Details for: HAUS5

Gene ID: 23354

Symbol: HAUS5

Ensembl ID: ENSG00000249115

Description: HAUS augmin like complex subunit 5

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169,112
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,781
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,005
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,404
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 487
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 442
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,724
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5,060
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.89
    Marker Score: 355
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,265
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,263
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 378
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 555
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.72
    Marker Score: 1,042
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 648
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2,889
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 169
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.63
    Marker Score: 840
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.63
    Marker Score: 1,064
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.62
    Marker Score: 467
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.61
    Marker Score: 1,824
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.57
    Marker Score: 712
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 439
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.54
    Marker Score: 364
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.53
    Marker Score: 1,108
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.51
    Marker Score: 1,400
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.5
    Marker Score: 466
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.49
    Marker Score: 934
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.48
    Marker Score: 320
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.47
    Marker Score: 346
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.47
    Marker Score: 1,271
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.46
    Marker Score: 489
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.44
    Marker Score: 899
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.44
    Marker Score: 117
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.43
    Marker Score: 433
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.42
    Marker Score: 1,459
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.42
    Marker Score: 6,537
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.41
    Marker Score: 279
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.41
    Marker Score: 497
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.41
    Marker Score: 436
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.41
    Marker Score: 171
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.41
    Marker Score: 142
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.41
    Marker Score: 223
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.4
    Marker Score: 383
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.39
    Marker Score: 286
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.39
    Marker Score: 96
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.38
    Marker Score: 215
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.38
    Marker Score: 123
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.38
    Marker Score: 1,506
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.37
    Marker Score: 152
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.36
    Marker Score: 115
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.36
    Marker Score: 178
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.36
    Marker Score: 1,483
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.36
    Marker Score: 215
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.35
    Marker Score: 21,820
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.35
    Marker Score: 105
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.34
    Marker Score: 2,952
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.34
    Marker Score: 3,216
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.34
    Marker Score: 387
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.34
    Marker Score: 3,221
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.34
    Marker Score: 2,202
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.34
    Marker Score: 210
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.34
    Marker Score: 1,297
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.33
    Marker Score: 4,409
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.33
    Marker Score: 153
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.33
    Marker Score: 138
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.33
    Marker Score: 177
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.32
    Marker Score: 229
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.32
    Marker Score: 2,791
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.32
    Marker Score: 754
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.32
    Marker Score: 212
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.32
    Marker Score: 341
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.31
    Marker Score: 287
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.31
    Marker Score: 151
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.31
    Marker Score: 477
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.31
    Marker Score: 1,144
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.31
    Marker Score: 193
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.31
    Marker Score: 72
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3
    Marker Score: 1,176
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.3
    Marker Score: 106
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.3
    Marker Score: 192
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.3
    Marker Score: 300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.3
    Marker Score: 2,316
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.3
    Marker Score: 200
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.3
    Marker Score: 71
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.3
    Marker Score: 264
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.3
    Marker Score: 3,974
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.3
    Marker Score: 15,623
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.3
    Marker Score: 281
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.29
    Marker Score: 6,269
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.29
    Marker Score: 64
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.29
    Marker Score: 187
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.29
    Marker Score: 62
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.29
    Marker Score: 132
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.29
    Marker Score: 10,954
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.29
    Marker Score: 10,619
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.29
    Marker Score: 56
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.28
    Marker Score: 1,706

