Details for: NEDD4L

Gene ID: 23327

Symbol: NEDD4L

Ensembl ID: ENSG00000049759

Description: NEDD4 like E3 ubiquitin protein ligase

Associated with

Other Information

Genular Protein ID: 2085324608

Symbol: NED4L_HUMAN

Name: E3 ubiquitin-protein ligase NEDD4-like

UniProtKB Accession Codes:

Q96PU5 O43165 Q3LSM7 Q7Z5F1 Q7Z5F2 Q7Z5N3 Q8N5A7 Q8WUU9 Q9BW58 Q9H2W4 Q9NT88

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 2 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 7 CDD 3 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EC 2 EMBL 17 EPD 1 Ensembl 15 EvolutionaryTrace 1 ExpressionAtlas 1 GO 36 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 30 PDBsum 17 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 4 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 8 Pumba 1 RNAct 1 Reactome 5 RefSeq 11 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11840194

Title: NEDD4L on human chromosome 18q21 has multiple forms of transcripts and is a homologue of the mouse Nedd4-2 gene.

PubMed ID: 11840194

DOI: 10.1038/sj.ejhg.5200747

PubMed ID: 14556380

Title: Identification of new partners of the epithelial sodium channel alpha subunit.

PubMed ID: 14556380

DOI: 10.1016/s1631-0691(03)00154-9

PubMed ID: 14615060

Title: Androgens differentially regulate the expression of NEDD4L transcripts in LNCaP human prostate cancer cells.

PubMed ID: 14615060

DOI: 10.1016/j.mce.2003.08.009

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9455477

Title: Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9455477

DOI: 10.1093/dnares/4.5.307

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15677482

Title: 14-3-3 proteins modulate the expression of epithelial Na+ channels by phosphorylation-dependent interaction with Nedd4-2 ubiquitin ligase.

PubMed ID: 15677482

DOI: 10.1074/jbc.m412884200

PubMed ID: 11046148

Title: Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases.

PubMed ID: 11046148

DOI: 10.1128/mcb.20.22.8526-8535.2000

PubMed ID: 11244092

Title: The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel.

PubMed ID: 11244092

DOI: 10.1074/jbc.c000906200

PubMed ID: 11696533

Title: Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel.

PubMed ID: 11696533

DOI: 10.1074/jbc.c100623200

PubMed ID: 11748237

Title: N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein.

PubMed ID: 11748237

DOI: 10.1074/jbc.m110443200

PubMed ID: 12911626

Title: Regulation of the glutamate transporter EAAT1 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid-inducible kinase isoforms SGK1/3 and protein kinase B.

PubMed ID: 12911626

DOI: 10.1046/j.1471-4159.2003.01937.x

PubMed ID: 15217910

Title: Cardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4-2 mediated ubiquitination.

PubMed ID: 15217910

DOI: 10.1161/01.res.0000136816.05109.89

PubMed ID: 15489223

Title: Nedd4-2 functionally interacts with ClC-5: involvement in constitutive albumin endocytosis in proximal tubule cells.

PubMed ID: 15489223

DOI: 10.1074/jbc.m411491200

PubMed ID: 15328345

Title: cAMP and serum and glucocorticoid-inducible kinase (SGK) regulate the epithelial Na(+) channel through convergent phosphorylation of Nedd4-2.

PubMed ID: 15328345

DOI: 10.1074/jbc.m407858200

PubMed ID: 15040001

Title: Regulation of the voltage gated K+ channel Kv1.3 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid inducible kinase SGK1.

PubMed ID: 15040001

DOI: 10.1002/jcp.10430

PubMed ID: 15548568

Title: Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins.

PubMed ID: 15548568

DOI: 10.1152/ajpcell.00460.2004

PubMed ID: 15496141

Title: NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor.

PubMed ID: 15496141

DOI: 10.1042/bj20040738

PubMed ID: 15576372

Title: Nedd4-2 phosphorylation induces serum and glucocorticoid-regulated kinase (SGK) ubiquitination and degradation.

