Details for: DTX4
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 1.65
Marker Score: 1,104 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.22
Marker Score: 2,865 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,799 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,023 - Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.99
Marker Score: 795 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.99
Marker Score: 10,246 - Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.98
Marker Score: 284 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.98
Marker Score: 1,995 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,405 - Cell Name: neural crest cell (CL0011012)
Fold Change: 0.97
Marker Score: 1,035 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 499 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 453 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,411 - Cell Name: neuron (CL0000540)
Fold Change: 0.95
Marker Score: 3,849 - Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.93
Marker Score: 434 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.93
Marker Score: 1,433 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.92
Marker Score: 5,275 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,738 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.89
Marker Score: 319 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,276 - Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 0.81
Marker Score: 197 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.81
Marker Score: 6,222 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.81
Marker Score: 1,192 - Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 0.8
Marker Score: 752 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.79
Marker Score: 48,840 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,270 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.78
Marker Score: 1,480 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.78
Marker Score: 596 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.78
Marker Score: 7,310 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.77
Marker Score: 3,236 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.77
Marker Score: 308 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.76
Marker Score: 239 - Cell Name: ciliated cell (CL0000064)
Fold Change: 0.76
Marker Score: 2,620 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.75
Marker Score: 388 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.73
Marker Score: 2,817 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.72
Marker Score: 27,409 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.72
Marker Score: 232 - Cell Name: brush cell (CL0002204)
Fold Change: 0.71
Marker Score: 648 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.71
Marker Score: 6,717 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.71
Marker Score: 4,243 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.69
Marker Score: 1,562 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 175 - Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.68
Marker Score: 216 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.68
Marker Score: 705 - Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 0.68
Marker Score: 462 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.67
Marker Score: 13,310 - Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 0.67
Marker Score: 211 - Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 0.66
Marker Score: 325 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.65
Marker Score: 1,567 - Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.62
Marker Score: 3,280 - Cell Name: mesangial cell (CL0000650)
Fold Change: 0.61
Marker Score: 739 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.6
Marker Score: 2,499 - Cell Name: type I pneumocyte (CL0002062)
Fold Change: 0.6
Marker Score: 720 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.59
Marker Score: 9,294 - Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.59
Marker Score: 543 - Cell Name: alveolar macrophage (CL0000583)
Fold Change: 0.59
Marker Score: 15,109 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.59
Marker Score: 3,750 - Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 0.58
Marker Score: 4,281 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.57
Marker Score: 219 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.57
Marker Score: 567 - Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.56
Marker Score: 114 - Cell Name: lung goblet cell (CL1000143)
Fold Change: 0.56
Marker Score: 161 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.55
Marker Score: 479 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 437 - Cell Name: interneuron (CL0000099)
Fold Change: 0.55
Marker Score: 249 - Cell Name: germ cell (CL0000586)
Fold Change: 0.53
Marker Score: 926 - Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 0.53
Marker Score: 305 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.52
Marker Score: 335 - Cell Name: enterocyte (CL0000584)
Fold Change: 0.52
Marker Score: 2,496 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.51
Marker Score: 18,890 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.5
Marker Score: 7,522 - Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 0.49
Marker Score: 311 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.49
Marker Score: 4,227 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.47
Marker Score: 309 - Cell Name: stem cell (CL0000034)
Fold Change: 0.47
Marker Score: 1,109 - Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.47
Marker Score: 1,465 - Cell Name: pro-B cell (CL0000826)
Fold Change: 0.46
Marker Score: 445 - Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.46
Marker Score: 119 - Cell Name: astrocyte (CL0000127)
Fold Change: 0.45
Marker Score: 392 - Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 0.45
Marker Score: 165 - Cell Name: club cell (CL0000158)
Fold Change: 0.45
Marker Score: 525 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.45
Marker Score: 1,767 - Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.44
Marker Score: 167 - Cell Name: mucous neck cell (CL0000651)
Fold Change: 0.44
Marker Score: 999 - Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.44
Marker Score: 116 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.44
Marker Score: 263 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.44
Marker Score: 459 - Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 0.43
Marker Score: 1,791 - Cell Name: mucus secreting cell (CL0000319)
Fold Change: 0.43
Marker Score: 109 - Cell Name: secretory cell (CL0000151)
Fold Change: 0.43
Marker Score: 777 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.43
Marker Score: 203 - Cell Name: preosteoblast (CL0007010)
Fold Change: 0.42
Marker Score: 120 - Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 0.42
Marker Score: 236 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.41
Marker Score: 511 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.41
Marker Score: 200 - Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 0.41
Marker Score: 3,557 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.41
Marker Score: 1,748 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.4
Marker Score: 150 - Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 0.39
Marker Score: 162 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 0.38
Marker Score: 267
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3154592956
Symbol: DTX4_HUMAN
Name: E3 ubiquitin-protein ligase DTX4
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10231032
Title: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 10231032
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15684394
Title: Normal immune system development in mice lacking the Deltex-1 RING finger domain.
PubMed ID: 15684394
PubMed ID: 22388039
Title: NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4.
PubMed ID: 22388039
DOI: 10.1038/ni.2239
Sequence Information:
- Length: 619
- Mass: 67258
- Checksum: 5C851845B42630BD
- Sequence:
MLLASAVVVW EWLNEHGRWR PYSPAVSHHI EAVVRAGPRA GGSVVLGQVD SRLAPYIIDL QSMNQFRQDT GTLRPVRRNY YDPSSAPGKG VVWEWENDNG SWTPYDMEVG ITIQHAYEKQ HPWIDLTSIG FSYVIDFNTM GQINRQTQRQ RRVRRRLDLI YPMVTGTLPK AQSWPVSPGP ATSPPMSPCS CPQCVLVMSV KAAVVNGSTG PLQLPVTRKN MPPPGVVKLP PLPGSGAKPL DSTGTIRGPL KTAPSQVIRR QASSMPTGTT MGSPASPPGP NSKTGRVALA TLNRTNLQRL AIAQSRVLIA SGVPTVPVKN LNGSSPVNPA LAGITGILMS AAGLPVCLTR PPKLVLHPPP VSKSEIKSIP GVSNTSRKTT KKQAKKGKTP EEVLKKYLQK VRHPPDEDCT ICMERLTAPS GYKGPQPTVK PDLVGKLSRC GHVYHIYCLV AMYNNGNKDG SLQCPTCKTI YGVKTGTQPP GKMEYHLIPH SLPGHPDCKT IRIIYSIPPG IQGPEHPNPG KSFSARGFPR HCYLPDSEKG RKVLKLLLVA WDRRLIFAIG TSSTTGESDT VIWNEVHHKT EFGSNLTGHG YPDANYLDNV LAELAAQGIS EDSTAQEKD
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.