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** HAUS5 is a cytoplasmic protein that belongs to the HAUS complex, a multiprotein structure that regulates microtubule dynamics and centrosome function. The gene encodes a subunit of the HAUS complex, HAUS5, which is characterized by its ability to interact with other proteins, including Aurora A kinase (Aurka) and NIMA-related kinase 2 (Nek2). HAUS5 is highly expressed in cells undergoing rapid division, such as those found in the intestinal crypts and cerebral cortex, where it is thought to play a role in regulating cell proliferation and differentiation. **Pathways and Functions** HAUS5 is involved in several key cellular pathways, including: 1. **Centrosome maturation**: HAUS5 regulates the maturation of centrosomes, which are essential for microtubule organization and cell division. 2. **Microtubule organization**: HAUS5 interacts with microtubules to regulate their dynamics and stability, ensuring proper cellular architecture and ensuring proper cell division. 3. **Cell cycle progression**: HAUS5 plays a role in regulating the cell cycle, particularly during the G2/M transition, where it interacts with Aurora A kinase (Aurka) to regulate microtubule nucleation. 4. **Spindle assembly**: HAUS5 is involved in the assembly of the mitotic spindle, which is essential for proper chromosome segregation during cell division. **Clinical Significance** Dysregulation of HAUS5 has been implicated in several diseases, including: 1. **Cancer**: HAUS5 overexpression has been observed in various types of cancer, including colorectal cancer, where it is thought to contribute to tumorigenesis and tumor progression. 2. **Neurological disorders**: HAUS5 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it is thought to play a role in regulating centrosome function and microtubule organization. 3. **Intestinal disorders**: HAUS5 has been implicated in intestinal disorders, such as inflammatory bowel disease (IBD), where it is thought to contribute to the development of intestinal inflammation and tissue damage. In summary, HAUS5 is a critical regulator of centrosome maturation, microtubule organization, and cell cycle progression, and dysregulation of the gene has been implicated in various diseases. Further research is needed to fully understand the role of HAUS5 in human disease and to develop therapeutic strategies to target this gene in the treatment of related disorders.

Genular Protein ID: 2857914201

Symbol: HAUS5_HUMAN

Name: HAUS augmin-like complex subunit 5

UniProtKB Accession Codes:

O94927 B2RXK1 Q6P2P7 Q7L3D5 Q96CT8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 4 EMDB 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 8 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 7 RefSeq 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19427217

Title: HAUS, the 8-subunit human augmin complex, regulates centrosome and spindle integrity.

PubMed ID: 19427217

DOI: 10.1016/j.cub.2009.04.033

PubMed ID: 19369198

Title: The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells.

PubMed ID: 19369198

DOI: 10.1073/pnas.0901587106

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 30723163

Title: The microtubule-associated protein EML3 regulates mitotic spindle assembly by recruiting the Augmin complex to spindle microtubules.

PubMed ID: 30723163

DOI: 10.1074/jbc.ra118.007164

Sequence Information:

  • Length: 633
  • Mass: 71682
  • Checksum: 23D8746F2A81ABCB
  • Sequence:
    • MELAQEAREL GCWAVEEMGV PVAARAPEST LRRLCLGQGA DIWAYILQHV HSQRTVKKIR 
GNLLWYGHQD SPQVRRKLEL EAAVTRLRAE IQELDQSLEL MERDTEAQDT AMEQARQHTQ 
DTQRRALLLR AQAGAMRRQQ HTLRDPMQRL QNQLRRLQDM ERKAKVDVTF GSLTSAALGL 
EPVVLRDVRT ACTLRAQFLQ NLLLPQAKRG SLPTPHDDHF GTSYQQWLSS VETLLTNHPP 
GHVLAALEHL AAEREAEIRS LCSGDGLGDT EISRPQAPDQ SDSSQTLPSM VHLIQEGWRT 
VGVLVSQRST LLKERQVLTQ RLQGLVEEVE RRVLGSSERQ VLILGLRRCC LWTELKALHD 
QSQELQDAAG HRQLLLRELQ AKQQRILHWR QLVEETQEQV RLLIKGNSAS KTRLCRSPGE 
VLALVQRKVV PTFEAVAPQS RELLRCLEEE VRHLPHILLG TLLRHRPGEL KPLPTVLPSI 
HQLHPASPRG SSFIALSHKL GLPPGKASEL LLPAAASLRQ DLLLLQDQRS LWCWDLLHMK 
TSLPPGLPTQ ELLQIQASQE KQQKENLGQA LKRLEKLLKQ ALERIPELQG IVGDWWEQPG 
QAALSEELCQ GLSLPQWRLR WVQAQGALQK LCS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.