Details for: TUT4
Gene ID: 23318
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: TUT4
Ensembl ID: ENSG00000134744
Description: terminal uridylyl transferase 4
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 59.56rCSI 81.5%PRS 16.17
-
CSI 52.63rCSI 62.87%PRS 9.37
-
CSI 49.15rCSI 61.15%PRS 8.88
-
CSI 48.59rCSI 81.56%PRS 9.57
-
CSI 44.49rCSI 78.58%PRS 9.52
-
CSI 42.81rCSI 68.9%PRS 12.47
-
CSI 42.74rCSI 68.73%PRS 10.41
-
CSI 42.06rCSI 64.11%PRS 15.05
-
CSI 42.02rCSI 54.17%PRS 10.05
-
CSI 36.98rCSI 67.18%PRS 13.36
-
CSI 28.45rCSI 69.14%PRS 9.35
-
CSI 26.99rCSI 84.41%PRS 10.98
-
CSI 26.79rCSI 38.44%PRS 12.58
-
CSI 25rCSI 35.44%PRS 15.08
-
CSI 23.59rCSI 73.73%PRS 10.21
-
CSI 23.4rCSI 27.02%PRS 14.2
-
CSI 22.62rCSI 42.37%PRS 11.64
-
CSI 21.83rCSI 74.78%PRS 14.02
-
CSI 21.64rCSI 38.88%PRS 13.46
-
CSI 21.45rCSI 81.07%PRS 9.81
-
CSI 21rCSI 46.39%PRS 11.61
-
CSI 20.03rCSI 79.35%PRS 22.12
-
CSI 19.95rCSI 87.65%PRS 13.22
-
CSI 18.78rCSI 67.58%PRS 8.94
-
CSI 18.22rCSI 48.51%PRS 13.1
-
CSI 17.28rCSI 85.89%PRS 17.23
-
CSI 15.18rCSI 12.16%PRS 29.14
-
CSI 14.93rCSI 78.52%PRS 18.65
-
CSI 14.8rCSI 20.57%PRS 16.65
-
CSI 14.32rCSI 25.24%PRS 16.01
-
CSI 13.92rCSI 18.61%PRS 21.36
-
CSI 13.87rCSI 10.38%PRS 26.09
-
CSI 13.77rCSI 11.4%PRS 16.34
-
CSI 13.39rCSI 19.11%PRS 18.28
-
CSI 13.37rCSI 38.74%PRS 12.45
-
CSI 13.35rCSI 9.28%PRS 19.21
-
CSI 13.27rCSI 90.29%PRS 16.26
-
CSI 13.16rCSI 87.34%PRS 16.48
-
CSI 12.83rCSI 75.79%PRS 16.83
-
CSI 12.01rCSI 56.51%PRS 16.61
-
CSI 12.01rCSI 70.7%PRS 10.01
-
CSI 11.75rCSI 30.61%PRS 16.01
-
CSI 11.73rCSI 15.05%PRS 15.76
-
CSI 11.6rCSI 25.53%PRS 11.11
-
CSI 10.85rCSI 77.59%PRS 16.07
-
CSI 10.8rCSI 83.65%PRS 16.75
-
CSI 10.33rCSI 6.96%PRS 19.59
-
CSI 10.33rCSI 77.65%PRS 15.29
-
CSI 10.25rCSI 41.37%PRS 14.55
-
CSI 9.88rCSI 27.15%PRS 26.76
-
CSI 9.84rCSI 72.34%PRS 8.92
-
CSI 9.81rCSI 21.99%PRS 10.01
-
CSI 9.47rCSI 15.11%PRS 13.93
-
CSI 9.23rCSI 11.86%PRS 15.93
-
CSI 9.14rCSI 18.35%PRS 12
-
CSI 8.73rCSI 7.49%PRS 27.21
-
CSI 8.62rCSI 22.39%PRS 21.14
-
CSI 8.59rCSI 6.94%PRS 25.65
-
CSI 8.54rCSI 9.61%PRS 26
-
CSI 8.51rCSI 11.64%PRS 25.88
-
CSI 8.4rCSI 18.21%PRS 10.03
-
CSI 8.36rCSI 12.29%PRS 14.86
-
CSI 8.01rCSI 11.09%PRS 23.12
-
CSI 7.98rCSI 31.07%PRS 26.57
-
