Details for: DTX4

Gene ID: 23220

Symbol: DTX4

Ensembl ID: ENSG00000110042

Description: deltex E3 ubiquitin ligase 4

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.65
    Marker Score: 1,104
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.22
    Marker Score: 2,865
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,799
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,023
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.99
    Marker Score: 795
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.99
    Marker Score: 10,246
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.98
    Marker Score: 284
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.98
    Marker Score: 1,995
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,405
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.97
    Marker Score: 1,035
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 499
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 453
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.95
    Marker Score: 3,849
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.93
    Marker Score: 434
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.93
    Marker Score: 1,433
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,275
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,738
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,276
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.81
    Marker Score: 197
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.81
    Marker Score: 6,222
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.81
    Marker Score: 1,192
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.8
    Marker Score: 752
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.79
    Marker Score: 48,840
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,270
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.78
    Marker Score: 1,480
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 596
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.78
    Marker Score: 7,310
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.77
    Marker Score: 3,236
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 308
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.76
    Marker Score: 239
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.76
    Marker Score: 2,620
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 388
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.73
    Marker Score: 2,817
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.72
    Marker Score: 27,409
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.72
    Marker Score: 232
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 648
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.71
    Marker Score: 6,717
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.71
    Marker Score: 4,243
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.69
    Marker Score: 1,562
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.68
    Marker Score: 216
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.68
    Marker Score: 705
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.68
    Marker Score: 462
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.67
    Marker Score: 13,310
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.67
    Marker Score: 211
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.66
    Marker Score: 325
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.65
    Marker Score: 1,567
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.62
    Marker Score: 3,280
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.61
    Marker Score: 739
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.6
    Marker Score: 2,499
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.6
    Marker Score: 720
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.59
    Marker Score: 9,294
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.59
    Marker Score: 543
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.59
    Marker Score: 15,109
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.59
    Marker Score: 3,750
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.58
    Marker Score: 4,281
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.57
    Marker Score: 219
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.57
    Marker Score: 567
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.56
    Marker Score: 114
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.56
    Marker Score: 161
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.55
    Marker Score: 479
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 437
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.55
    Marker Score: 249
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.53
    Marker Score: 926
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.53
    Marker Score: 305
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.52
    Marker Score: 335
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.52
    Marker Score: 2,496
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.51
    Marker Score: 18,890
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.5
    Marker Score: 7,522
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.49
    Marker Score: 311
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.49
    Marker Score: 4,227
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.47
    Marker Score: 309
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.47
    Marker Score: 1,109
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.47
    Marker Score: 1,465
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.46
    Marker Score: 445
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.46
    Marker Score: 119
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.45
    Marker Score: 392
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.45
    Marker Score: 165
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.45
    Marker Score: 525
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.45
    Marker Score: 1,767
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.44
    Marker Score: 167
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.44
    Marker Score: 999
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.44
    Marker Score: 116
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.44
    Marker Score: 263
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.44
    Marker Score: 459
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.43
    Marker Score: 1,791
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.43
    Marker Score: 109
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.43
    Marker Score: 777
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.43
    Marker Score: 203
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.42
    Marker Score: 120
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.42
    Marker Score: 236
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.41
    Marker Score: 511
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.41
    Marker Score: 200
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.41
    Marker Score: 3,557
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.41
    Marker Score: 1,748
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.4
    Marker Score: 150
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.39
    Marker Score: 162
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.38
    Marker Score: 267

