Details for: EXOC6B

Gene ID: 23233

Symbol: EXOC6B

Ensembl ID: ENSG00000144036

Description: exocyst complex component 6B

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 5.58
    Marker Score: 4,580
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 5.43
    Marker Score: 183,308
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 4.93
    Marker Score: 110,108
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 4.49
    Marker Score: 24,105
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 4.48
    Marker Score: 15,017
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 4.29
    Marker Score: 22,498
  • Cell Name: granule cell (CL0000120)
    Fold Change: 4.17
    Marker Score: 31,426
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 4.02
    Marker Score: 9,229
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 3.86
    Marker Score: 9,240
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.71
    Marker Score: 8,136
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.58
    Marker Score: 4,056
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 3.57
    Marker Score: 4,799
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.44
    Marker Score: 4,158
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 3.41
    Marker Score: 12,126
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 3.38
    Marker Score: 14,158
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 3.37
    Marker Score: 15,601
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 3.36
    Marker Score: 14,005
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 3.34
    Marker Score: 1,858
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 3.28
    Marker Score: 2,833
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 3.26
    Marker Score: 2,894
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 3.23
    Marker Score: 1,875
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 3.19
    Marker Score: 2,460
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 3.05
    Marker Score: 5,877
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.97
    Marker Score: 3,701
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 2.96
    Marker Score: 2,231
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.9
    Marker Score: 61,855
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.88
    Marker Score: 1,722
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.88
    Marker Score: 3,313
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.83
    Marker Score: 828
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 2.8
    Marker Score: 1,344
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.77
    Marker Score: 55,191
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.72
    Marker Score: 48,317
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.72
    Marker Score: 1,431
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.69
    Marker Score: 20,641
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.69
    Marker Score: 40,251
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 2.64
    Marker Score: 1,154
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.64
    Marker Score: 4,439
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.62
    Marker Score: 99,519
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.57
    Marker Score: 7,329
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.56
    Marker Score: 10,603
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.55
    Marker Score: 1,773
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.55
    Marker Score: 810
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.54
    Marker Score: 1,479
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.52
    Marker Score: 725
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.51
    Marker Score: 1,409
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.46
    Marker Score: 777
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.43
    Marker Score: 1,419
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 2.42
    Marker Score: 885
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.41
    Marker Score: 1,011
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.41
    Marker Score: 6,036
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.4
    Marker Score: 88,606
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.38
    Marker Score: 1,292
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.35
    Marker Score: 3,305
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.32
    Marker Score: 892
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.3
    Marker Score: 8,888
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.29
    Marker Score: 1,509
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.28
    Marker Score: 2,519
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.17
    Marker Score: 20,459
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.17
    Marker Score: 1,071
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.12
    Marker Score: 1,187
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.11
    Marker Score: 2,012
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.06
    Marker Score: 126,739
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 2.02
    Marker Score: 2,519
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2
    Marker Score: 20,669
  • Cell Name: neuron (CL0000540)
    Fold Change: 2
    Marker Score: 8,144
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.99
    Marker Score: 517
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.95
    Marker Score: 709
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.92
    Marker Score: 18,233
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.92
    Marker Score: 953
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.87
    Marker Score: 2,314
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.86
    Marker Score: 16,012
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.82
    Marker Score: 6,455
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.81
    Marker Score: 494
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.78
    Marker Score: 1,923
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.78
    Marker Score: 28,535
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 1.71
    Marker Score: 519
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.68
    Marker Score: 1,453
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.66
    Marker Score: 615
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.63
    Marker Score: 2,365
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.62
    Marker Score: 2,503
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.62
    Marker Score: 512
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.6
    Marker Score: 1,715
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.59
    Marker Score: 573
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.58
    Marker Score: 596
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.58
    Marker Score: 401
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.57
    Marker Score: 5,144
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.56
    Marker Score: 515
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.55
    Marker Score: 1,017
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.51
    Marker Score: 474
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.41
    Marker Score: 284
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.38
    Marker Score: 712
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.36
    Marker Score: 1,929
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.36
    Marker Score: 357
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.34
    Marker Score: 21,035
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.33
    Marker Score: 1,602
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 1.31
    Marker Score: 425
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.3
    Marker Score: 442
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.3
    Marker Score: 8,352
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.24
    Marker Score: 465
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.22
    Marker Score: 390

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** EXOC6B is predominantly expressed in cells of the nervous system, including Purkinje cells, neurons, and glial cells. It is also found in cardiac myocytes, particularly in regular ventricular cardiac myocytes. 2. **Protein Structure:** EXOC6B is a component of the exocyst complex, a multi-protein complex that regulates vesicle docking and fusion with the plasma membrane. 3. **Function:** EXOC6B is essential for the formation and fusion of vesicles with the plasma membrane, thereby facilitating the release of proteins, lipids, and other molecules to the extracellular environment. **Pathways and Functions:** 1. **Exocytosis:** EXOC6B is involved in the regulation of exocytosis, a process by which cells release proteins, lipids, and other molecules to the extracellular environment. 2. **Protein Binding:** EXOC6B interacts with other proteins, such as EXOC8 and EXOC10, to regulate the formation and fusion of vesicles with the plasma membrane. 3. **Golgi to Plasma Membrane Transport:** EXOC6B is involved in the transport of proteins and lipids from the Golgi apparatus to the plasma membrane. 4. **Vesicle Docking and Fusion:** EXOC6B regulates the docking and fusion of vesicles with the plasma membrane, thereby modulating the release of various cargoes. **Clinical Significance:** Dysregulation of EXOC6B has been implicated in various diseases, including: 1. **Neurological Disorders:** Mutations in EXOC6B have been associated with neurological disorders, such as epilepsy and neurodegenerative diseases. 2. **Cardiovascular Disease:** Alterations in EXOC6B expression have been linked to cardiovascular disease, including hypertension and cardiac fibrosis. 3. **Cancer:** EXOC6B has been implicated in cancer progression, including metastasis and tumor growth. In conclusion, EXOC6B is a critical component of the exocyst complex, regulating exocytosis and protein transport in various cell types. Its dysregulation has significant implications for human disease, highlighting the importance of further research into the molecular mechanisms underlying EXOC6B function.

