PLCB1 | ENSG00000182621 | NCBI 23236

Details for: PLCB1

Gene ID: 23236

Symbol: PLCB1

Ensembl ID: ENSG00000182621

Description: phospholipase C beta 1

Associated with

Acetylcholine regulates insulin secretion
(R-HSA-399997)
Activation of kainate receptors upon glutamate binding
(R-HSA-451326)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
Ca2+ pathway
(R-HSA-4086398)
Fatty acids bound to gpr40 (ffar1) regulate insulin secretion
(R-HSA-434316)
Free fatty acids regulate insulin secretion
(R-HSA-400451)
G-protein beta:gamma signalling
(R-HSA-397795)
G-protein mediated events
(R-HSA-112040)
G alpha (i) signalling events
(R-HSA-418594)
G alpha (q) signalling events
(R-HSA-416476)
G beta:gamma signalling through plc beta
(R-HSA-418217)
Gpcr downstream signalling
(R-HSA-388396)
Inositol phosphate metabolism
(R-HSA-1483249)
Integration of energy metabolism
(R-HSA-163685)
Metabolism
(R-HSA-1430728)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Opioid signalling
(R-HSA-111885)
Plc beta mediated events
(R-HSA-112043)
Presynaptic function of kainate receptors
(R-HSA-500657)
Regulation of insulin secretion
(R-HSA-422356)
Signaling by gpcr
(R-HSA-372790)
Signaling by wnt
(R-HSA-195721)
Synthesis of ip3 and ip4 in the cytosol
(R-HSA-1855204)
Transmission across chemical synapses
(R-HSA-112315)
Activation of meiosis involved in egg activation
(GO:0060466)
Calcium ion binding
(GO:0005509)
Calmodulin binding
(GO:0005516)
Cellular response to fluoride
(GO:1902618)
Cellular response to glyceraldehyde
(GO:1905631)
Cellular response to ionomycin
(GO:1904637)
Cellular response to vasopressin
(GO:1904117)
Cerebral cortex development
(GO:0021987)
Chromatin
(GO:0000785)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Enzyme binding
(GO:0019899)
Extracellular exosome
(GO:0070062)
Fat cell differentiation
(GO:0045444)
G2/m transition of mitotic cell cycle
(GO:0000086)
Gaba-ergic synapse
(GO:0098982)
Glutamate receptor signaling pathway
(GO:0007215)
Glutamatergic synapse
(GO:0098978)
G protein-coupled acetylcholine receptor signaling pathway
(GO:0007213)
G protein-coupled receptor signaling pathway
(GO:0007186)
Gtpase activator activity
(GO:0005096)
Identical protein binding
(GO:0042802)
Inositol trisphosphate metabolic process
(GO:0032957)
Insulin-like growth factor receptor signaling pathway
(GO:0048009)
Interleukin-1-mediated signaling pathway
(GO:0070498)
Interleukin-12-mediated signaling pathway
(GO:0035722)
Interleukin-15-mediated signaling pathway
(GO:0035723)
Ion channel modulating, g protein-coupled receptor signaling pathway
(GO:0099105)
Lamin binding
(GO:0005521)
Learning
(GO:0007612)
Ligand-gated ion channel signaling pathway
(GO:1990806)
Memory
(GO:0007613)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of monocyte extravasation
(GO:2000438)
Nuclear membrane
(GO:0031965)
Nuclear speck
(GO:0016607)
Nucleus
(GO:0005634)
Phosphatidylinositol-4,5-bisphosphate binding
(GO:0005546)
Phosphatidylinositol-mediated signaling
(GO:0048015)
Phosphatidylinositol catabolic process
(GO:0031161)
Phosphatidylinositol metabolic process
(GO:0046488)
Phosphatidylinositol phospholipase c activity
(GO:0004435)
Phospholipase c-activating g protein-coupled acetylcholine receptor signaling pathway
(GO:0007207)
Phospholipase c activity
(GO:0004629)
Positive regulation of acrosome reaction
(GO:2000344)
Positive regulation of cd24 production
(GO:2000560)
Positive regulation of developmental growth
(GO:0048639)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of embryonic development
(GO:0040019)
Positive regulation of g1/s transition of mitotic cell cycle
(GO:1900087)
Positive regulation of insulin secretion
(GO:0032024)
Positive regulation of interleukin-12 production
(GO:0032735)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of myoblast differentiation
(GO:0045663)
Postsynaptic cytosol
(GO:0099524)
Postsynaptic modulation of chemical synaptic transmission
(GO:0099170)
Protein binding
(GO:0005515)
Regulation of establishment of endothelial barrier
(GO:1903140)
Regulation of fertilization
(GO:0080154)
Regulation of g protein-coupled receptor signaling pathway
(GO:0008277)
Regulation of retrograde trans-synaptic signaling by endocanabinoid
(GO:0099178)
Release of sequestered calcium ion into cytosol
(GO:0051209)
Signal transduction
(GO:0007165)

Other Information

Proteins

PLC-154

Genular Protein ID: 659737867

Symbol: PLCB1_HUMAN

Name: PLC-154

UniProtKB Accession Codes:

Q9NQ66 D3DW12 D3DW13 O60325 Q17RQ6 Q5TFF7 Q5TGC9 Q8IV93 Q9BQW2 Q9H4H2 Q9H8H5 Q9NQ65 Q9NQH9 Q9NTH4 Q9UJP6 Q9UM26

Database IDs:

Citations:

PubMed ID: 11118617

Title: Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLCbeta1).

