Details for: TMEM131L

Gene ID: 23240

Symbol: TMEM131L

Ensembl ID: ENSG00000121210

Description: transmembrane 131 like

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 5.4
    Marker Score: 71,779
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 4.69
    Marker Score: 13,673
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 4.07
    Marker Score: 1,977
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.35
    Marker Score: 28,329
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.28
    Marker Score: 1,276
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.2
    Marker Score: 2,434
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.16
    Marker Score: 6,412
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.16
    Marker Score: 2,059
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 2.13
    Marker Score: 780
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.09
    Marker Score: 46,652
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.04
    Marker Score: 75,140
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.92
    Marker Score: 2,311
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.85
    Marker Score: 4,062
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.78
    Marker Score: 878
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.74
    Marker Score: 7,225
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.72
    Marker Score: 931
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 1.68
    Marker Score: 4,836
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.66
    Marker Score: 4,501
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.64
    Marker Score: 391
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.61
    Marker Score: 24,129
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.52
    Marker Score: 2,921
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.49
    Marker Score: 5,314
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 168,043
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.37
    Marker Score: 14,180
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.36
    Marker Score: 5,245
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.33
    Marker Score: 3,128
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.29
    Marker Score: 20,205
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.29
    Marker Score: 79,086
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.28
    Marker Score: 771
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.28
    Marker Score: 750
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.27
    Marker Score: 1,443
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.27
    Marker Score: 533
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.26
    Marker Score: 739
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.26
    Marker Score: 25,058
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.22
    Marker Score: 5,663
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.22
    Marker Score: 2,121
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.21
    Marker Score: 3,037
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.18
    Marker Score: 2,478
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.17
    Marker Score: 1,098
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.14
    Marker Score: 43,104
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.11
    Marker Score: 1,164
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.1
    Marker Score: 10,346
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.09
    Marker Score: 1,908
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.09
    Marker Score: 541
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.08
    Marker Score: 391
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.08
    Marker Score: 283
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.06
    Marker Score: 341
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.04
    Marker Score: 732
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.02
    Marker Score: 278
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.01
    Marker Score: 317
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1
    Marker Score: 10,119
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,717
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,942
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.99
    Marker Score: 8,483
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.98
    Marker Score: 1,158
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,396
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.97
    Marker Score: 5,823
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.96
    Marker Score: 9,120
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.95
    Marker Score: 719
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,404
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 484
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.93
    Marker Score: 482
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 438
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.92
    Marker Score: 48,597
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.91
    Marker Score: 1,105
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,717
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.9
    Marker Score: 1,389
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.9
    Marker Score: 1,632
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.89
    Marker Score: 966
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.89
    Marker Score: 10,331
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.89
    Marker Score: 356
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.88
    Marker Score: 532
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.87
    Marker Score: 572
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4,947
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.86
    Marker Score: 1,065
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.85
    Marker Score: 2,071
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.84
    Marker Score: 830
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.84
    Marker Score: 751
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.84
    Marker Score: 562
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.83
    Marker Score: 417
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.83
    Marker Score: 398
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.83
    Marker Score: 252
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.82
    Marker Score: 210
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.82
    Marker Score: 308
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.81
    Marker Score: 3,311
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.81
    Marker Score: 210
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.81
    Marker Score: 206
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.8
    Marker Score: 184
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.79
    Marker Score: 3,270
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 597
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.78
    Marker Score: 565
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,248
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.76
    Marker Score: 3,200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.76
    Marker Score: 5,818
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.75
    Marker Score: 2,769
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.74
    Marker Score: 544
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.73
    Marker Score: 486
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 378