CSI 7.82rCSI 5.49%PRS 39.68
-
CSI 7.74rCSI 7.45%PRS 16.77
-
CSI 7.68rCSI 21.6%PRS 22.33
-
CSI 7.55rCSI 63.53%PRS 16.31
-
CSI 7.47rCSI 15.16%PRS 7.65
-
CSI 7.38rCSI 18.97%PRS 21.73
-
CSI 7.28rCSI 5.06%PRS 22.98
-
CSI 7.19rCSI 19.22%PRS 13.45
-
CSI 6.95rCSI 18.33%PRS 19.4
-
CSI 6.87rCSI 5.43%PRS 11.14
-
CSI 6.69rCSI 5.09%PRS 21.35
-
CSI 6.67rCSI 4.44%PRS 19.48
-
CSI 6.61rCSI 75.73%PRS 17.76
-
CSI 6.53rCSI 12.46%PRS 25.84
-
CSI 6.45rCSI 52.5%PRS 16.57
-
CSI 6.41rCSI 18.93%PRS 19.59
-
CSI 6.35rCSI 11.91%PRS 31.71
-
CSI 6.25rCSI 4.73%PRS 22.26
-
CSI 6.23rCSI 4.15%PRS 40.53
-
CSI 6.08rCSI 52.42%PRS 6.68
-
CSI 6.03rCSI 4.69%PRS 23.56
-
CSI 5.97rCSI 22.35%PRS 13.74
-
CSI 5.93rCSI 5.21%PRS 18.44
-
CSI 5.84rCSI 5.77%PRS 56.4
-
CSI 5.82rCSI 5.1%PRS 21.55
-
CSI 5.79rCSI 7.75%PRS 58.1
-
CSI 5.79rCSI 4.3%PRS 23.97
-
CSI 5.76rCSI 4.3%PRS 27.31
-
CSI 5.75rCSI 8.55%PRS 19.55
-
CSI 5.75rCSI 15.85%PRS 15.08
-
CSI 5.74rCSI 29.42%PRS 15.44
-
CSI 5.7rCSI 6.93%PRS 20.44
-
CSI 5.62rCSI 8.68%PRS 15.15
-
CSI 5.52rCSI 6.47%PRS 21.73
-
CSI 5.49rCSI 5.08%PRS 29.3
-
CSI 5.47rCSI 8.36%PRS 26.35
-
CSI -2.6rCSI -14.1%PRS 28.9%
-
CSI -2.1rCSI -2.0%PRS 25.4%
-
CSI 0.0rCSI 0.1%PRS 31.6%
-
CSI 0.1rCSI 2.4%PRS 61.4%
-
CSI 0.1rCSI 0.6%PRS 23.7%
-
CSI 0.1rCSI 0.3%PRS 20.3%
-
CSI 0.1rCSI 1.5%PRS 31.0%
-
CSI 0.3rCSI 1.0%PRS 26.4%
-
CSI 0.3rCSI 0.3%PRS 14.9%
-
CSI 0.4rCSI 1.5%PRS 28.2%
-
CSI 0.4rCSI 2.2%PRS 38.8%
-
CSI 0.4rCSI 12.3%PRS 36.3%
-
CSI 0.5rCSI 6.1%PRS 51.9%
-
CSI 0.5rCSI 2.9%PRS 35.9%
-
CSI 0.5rCSI 0.9%PRS 24.8%
-
CSI 0.6rCSI 5.9%PRS 17.4%
-
CSI 0.6rCSI 5.3%PRS 9.1%
-
CSI 0.6rCSI 3.3%PRS 28.3%
-
CSI 0.7rCSI 7.4%PRS 29.1%
-
CSI 0.7rCSI 3.1%PRS 8.4%
-
CSI 0.7rCSI 1.1%PRS 16.3%
-
CSI 0.7rCSI 16.3%PRS 29.9%
-
CSI 0.7rCSI 1.0%PRS 17.7%
-
CSI 0.7rCSI 3.4%PRS 37.1%
-
CSI 0.7rCSI 4.9%PRS 49.1%
-
CSI 0.8rCSI 0.8%PRS 17.0%
-
CSI 0.8rCSI 9.4%PRS 56.8%
-
CSI 0.8rCSI 1.0%PRS 28.2%
-
CSI 0.8rCSI 0.8%PRS 33.1%
-
CSI 0.9rCSI 1.6%PRS 34.8%
-
CSI 0.9rCSI 8.4%PRS 60.3%
-
CSI 0.9rCSI 2.5%PRS 31.6%
-
CSI 1.0rCSI 1.4%PRS 24.1%
-
CSI 1.0rCSI 3.8%PRS 32.5%
-
CSI 1.0rCSI 6.6%PRS 36.7%
-
CSI 1.0rCSI 1.5%PRS 22.5%
-
CSI 1.0rCSI 1.3%PRS 20.9%
-
CSI 1.1rCSI 2.7%PRS 15.0%
-
CSI 1.1rCSI 1.2%PRS 16.6%
-
CSI 1.1rCSI 3.7%PRS 9.2%
-
CSI 1.1rCSI 1.7%PRS 18.6%