PubMed ID: 15576372

DOI: 10.1074/jbc.m411053200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18819914

Title: Nedd4 family-interacting protein 1 (Ndfip1) is required for the exosomal secretion of Nedd4 family proteins.

PubMed ID: 18819914

DOI: 10.1074/jbc.m804120200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19664597

Title: Identification of NPC2 protein as interaction molecule with C2 domain of human Nedd4L.

PubMed ID: 19664597

DOI: 10.1016/j.bbrc.2009.07.158

PubMed ID: 19343052

Title: Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins.

PubMed ID: 19343052

DOI: 10.1038/embor.2009.30

PubMed ID: 19144635

Title: Down-regulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2.

PubMed ID: 19144635

DOI: 10.1074/jbc.m806877200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20525693

Title: Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members.

PubMed ID: 20525693

DOI: 10.1074/jbc.m110.103432

PubMed ID: 20086093

Title: HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK.

PubMed ID: 20086093

DOI: 10.1128/mcb.00013-10

PubMed ID: 20730100

Title: Interaction of serum- and glucocorticoid regulated kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulation.

PubMed ID: 20730100

DOI: 10.1371/journal.pone.0012163

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22024150

Title: Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels.

PubMed ID: 22024150

DOI: 10.1016/j.hrthm.2011.10.026

PubMed ID: 23236378

Title: Mammalian alpha arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with beta arrestins.

PubMed ID: 23236378

DOI: 10.1371/journal.pone.0050557

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23873930

Title: Cellular localization and characterization of cytosolic binding partners for Gla domain-containing proteins PRRG4 and PRRG2.

PubMed ID: 23873930

DOI: 10.1074/jbc.m113.484683

PubMed ID: 23999003

Title: SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation.

PubMed ID: 23999003

DOI: 10.1016/j.jdermsci.2013.07.010

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26363003

Title: Regulation of the human ether-a-go-go-related gene (hERG) potassium channel by Nedd4 family interacting proteins (Ndfips).

PubMed ID: 26363003

DOI: 10.1042/bj20141282

PubMed ID: 25631046

Title: Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response.

PubMed ID: 25631046

DOI: 10.1074/jbc.m114.613687

PubMed ID: 26854353

Title: Regulation of Itch and Nedd4 E3 Ligase Activity and Degradation by LRAD3.

PubMed ID: 26854353

DOI: 10.1021/acs.biochem.5b01218

PubMed ID: 27445338

Title: Ubiquitin-specific Protease 36 (USP36) Controls Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-2 (Nedd4-2) Actions over the Neurotrophin Receptor TrkA and Potassium Voltage-gated Channels 7.2/3 (Kv7.2/3).

PubMed ID: 27445338

DOI: 10.1074/jbc.m116.722637

PubMed ID: 27694961

Title: Mutations in the HECT domain of NEDD4L lead to AKT-mTOR pathway deregulation and cause periventricular nodular heterotopia.

PubMed ID: 27694961

DOI: 10.1038/ng.3676

PubMed ID: 28820317

Title: ULK1 ubiquitylation is regulated by phosphorylation on its carboxy terminus.

PubMed ID: 28820317

DOI: 10.1080/15384101.2017.1361063

PubMed ID: 31959741

Title: NEDD4L downregulates autophagy and cell growth by modulating ULK1 and a glutamine transporter.

PubMed ID: 31959741

DOI: 10.1038/s41419-020-2242-5

PubMed ID: 33608556

Title: E3 ligase Nedd4l promotes antiviral innate immunity by catalyzing K29-linked cysteine ubiquitination of TRAF3.

PubMed ID: 33608556

DOI: 10.1038/s41467-021-21456-1

PubMed ID: 15140763

Title: A naturally occurring human Nedd4-2 variant displays impaired ENaC regulation in Xenopus laevis oocytes.

