WWC1 | ENSG00000113645 | NCBI 23286

Details for: WWC1

Gene ID: 23286

Symbol: WWC1

Ensembl ID: ENSG00000113645

Description: WW and C2 domain containing 1

Associated with

Notch3 intracellular domain regulates transcription
(R-HSA-9013508)
Signaling by hippo
(R-HSA-2028269)
Signaling by notch
(R-HSA-157118)
Signaling by notch3
(R-HSA-9012852)
Signal transduction
(R-HSA-162582)
Cell migration
(GO:0016477)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Establishment of cell polarity
(GO:0030010)
Kinase binding
(GO:0019900)
Molecular adaptor activity
(GO:0060090)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of hippo signaling
(GO:0035331)
Negative regulation of organ growth
(GO:0046621)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of mapk cascade
(GO:0043410)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of hippo signaling
(GO:0035330)
Regulation of intracellular transport
(GO:0032386)
Ruffle membrane
(GO:0032587)
Transcription coactivator activity
(GO:0003713)

Other Information

Proteins

Protein KIBRA

Genular Protein ID: 1955199369

Symbol: KIBRA_HUMAN

Name: Protein KIBRA

UniProtKB Accession Codes:

Q8IX03 B4DK05 O94946 Q6MZX4 Q6Y2F8 Q7Z4G8 Q8WVM4 Q9BT29

Database IDs:

Citations:

PubMed ID: 12559952

Title: Characterization of KIBRA, a novel WW domain-containing protein.

PubMed ID: 12559952

DOI: 10.1016/s0006-291x(02)02945-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15081397

Title: KIBRA is a novel substrate for protein kinase Czeta.

PubMed ID: 15081397

DOI: 10.1016/j.bbrc.2004.03.107

PubMed ID: 16684779

Title: Essential role of KIBRA in co-activator function of dynein light chain 1 in mammalian cells.

PubMed ID: 16684779

DOI: 10.1074/jbc.m600021200

PubMed ID: 17053149

Title: Common Kibra alleles are associated with human memory performance.

PubMed ID: 17053149

DOI: 10.1126/science.1129837

PubMed ID: 17994011

Title: SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment.

PubMed ID: 17994011

DOI: 10.1038/ncb1656

PubMed ID: 18596123

Title: KIBRA modulates directional migration of podocytes.

PubMed ID: 18596123

DOI: 10.1681/asn.2007080916

PubMed ID: 18190796

Title: KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling.

PubMed ID: 18190796

DOI: 10.1016/j.bbamcr.2007.12.007

PubMed ID: 18672031

Title: Temporal-spatial expression and novel biochemical properties of the memory-related protein KIBRA.

PubMed ID: 18672031

DOI: 10.1016/j.neuroscience.2008.06.054

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20159598

Title: Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded.

PubMed ID: 20159598

DOI: 10.1016/j.devcel.2009.12.012

PubMed ID: 20159599

Title: Kibra Is a regulator of the Salvador/Warts/Hippo signaling network.

PubMed ID: 20159599

DOI: 10.1016/j.devcel.2009.12.011

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23065961

Title: Association of KIBRA with episodic and working memory: a meta-analysis.

PubMed ID: 23065961

DOI: 10.1002/ajmg.b.32101

PubMed ID: 22784093

Title: Phospho-regulation of KIBRA by CDK1 and CDC14 phosphatase controls cell-cycle progression.

PubMed ID: 22784093

DOI: 10.1042/bj20120751

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23778582

Title: Common exonic missense variants in the C2 domain of the human KIBRA protein modify lipid binding and cognitive performance.

PubMed ID: 23778582

DOI: 10.1038/tp.2013.49

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24682284

Title: Evolutionary and Molecular Facts Link the WWC Protein Family to Hippo Signaling.