PubMed ID: 11118617

DOI: 10.1016/s0167-4781(00)00260-8

PubMed ID: 10760467

Title: Identification and chromosomal localisation by fluorescence in situ hybridisation of human gene of phosphoinositide-specific phospholipase C beta 1.

PubMed ID: 10760467

DOI: 10.1016/s1388-1981(00)00012-3

PubMed ID: 9628581

Title: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9628581

DOI: 10.1093/dnares/5.1.31

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 9188725

Title: Phosphoinositide binding specificity among phospholipase C isozymes as determined by photo-cross-linking to novel substrate and product analogs.

PubMed ID: 9188725

DOI: 10.1021/bi9702288

PubMed ID: 12799190

Title: Diacylglycerol kinase-theta is localized in the speckle domains of the nucleus.

PubMed ID: 12799190

DOI: 10.1016/s0014-4827(03)00115-0

PubMed ID: 20833646

Title: Phospholipase C beta 1 deficiency is associated with early-onset epileptic encephalopathy.

PubMed ID: 20833646

DOI: 10.1093/brain/awq238

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

Length: 1216
Mass: 138567
Checksum: 6F4263D1A50C6FD1
Sequence:

MAGAQPGVHA LQLKPVCVSD SLKKGTKFVK WDDDSTIVTP IILRTDPQGF FFYWTDQNKE 
TELLDLSLVK DARCGRHAKA PKDPKLRELL DVGNIGRLEQ RMITVVYGPD LVNISHLNLV 
AFQEEVAKEW TNEVFSLATN LLAQNMSRDA FLEKAYTKLK LQVTPEGRIP LKNIYRLFSA 
DRKRVETALE ACSLPSSRND SIPQEDFTPE VYRVFLNNLC PRPEIDNIFS EFGAKSKPYL 
TVDQMMDFIN LKQRDPRLNE ILYPPLKQEQ VQVLIEKYEP NNSLARKGQI SVDGFMRYLS 
GEENGVVSPE KLDLNEDMSQ PLSHYFINSS HNTYLTAGQL AGNSSVEMYR QVLLSGCRCV 
ELDCWKGRTA EEEPVITHGF TMTTEISFKE VIEAIAECAF KTSPFPILLS FENHVDSPKQ 
QAKMAEYCRL IFGDALLMEP LEKYPLESGV PLPSPMDLMY KILVKNKKKS HKSSEGSGKK 
KLSEQASNTY SDSSSMFEPS SPGAGEADTE SDDDDDDDDC KKSSMDEGTA GSEAMATEEM 
SNLVNYIQPV KFESFEISKK RNKSFEMSSF VETKGLEQLT KSPVEFVEYN KMQLSRIYPK 
GTRVDSSNYM PQLFWNAGCQ MVALNFQTMD LAMQINMGMY EYNGKSGYRL KPEFMRRPDK 
HFDPFTEGIV DGIVANTLSV KIISGQFLSD KKVGTYVEVD MFGLPVDTRR KAFKTKTSQG 
NAVNPVWEEE PIVFKKVVLP TLACLRIAVY EEGGKFIGHR ILPVQAIRPG YHYICLRNER 
NQPLTLPAVF VYIEVKDYVP DTYADVIEAL SNPIRYVNLM EQRAKQLAAL TLEDEEEVKK 
EADPGETPSE APSEARTTPA ENGVNHTTTL TPKPPSQALH SQPAPGSVKA PAKTEDLIQS 
VLTEVEAQTI EELKQQKSFV KLQKKHYKEM KDLVKRHHKK TTDLIKEHTT KYNEIQNDYL 
RRRAALEKSA KKDSKKKSEP SSPDHGSSTI EQDLAALDAE MTQKLIDLKD KQQQQLLNLR 
QEQYYSEKYQ KREHIKLLIQ KLTDVAEECQ NNQLKKLKEI CEKEKKELKK KMDKKRQEKI 
TEAKSKDKSQ MEEEKTEMIR SYIQEVVQYI KRLEEAQSKR QEKLVEKHKE IRQQILDEKP 
KLQVELEQEY QDKFKRLPLE ILEFVQEAMK GKISEDSNHG SAPLSLSSDP GKVNHKTPSS 
EELGGDIPGK EFDTPL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PLCB1

Associated with

Other Information

Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLCbeta1). PubMed ID: 11118617

Identification and chromosomal localisation by fluorescence in situ hybridisation of human gene of phosphoinositide-specific phospholipase C beta 1. PubMed ID: 10760467

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. PubMed ID: 9628581

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. PubMed ID: 12168954

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Phosphoinositide binding specificity among phospholipase C isozymes as determined by photo-cross-linking to novel substrate and product analogs. PubMed ID: 9188725

Diacylglycerol kinase-theta is localized in the speckle domains of the nucleus. PubMed ID: 12799190

Phospholipase C beta 1 deficiency is associated with early-onset epileptic encephalopathy. PubMed ID: 20833646

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974