USP22 | ENSG00000124422 | NCBI 23326

Details for: USP22

Gene ID: 23326

Symbol: USP22

Ensembl ID: ENSG00000124422

Description: ubiquitin specific peptidase 22

Associated with

Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Deubiquitination
(R-HSA-5688426)
Hats acetylate histones
(R-HSA-3214847)
Metabolism of proteins
(R-HSA-392499)
Post-translational protein modification
(R-HSA-597592)
Ub-specific processing proteases
(R-HSA-5689880)
Cell cycle
(GO:0007049)
Chromatin remodeling
(GO:0006338)
Cysteine-type deubiquitinase activity
(GO:0004843)
Embryo development ending in birth or egg hatching
(GO:0009792)
Enzyme binding
(GO:0019899)
Histone h2a deubiquitinase activity
(GO:0140950)
Histone h2b deubiquitinase activity
(GO:0140936)
Histone h4 acetyltransferase activity
(GO:0010485)
Nuclear receptor coactivator activity
(GO:0030374)
Nucleoplasm
(GO:0005654)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of mitotic cell cycle
(GO:0045931)
Protein binding
(GO:0005515)
Protein deubiquitination
(GO:0016579)
Proteolysis
(GO:0006508)
Regulation of dna repair
(GO:0006282)
Regulation of rna splicing
(GO:0043484)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Saga complex
(GO:0000124)
Transcription coactivator activity
(GO:0003713)
Transcription factor tftc complex
(GO:0033276)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Ubiquitin carboxyl-terminal hydrolase 22

Genular Protein ID: 3425502644

Symbol: UBP22_HUMAN

Name: Ubiquitin carboxyl-terminal hydrolase 22

UniProtKB Accession Codes:

Q9UPT9 A0JNS3 Q2NLE2 Q6MZY4 Q8TBS8 Q96IW5

Database IDs:

Citations:

PubMed ID: 10470851

Title: Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10470851

DOI: 10.1093/dnares/6.3.197

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16378762

Title: The expression patterns of deubiquitinating enzymes, USP22 and Usp22.

PubMed ID: 16378762

DOI: 10.1016/j.modgep.2005.07.007

PubMed ID: 18206972

Title: A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing.

PubMed ID: 18206972

DOI: 10.1016/j.molcel.2007.12.011

PubMed ID: 18206973

Title: The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression.

PubMed ID: 18206973

DOI: 10.1016/j.molcel.2007.12.015

PubMed ID: 18469533

Title: USP22, an hSAGA subunit and potential cancer stem cell marker, reverses the polycomb-catalyzed ubiquitylation of histone H2A.

PubMed ID: 18469533

DOI: 10.4161/cc.7.11.5962

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 27601583

Title: Cytoplasmic ATXN7L3B interferes with nuclear functions of the SAGA deubiquitinase module.

PubMed ID: 27601583

DOI: 10.1128/mcb.00193-16

Sequence Information:

Length: 525
Mass: 59961
Checksum: D18BFE84BE8E5915
Sequence:

MVSRPEPEGE AMDAELAVAP PGCSHLGSFK VDNWKQNLRA IYQCFVWSGT AEARKRKAKS 
CICHVCGVHL NRLHSCLYCV FFGCFTKKHI HEHAKAKRHN LAIDLMYGGI YCFLCQDYIY 
DKDMEIIAKE EQRKAWKMQG VGEKFSTWEP TKRELELLKH NPKRRKITSN CTIGLRGLIN 
LGNTCFMNCI VQALTHTPLL RDFFLSDRHR CEMQSPSSCL VCEMSSLFQE FYSGHRSPHI 
PYKLLHLVWT HARHLAGYEQ QDAHEFLIAA LDVLHRHCKG DDNGKKANNP NHCNCIIDQI 
FTGGLQSDVT CQVCHGVSTT IDPFWDISLD LPGSSTPFWP LSPGSEGNVV NGESHVSGTT 
TLTDCLRRFT RPEHLGSSAK IKCSGCHSYQ ESTKQLTMKK LPIVACFHLK RFEHSAKLRR 
KITTYVSFPL ELDMTPFMAS SKESRMNGQY QQPTDSLNND NKYSLFAVVN HQGTLESGHY 
TSFIRQHKDQ WFKCDDAIIT KASIKDVLDS EGYLLFYHKQ FLEYE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: USP22

Associated with

Other Information

Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 10470851

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The expression patterns of deubiquitinating enzymes, USP22 and Usp22. PubMed ID: 16378762

A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. PubMed ID: 18206972

The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression. PubMed ID: 18206973

USP22, an hSAGA subunit and potential cancer stem cell marker, reverses the polycomb-catalyzed ubiquitylation of histone H2A. PubMed ID: 18469533

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Cytoplasmic ATXN7L3B interferes with nuclear functions of the SAGA deubiquitinase module. PubMed ID: 27601583