Details for: TUT4

Gene ID: 23318

Symbol: TUT4

Ensembl ID: ENSG00000134744

Description: terminal uridylyl transferase 4

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 7.14
    Marker Score: 94,981
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.7
    Marker Score: 9,259
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 3.4
    Marker Score: 4,578
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.25
    Marker Score: 3,933
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 3.11
    Marker Score: 1,512
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.83
    Marker Score: 11,863
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.63
    Marker Score: 1,535
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.57
    Marker Score: 57,498
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.57
    Marker Score: 54,866
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.54
    Marker Score: 11,740
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.52
    Marker Score: 5,541
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.51
    Marker Score: 8,919
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.49
    Marker Score: 37,264
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.48
    Marker Score: 49,357
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.46
    Marker Score: 93,332
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.42
    Marker Score: 18,577
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.39
    Marker Score: 697
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.37
    Marker Score: 20,801
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.34
    Marker Score: 9,685
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.31
    Marker Score: 2,552
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.3
    Marker Score: 730
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.29
    Marker Score: 2,033
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.27
    Marker Score: 1,329
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.26
    Marker Score: 83,309
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2.21
    Marker Score: 1,157
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.21
    Marker Score: 2,751
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.2
    Marker Score: 5,257
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.19
    Marker Score: 2,519
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 2.16
    Marker Score: 1,980
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.15
    Marker Score: 8,330
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 2.13
    Marker Score: 2,297
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.13
    Marker Score: 4,096
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.06
    Marker Score: 2,027
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.05
    Marker Score: 648
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.05
    Marker Score: 19,260
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.03
    Marker Score: 1,001
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.99
    Marker Score: 1,048
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.98
    Marker Score: 1,677
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.94
    Marker Score: 119,407
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.93
    Marker Score: 1,269
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.9
    Marker Score: 946
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.86
    Marker Score: 2,019
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.84
    Marker Score: 1,421
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.84
    Marker Score: 770
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.83
    Marker Score: 2,257
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.82
    Marker Score: 787
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.79
    Marker Score: 16,978
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.78
    Marker Score: 1,193
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.78
    Marker Score: 2,214
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.77
    Marker Score: 1,229
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.77
    Marker Score: 654
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.76
    Marker Score: 15,091
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.75
    Marker Score: 1,671
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.75
    Marker Score: 636
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.75
    Marker Score: 1,042
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 1.74
    Marker Score: 526
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.74
    Marker Score: 1,154
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.72
    Marker Score: 584
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.7
    Marker Score: 907
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.7
    Marker Score: 948
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.7
    Marker Score: 1,162
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.7
    Marker Score: 17,551
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.68
    Marker Score: 501
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.67
    Marker Score: 1,262
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.66
    Marker Score: 600
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.66
    Marker Score: 2,894
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.66
    Marker Score: 926
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.65
    Marker Score: 823
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.63
    Marker Score: 1,108
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.62
    Marker Score: 574
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.61
    Marker Score: 969
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.6
    Marker Score: 5,940
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.6
    Marker Score: 18,003
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.59
    Marker Score: 1,044
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.58
    Marker Score: 800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.58
    Marker Score: 9,395
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.56
    Marker Score: 634
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.56
    Marker Score: 82,442
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.55
    Marker Score: 908
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 1.55
    Marker Score: 1,136
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.55
    Marker Score: 1,340
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.55
    Marker Score: 6,293
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.54
    Marker Score: 2,220
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.54
    Marker Score: 1,624
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.54
    Marker Score: 391
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.53
    Marker Score: 1,736
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.52
    Marker Score: 735
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.51
    Marker Score: 361
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.5
    Marker Score: 15,126
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.5
    Marker Score: 1,513
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.49
    Marker Score: 521
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.49
    Marker Score: 1,397
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.49
    Marker Score: 1,125
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.48
    Marker Score: 2,281
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.47
    Marker Score: 1,564
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.46
    Marker Score: 813
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.46
    Marker Score: 1,556
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.45
    Marker Score: 2,059
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.45
    Marker Score: 14,728
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.45
    Marker Score: 4,074

