Details for: VPS39

Gene ID: 23339

Symbol: VPS39

Ensembl ID: ENSG00000166887

Description: VPS39 subunit of HOPS complex

Associated with

Other Information

Genular Protein ID: 2832942293

Symbol: VPS39_HUMAN

Name: TRAP1-like protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11448994

Title: Human Vam6p promotes lysosome clustering and fusion in vivo.

PubMed ID: 11448994

DOI: 10.1083/jcb.200102142

PubMed ID: 9872452

Title: Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9872452

DOI: 10.1093/dnares/5.5.277

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12941698

Title: TLP, a novel modulator of TGF-beta signaling, has opposite effects on Smad2- and Smad3-dependent signaling.

PubMed ID: 12941698

DOI: 10.1093/emboj/cdg428

PubMed ID: 17897319

Title: Integral and associated lysosomal membrane proteins.

PubMed ID: 17897319

DOI: 10.1111/j.1600-0854.2007.00643.x

PubMed ID: 23351085

Title: Tethering complexes in the endocytic pathway: CORVET and HOPS.

PubMed ID: 23351085

DOI: 10.1111/febs.12151

PubMed ID: 23901104

Title: Structural basis of Vps33A recruitment to the human HOPS complex by Vps16.

PubMed ID: 23901104

DOI: 10.1073/pnas.1307074110

PubMed ID: 23167963

Title: The HOPS proteins hVps41 and hVps39 are required for homotypic and heterotypic late endosome fusion.

PubMed ID: 23167963

DOI: 10.1111/tra.12027

PubMed ID: 25908847

Title: The small GTPase Arl8b regulates assembly of the mammalian HOPS complex on lysosomes.

PubMed ID: 25908847

DOI: 10.1242/jcs.162651

PubMed ID: 25783203

Title: Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes.

PubMed ID: 25783203

DOI: 10.1111/tra.12283

PubMed ID: 31806350

Title: The ER-Localized Transmembrane Protein TMEM39A/SUSR2 Regulates Autophagy by Controlling the Trafficking of the PtdIns(4)P Phosphatase SAC1.

PubMed ID: 31806350

DOI: 10.1016/j.molcel.2019.10.035

PubMed ID: 33422265

Title: ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation.

PubMed ID: 33422265

DOI: 10.1016/j.devcel.2020.12.010

Sequence Information:

  • Length: 886
  • Mass: 101809
  • Checksum: E5A40A3C787EB112
  • Sequence:
  • MHDAFEPVPI LEKLPLQIDC LAAWEEWLLV GTKQGHLLLY RIRKDVVPAD VASPESGSCN 
    RFEVTLEKSN KNFSKKIQQI HVVSQFKILV SLLENNIYVH DLLTFQQITT VSKAKGASLF 
    TCDLQHTETG EEVLRMCVAV KKKLQLYFWK DREFHELQGD FSVPDVPKSM AWCENSICVG 
    FKRDYYLIRV DGKGSIKELF PTGKQLEPLV APLADGKVAV GQDDLTVVLN EEGICTQKCA 
    LNWTDIPVAM EHQPPYIIAV LPRYVEIRTF EPRLLVQSIE LQRPRFITSG GSNIIYVASN 
    HFVWRLIPVP MATQIQQLLQ DKQFELALQL AEMKDDSDSE KQQQIHHIKN LYAFNLFCQK 
    RFDESMQVFA KLGTDPTHVM GLYPDLLPTD YRKQLQYPNP LPVLSGAELE KAHLALIDYL 
    TQKRSQLVKK LNDSDHQSST SPLMEGTPTI KSKKKLLQII DTTLLKCYLH TNVALVAPLL 
    RLENNHCHIE ESEHVLKKAH KYSELIILYE KKGLHEKALQ VLVDQSKKAN SPLKGHERTV 
    QYLQHLGTEN LHLIFSYSVW VLRDFPEDGL KIFTEDLPEV ESLPRDRVLG FLIENFKGLA 
    IPYLEHIIHV WEETGSRFHN CLIQLYCEKV QGLMKEYLLS FPAGKTPVPA GEEEGELGEY 
    RQKLLMFLEI SSYYDPGRLI CDFPFDGLLE ERALLLGRMG KHEQALFIYV HILKDTRMAE 
    EYCHKHYDRN KDGNKDVYLS LLRMYLSPPS IHCLGPIKLE LLEPKANLQA ALQVLELHHS 
    KLDTTKALNL LPANTQINDI RIFLEKVLEE NAQKKRFNQV LKNLLHAEFL RVQEERILHQ 
    QVKCIITEEK VCMVCKKKIG NSAFARYPNG VVVHYFCSKE VNPADT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.