-
CSI 1.2rCSI 1.4%PRS 28.1%
-
CSI 1.2rCSI 12.8%PRS 21.8%
-
CSI 1.2rCSI 11.3%PRS 43.6%
-
CSI 1.2rCSI 1.7%PRS 32.8%
-
CSI 1.3rCSI 4.4%PRS 49.2%
-
CSI 1.3rCSI 3.4%PRS 21.0%
-
CSI 1.3rCSI 3.2%PRS 16.4%
-
CSI 1.3rCSI 1.6%PRS 19.3%
-
CSI 1.3rCSI 2.5%PRS 16.6%
-
CSI 1.3rCSI 3.4%PRS 41.8%
-
CSI 1.3rCSI 6.9%PRS 28.4%
-
CSI 1.4rCSI 2.0%PRS 22.7%
-
CSI 1.4rCSI 7.6%PRS 43.7%
-
CSI 1.4rCSI 3.1%PRS 15.1%
-
CSI 1.4rCSI 1.7%PRS 20.8%
-
CSI 1.4rCSI 3.4%PRS 25.8%
-
CSI 1.4rCSI 2.2%PRS 18.6%
-
CSI 1.4rCSI 3.1%PRS 24.7%
-
CSI 1.4rCSI 4.1%PRS 18.4%
-
CSI 1.4rCSI 2.2%PRS 16.2%
-
CSI 1.5rCSI 5.3%PRS 27.8%
-
CSI 1.5rCSI 6.6%PRS 59.5%
-
CSI 1.5rCSI 3.5%PRS 20.2%
-
CSI 1.5rCSI 3.2%PRS 26.7%
-
CSI 1.5rCSI 9.6%PRS 12.7%
-
CSI 1.5rCSI 3.7%PRS 24.9%
-
CSI 1.6rCSI 2.7%PRS 21.9%
-
CSI 1.6rCSI 6.3%PRS 4.4%
-
CSI 1.6rCSI 2.4%PRS 17.2%
-
CSI 1.6rCSI 3.8%PRS 37.9%
-
CSI 1.6rCSI 1.5%PRS 18.8%
-
CSI 1.7rCSI 3.7%PRS 18.6%
-
CSI 1.7rCSI 3.2%PRS 36.2%
-
CSI 1.7rCSI 4.9%PRS 27.9%
-
CSI 1.7rCSI 3.0%PRS 21.4%
-
CSI 1.7rCSI 4.4%PRS 20.1%
-
CSI 1.8rCSI 1.5%PRS 15.3%
-
CSI 1.8rCSI 4.1%PRS 16.8%
-
CSI 1.8rCSI 5.8%PRS 43.2%
-
CSI 1.8rCSI 3.2%PRS 27.3%
-
CSI 1.8rCSI 3.6%PRS 17.2%
-
CSI 1.8rCSI 7.7%PRS 40.3%
-
CSI 1.9rCSI 2.4%PRS 18.7%
-
CSI 1.9rCSI 8.4%PRS 15.9%
-
CSI 1.9rCSI 3.0%PRS 20.9%
-
CSI 2.0rCSI 4.7%PRS 24.2%
-
CSI 2.0rCSI 7.5%PRS 16.0%
-
CSI 2.0rCSI 3.0%PRS 28.4%
-
CSI 2.0rCSI 10.7%PRS 52.0%
-
CSI 2.0rCSI 13.1%PRS 41.2%
-
CSI 2.0rCSI 5.8%PRS 23.8%
-
CSI 2.0rCSI 2.0%PRS 13.9%
-
CSI 2.0rCSI 17.5%PRS 27.0%
-
CSI 2.1rCSI 2.8%PRS 18.4%
-
CSI 2.1rCSI 2.2%PRS 14.9%
-
CSI 2.1rCSI 2.5%PRS 16.0%
-
CSI 2.1rCSI 4.6%PRS 21.7%
-
CSI 2.2rCSI 3.2%PRS 21.3%
-
CSI 2.2rCSI 9.4%PRS 19.8%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2091340657
Symbol: TUT4_HUMAN
Name: Zinc finger CCHC domain-containing protein 11
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8724849
Title: Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.
PubMed ID: 8724849
PubMed ID: 16643855
Title: A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling.
PubMed ID: 16643855
PubMed ID: 17525332
Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
PubMed ID: 17525332
PubMed ID: 18172165
Title: Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'.
