Details for: ARHGEF9

Gene ID: 23229

Symbol: ARHGEF9

Ensembl ID: ENSG00000131089

Description: Cdc42 guanine nucleotide exchange factor 9

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 4.3
    Marker Score: 57,244
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.15
    Marker Score: 642
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.07
    Marker Score: 7,359
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2
    Marker Score: 1,045
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.99
    Marker Score: 29,692
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.95
    Marker Score: 72,085
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.95
    Marker Score: 38,828
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.95
    Marker Score: 73,974
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.94
    Marker Score: 8,952
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.92
    Marker Score: 3,902
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.88
    Marker Score: 115,656
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.87
    Marker Score: 7,225
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.81
    Marker Score: 7,497
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.8
    Marker Score: 13,801
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.8
    Marker Score: 16,928
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.8
    Marker Score: 17,086
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.76
    Marker Score: 15,112
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.59
    Marker Score: 4,537
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.56
    Marker Score: 907
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.55
    Marker Score: 491
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.54
    Marker Score: 2,383
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.46
    Marker Score: 32,611
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.46
    Marker Score: 31,095
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.45
    Marker Score: 608
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.43
    Marker Score: 3,131
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.31
    Marker Score: 1,587
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.28
    Marker Score: 718
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.2
    Marker Score: 461
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.18
    Marker Score: 1,115
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.14
    Marker Score: 660
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.11
    Marker Score: 17,387
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.07
    Marker Score: 292
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1
    Marker Score: 480
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,715
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,942
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.99
    Marker Score: 2,340
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,397
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.96
    Marker Score: 4,025
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,401
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.94
    Marker Score: 458
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 480
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 434
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,711
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.88
    Marker Score: 1,529
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,293
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.86
    Marker Score: 8,659
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4,910
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.85
    Marker Score: 943
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.84
    Marker Score: 797
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.84
    Marker Score: 416
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.82
    Marker Score: 3,325
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.79
    Marker Score: 251
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,268
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.76
    Marker Score: 254
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.75
    Marker Score: 325
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.75
    Marker Score: 371
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 568
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 293
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 374
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.71
    Marker Score: 770
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7
    Marker Score: 695
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.7
    Marker Score: 418
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2,902
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 628
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.68
    Marker Score: 785
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.68
    Marker Score: 433
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.67
    Marker Score: 442
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.65
    Marker Score: 192
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.64
    Marker Score: 685
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.64
    Marker Score: 221
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.63
    Marker Score: 161
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.63
    Marker Score: 215
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.63
    Marker Score: 335
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.63
    Marker Score: 531
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.62
    Marker Score: 1,186
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.62
    Marker Score: 180
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.61
    Marker Score: 332
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.61
    Marker Score: 470
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.61
    Marker Score: 355
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.6
    Marker Score: 652
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.59
    Marker Score: 312
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.59
    Marker Score: 3,555
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.59
    Marker Score: 190
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.59
    Marker Score: 219
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.58
    Marker Score: 820
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.57
    Marker Score: 179
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.57
    Marker Score: 171
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.57
    Marker Score: 704
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.57
    Marker Score: 235
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.56
    Marker Score: 228
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.56
    Marker Score: 208
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.56
    Marker Score: 756
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.56
    Marker Score: 1,518
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.56
    Marker Score: 369
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.55
    Marker Score: 263
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.55
    Marker Score: 680
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.54
    Marker Score: 498
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.54
    Marker Score: 267

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ARHGEF9 is a member of the Rho GEF family, which are essential for regulating the activity of small GTPases, including Cdc42. Cdc42 is a key regulator of various cellular processes, including cell migration, adhesion, and survival. ARHGEF9's unique ability to activate Cdc42 makes it an important player in regulating immune responses, neuronal signaling, and cell death pathways. **Pathways and Functions:** ARHGEF9's involvement in various signaling pathways highlights its complex role in immune regulation and neurotransmission. Some of the key pathways and functions of ARHGEF9 include: 1. **Cdc42 GTPase Cycle:** ARHGEF9's ability to activate Cdc42 is crucial for regulating the Cdc42 GTPase cycle, which in turn controls cell migration, adhesion, and survival. 2. **Cell Death Signaling:** ARHGEF9's interaction with the N-RAGE signaling pathway, which involves the activation of JNK, highlights its role in regulating cell death and immune responses. 3. **Neuronal Signaling:** ARHGEF9's involvement in the GABAergic synapse and postsynaptic density formation underscores its importance in regulating neuronal signaling and synaptic plasticity. 4. **Rho GTPase Cycle:** ARHGEF9's role in regulating the Rho GTPase cycle highlights its involvement in controlling cell migration, adhesion, and survival. **Clinical Significance:** The dysregulation of ARHGEF9's functions has been implicated in various diseases, including: 1. **Immune Disorders:** Dysregulation of ARHGEF9's role in immune responses has been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Neurological Disorders:** ARHGEF9's involvement in neuronal signaling and synaptic plasticity has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer:** ARHGEF9's role in regulating cell migration and adhesion has been implicated in cancer progression and metastasis. In conclusion, ARHGEF9's multifunctional role in regulating immune responses, neuronal signaling, and cell death pathways highlights its importance in maintaining cellular homeostasis. Further research is necessary to fully elucidate the mechanisms underlying ARHGEF9's functions and to explore its therapeutic potential in various diseases.

