ARC | ENSG00000198576 | NCBI 23237

Details for: ARC

Gene ID: 23237

Symbol: ARC

Ensembl ID: ENSG00000198576

Description: activity regulated cytoskeleton associated protein

Associated with

Ngf-stimulated transcription
(R-HSA-9031628)
Nuclear events (kinase and transcription factor activation)
(R-HSA-198725)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Acrosomal vesicle
(GO:0001669)
Actin cytoskeleton
(GO:0015629)
Anterior/posterior pattern specification
(GO:0009952)
Cell cortex
(GO:0005938)
Cell migration
(GO:0016477)
Clathrin-coated vesicle membrane
(GO:0030665)
Cytoplasm
(GO:0005737)
Cytoskeleton organization
(GO:0007010)
Cytosol
(GO:0005829)
Dendritic spine
(GO:0043197)
Dendritic spine morphogenesis
(GO:0060997)
Early endosome membrane
(GO:0031901)
Endocytosis
(GO:0006897)
Endoderm development
(GO:0007492)
Extracellular vesicle
(GO:1903561)
Glutamatergic synapse
(GO:0098978)
Learning
(GO:0007612)
Long-term memory
(GO:0007616)
Long-term synaptic potentiation
(GO:0060291)
Membrane raft
(GO:0045121)
Modulation of chemical synaptic transmission
(GO:0050804)
Mrna binding
(GO:0003729)
Mrna transport
(GO:0051028)
Neuronal cell body
(GO:0043025)
Neuronal ribonucleoprotein granule
(GO:0071598)
Plasma membrane
(GO:0005886)
Postsynaptic density membrane
(GO:0098839)
Postsynaptic endosome
(GO:0098845)
Protein binding
(GO:0005515)
Protein homooligomerization
(GO:0051260)
Regulation of cell morphogenesis
(GO:0022604)
Regulation of dendritic spine morphogenesis
(GO:0061001)
Regulation of long-term synaptic depression
(GO:1900452)
Regulation of long-term synaptic potentiation
(GO:1900271)
Regulation of neuronal synaptic plasticity
(GO:0048168)
Regulation of postsynaptic neurotransmitter receptor internalization
(GO:0099149)
Vesicle-mediated intercellular transport
(GO:0110077)

Other Information

Proteins

ARC_HUMAN

Genular Protein ID: 3441074389

Symbol: ARC_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7LC44 Q9UJW6 Q9Y469

Database IDs:

Citations:

PubMed ID: 10970730

Title: Mutation screening of the chromosome 8q24.3-human activity-regulated cytoskeleton-associated gene (ARC) in idiopathic generalized epilepsy.

PubMed ID: 10970730

DOI: 10.1006/mcpr.2000.0314

PubMed ID: 9039502

Title: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.

PubMed ID: 9039502

DOI: 10.1093/dnares/3.5.321

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21834987

Title: Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration.

PubMed ID: 21834987

DOI: 10.1186/1741-7007-9-54

PubMed ID: 24945773

Title: Triad3A regulates synaptic strength by ubiquitination of Arc.

PubMed ID: 24945773

DOI: 10.1016/j.neuron.2014.05.016

PubMed ID: 25748042

Title: Arc is a flexible modular protein capable of reversible self-oligomerization.

PubMed ID: 25748042

DOI: 10.1042/bj20141446

Sequence Information:

Length: 396
Mass: 45316
Checksum: D5C8A8A07FE9615D
Sequence:

MELDHRTSGG LHAYPGPRGG QVAKPNVILQ IGKCRAEMLE HVRRTHRHLL AEVSKQVERE 
LKGLHRSVGK LESNLDGYVP TSDSQRWKKS IKACLCRCQE TIANLERWVK REMHVWREVF 
YRLERWADRL ESTGGKYPVG SESARHTVSV GVGGPESYCH EADGYDYTVS PYAITPPPAA 
GELPGQEPAE AQQYQPWVPG EDGQPSPGVD TQIFEDPREF LSHLEEYLRQ VGGSEEYWLS 
QIQNHMNGPA KKWWEFKQGS VKNWVEFKKE FLQYSEGTLS REAIQRELDL PQKQGEPLDQ 
FLWRKRDLYQ TLYVDADEEE IIQYVVGTLQ PKLKRFLRHP LPKTLEQLIQ RGMEVQDDLE 
QAAEPAGPHL PVEDEAETLT PAPNSESVAS DRTQPE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ARC

Associated with

Other Information

Mutation screening of the chromosome 8q24.3-human activity-regulated cytoskeleton-associated gene (ARC) in idiopathic generalized epilepsy. PubMed ID: 10970730

Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. PubMed ID: 9039502

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. PubMed ID: 21834987

Triad3A regulates synaptic strength by ubiquitination of Arc. PubMed ID: 24945773