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TUT4 is characterized by its ability to catalyze the transfer of terminal uridyl groups from UTP to RNA molecules, a process known as polyuridylation. This reaction is essential for the regulation of RNA stability and translation. TUT4 is also a zinc finger protein, which allows it to bind to specific DNA sequences and regulate gene expression. The protein has two distinct CCHC domains, which are involved in binding to RNA and DNA molecules, respectively. **Pathways and Functions** TUT4 is involved in several RNA processing pathways, including: 1. **Deadenylation-dependent mRNA decay**: TUT4 catalyzes the removal of polyuridylylated tails from mRNA, leading to its degradation. 2. **Polyuridylation-dependent mRNA catabolic process**: TUT4 polyuridylates mRNA, which can regulate its stability and translation. 3. **mRNA 3'-end processing**: TUT4 is involved in the processing of mRNA 3'-ends, which is essential for the regulation of translation. 4. **Retrotransposon silencing by mRNA destabilization**: TUT4 can destabilize retrotransposon mRNAs, which helps to prevent their mobilization. TUT4 also plays a role in regulating immune responses by modulating the expression of immune-related genes. For example, TUT4 has been shown to regulate the expression of interferon-stimulated genes (ISGs), which are involved in antiviral immune responses. **Clinical Significance** Dysregulation of TUT4 has been implicated in various diseases, including: 1. **Autoimmune disorders**: TUT4 has been shown to regulate the expression of autoimmune-related genes, which can contribute to autoimmune diseases such as rheumatoid arthritis and lupus. 2. **Cancer**: TUT4 has been implicated in the regulation of cancer-related genes, which can contribute to tumorigenesis. 3. **Neurological disorders**: TUT4 has been shown to regulate the expression of genes involved in neurological disorders such as Alzheimer's disease and Parkinson's disease. In conclusion, TUT4 is a critical regulator of RNA processing and immune function. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its role in maintaining immune homeostasis and preventing disease. Further research is needed to fully elucidate the mechanisms by which TUT4 regulates RNA processing and immune responses.

Genular Protein ID: 2091340657

Symbol: TUT4_HUMAN

Name: Zinc finger CCHC domain-containing protein 11

UniProtKB Accession Codes:

Q5TAX3 A2RRP0 B7Z8J5 D3DQ35 Q12764 Q5TAX2 Q5TAX4 Q86XZ3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 18 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 6 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 20 Gene3D 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 Rhea 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8724849

Title: Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 8724849

DOI: 10.1093/dnares/3.1.17

PubMed ID: 16643855

Title: A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling.

PubMed ID: 16643855

DOI: 10.1016/j.bbrc.2006.04.006

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18172165

Title: Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'.

PubMed ID: 18172165

DOI: 10.1101/gad.1622708

PubMed ID: 19703396

Title: TUT4 in concert with Lin28 suppresses MicroRNA biogenesis through pre-microRNA uridylation.

PubMed ID: 19703396

DOI: 10.1016/j.cell.2009.08.002

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22118463

Title: Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms.

PubMed ID: 22118463

DOI: 10.1016/j.cell.2011.10.039

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25480299

Title: Uridylation by TUT4 and TUT7 marks mRNA for degradation.

PubMed ID: 25480299

DOI: 10.1016/j.cell.2014.10.055

PubMed ID: 25979828

Title: TUT7 controls the fate of precursor microRNAs by using three different uridylation mechanisms.

PubMed ID: 25979828

DOI: 10.15252/embj.201590931

PubMed ID: 30122351

Title: Uridylation by TUT4/7 Restricts Retrotransposition of Human LINE-1s.

PubMed ID: 30122351

DOI: 10.1016/j.cell.2018.07.022

PubMed ID: 31036859

Title: Crystal structure of the Lin28-interacting module of human terminal uridylyltransferase that regulates let-7 expression.