Genular Protein ID: 583494534

Symbol: ARHG9_HUMAN

Name: Rho guanine nucleotide exchange factor 9

UniProtKB Accession Codes:

O43307 A8K1S8 B4DHC7 F8W7P8 Q5JSL6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PROSITE 3 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 5 RefSeq 5 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9455477

Title: Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9455477

DOI: 10.1093/dnares/4.5.307

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10559246

Title: Identification and characterization of hPEM-2, a guanine nucleotide exchange factor specific for Cdc42.

PubMed ID: 10559246

DOI: 10.1074/jbc.274.47.33587

PubMed ID: 15215304

Title: The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering.

PubMed ID: 15215304

DOI: 10.1523/jneurosci.1184-04.2004

PubMed ID: 22612257

Title: Targeted next generation sequencing as a diagnostic tool in epileptic disorders.

PubMed ID: 22612257

DOI: 10.1111/j.1528-1167.2012.03516.x

PubMed ID: 23033978

Title: Diagnostic exome sequencing in persons with severe intellectual disability.

PubMed ID: 23033978

DOI: 10.1056/nejmoa1206524

PubMed ID: 25678704

Title: Lipid binding defects and perturbed synaptogenic activity of a collybistinR290H mutant that causes epilepsy and intellectual disability.

PubMed ID: 25678704

DOI: 10.1074/jbc.m114.633024

Sequence Information:

  • Length: 516
  • Mass: 60982
  • Checksum: AAEE17366B46B707
  • Sequence:
    • MTLLITGDSI VSAEAVWDHV TMANRELAFK AGDVIKVLDA SNKDWWWGQI DDEEGWFPAS 
FVRLWVNQED EVEEGPSDVQ NGHLDPNSDC LCLGRPLQNR DQMRANVINE IMSTERHYIK 
HLKDICEGYL KQCRKRRDMF SDEQLKVIFG NIEDIYRFQM GFVRDLEKQY NNDDPHLSEI 
GPCFLEHQDG FWIYSEYCNN HLDACMELSK LMKDSRYQHF FEACRLLQQM IDIAIDGFLL 
TPVQKICKYP LQLAELLKYT AQDHSDYRYV AAALAVMRNV TQQINERKRR LENIDKIAQW 
QASVLDWEGE DILDRSSELI YTGEMAWIYQ PYGRNQQRVF FLFDHQMVLC KKDLIRRDIL 
YYKGRIDMDK YEVVDIEDGR DDDFNVSMKN AFKLHNKETE EIHLFFAKKL EEKIRWLRAF 
REERKMVQED EKIGFEISEN QKRQAAMTVR KVPKQKGVNS ARSVPPSYPP PQDPLNHGQY 
LVPDGIAQSQ VFEFTEPKRS QSPFWQNFSR LTPFKK

Genular Protein ID: 3394914179

Symbol: B1AMR3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B1AMR3 A0A096LNY0 A0A1B0GTC2

Database IDs:

ARBA 8 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 EMBL 5 EPD 1 Ensembl 12 GO 3 Gene3D 3 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 7 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 6 PROSITE-ProRule 1 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 5 SAM 1 SMART 3 SUPFAM 3 UCSC 2 VEuPathDB 1

Citations:

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

Sequence Information:

  • Length: 495
  • Mass: 58742
  • Checksum: 7AF060648E687B56
  • Sequence:
    • MANRELAFKA GDVIKVLDAS NKDWWWGQID DEEGWFPASF VRLWVNQEDE VEEGPSDVQN 
GHLDPNSDCL CLGRPLQNRD QMRANVINEI MSTERHYIKH LKDICEGYLK QCRKRRDMFS 
DEQLKVIFGN IEDIYRFQMG FVRDLEKQYN NDDPHLSEIG PCFLEHQDGF WIYSEYCNNH 
LDACMELSKL MKDSRYQHFF EACRLLQQMI DIAIDGFLLT PVQKICKYPL QLAELLKYTA 
QDHSDYRYVA AALAVMRNVT QQINERKRRL ENIDKIAQWQ ASVLDWEGED ILDRSSELIY 
TGEMAWIYQP YGRNQQRVFF LFDHQMVLCK KDLIRRDILY YKGRIDMDKY EVVDIEDGRD 
DDFNVSMKNA FKLHNKETEE IHLFFAKKLE EKIRWLRAFR EERKMVQEDE KIGFEISENQ 
KRQAAMTVRK VPKQKGVNSA RSVPPSYPPP QDPLNHGQYL VPDGIAQSQV FEFTEPKRSQ 
SPFWQNFSRL TPFKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.