PubMed ID: 24682284

DOI: 10.1093/molbev/msu115

Sequence Information:

Length: 1113
Mass: 125301
Checksum: 9010B9C127129165
Sequence:

MPRPELPLPE GWEEARDFDG KVYYIDHTNR TTSWIDPRDR YTKPLTFADC ISDELPLGWE 
EAYDPQVGDY FIDHNTKTTQ IEDPRVQWRR EQEHMLKDYL VVAQEALSAQ KEIYQVKQQR 
LELAQQEYQQ LHAVWEHKLG SQVSLVSGSS SSSKYDPEIL KAEIATAKSR VNKLKREMVH 
LQHELQFKER GFQTLKKIDK KMSDAQGSYK LDEAQAVLRE TKAIKKAITC GEKEKQDLIK 
SLAMLKDGFR TDRGSHSDLW SSSSSLESSS FPLPKQYLDV SSQTDISGSF GINSNNQLAE 
KVRLRLRYEE AKRRIANLKI QLAKLDSEAW PGVLDSERDR LILINEKEEL LKEMRFISPR 
KWTQGEVEQL EMARKRLEKD LQAARDTQSK ALTERLKLNS KRNQLVRELE EATRQVATLH 
SQLKSLSSSM QSLSSGSSPG SLTSSRGSLV ASSLDSSTSA SFTDLYYDPF EQLDSELQSK 
VEFLLLEGAT GFRPSGCITT IHEDEVAKTQ KAEGGGRLQA LRSLSGTPKS MTSLSPRSSL 
SSPSPPCSPL MADPLLAGDA FLNSLEFEDP ELSATLCELS LGNSAQERYR LEEPGTEGKQ 
LGQAVNTAQG CGLKVACVSA AVSDESVAGD SGVYEASVQR LGASEAAAFD SDESEAVGAT 
RIQIALKYDE KNKQFAILII QLSNLSALLQ QQDQKVNIRV AVLPCSESTT CLFRTRPLDA 
SDTLVFNEVF WVSMSYPALH QKTLRVDVCT TDRSHLEECL GGAQISLAEV CRSGERSTRW 
YNLLSYKYLK KQSRELKPVG VMAPASGPAS TDAVSALLEQ TAVELEKRQE GRSSTQTLED 
SWRYEETSEN EAVAEEEEEE VEEEEGEEDV FTEKASPDMD GYPALKVDKE TNTETPAPSP 
TVVRPKDRRV GTPSQGPFLR GSTIIRSKTF SPGPQSQYVC RLNRSDSDSS TLSKKPPFVR 
NSLERRSVRM KRPSSVKSLR SERLIRTSLD LELDLQATRT WHSQLTQEIS VLKELKEQLE 
QAKSHGEKEL PQWLREDERF RLLLRMLEKR QMDRAEHKGE LQTDKMMRAA AKDVHRLRGQ 
SCKEPPEVQS FREKMAFFTR PRMNIPALSA DDV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: WWC1

Associated with

Other Information

Characterization of KIBRA, a novel WW domain-containing protein. PubMed ID: 12559952

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 5. PubMed ID: 15372022

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 10048485

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

KIBRA is a novel substrate for protein kinase Czeta. PubMed ID: 15081397

Essential role of KIBRA in co-activator function of dynein light chain 1 in mammalian cells. PubMed ID: 16684779

Common Kibra alleles are associated with human memory performance. PubMed ID: 17053149

SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment. PubMed ID: 17994011

KIBRA modulates directional migration of podocytes. PubMed ID: 18596123

KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling. PubMed ID: 18190796

Temporal-spatial expression and novel biochemical properties of the memory-related protein KIBRA. PubMed ID: 18672031

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded. PubMed ID: 20159598

Kibra Is a regulator of the Salvador/Warts/Hippo signaling network. PubMed ID: 20159599

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Association of KIBRA with episodic and working memory: a meta-analysis. PubMed ID: 23065961

Phospho-regulation of KIBRA by CDK1 and CDC14 phosphatase controls cell-cycle progression. PubMed ID: 22784093

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Common exonic missense variants in the C2 domain of the human KIBRA protein modify lipid binding and cognitive performance. PubMed ID: 23778582

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Evolutionary and Molecular Facts Link the WWC Protein Family to Hippo Signaling. PubMed ID: 24682284