Details for: ANKRD12

Gene ID: 23253

Symbol: ANKRD12

Ensembl ID: ENSG00000101745

Description: ankyrin repeat domain 12

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 4.44
    Marker Score: 18,498
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.36
    Marker Score: 113,322
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 3.14
    Marker Score: 1,643
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 3.14
    Marker Score: 16,482
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 3.1
    Marker Score: 14,344
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.08
    Marker Score: 3,035
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.99
    Marker Score: 3,616
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.98
    Marker Score: 29,482
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.94
    Marker Score: 155,675
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 2.86
    Marker Score: 1,840
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 2.84
    Marker Score: 9,511
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.82
    Marker Score: 60,097
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.8
    Marker Score: 2,622
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.8
    Marker Score: 2,640
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.79
    Marker Score: 11,652
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 2.79
    Marker Score: 975
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.79
    Marker Score: 62,243
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.76
    Marker Score: 659
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.74
    Marker Score: 7,682
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.73
    Marker Score: 3,090
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.73
    Marker Score: 5,540
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.73
    Marker Score: 14,643
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 2.72
    Marker Score: 2,061
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.71
    Marker Score: 1,634
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.68
    Marker Score: 53,280
  • Cell Name: podocyte (CL0000653)
    Fold Change: 2.65
    Marker Score: 979
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.64
    Marker Score: 934
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.64
    Marker Score: 1,317
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.62
    Marker Score: 5,045
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.62
    Marker Score: 2,325
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.62
    Marker Score: 1,272
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.59
    Marker Score: 38,762
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.58
    Marker Score: 6,473
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.58
    Marker Score: 2,461
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.57
    Marker Score: 19,704
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.56
    Marker Score: 739
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.56
    Marker Score: 97,242
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 2.54
    Marker Score: 647
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.54
    Marker Score: 2,924
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.54
    Marker Score: 1,669
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.53
    Marker Score: 2,129
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.52
    Marker Score: 1,945
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.52
    Marker Score: 1,401
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.52
    Marker Score: 1,749
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 2.52
    Marker Score: 2,715
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.51
    Marker Score: 1,501
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.49
    Marker Score: 1,313
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.49
    Marker Score: 1,458
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 2.48
    Marker Score: 539
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.46
    Marker Score: 1,376
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.45
    Marker Score: 2,612
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.45
    Marker Score: 758
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 2.44
    Marker Score: 717
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 2.43
    Marker Score: 991
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.43
    Marker Score: 1,047
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.43
    Marker Score: 10,403
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 2.42
    Marker Score: 556
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.42
    Marker Score: 3,015
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.41
    Marker Score: 28,028
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 2.41
    Marker Score: 539
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 2.39
    Marker Score: 895
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 2.39
    Marker Score: 1,227
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 2.39
    Marker Score: 832
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 2.38
    Marker Score: 2,566
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 2.37
    Marker Score: 583
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.37
    Marker Score: 1,856
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.36
    Marker Score: 2,571
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.36
    Marker Score: 1,374
  • Cell Name: granule cell (CL0000120)
    Fold Change: 2.35
    Marker Score: 17,724
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 2.35
    Marker Score: 4,925
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.33
    Marker Score: 5,699
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.33
    Marker Score: 2,455
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.33
    Marker Score: 3,212
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.32
    Marker Score: 1,530
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.32
    Marker Score: 37,242
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 2.31
    Marker Score: 1,740
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 2.3
    Marker Score: 573
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.3
    Marker Score: 84,822
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 2.3
    Marker Score: 572
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 2.28
    Marker Score: 821
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.28
    Marker Score: 1,128
  • Cell Name: interneuron (CL0000099)
    Fold Change: 2.28
    Marker Score: 1,042
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.28
    Marker Score: 9,458
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.27
    Marker Score: 677
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.27
    Marker Score: 7,167
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 2.25
    Marker Score: 817
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.25
    Marker Score: 641
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 2.25
    Marker Score: 492
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 2.24
    Marker Score: 1,400
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.24
    Marker Score: 2,378
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 2.24
    Marker Score: 624
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 2.23
    Marker Score: 677
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 2.23
    Marker Score: 805
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 2.23
    Marker Score: 504
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 2.23
    Marker Score: 540
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.23
    Marker Score: 5,327
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 2.22
    Marker Score: 436
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 2.22
    Marker Score: 837
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.21
    Marker Score: 3,925
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.21
    Marker Score: 1,673