PubMed ID: 31036859

DOI: 10.1038/s41467-019-09966-5

Sequence Information:

  • Length: 1644
  • Mass: 185166
  • Checksum: B7C88D7DCF0F3356
  • Sequence:
    • MEESKTLKSE NHEPKKNVIC EESKAVQVIG NQTLKARNDK SVKEIENSSP NRNSSKKNKQ 
NDICIEKTEV KSCKVNAANL PGPKDLGLVL RDQSHCKAKK FPNSPVKAEK ATISQAKSEK 
ATSLQAKAEK SPKSPNSVKA EKASSYQMKS EKVPSSPAEA EKGPSLLLKD MRQKTELQQI 
GKKIPSSFTS VDKVNIEAVG GEKCALQNSP RSQKQQTCTD NTGDSDDSAS GIEDVSDDLS 
KMKNDESNKE NSSEMDYLEN ATVIDESALT PEQRLGLKQA EERLERDHIF RLEKRSPEYT 
NCRYLCKLCL IHIENIQGAH KHIKEKRHKK NILEKQEESE LRSLPPPSPA HLAALSVAVI 
ELAKEHGITD DDLRVRQEIV EEMSKVITTF LPECSLRLYG SSLTRFALKS SDVNIDIKFP 
PKMNHPDLLI KVLGILKKNV LYVDVESDFH AKVPVVVCRD RKSGLLCRVS AGNDMACLTT 
DLLTALGKIE PVFIPLVLAF RYWAKLCYID SQTDGGIPSY CFALMVMFFL QQRKPPLLPC 
LLGSWIEGFD PKRMDDFQLK GIVEEKFVKW ECNSSSATEK NSIAEENKAK ADQPKDDTKK 
TETDNQSNAM KEKHGKSPLA LETPNRVSLG QLWLELLKFY TLDFALEEYV ICVRIQDILT 
RENKNWPKRR IAIEDPFSVK RNVARSLNSQ LVYEYVVERF RAAYRYFACP QTKGGNKSTV 
DFKKREKGKI SNKKPVKSNN MATNGCILLG ETTEKINAER EQPVQCDEMD CTSQRCIIDN 
NNLLVNELDF ADHGQDSSSL STSKSSEIEP KLDKKQDDLA PSETCLKKEL SQCNCIDLSK 
SPDPDKSTGT DCRSNLETES SHQSVCTDTS ATSCNCKATE DASDLNDDDN LPTQELYYVF 
DKFILTSGKP PTIVCSICKK DGHSKNDCPE DFRKIDLKPL PPMTNRFREI LDLVCKRCFD 
ELSPPCSEQH NREQILIGLE KFIQKEYDEK ARLCLFGSSK NGFGFRDSDL DICMTLEGHE 
NAEKLNCKEI IENLAKILKR HPGLRNILPI TTAKVPIVKF EHRRSGLEGD ISLYNTLAQH 
NTRMLATYAA IDPRVQYLGY TMKVFAKRCD IGDASRGSLS SYAYILMVLY FLQQRKPPVI 
PVLQEIFDGK QIPQRMVDGW NAFFFDKTEE LKKRLPSLGK NTESLGELWL GLLRFYTEEF 
DFKEYVISIR QKKLLTTFEK QWTSKCIAIE DPFDLNHNLG AGVSRKMTNF IMKAFINGRK 
LFGTPFYPLI GREAEYFFDS RVLTDGELAP NDRCCRVCGK IGHYMKDCPK RKSLLFRLKK 
KDSEEEKEGN EEEKDSRDVL DPRDLHDTRD FRDPRDLRCF ICGDAGHVRR ECPEVKLARQ 
RNSSVAAAQL VRNLVNAQQV AGSAQQQGDQ SIRTRQSSEC SESPSYSPQP QPFPQNSSQS 
AAITQPSSQP GSQPKLGPPQ QGAQPPHQVQ MPLYNFPQSP PAQYSPMHNM GLLPMHPLQI 
PAPSWPIHGP VIHSAPGSAP SNIGLNDPSI IFAQPAARPV AIPNTSHDGH WPRTVAPNSL 
VNSGAVGNSE PGFRGLTPPI PWEHAPRPHF PLVPASWPYG LHQNFMHQGN ARFQPNKPFY 
TQDRCATRRC RERCPHPPRG NVSE

Genular Protein ID: 3014275622

Symbol: A0A0C4DFM7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0C4DFM7

Database IDs:

ARBA 5 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 6 ChiTaRS 1 DNASU 1 EC 1 EMBL 4 EPD 2 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 3 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 6 MANE-Select 1 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 4 PhylomeDB 1 Proteomes 2 RefSeq 1 Rhea 3 SAM 1 SMART 1 SMR 1 SUPFAM 3 VEuPathDB 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 1645
  • Mass: 185253
  • Checksum: 8DA909D3F7796B15
  • Sequence:
    • MEESKTLKSE NHEPKKNVIC EESKAVQVIG NQTLKARNDK SVKEIENSSP NRNSSKKNKQ 
NDICIEKTEV KSCKVNAANL PGPKDLGLVL RDQSHCKAKK FPNSPVKAEK ATISQAKSEK 
ATSLQAKAEK SPKSPNSVKA EKASSYQMKS EKVPSSPAEA EKGPSLLLKD MRQKTELQQI 
GKKIPSSFTS VDKVNIEAVG GEKCALQNSP RSQKQQTCTD NTGDSDDSAS GIEDVSDDLS 
KMKNDESNKE NSSEMDYLEN ATVIDESALT PEQRLGLKQA EERLERDHIF RLEKRSPEYT 
NCRYLCKLCL IHIENIQGAH KHIKEKRHKK NILEKQEESE LRSLPPPSPA HLAALSVAVI 
ELAKEHGITD DDLRVRQEIV EEMSKVITTF LPECSLRLYG SSLTRFALKS SDVNIDIKFP 
PKMNHPDLLI KVLGILKKNV LYVDVESDFH AKVPVVVCRD RKSGLLCRVS AGNDMACLTT 
DLLTALGKIE PVFIPLVLAF RYWAKLCYID SQTDGGIPSY CFALMVMFFL QQRKPPLLPC 
LLGSWIEGFD PKRMDDFQLK GIVEEKFVKW ECNSSSATEK NSIAEENKAK ADQPKDDTKK 
TETDNQSNAM KEKHGKSPLA LETPNRVSLG QLWLELLKFY TLDFALEEYV ICVRIQDILT 
RENKNWPKRR IAIEDPFSVK RNVARSLNSQ LVYEYVVERF RAAYRYFACP QTKGGNKSTV 
DFKKREKGKI SNKKPVKSNN MATNGCILLG ETTEKINAER EQPVQCDEMD CTSQRCIIDN 
NNLLVNELDF ADHGQDSSSL STSKSSEIEP KLDKKQDDLA PSETCLKKEL SQCNCIDLSK 
SPDPDKSTGT DCRSNLETES SHQSVCTDTS ATSCNCKATE DASDLNDDDN LPTQELYYVF 
DKFILTSGKP PTIVCSICKK DGHSKNDCPE DFRKIDLKPL PPMTNRFREI LDLVCKRCFD 
ELSPPCSEQH NREQILIGLE KFIQKEYDEK ARLCLFGSSK NGFGFRDSDL DICMTLEGHE 
NAEKLNCKEI IENLAKILKR HPGLRNILPI TTAKVPIVKF EHRRSGLEGD ISLYNTLAQH 
NTRMLATYAA IDPRVQYLGY TMKVFAKRCD IGDASRGSLS SYAYILMVLY FLQQRKPPVI 
PVLQEIFDGK QIPQRMVDGW NAFFFDKTEE LKKRLPSLGK NTESLGELWL GLLRFYTEEF 
DFKEYVISIR QKKLLTTFEK QWTSKCIAIE DPFDLNHNLG AGVSRKMTNF IMKAFINGRK 
LFGTPFYPLI GREAEYFFDS RVLTDGELAP NDRCCRVCGK IGHYMKDCPK RKSSLLFRLK 
KKDSEEEKEG NEEEKDSRDV LDPRDLHDTR DFRDPRDLRC FICGDAGHVR RECPEVKLAR 
QRNSSVAAAQ LVRNLVNAQQ VAGSAQQQGD QSIRTRQSSE CSESPSYSPQ PQPFPQNSSQ 
SAAITQPSSQ PGSQPKLGPP QQGAQPPHQV QMPLYNFPQS PPAQYSPMHN MGLLPMHPLQ 
IPAPSWPIHG PVIHSAPGSA PSNIGLNDPS IIFAQPAARP VAIPNTSHDG HWPRTVAPNS 
LVNSGAVGNS EPGFRGLTPP IPWEHAPRPH FPLVPASWPY GLHQNFMHQG NARFQPNKPF 
YTQDRCATRR CRERCPHPPR GNVSE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.