PubMed ID: 18172165
DOI: 10.1101/gad.1622708
PubMed ID: 19703396
Title: TUT4 in concert with Lin28 suppresses MicroRNA biogenesis through pre-microRNA uridylation.
PubMed ID: 19703396
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22118463
Title: Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms.
PubMed ID: 22118463
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25480299
Title: Uridylation by TUT4 and TUT7 marks mRNA for degradation.
PubMed ID: 25480299
PubMed ID: 25979828
Title: TUT7 controls the fate of precursor microRNAs by using three different uridylation mechanisms.
PubMed ID: 25979828
PubMed ID: 30122351
Title: Uridylation by TUT4/7 Restricts Retrotransposition of Human LINE-1s.
PubMed ID: 30122351
PubMed ID: 31036859
Title: Crystal structure of the Lin28-interacting module of human terminal uridylyltransferase that regulates let-7 expression.
PubMed ID: 31036859
Sequence Information:
- Length: 1644
- Mass: 185166
- Checksum: B7C88D7DCF0F3356
- Sequence:
MEESKTLKSE NHEPKKNVIC EESKAVQVIG NQTLKARNDK SVKEIENSSP NRNSSKKNKQ NDICIEKTEV KSCKVNAANL PGPKDLGLVL RDQSHCKAKK FPNSPVKAEK ATISQAKSEK ATSLQAKAEK SPKSPNSVKA EKASSYQMKS EKVPSSPAEA EKGPSLLLKD MRQKTELQQI GKKIPSSFTS VDKVNIEAVG GEKCALQNSP RSQKQQTCTD NTGDSDDSAS GIEDVSDDLS KMKNDESNKE NSSEMDYLEN ATVIDESALT PEQRLGLKQA EERLERDHIF RLEKRSPEYT NCRYLCKLCL IHIENIQGAH KHIKEKRHKK NILEKQEESE LRSLPPPSPA HLAALSVAVI ELAKEHGITD DDLRVRQEIV EEMSKVITTF LPECSLRLYG SSLTRFALKS SDVNIDIKFP PKMNHPDLLI KVLGILKKNV LYVDVESDFH AKVPVVVCRD RKSGLLCRVS AGNDMACLTT DLLTALGKIE PVFIPLVLAF RYWAKLCYID SQTDGGIPSY CFALMVMFFL QQRKPPLLPC LLGSWIEGFD PKRMDDFQLK GIVEEKFVKW ECNSSSATEK NSIAEENKAK ADQPKDDTKK TETDNQSNAM KEKHGKSPLA LETPNRVSLG QLWLELLKFY TLDFALEEYV ICVRIQDILT RENKNWPKRR IAIEDPFSVK RNVARSLNSQ LVYEYVVERF RAAYRYFACP QTKGGNKSTV DFKKREKGKI SNKKPVKSNN MATNGCILLG ETTEKINAER EQPVQCDEMD CTSQRCIIDN NNLLVNELDF ADHGQDSSSL STSKSSEIEP KLDKKQDDLA PSETCLKKEL SQCNCIDLSK SPDPDKSTGT DCRSNLETES SHQSVCTDTS ATSCNCKATE DASDLNDDDN LPTQELYYVF DKFILTSGKP PTIVCSICKK DGHSKNDCPE DFRKIDLKPL PPMTNRFREI LDLVCKRCFD ELSPPCSEQH NREQILIGLE KFIQKEYDEK ARLCLFGSSK NGFGFRDSDL DICMTLEGHE NAEKLNCKEI IENLAKILKR HPGLRNILPI TTAKVPIVKF EHRRSGLEGD ISLYNTLAQH NTRMLATYAA IDPRVQYLGY TMKVFAKRCD IGDASRGSLS SYAYILMVLY FLQQRKPPVI PVLQEIFDGK QIPQRMVDGW NAFFFDKTEE LKKRLPSLGK NTESLGELWL GLLRFYTEEF DFKEYVISIR QKKLLTTFEK QWTSKCIAIE DPFDLNHNLG AGVSRKMTNF IMKAFINGRK LFGTPFYPLI GREAEYFFDS RVLTDGELAP NDRCCRVCGK IGHYMKDCPK RKSLLFRLKK KDSEEEKEGN EEEKDSRDVL DPRDLHDTRD FRDPRDLRCF ICGDAGHVRR ECPEVKLARQ RNSSVAAAQL VRNLVNAQQV AGSAQQQGDQ SIRTRQSSEC SESPSYSPQP QPFPQNSSQS AAITQPSSQP GSQPKLGPPQ QGAQPPHQVQ MPLYNFPQSP PAQYSPMHNM GLLPMHPLQI PAPSWPIHGP VIHSAPGSAP SNIGLNDPSI IFAQPAARPV AIPNTSHDGH WPRTVAPNSL VNSGAVGNSE PGFRGLTPPI PWEHAPRPHF PLVPASWPYG LHQNFMHQGN ARFQPNKPFY TQDRCATRRC RERCPHPPRG NVSE