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DTX4 is a member of the deltex family of E3 ubiquitin ligases, which are known for their ability to regulate protein degradation and signaling pathways. DTX4 is specifically expressed in various cell types, including nasal mucosa goblet cells, kidney proximal straight tubule epithelial cells, and dopaminergic neurons. Its expression is also observed in immune cells, such as immature innate lymphoid cells, highlighting its involvement in immune regulation. **Pathways and Functions:** DTX4 is involved in several key signaling pathways, including: 1. **Notch Signaling:** DTX4 is part of the Notch signaling pathway, which plays a crucial role in cell fate determination, differentiation, and proliferation. Notch signaling is also involved in immune regulation, and DTX4's involvement in this pathway suggests its role in modulating immune responses. 2. **Innate Immune Response:** DTX4 is involved in the regulation of innate immune responses, particularly in response to pathogen-associated DNA (PAMPs). Its expression in immune cells, such as innate lymphoid cells, highlights its role in initiating immune responses. 3. **Type I Interferon Production:** DTX4 is also involved in the regulation of type I interferon (IFN) production, which is a key component of the innate immune response. Its expression in cells that produce IFN suggests its role in modulating IFN production. 4. **Protein Degradation:** As an E3 ubiquitin ligase, DTX4 is involved in the degradation of proteins through the ubiquitin-proteasome pathway. This process is crucial for regulating protein levels and activity within cells. **Clinical Significance:** The clinical significance of DTX4 lies in its potential role in immune-related disorders. Dysregulation of the Notch signaling pathway and innate immune response has been implicated in various diseases, including autoimmune disorders, cancer, and neurological disorders. DTX4's involvement in these pathways suggests its potential role in modulating immune responses and influencing disease progression. Furthermore, DTX4's expression in various cell types, including dopaminergic neurons, highlights its potential role in neurological disorders, such as Parkinson's disease. Its involvement in protein degradation and ubiquitination suggests its potential role in regulating protein levels and activity within cells, which could be relevant in understanding disease progression. In conclusion, DTX4 is a crucial gene that plays a pivotal role in regulating immune responses, Notch signaling, and cellular homeostasis. Its clinical significance lies in its potential role in immune-related disorders and neurological diseases. Further research is needed to fully understand the mechanisms by which DTX4 regulates these processes and to explore its potential as a therapeutic target. **Recommendations:** 1. Further research is needed to elucidate the mechanisms by which DTX4 regulates Notch signaling and innate immune responses. 2. The role of DTX4 in protein degradation and ubiquitination should be further investigated to understand its potential impact on disease progression. 3. The clinical significance of DTX4 should be further explored in various disease models, including autoimmune disorders, cancer, and neurological disorders. By further understanding the mechanisms by which DTX4 regulates immune responses and cellular homeostasis, we can gain insights into the development of novel therapeutic strategies for immune-related disorders and neurological diseases.

Genular Protein ID: 3154592956

Symbol: DTX4_HUMAN

Name: E3 ubiquitin-protein ligase DTX4

UniProtKB Accession Codes:

Q9Y2E6 Q0VF38

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 2 GO 14 Gene3D 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 4 RefSeq 3 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10231032

Title: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10231032

DOI: 10.1093/dnares/6.1.63

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15684394

Title: Normal immune system development in mice lacking the Deltex-1 RING finger domain.

PubMed ID: 15684394

DOI: 10.1128/mcb.25.4.1437-1445.2005

PubMed ID: 22388039

Title: NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4.

PubMed ID: 22388039

DOI: 10.1038/ni.2239

Sequence Information:

  • Length: 619
  • Mass: 67258
  • Checksum: 5C851845B42630BD
  • Sequence:
    • MLLASAVVVW EWLNEHGRWR PYSPAVSHHI EAVVRAGPRA GGSVVLGQVD SRLAPYIIDL 
QSMNQFRQDT GTLRPVRRNY YDPSSAPGKG VVWEWENDNG SWTPYDMEVG ITIQHAYEKQ 
HPWIDLTSIG FSYVIDFNTM GQINRQTQRQ RRVRRRLDLI YPMVTGTLPK AQSWPVSPGP 
ATSPPMSPCS CPQCVLVMSV KAAVVNGSTG PLQLPVTRKN MPPPGVVKLP PLPGSGAKPL 
DSTGTIRGPL KTAPSQVIRR QASSMPTGTT MGSPASPPGP NSKTGRVALA TLNRTNLQRL 
AIAQSRVLIA SGVPTVPVKN LNGSSPVNPA LAGITGILMS AAGLPVCLTR PPKLVLHPPP 
VSKSEIKSIP GVSNTSRKTT KKQAKKGKTP EEVLKKYLQK VRHPPDEDCT ICMERLTAPS 
GYKGPQPTVK PDLVGKLSRC GHVYHIYCLV AMYNNGNKDG SLQCPTCKTI YGVKTGTQPP 
GKMEYHLIPH SLPGHPDCKT IRIIYSIPPG IQGPEHPNPG KSFSARGFPR HCYLPDSEKG 
RKVLKLLLVA WDRRLIFAIG TSSTTGESDT VIWNEVHHKT EFGSNLTGHG YPDANYLDNV 
LAELAAQGIS EDSTAQEKD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.