Details for: FBXW11
Associated with
Other Information
Genular Protein ID: 1563414864
Symbol: FBW1B_HUMAN
Name: F-box/WD repeat-containing protein 11
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10531035
Title: Identification of a family of human F-box proteins.
PubMed ID: 10531035
PubMed ID: 10694485
Title: Molecular cloning and genomic structure of the betaTRCP2 gene on chromosome 5q35.1.
PubMed ID: 10694485
PubMed ID: 9734811
Title: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
PubMed ID: 9734811
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10066435
Title: IkappaBalpha ubiquitination is catalyzed by an SCF-like complex containing Skp1, cullin-1, and two F-box/WD40-repeat proteins, betaTrCP1 and betaTrCP2.
PubMed ID: 10066435
PubMed ID: 10321728
Title: HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin.
PubMed ID: 10321728
PubMed ID: 10644755
Title: Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination.
PubMed ID: 10644755
PubMed ID: 14532120
Title: SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor.
PubMed ID: 14532120
DOI: 10.1093/emboj/cdg524
PubMed ID: 10437795
Title: A complex containing betaTrCP recruits Cdc34 to catalyse ubiquitination of IkappaBalpha.
PubMed ID: 10437795
PubMed ID: 11158290
Title: Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha.
PubMed ID: 11158290
PubMed ID: 15337770
Title: Phosphorylation and specific ubiquitin acceptor sites are required for ubiquitination and degradation of the IFNAR1 subunit of type I interferon receptor.
PubMed ID: 15337770
PubMed ID: 16880511
Title: Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein.
PubMed ID: 16880511
DOI: 10.1128/mcb.01630-05
PubMed ID: 10648623
Title: The SCF(HOS/beta-TRCP)-ROC1 E3 ubiquitin ligase utilizes two distinct domains within CUL1 for substrate targeting and ubiquitin ligation.
PubMed ID: 10648623
PubMed ID: 11850814
Title: Inhibition of HOS expression and activities by Wnt pathway.
PubMed ID: 11850814
PubMed ID: 14603323
Title: Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage.
PubMed ID: 14603323
DOI: 10.1038/nature02082
PubMed ID: 15917222
Title: SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein.
PubMed ID: 15917222
PubMed ID: 18575781
Title: Oxidative stress-induced ubiquitination of RCAN1 mediated by SCFbeta-TrCP ubiquitin ligase.
PubMed ID: 18575781
PubMed ID: 18354482
Title: Control of chromosome stability by the beta-TrCP-REST-Mad2 axis.
PubMed ID: 18354482
DOI: 10.1038/nature06641
PubMed ID: 19730691
Title: HIV-1 Vpu neutralizes the antiviral factor Tetherin/BST-2 by binding it and directing its beta-TrCP2-dependent degradation.
PubMed ID: 19730691
PubMed ID: 20347421
Title: Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate.
PubMed ID: 20347421
PubMed ID: 19966869
Title: The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival.
PubMed ID: 19966869
DOI: 10.1038/onc.2009.430
PubMed ID: 22017875
Title: mTOR drives its own activation via SCF(betaTrCP)-dependent degradation of the mTOR inhibitor DEPTOR.
PubMed ID: 22017875
PubMed ID: 22017876
Title: DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(betaTrCP) E3 ubiquitin ligase and regulates survival and autophagy.
PubMed ID: 22017876
PubMed ID: 25503564
Title: Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing.
PubMed ID: 25503564
DOI: 10.1038/ncb3076
PubMed ID: 26837067
Title: Protein Kinase R degradation is essential for Rift valley fever Virus infection and is regulated by SKP1-CUL1-F-box (SCF)FBXW11-NSs E3 ligase.
PubMed ID: 26837067
PubMed ID: 29420262
Title: C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions.
PubMed ID: 29420262
PubMed ID: 31402090
Title: De novo missense variants in FBXW11 cause diverse developmental phenotypes including brain, eye, and digit anomalies.
PubMed ID: 31402090
PubMed ID: 36608670
Title: A central role for regulated protein stability in the control of TFE3 and MITF by nutrients.
PubMed ID: 36608670
Sequence Information:
- Length: 542
- Mass: 62091
- Checksum: 7CD40087EFAA5C8A
- Sequence:
MEPDSVIEDK TIELMCSVPR SLWLGCANLV ESMCALSCLQ SMPSVRCLQI SNGTSSVIVS RKRPSEGNYQ KEKDLCIKYF DQWSESDQVE FVEHLISRMC HYQHGHINSY LKPMLQRDFI TALPEQGLDH IAENILSYLD ARSLCAAELV CKEWQRVISE GMLWKKLIER MVRTDPLWKG LSERRGWDQY LFKNRPTDGP PNSFYRSLYP KIIQDIETIE SNWRCGRHNL QRIQCRSENS KGVYCLQYDD EKIISGLRDN SIKIWDKTSL ECLKVLTGHT GSVLCLQYDE RVIVTGSSDS TVRVWDVNTG EVLNTLIHHN EAVLHLRFSN GLMVTCSKDR SIAVWDMASA TDITLRRVLV GHRAAVNVVD FDDKYIVSAS GDRTIKVWST STCEFVRTLN GHKRGIACLQ YRDRLVVSGS SDNTIRLWDI ECGACLRVLE GHEELVRCIR FDNKRIVSGA YDGKIKVWDL QAALDPRAPA STLCLRTLVE HSGRVFRLQF DEFQIISSSH DDTILIWDFL NVPPSAQNET RSPSRTYTYI SR
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.