Genular Protein ID: 2312276850

Symbol: EXC6B_HUMAN

Name: Exocyst complex component 6B

UniProtKB Accession Codes:

Q9Y2D4 B8ZZY3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10231032

Title: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10231032

DOI: 10.1093/dnares/6.1.63

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11406615

Title: The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene.

PubMed ID: 11406615

DOI: 10.1074/jbc.c100320200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 26669664

Title: A novel multiple joint dislocation syndrome associated with a homozygous nonsense variant in the EXOC6B gene.

PubMed ID: 26669664

DOI: 10.1038/ejhg.2015.261

PubMed ID: 30284759

Title: Confirmation of spondylo-epi-metaphyseal dysplasia with joint laxity, EXOC6B type.

PubMed ID: 30284759

DOI: 10.1002/ajmg.a.40631

Sequence Information:

  • Length: 811
  • Mass: 94201
  • Checksum: A666EC6A0B82D9A2
  • Sequence:
    • MERGKMAEAE SLETAAEHER ILREIESTDT ACIGPTLRSV YDGEEHGRFM EKLETRIRNH 
DREIEKMCNF HYQGFVDSIT ELLKVRGEAQ KLKNQVTDTN RKLQHEGKEL VIAMEELKQC 
RLQQRNISAT VDKLMLCLPV LEMYSKLRDQ MKTKRHYPAL KTLEHLEHTY LPQVSHYRFC 
KVMVDNIPKL REEIKDVSMS DLKDFLESIR KHSDKIGETA MKQAQQQRNL DNIVLQQPRI 
GSKRKSKKDA YIIFDTEIES TSPKSEQDSG ILDVEDEEDD EEVPGAQDLV DFSPVYRCLH 
IYSVLGARET FENYYRKQRR KQARLVLQPP SNMHETLDGY RKYFNQIVGF FVVEDHILHT 
TQGLVNRAYI DELWEMALSK TIAALRTHSS YCSDPNLVLD LKNLIVLFAD TLQVYGFPVN 
QLFDMLLEIR DQYSETLLKK WAGIFRNILD SDNYSPIPVT SEEMYKKVVG QFPFQDIELE 
KQPFPKKFPF SEFVPKVYNQ IKEFIYACLK FSEDLHLSST EVDDMIRKST NLLLTRTLSN 
SLQNVIKRKN IGLTELVQII INTTHLEKSC KYLEEFITNI TNVLPETVHT TKLYGTTTFK 
DARHAAEEEI YTNLNQKIDQ FLQLADYDWM TGDLGNKASD YLVDLIAFLR STFAVFTHLP 
GKVAQTACMS ACKHLATSLM QLLLEAEVRQ LTLGALQQFN LDVRECEQFA RSGPVPGFQE 
DTLQLAFIDL RQLLDLFIQW DWSTYLADYG QPNCKYLRVN PVTALTLLEK MKDTSRKNNM 
FAQFRKNERD KQKLIDTVAK QLRGLISSHH S

Genular Protein ID: 2310440468

Symbol: A0A0U1RRB6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0U1RRB6

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 5 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 5 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PeptideAtlas 1 Pfam 4 Proteomes 2 RefSeq 1 SAM 2 SMR 1 VEuPathDB 1

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 815
  • Mass: 94686
  • Checksum: C672B5D74D071BD7
  • Sequence:
    • MERGKMAEAE SLETAAEHER ILREIESTDT ACIGPTLRSV YDGEEHGRFM EKLETRIRNH 
DREIEKMCNF HYQGFVDSIT ELLKVRGEAQ KLKNQVTDTN RKLQHEGKEL VIAMEELKQC 
RLQQRNISAT VDKLMLCLPV LEMYSKLRDQ MKTKRHYPAL KTLEHLEHTY LPQVSHYRFC 
KVMVDNIPKL REEIKDVSMS DLKDFLESIR KHSDKIGETA MKQAQQQRNL DNIVLQQPRI 
GSKRKSKKDA YIIFDTEIES TSPKSEQDSG ILDVEDEEDD EEVPGAQDLV DFSPVYRCLH 
IYSVLGARET FENYYRKQRR KQARLVLQPP SNMHETLDGY RKYFNQIVGF FVVEDHILHT 
TQGLVNRAYI DELWEMALSK TIAALRTHSS YCSDPNLVLD LKNLIVLFAD TLQVYGFPVN 
QLFDMLLEIR DQYSETLLKK WAGIFRNILD SDNYSPIPVT SEEMYKKVVG QFPFQDIELE 
KQPFPKKFPF SEFVPKVYNQ IKEFIYACLK FSEDLHLSST EVDDMIRKST NLLLTRTLSN 
SLQNVIKRKN IGLTELVQII INTTHLEKSC KYLEEFITNI TNVLPETVHT TKLYGTTTFK 
DARHAAEEEI YTNLNQKIDQ FLQLADYDWM TGDLGNKASD YLVDLIAFLR STFAVFTHLP 
GKVAQTACMS ACKHLATSLM QLLLEAEVRQ LTLGALQQFN LDVRECEQFA RSGPVPGFQE 
DTLQLAFIDL RQLLDLFIQW DWSTYLADYG QPNCKYLRVN PVTALTLLEK ISREMKDTSR 
KNNMFAQFRK NERDKQKLID TVAKQLRGLI SSHHS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.