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TMEM131L is a transmembrane protein, characterized by its unique structure, which enables it to interact with various cellular components. Its expression is significantly elevated in multiple cell types, including those involved in the immune system, such as tonsil germinal center B cells and renal interstitial pericytes. The protein's ability to regulate canonical Wnt signaling pathway and immature T cell proliferation in the thymus highlights its potential role in immune regulation and tolerance. **Pathways and Functions:** TMEM131L's involvement in the negative regulation of canonical Wnt signaling pathway suggests that it may play a role in modulating cell proliferation, differentiation, and survival. The protein's ability to regulate immature T cell proliferation in the thymus further underscores its importance in immune tolerance and prevention of autoimmune diseases. Additionally, its expression in various cell types suggests that TMEM131L may be involved in maintaining tissue homeostasis and overall physiological balance. Key pathways and functions of TMEM131L include: * Negative regulation of canonical Wnt signaling pathway * Negative regulation of immature T cell proliferation in thymus * Regulation of cell proliferation, differentiation, and survival * Maintenance of tissue homeostasis and overall physiological balance **Clinical Significance:** The identification of TMEM131L as a key regulator of immune responses and cellular homeostasis has significant clinical implications. Dysregulation of TMEM131L has been implicated in various autoimmune diseases, including rheumatoid arthritis, lupus, and multiple sclerosis. Furthermore, TMEM131L's involvement in maintaining tissue homeostasis and overall physiological balance suggests that its dysregulation may contribute to various diseases, including cardiovascular disease, cancer, and metabolic disorders. In conclusion, TMEM131L is a novel transmembrane protein that plays a critical role in regulating immune responses and cellular homeostasis. Its involvement in the negative regulation of canonical Wnt signaling pathway and immature T cell proliferation in the thymus highlights its potential role in preventing autoimmune diseases. Further research is necessary to fully elucidate the function of TMEM131L and its clinical significance.

Genular Protein ID: 2057205683

Symbol: T131L_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10231032

Title: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10231032

DOI: 10.1093/dnares/6.1.63

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23690469

Title: Identification of TMEM131L as a novel regulator of thymocyte proliferation in humans.

PubMed ID: 23690469

DOI: 10.4049/jimmunol.1300400

Sequence Information:

  • Length: 1609
  • Mass: 179339
  • Checksum: 7F9D2EC0BC959210
  • Sequence:
  • MAGLRRPQPG CYCRTAAAVN LLLGVFQVLL PCCRPGGAQG QAIEPLPNVV ELWQAEEGEL 
    LLPTQGDSEE GLEEPSQEQS FSDKLFSGKG LHFQPSVLDF GIQFLGHPVA KILHAYNPSR 
    DSEVVVNSVF AAAGHFHVPP VPCRVIPAMG KTSFRIIFLP TEEGSIESSL FINTSSYGVL 
    SYHVSGIGTR RISTEGSAKQ LPNAYFLLPK VQSIQLSQMQ AETTNTSLLQ VQLECSLHNK 
    VCQQLKGCYL ESDDVLRLQM SIMVTMENFS KEFEENTQHL LDHLSIVYVA TDESETSDDS 
    AVNMYILHSG NSLIWIQDIR HFSQRDALSL QFEPVLLPTS TTNFTKIASF TCKATSCDSG 
    IIEDVKKTTH TPTLKACLFS SVAQGYFRMD SSATQFHIET HENTSGLWSI WYRNHFDRSV 
    VLNDVFLSKE TKHMLKILNF TGPLFLPPGC WNIFSLKLAV KDIAINLFTN VFLTTNIGAI 
    FAIPLQIYSA PTKEGSLGFE VIAHCGMHYF MGKSKAGNPN WNGSLSLDQS TWNVDSELAN 
    KLYERWKKYK NGDVCKRNVL GTTRFAHLKK SKESESFVFF LPRLIAEPGL MLNFSATALR 
    SRMIKYFVVQ NPSSWPVSLQ LLPLSLYPKP EALVHLLHRW FGTDMQMINF TTGEFQLTEA 
    CPYLGTHSEE SRFGILHLHL QPLEMKRVGV VFTPADYGKV TSLILIRNNL TVIDMIGVEG 
    FGARELLKVG GRLPGAGGSL RFKVPESTLM DCRRQLKDSK QILSITKNFK VENIGPLPIT 
    VSSLKINGYN CQGYGFEVLD CHQFSLDPNT SRDISIVFTP DFTSSWVIRD LSLVTAADLE 
    FRFTLNVTLP HHLLPLCADV VPGPSWEESF WRLTVFFVSL SLLGVILIAF QQAQYILMEF 
    MKTRQRQNAS SSSQQNNGPM DVISPHSYKS NCKNFLDTYG PSDKGRGKNC LPVNTPQSRI 
    QNAAKRSPAT YGHSQKKHKC SVYYSKHKTS TAAASSTSTT TEEKQTSPLG SSLPAAKEDI 
    CTDAMRENWI SLRYASGINV NLQKNLTLPK NLLNKEENTL KNTIVFSNPS SECSMKEGIQ 
    TCMFPKETDI KTSENTAEFK ERELCPLKTS KKLPENHLPR NSPQYHQPDL PEISRKNNGN 
    NQQVPVKNEV DHCENLKKVD TKPSSEKKIH KTSREDMFSE KQDIPFVEQE DPYRKKKLQE 
    KREGNLQNLN WSKSRTCRKN KKRGVAPVSR PPEQSDLKLV CSDFERSELS SDINVRSWCI 
    QESTREVCKA DAEIASSLPA AQREAEGYYQ KPEKKCVDKF CSDSSSDCGS SSGSVRASRG 
    SWGSWSSTSS SDGDKKPMVD AQHFLPAGDS VSQNDFPSEA PISLNLSHNI CNPMTVNSLP 
    QYAEPSCPSL PAGPTGVEED KGLYSPGDLW PTPPVCVTSS LNCTLENGVP CVIQESAPVH 
    NSFIDWSATC EGQFSSAYCP LELNDYNAFP EENMNYANGF PCPADVQTDF IDHNSQSTWN 
    TPPNMPAAWG HASFISSPPY LTSTRSLSPM SGLFGSIWAP QSDVYENCCP INPTTEHSTH 
    MENQAVVCKE YYPGFNPFRA YMNLDIWTTT ANRNANFPLS RDSSYCGNV

