Details for: ANKRD28

Gene ID: 23243

Symbol: ANKRD28

Ensembl ID: ENSG00000206560

Description: ankyrin repeat domain 28

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 3.84
    Marker Score: 3,073
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 3.4
    Marker Score: 2,897
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 3.25
    Marker Score: 4,370
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.92
    Marker Score: 1,919
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.77
    Marker Score: 3,355
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.63
    Marker Score: 11,008
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.48
    Marker Score: 5,930
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.45
    Marker Score: 1,430
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.45
    Marker Score: 2,709
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.43
    Marker Score: 6,073
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.38
    Marker Score: 2,544
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.37
    Marker Score: 12,744
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.35
    Marker Score: 12,325
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.32
    Marker Score: 1,791
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.32
    Marker Score: 46,120
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.3
    Marker Score: 87,309
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.27
    Marker Score: 1,641
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.22
    Marker Score: 1,269
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.22
    Marker Score: 1,289
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.2
    Marker Score: 644
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.19
    Marker Score: 74,057
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.17
    Marker Score: 1,143
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.16
    Marker Score: 1,263
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.16
    Marker Score: 16,551
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.15
    Marker Score: 73,201
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.11
    Marker Score: 2,614
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.11
    Marker Score: 31,593
  • Cell Name: granule cell (CL0000120)
    Fold Change: 2.09
    Marker Score: 15,787
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.03
    Marker Score: 8,416
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.01
    Marker Score: 8,240
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.99
    Marker Score: 8,099
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.98
    Marker Score: 4,548
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.91
    Marker Score: 1,652
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.91
    Marker Score: 7,384
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.9
    Marker Score: 19,247
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.89
    Marker Score: 115,963
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.84
    Marker Score: 39,285
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.83
    Marker Score: 1,621
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.83
    Marker Score: 785
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.8
    Marker Score: 1,937
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.78
    Marker Score: 16,922
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.74
    Marker Score: 7,266
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.74
    Marker Score: 64,190
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.73
    Marker Score: 8,024
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.73
    Marker Score: 671
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.72
    Marker Score: 14,788
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.72
    Marker Score: 27,582
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.7
    Marker Score: 2,123
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.7
    Marker Score: 3,729
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.69
    Marker Score: 536
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.68
    Marker Score: 4,791
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.67
    Marker Score: 586
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.66
    Marker Score: 15,578
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.65
    Marker Score: 414
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.65
    Marker Score: 428
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.65
    Marker Score: 805
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.63
    Marker Score: 524
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.62
    Marker Score: 600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.62
    Marker Score: 16,744
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.61
    Marker Score: 1,096
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.59
    Marker Score: 894
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.59
    Marker Score: 1,804
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.58
    Marker Score: 1,148
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.58
    Marker Score: 40,481
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.57
    Marker Score: 602
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.56
    Marker Score: 450
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.54
    Marker Score: 919
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.53
    Marker Score: 2,576
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.53
    Marker Score: 2,162
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.52
    Marker Score: 852
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.52
    Marker Score: 2,345
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.51
    Marker Score: 2,904
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.5
    Marker Score: 5,160
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.5
    Marker Score: 3,167
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.5
    Marker Score: 9,755
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.49
    Marker Score: 2,168
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.46
    Marker Score: 9,400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.46
    Marker Score: 25,842
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166,523
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.45
    Marker Score: 526
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.43
    Marker Score: 454
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.42
    Marker Score: 985
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.4
    Marker Score: 477
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.39
    Marker Score: 703
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.38
    Marker Score: 437
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.38
    Marker Score: 516
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.38
    Marker Score: 1,364
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.36
    Marker Score: 2,369
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.34
    Marker Score: 1,544
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.33
    Marker Score: 299
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.33
    Marker Score: 5,729
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.33
    Marker Score: 29,654
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.32
    Marker Score: 4,323
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 1.32
    Marker Score: 864
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.31
    Marker Score: 7,033
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.3
    Marker Score: 1,381
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.3
    Marker Score: 1,128
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 1.29
    Marker Score: 565
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.28
    Marker Score: 675
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.28
    Marker Score: 11,097