Genular Protein ID: 3014275622
Symbol: A0A0C4DFM7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 17525332
Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
PubMed ID: 17525332
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
Sequence Information:
- Length: 1645
- Mass: 185253
- Checksum: 8DA909D3F7796B15
- Sequence:
MEESKTLKSE NHEPKKNVIC EESKAVQVIG NQTLKARNDK SVKEIENSSP NRNSSKKNKQ NDICIEKTEV KSCKVNAANL PGPKDLGLVL RDQSHCKAKK FPNSPVKAEK ATISQAKSEK ATSLQAKAEK SPKSPNSVKA EKASSYQMKS EKVPSSPAEA EKGPSLLLKD MRQKTELQQI GKKIPSSFTS VDKVNIEAVG GEKCALQNSP RSQKQQTCTD NTGDSDDSAS GIEDVSDDLS KMKNDESNKE NSSEMDYLEN ATVIDESALT PEQRLGLKQA EERLERDHIF RLEKRSPEYT NCRYLCKLCL IHIENIQGAH KHIKEKRHKK NILEKQEESE LRSLPPPSPA HLAALSVAVI ELAKEHGITD DDLRVRQEIV EEMSKVITTF LPECSLRLYG SSLTRFALKS SDVNIDIKFP PKMNHPDLLI KVLGILKKNV LYVDVESDFH AKVPVVVCRD RKSGLLCRVS AGNDMACLTT DLLTALGKIE PVFIPLVLAF RYWAKLCYID SQTDGGIPSY CFALMVMFFL QQRKPPLLPC LLGSWIEGFD PKRMDDFQLK GIVEEKFVKW ECNSSSATEK NSIAEENKAK ADQPKDDTKK TETDNQSNAM KEKHGKSPLA LETPNRVSLG QLWLELLKFY TLDFALEEYV ICVRIQDILT RENKNWPKRR IAIEDPFSVK RNVARSLNSQ LVYEYVVERF RAAYRYFACP QTKGGNKSTV DFKKREKGKI SNKKPVKSNN MATNGCILLG ETTEKINAER EQPVQCDEMD CTSQRCIIDN NNLLVNELDF ADHGQDSSSL STSKSSEIEP KLDKKQDDLA PSETCLKKEL SQCNCIDLSK SPDPDKSTGT DCRSNLETES SHQSVCTDTS ATSCNCKATE DASDLNDDDN LPTQELYYVF DKFILTSGKP PTIVCSICKK DGHSKNDCPE DFRKIDLKPL PPMTNRFREI LDLVCKRCFD ELSPPCSEQH NREQILIGLE KFIQKEYDEK ARLCLFGSSK NGFGFRDSDL DICMTLEGHE NAEKLNCKEI IENLAKILKR HPGLRNILPI TTAKVPIVKF EHRRSGLEGD ISLYNTLAQH NTRMLATYAA IDPRVQYLGY TMKVFAKRCD IGDASRGSLS SYAYILMVLY FLQQRKPPVI PVLQEIFDGK QIPQRMVDGW NAFFFDKTEE LKKRLPSLGK NTESLGELWL GLLRFYTEEF DFKEYVISIR QKKLLTTFEK QWTSKCIAIE DPFDLNHNLG AGVSRKMTNF IMKAFINGRK LFGTPFYPLI GREAEYFFDS RVLTDGELAP NDRCCRVCGK IGHYMKDCPK RKSSLLFRLK KKDSEEEKEG NEEEKDSRDV LDPRDLHDTR DFRDPRDLRC FICGDAGHVR RECPEVKLAR QRNSSVAAAQ LVRNLVNAQQ VAGSAQQQGD QSIRTRQSSE CSESPSYSPQ PQPFPQNSSQ SAAITQPSSQ PGSQPKLGPP QQGAQPPHQV QMPLYNFPQS PPAQYSPMHN MGLLPMHPLQ IPAPSWPIHG PVIHSAPGSA PSNIGLNDPS IIFAQPAARP VAIPNTSHDG HWPRTVAPNS LVNSGAVGNS EPGFRGLTPP IPWEHAPRPH FPLVPASWPY GLHQNFMHQG NARFQPNKPF YTQDRCATRR CRERCPHPPR GNVSE