MGRN1 | ENSG00000102858 | NCBI 23295

Details for: MGRN1

Gene ID: 23295

Symbol: MGRN1

Ensembl ID: ENSG00000102858

Description: mahogunin ring finger 1

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Immune system
(R-HSA-168256)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Early endosome
(GO:0005769)
Endoplasmic reticulum
(GO:0005783)
Endosome to lysosome transport
(GO:0008333)
Extracellular exosome
(GO:0070062)
Intracellular membrane-bounded organelle
(GO:0043231)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Negative regulation of camp-mediated signaling
(GO:0043951)
Negative regulation of g protein-coupled receptor signaling pathway
(GO:0045744)
Negative regulation of smoothened signaling pathway
(GO:0045879)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Protein monoubiquitination
(GO:0006513)
Protein polyubiquitination
(GO:0000209)
Protein ubiquitination
(GO:0016567)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin protein ligase activity
(GO:0061630)

Other Information

Proteins

E3 ubiquitin-protein ligase MGRN1

Genular Protein ID: 3513610578

Symbol: MGRN1_HUMAN

Name: E3 ubiquitin-protein ligase MGRN1

UniProtKB Accession Codes:

O60291 A4URL3 A4URL4 Q86W76

Database IDs:

Citations:

PubMed ID: 19737927

Title: Mahogunin ring finger-1 (MGRN1) E3 ubiquitin ligase inhibits signaling from melanocortin receptor by competition with Galphas.

PubMed ID: 19737927

DOI: 10.1074/jbc.m109.028100

PubMed ID: 9628581

Title: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9628581

DOI: 10.1093/dnares/5.1.31

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17229889

Title: Spongiform neurodegeneration-associated E3 ligase Mahogunin ubiquitylates TSG101 and regulates endosomal trafficking.

PubMed ID: 17229889

DOI: 10.1091/mbc.e06-09-0787

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19703557

Title: Abnormal regulation of TSG101 in mice with spongiform neurodegeneration.

PubMed ID: 19703557

DOI: 10.1016/j.bbadis.2009.08.009

PubMed ID: 20213681

Title: Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system.

PubMed ID: 20213681

DOI: 10.1002/pmic.200900783

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

Length: 552
Mass: 60753
Checksum: 1F923D25FB49DB4D
Sequence:

MGSILSRRIA GVEDIDIQAN SAYRYPPKSG NYFASHFFMG GEKFDTPHPE GYLFGENMDL 
NFLGSRPVQF PYVTPAPHEP VKTLRSLVNI RKDSLRLVRY KDDADSPTED GDKPRVLYSL 
EFTFDADARV AITIYCQASE EFLNGRAVYS PKSPSLQSET VHYKRGVSQQ FSLPSFKIDF 
SEWKDDELNF DLDRGVFPVV IQAVVDEGDV VEVTGHAHVL LAAFEKHMDG SFSVKPLKQK 
QIVDRVSYLL QEIYGIENKN NQETKPSDDE NSDNSNECVV CLSDLRDTLI LPCRHLCLCT 
SCADTLRYQA NNCPICRLPF RALLQIRAVR KKPGALSPVS FSPVLAQSLE HDEHSCPFKK 
SKPHPASLAS KKPKRETNSD SVPPGYEPIS LLEALNGLRA VSPAIPSAPL YEEITYSGIS 
DGLSQASCPL AAIDHILDSS RQKGRPQSKA PDSTLRSPSS PIHEEDEEKL SEDVDAPPPL 
GGAELALRES SSPESFITEE VDESSSPQQG TRAASIENVL QDSSPEHCGR GPPADIYLPA 
LGPDSCSVGI DE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: MGRN1

Associated with

Other Information

Mahogunin ring finger-1 (MGRN1) E3 ubiquitin ligase inhibits signaling from melanocortin receptor by competition with Galphas. PubMed ID: 19737927

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. PubMed ID: 9628581

The sequence and analysis of duplication-rich human chromosome 16. PubMed ID: 15616553

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Spongiform neurodegeneration-associated E3 ligase Mahogunin ubiquitylates TSG101 and regulates endosomal trafficking. PubMed ID: 17229889

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Abnormal regulation of TSG101 in mice with spongiform neurodegeneration. PubMed ID: 19703557

Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system. PubMed ID: 20213681

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163