PubMed ID: 15140763

DOI: 10.1152/ajprenal.00353.2003

PubMed ID: 20064473

Title: Insights into ubiquitin transfer cascades from a structure of a UbcH5B approximately ubiquitin-HECT(NEDD4L) complex.

PubMed ID: 20064473

DOI: 10.1016/j.molcel.2009.11.010

Sequence Information:

  • Length: 975
  • Mass: 111932
  • Checksum: 2C958625B4A1AB3F
  • Sequence:
    • MATGLGEPVY GLSEDEGESR ILRVKVVSGI DLAKKDIFGA SDPYVKLSLY VADENRELAL 
VQTKTIKKTL NPKWNEEFYF RVNPSNHRLL FEVFDENRLT RDDFLGQVDV PLSHLPTEDP 
TMERPYTFKD FLLRPRSHKS RVKGFLRLKM AYMPKNGGQD EENSDQRDDM EHGWEVVDSN 
DSASQHQEEL PPPPLPPGWE EKVDNLGRTY YVNHNNRTTQ WHRPSLMDVS SESDNNIRQI 
NQEAAHRRFR SRRHISEDLE PEPSEGGDVP EPWETISEEV NIAGDSLGLA LPPPPASPGS 
RTSPQELSEE LSRRLQITPD SNGEQFSSLI QREPSSRLRS CSVTDAVAEQ GHLPPPSAPA 
GRARSSTVTG GEEPTPSVAY VHTTPGLPSG WEERKDAKGR TYYVNHNNRT TTWTRPIMQL 
AEDGASGSAT NSNNHLIEPQ IRRPRSLSSP TVTLSAPLEG AKDSPVRRAV KDTLSNPQSP 
QPSPYNSPKP QHKVTQSFLP PGWEMRIAPN GRPFFIDHNT KTTTWEDPRL KFPVHMRSKT 
SLNPNDLGPL PPGWEERIHL DGRTFYIDHN SKITQWEDPR LQNPAITGPA VPYSREFKQK 
YDYFRKKLKK PADIPNRFEM KLHRNNIFEE SYRRIMSVKR PDVLKARLWI EFESEKGLDY 
GGVAREWFFL LSKEMFNPYY GLFEYSATDN YTLQINPNSG LCNEDHLSYF TFIGRVAGLA 
VFHGKLLDGF FIRPFYKMML GKQITLNDME SVDSEYYNSL KWILENDPTE LDLMFCIDEE 
NFGQTYQVDL KPNGSEIMVT NENKREYIDL VIQWRFVNRV QKQMNAFLEG FTELLPIDLI 
KIFDENELEL LMCGLGDVDV NDWRQHSIYK NGYCPNHPVI QWFWKAVLLM DAEKRIRLLQ 
FVTGTSRVPM NGFAELYGSN GPQLFTIEQW GSPEKLPRAH TCFNRLDLPP YETFEDLREK 
LLMAVENAQG FEGVD

Genular Protein ID: 2719907530

Symbol: B7Z2P9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z2P9

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EC 1 EMBL 2 GO 3 Gene3D 5 Genevisible 1 GenomeRNAi 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 1 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMART 2 SUPFAM 2 UniPathway 1

Sequence Information:

  • Length: 835
  • Mass: 96399
  • Checksum: 29BDAFCE06FC62F8
  • Sequence:
    • MERPYTFKDF LLRPRSHKSR VRGFLRLKMA YMPKNGGQDE ENSDQRDDME HGWEVVDSND 
SASQHQEELP PPPLPPGWEE KVDNLGRTYY VNHNNRTTQW HRPSLMDVSS ESDNNIRQIN 
QEAAHRRFRS RRHISEDLEP EPSEGGDVPE PWETISEEVN IAGDSRGLAL PPPPASPGSR 
TSPQGLSEEL SRRLQITPDS NGEQFSSLIQ REPSSRLRSC SVTDAVAEQG HLPPPSVAYV 
HTTPGLPSGW EERKDAKGRT YYVNHNNRTT TWTRPIMQLA EDGASGSATN SNNHLIEPQI 
RRPRSLSSPT VTLSAPLEGA KDSPVRRAVK DTLSNPQSPQ PSPYNSPKPQ HKVTQSFLPP 
GWEMRIAPNG RPFFIDHNTK TTTWEDPRLK FPVHMRSKTS LNPNDLGPLP PGWEERIHLD 
GRTFYIDHNS KITQWEDPRL QNPAITGPKA VPYSREFKQK YDYFRKKLKK PADIPNRFEM 
KLHRNNIFEE SYRRIMSVKR PDVLKARLWI EFESEKGLDY GGVAREWFFL LSKEMFNPYY 
GLFEYSATDN YTLQINPNSG LCNEDHLSYF TFIGRVAGLA VFHGKLLDGF FIRPFYKMML 
GKQITLNDME SVDSEYYNSL KWILENDPTE LDLMFCIDEE DFGQTYQVDL KPNGSEIMVT 
NENKREYIDL VIQWRFVNRV QKQMNAFLEG FTELLPIDLI KIFDENELEL LMCGLGDVDV 
NDWRQHSIYK NGYCPNHPVI QWFWKAVLLM DAEKRIRLLQ FVTGTSRVPM NGFAELYGSN 
GPQLFTIEQW GSPEKLPRAH TCFNRLDLPP YETFEDLREK LLMAVENAQG FEGVD

Genular Protein ID: 401891964

Symbol: B7Z6K0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z6K0

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EC 1 EMBL 2 GO 3 Gene3D 5 Genevisible 1 GenomeRNAi 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 1 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMART 2 SUPFAM 2 UniPathway 1

Sequence Information:

  • Length: 854
  • Mass: 98154
  • Checksum: 90FBB215570DEA74
  • Sequence:
    • MERPYTFKDF LLRPRSHKSR VKGFLRLKMA YMPKNGGQDE ENSDQRDDME HGWEVVDSND 
SASQHQEELP PPPLPPGWEE KVDNLGRTYY VNHNNRTTQW HRPSLMDVSS ESDNNIRQIN 
QEAAHRRFRS RRHISEDLEP EPSEGGDVPE PWETISEEVN IAGDSLGLAL PPPPASPGSR 
TSPQELSEEL SRRLQITPDS NGEQFSSLIQ REPSSRLRSC SVTDAVAEQG HLPPPSAPAG 
RARSSTVTGG EEPTPSVAYV HTTPGLPSGW EERKDAKGRT YYVNHNNRTT TWTRPIMQLA 
EDGASGSATN SNNHLIEPQI RRPRSLSSPT VTLSAPLEGA KDSPVRRAVK DTLSNPQSPQ 
PSPYNSPKPQ HKVTQSFLPP GWEMRIAPNG RPFFIDHNTK TTTWEDPRLK FPVHMRSKTS 
LNPNDLGPLP PGWEERIHLD GRTFYIDHNS KITQWEDPRL QSPAITGPAV PYSREFKQKY 
DYFRKKLKKP ADIPNRFEMK LHRNNIFEES YRRIMSVKRP DVLKARLWIE FESEKGLDYG 
GVAREWFFLL SKEMFNPYYG LFEYSATDNY TLQINPNSGL CNEDHLSYFT FIGRVAGLAV 
FHGKLLDGFF IRPFYKMMLG KQITLNDMES VDSEYYNSLK WILENDPTEL DLMFCIDEEN 
FGQTYQVDLK PNGSEIMVTN ENKREYIDLV IQWRFVNRVQ KQMNAFLEGF TELLPIDLIK 
IFDENELELL MCGLGDVDVN DWRQHSIYKN GYCPNHPVIQ WFWKAVLLMD AEKRIRLLQF 
VTGTSRVPMN GFAELYGSNG PQLFTIEQWG SPEKLPRAHT CFNRLDLPPY ETFEDLREKL 
LMAVENAQGF EGVD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.