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ANKRD28 is a member of the ankyrin repeat family, which is characterized by the presence of repeated ankyrin domains. These domains are involved in protein-protein interactions and are often found in proteins that regulate cellular signaling and protein activity. ANKRD28 is specifically involved in regulating the activity of protein phosphatase 6 (PP6), a serine/threonine phosphatase that plays a crucial role in protein signaling pathways. The gene's expression is widespread, with significant expression in early promyelocytes, IgA plasma cells, and various epithelial and muscle cells. **Pathways and Functions** ANKRD28 is involved in several cellular pathways, including: 1. **Asparagine n-linked glycosylation**: ANKRD28 regulates the activity of enzymes involved in asparagine n-linked glycosylation, a post-translational modification that is essential for protein function and stability. 2. **Cell cycle**: ANKRD28 regulates the cell cycle by modulating the activity of proteins involved in cell cycle progression. 3. **Chromosome maintenance**: ANKRD28 is involved in maintaining chromosome stability by regulating the activity of proteins involved in chromosome segregation. 4. **Copii-mediated vesicle transport**: ANKRD28 regulates the activity of Copii, a protein involved in vesicle transport and protein sorting. 5. **Telomere extension**: ANKRD28 is involved in telomere extension by regulating the activity of telomerase, an enzyme involved in telomere maintenance. **Clinical Significance** ANKRD28 has been implicated in various diseases, including: 1. **Cancer**: ANKRD28 is overexpressed in certain types of cancer, including leukemia and lymphoma. 2. **Neurological disorders**: ANKRD28 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Muscular dystrophy**: ANKRD28 is involved in muscular dystrophy, a group of genetic disorders characterized by progressive muscle weakness and degeneration. In conclusion, ANKRD28 is a gene that plays a crucial role in regulating various cellular processes, including protein activity, signaling pathways, and telomere maintenance. Its involvement in multiple diseases suggests its importance in maintaining cellular homeostasis and regulating cellular processes. Further research is needed to fully understand the role of ANKRD28 in human disease and to develop therapeutic strategies to target this gene.

Genular Protein ID: 2616043569

Symbol: ANR28_HUMAN

Name: Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

UniProtKB Accession Codes:

O15084 B4DES5 Q1WWL4 Q29RW6 Q3B857 Q6ULS0 Q6ZT57

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 2 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 2 RefSeq 7 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9205841

Title: Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9205841

DOI: 10.1093/dnares/4.2.141

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16564677

Title: PITK, a PP1 targeting subunit that modulates the phosphorylation of the transcriptional regulator hnRNP K.

PubMed ID: 16564677

DOI: 10.1016/j.cellsig.2006.01.019

PubMed ID: 18186651

Title: Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains.

PubMed ID: 18186651

DOI: 10.1021/bi7022877

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 1053
  • Mass: 112966
  • Checksum: BDB4855193364585
  • Sequence:
    • MAFLKLRDQP SLVQAIFNGD PDEVRALIFK KEDVNFQDNE KRTPLHAAAY LGDAEIIELL 
ILSGARVNAK DSKWLTPLHR AVASCSEEAV QVLLKHSADV NARDKNWQTP LHIAAANKAV 
KCAEALVPLL SNVNVSDRAG RTALHHAAFS GHGEMVKLLL SRGANINAFD KKDRRAIHWA 
AYMGHIEVVK LLVSHGAEVT CKDKKSYTPL HAAASSGMIS VVKYLLDLGV DMNEPNAYGN 
TPLHVACYNG QDVVVNELID CGAIVNQKNE KGFTPLHFAA ASTHGALCLE LLVGNGADVN 
MKSKDGKTPL HMTALHGRFS RSQTIIQSGA VIDCEDKNGN TPLHIAARYG HELLINTLIT 
SGADTAKRGI HGMFPLHLAA LSGFSDCCRK LLSSGFDIDT PDDFGRTCLH AAAAGGNLEC 
LNLLLNTGAD FNKKDKFGRS PLHYAAANCN YQCLFALVGS GASVNDLDER GCTPLHYAAT 
SDTDGKCLEY LLRNDANPGI RDKQGYNAVH YSAAYGHRLC LQLIASETPL DVLMETSGTD 
MLSDSDNRAT ISPLHLAAYH GHHQALEVLV QSLLDLDVRN SSGRTPLDLA AFKGHVECVD 
VLINQGASIL VKDYILKRTP IHAAATNGHS ECLRLLIGNA EPQNAVDIQD GNGQTPLMLS 
VLNGHTDCVY SLLNKGANVD AKDKWGRTAL HRGAVTGHEE CVDALLQHGA KCLLRDSRGR 
TPIHLSAACG HIGVLGALLQ SAASMDANPA TADNHGYTAL HWACYNGHET CVELLLEQEV 
FQKTEGNAFS PLHCAVINDN EGAAEMLIDT LGASIVNATD SKGRTPLHAA AFTDHVECLQ 
LLLSHNAQVN SVDSTGKTPL MMAAENGQTN TVEMLVSSAS AELTLQDNSK NTALHLACSK 
GHETSALLIL EKITDRNLIN ATNAALQTPL HVAARNGLTM VVQELLGKGA SVLAVDENGY 
TPALACAPNK DVADCLALIL ATMMPVSSSS PLSSLTFNAI NRYTNTSKTV SFEALPIMRN 
EPSSYCSFNN IGGEQEYLYT DVDELNDSDS ETY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.