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ANKRD12 shares structural homology with other ankyrin repeat-containing proteins, which are known for their involvement in protein-protein interactions and regulation of cellular processes. The protein's ankyrin repeat domains are likely to facilitate its interactions with other proteins, influencing its subcellular localization and function. Notably, ANKRD12 is primarily expressed in the cytosol and nucleoplasm of neurons, suggesting its involvement in signaling pathways and regulation of gene expression within these cells. **Pathways and Functions** The expression of ANKRD12 in various cell types, including neurons, inhibitory interneurons, and mature T cells, suggests its involvement in multiple signaling pathways. These pathways may include: 1. **Neurotransmitter regulation**: ANKRD12 may interact with neurotransmitter receptors or modulate their activity, influencing neuronal excitability and synaptic transmission. 2. **Neuroinflammation**: The protein's expression in neurons and T cells suggests its potential role in regulating immune responses and inflammation within the nervous system. 3. **Gene expression regulation**: ANKRD12 may interact with transcription factors or other regulatory proteins to modulate the expression of genes involved in neuronal development, maintenance, and function. **Clinical Significance** The identification of ANKRD12 as a gene with significant expression in neurons and T cells highlights its potential role in neurological and immunological disorders. Some potential clinical implications of ANKRD12 dysfunction include: 1. **Neurological disorders**: Alterations in ANKRD12 expression or function may contribute to the pathogenesis of neurodegenerative diseases, such as Alzheimer's or Parkinson's disease. 2. **Immune-mediated disorders**: Dysregulation of ANKRD12 in T cells may contribute to autoimmune diseases, such as multiple sclerosis or rheumatoid arthritis. 3. **Neuroinflammatory disorders**: ANKRD12's role in regulating neuroinflammation suggests its potential involvement in disorders characterized by excessive or inappropriate immune responses, such as Guillain-Barré syndrome. In conclusion, ANKRD12 is a gene with significant implications for our understanding of neuronal function and immune cell regulation. Further research is necessary to elucidate the protein's precise mechanisms of action and its clinical significance in various neurological and immunological disorders.

Genular Protein ID: 3042943051

Symbol: ANR12_HUMAN

Name: Ankyrin repeat domain-containing protein 12

UniProtKB Accession Codes:

Q6UB98 O94951 Q658K1 Q6QMF7 Q9H231 Q9H784

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 CarbonylDB 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 6 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15184363

Title: Identification of a novel family of ankyrin repeats-containing cofactors for p160 nuclear receptor coactivators.

PubMed ID: 15184363

DOI: 10.1074/jbc.m403997200

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 29463886

Title: A set of regulatory genes co-expressed in embryonic human brain is implicated in disrupted speech development.

PubMed ID: 29463886

DOI: 10.1038/s41380-018-0020-x

Sequence Information:

  • Length: 2062
  • Mass: 235652
  • Checksum: 3CAFAA05E4AA1753
  • Sequence:
    • MPKSGFTKPI QSENSDSDSN MVEKPYGRKS KDKIASYSKT PKIERSDVSK EMKEKSSMKR 
KLPFTISPSR NEERDSDTDS DPGHTSENWG ERLISSYRTY SEKEGPEKKK TKKEAGNKKS 
TPVSILFGYP LSERKQMALL MQMTARDNSP DSTPNHPSQT TPAQKKTPSS SSRQKDKVNK 
RNERGETPLH MAAIRGDVKQ VKELISLGAN VNVKDFAGWT PLHEACNVGY YDVAKILIAA 
GADVNTQGLD DDTPLHDSAS SGHRDIVKLL LRHGGNPFQA NKHGERPVDV AETEELELLL 
KREVPLSDDD ESYTDSEEAQ SVNPSSVDEN IDSETEKDSL ICESKQILPS KTPLPSALDE 
YEFKDDDDEE INKMIDDRHI LRKEQRKENE PEAEKTHLFA KQEKAFYPKS FKSKKQKPSR 
VLYSSTESSD EEALQNKKIS TSCSVIPETS NSDMQTKKEY VVSGEHKQKG KVKRKLKNQN 
KNKENQELKQ EKEGKENTRI TNLTVNTGLD CSEKTREEGN FRKSFSPKDD TSLHLFHIST 
GKSPKHSCGL SEKQSTPLKQ EHTKTCLSPG SSEMSLQPDL VRYDNTESEF LPESSSVKSC 
KHKEKSKHQK DFHLEFGEKS NAKIKDEDHS PTFENSDCTL KKMDKEGKTL KKHKLKHKER 
EKEKHKKEIE GEKEKYKTKD SAKELQRSVE FDREFWKENF FKSDETEDLF LNMEHESLTL 
EKKSKLEKNI KDDKSTKEKH VSKERNFKEE RDKIKKESEK SFREEKIKDL KEERENIPTD 
KDSEFTSLGM SAIEESIGLH LVEKEIDIEK QEKHIKESKE KPEKRSQIKE KDIEKMERKT 
FEKEKKIKHE HKSEKDKLDL SECVDKIKEK DKLYSHHTEK CHKEGEKSKN TAAIKKTDDR 
EKSREKMDRK HDKEKPEKER HLAESKEKHL MEKKNKQSDN SEYSKSEKGK NKEKDRELDK 
KEKSRDKESI NITNSKHIQE EKKSSIVDGN KAQHEKPLSL KEKTKDEPLK TPDGKEKDKK 
DKDIDRYKER DKHKDKIQIN SLLKLKSEAD KPKPKSSPAS KDTRPKEKRL VNDDLMQTSF 
ERMLSLKDLE IEQWHKKHKE KIKQKEKERL RNRNCLELKI KDKEKTKHTP TESKNKELTR 
SKSSEVTDAY TKEKQPKDAV SNRSQSVDTK NVMTLGKSSF VSDNSLNRSP RSENEKPGLS 
SRSVSMISVA SSEDSCHTTV TTPRPPVEYD SDFMLESSES QMSFSQSPFL SIAKSPALHE 
RELDSLADLP ERIKPPYANR LSTSHLRSSS VEDVKLIISE GRPTIEVRRC SMPSVICEHT 
KQFQTISEES NQGSLLTVPG DTSPSPKPEV FSNVPERDLS NVSNIHSSFA TSPTGASNSK 
YVSADRNLIK NTAPVNTVMD SPVHLEPSSQ VGVIQNKSWE MPVDRLETLS TRDFICPNSN 
IPDQESSLQS FCNSENKVLK ENADFLSLRQ TELPGNSCAQ DPASFMPPQQ PCSFPSQSLS 
DAESISKHMS LSYVANQEPG ILQQKNAVQI ISSALDTDNE STKDTENTFV LGDVQKTDAF 
VPVYSDSTIQ EASPNFEKAY TLPVLPSEKD FNGSDASTQL NTHYAFSKLT YKSSSGHEVE 
NSTTDTQVIS HEKENKLESL VLTHLSRCDS DLCEMNAGMP KGNLNEQDPK HCPESEKCLL 
SIEDEESQQS ILSSLENHSQ QSTQPEMHKY GQLVKVELEE NAEDDKTENQ IPQRMTRNKA 
NTMANQSKQI LASCTLLSEK DSESSSPRGR IRLTEDDDPQ IHHPRKRKVS RVPQPVQVSP 
SLLQAKEKTQ QSLAAIVDSL KLDEIQPYSS ERANPYFEYL HIRKKIEEKR KLLCSVIPQA 
PQYYDEYVTF NGSYLLDGNP LSKICIPTIT PPPSLSDPLK ELFRQQEVVR MKLRLQHSIE 
REKLIVSNEQ EVLRVHYRAA RTLANQTLPF SACTVLLDAE VYNVPLDSQS DDSKTSVRDR 
FNARQFMSWL QDVDDKFDKL KTCLLMRQQH EAAALNAVQR LEWQLKLQEL DPATYKSISI 
YEIQEFYVPL VDVNDDFELT PI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.