: 828
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 315
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 594
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.77
    Marker Score: 1,301
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.77
    Marker Score: 1,812
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.76
    Marker Score: 12,165
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.76
    Marker Score: 913
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.75
    Marker Score: 1,063
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.74
    Marker Score: 272
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.74
    Marker Score: 24,895
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.73
    Marker Score: 1,487
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.72
    Marker Score: 422
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 375
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3,025
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.72
    Marker Score: 660
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.72
    Marker Score: 489
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.72
    Marker Score: 300
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.71
    Marker Score: 356
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.71
    Marker Score: 2,945
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.71
    Marker Score: 872
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7
    Marker Score: 12,460
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.7
    Marker Score: 1,673
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.7
    Marker Score: 1,985
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.69
    Marker Score: 432
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.69
    Marker Score: 596
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.69
    Marker Score: 737
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.69
    Marker Score: 654
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.68
    Marker Score: 370
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.68
    Marker Score: 462
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.67
    Marker Score: 1,196
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.67
    Marker Score: 712
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 612
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.67
    Marker Score: 182
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.66
    Marker Score: 851
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.66
    Marker Score: 969
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.66
    Marker Score: 287
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.66
    Marker Score: 538
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.65
    Marker Score: 934
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.65
    Marker Score: 165
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.65
    Marker Score: 413

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key characteristics:** FBXO28 is a small, evolutionary conserved protein that belongs to the F-box protein family, which consists of approximately 200 proteins. These proteins are characterized by a conserved F-box domain, a protein-protein interaction motif that mediates the binding of ubiquitin ligases to substrate proteins. FBXO28 shares several key characteristics with other F-box proteins, including: * High sequence similarity to other F-box proteins * Presence of the F-box domain * Association with the ubiquitin-proteasome pathway **Pathways and functions:** FBXO28 is involved in multiple cellular processes, including: * **Protein degradation:** FBXO28 acts as a ubiquitin ligase, recognizing and targeting specific proteins for degradation by the ubiquitin-proteasome pathway. This process is crucial for maintaining protein homeostasis and regulating cellular signaling pathways. * **Cell cycle progression:** FBXO28 has been implicated in the regulation of cell cycle progression, particularly in neurons. Its expression is tightly regulated during development and is required for proper neuronal differentiation and survival. * **Synaptic plasticity:** FBXO28 has been shown to play a role in regulating synaptic plasticity, a critical process underlying learning and memory. Its expression is altered in response to synaptic activity, suggesting a role in adapting to changing neural environments. **Clinical significance:** The clinical significance of FBXO28 is still being explored, but its expression in various neuronal populations suggests a role in neurological disorders. Some potential implications of FBXO28 dysregulation include: * **Neurodegenerative diseases:** FBXO28's involvement in protein degradation and cell cycle regulation may contribute to the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's. * **Neurodevelopmental disorders:** Dysregulation of FBXO28 may contribute to neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. * **Neurological disorders:** FBXO28's role in synaptic plasticity and neuronal survival may be relevant to neurological disorders, such as stroke and traumatic brain injury. In conclusion, FBXO28 is a complex protein with multiple roles in brain function and development. Further research is needed to fully elucidate its functions and implications in neurological disorders.

Genular Protein ID: 54284367

Symbol: FBX28_HUMAN

Name: F-box only protein 28

UniProtKB Accession Codes:

Q9NVF7 E9PEM8 O75070

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9455484

Title: Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.

PubMed ID: 9455484

DOI: 10.1093/dnares/4.5.345

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20813266

Title: The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics.

PubMed ID: 20813266

DOI: 10.1016/j.cell.2010.07.047

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 21248752

Title: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.

PubMed ID: 21248752

DOI: 10.1038/nature09639

PubMed ID: 33280099

Title: FBXO28 causes developmental and epileptic encephalopathy with profound intellectual disability.

PubMed ID: 33280099

DOI: 10.1111/epi.16784

Sequence Information:

  • Length: 368
  • Mass: 41149
  • Checksum: 500A2583AB7315E6
  • Sequence:
    • MAAAAEERMA EEGGGGQGDG GSSLASGSTQ RQPPPPAPQH PQPGSQALPA PALAPDQLPQ 
NNTLVALPIV AIENILSFMS YDEISQLRLV CKRMDLVCQR MLNQGFLKVE RYHNLCQKQV 
KAQLPRRESE RRNHSLARHA DILAAVETRL SLLNMTFMKY VDSNLCCFIP GKVIDEIYRV 
LRYVNSTRAP QRAHEVLQEL RDISSMAMEY FDEKIVPILK RKLPGSDVSG RLMGSPPVPG 
PSAALTTMQL FSKQNPSRQE VTKLQQQVKT NGAGVTVLRR EISELRTKVQ EQQKQLQDQD 
QKLLEQTQII GEQNARLAEL ERKLREVMES AVGNSSGSGQ NEESPRKRKK ATEAIDSLRK 
SKRLRNRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.