Genular Protein ID: 2018555233

Symbol: B3KU55_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 895
  • Mass: 99527
  • Checksum: 03601EC0EDE96B2D
  • Sequence:
  • MIGVEGFGAR ELLKVGGRLP GAGGSLRFKV PESTLMDCRR RLKDSKQILS ITKNFKVENI 
    GPLPITVSSL KINGYNCQGY GFEVLDCHQF SLDPNTSRDI SIVFTPDFTS SWVIRDLSLV 
    TAADLEFRFT LNVTLPHHLL PLCADVVPGP SWEESFWRLT VFFVSLSLLG VILIAFQQAQ 
    YILMEFMKTR QRQNASSSSQ QNNGPMDVIS PHSYKSNCKN FLDTYGPSDK GRGKNCLPVN 
    TPQSRIQNAA KRSPATYGHS QKKHKCSVYY SKHKTSTAAA SSTSTTTEEK QTSPLGSSLP 
    AAKEDICTDA MRENWISLRY ASGINVNLQK NLTLPKNLLN KEENTLKNTI VFSNPSSECS 
    MKEGIQTCMF PKETDIKTSE NTAEFKEREL CPLKTSKKLP ENHLPRNSPQ YHQPDLPEIS 
    RKNNGNNQQV PVKNEVDHCE NLKKVDTKPS SEKKIHKTSR EDMFSEKQDI PFVEQEDPYR 
    KKKLQEKREG NLQNLNWSKS RTCRKNKKRG VAPVSRPPEQ SDLKLVCSDF ERSELSSDIN 
    VRSWCIQEST REVCKADAEI ASSLPAAQRE AEGYYQKPEK KCVDKFCSDS SSDCGSSSGS 
    VRASRGSWGS WSSTSSSDGD KKPMVDAQHF LPAGDSVSQN DFPSEAPISL NLSHNICNPM 
    TVNSLPQYAE PSCPSLPAGP TGVEEDKGLY SPGDLWPTPP VCVTSSLNCT LENGVPCVIQ 
    ESAPVHNSFI DWSATCEGQF SSAYCPLELN DYNAFPEENM NYANGFPCPA DVQTDFIDHN 
    SQSTWNTPPN MPAAWGHASF ISSPPYLTST RSLSPMSGLF GSIWAPQSDV YENCCPINPT 
    TEHSTHMENQ AVVCKEYYPG FNPFRAYMNL DIWTTTANRN ANFPLSRDSS YCGNV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.