Details for: ANGEL1

Gene ID: 23357

Symbol: ANGEL1

Ensembl ID: ENSG00000013523

Description: angel homolog 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169,182
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.42
    Marker Score: 1,300
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.38
    Marker Score: 2,415
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,790
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,014
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.99
    Marker Score: 1,529
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 496
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.96
    Marker Score: 1,949
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 449
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,410
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.93
    Marker Score: 1,149
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.92
    Marker Score: 8,671
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,731
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5,125
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.88
    Marker Score: 8,351
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 315
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.85
    Marker Score: 305
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.84
    Marker Score: 51,761
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.81
    Marker Score: 402
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.79
    Marker Score: 30,146
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,257
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.77
    Marker Score: 15,354
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 384
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 562
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.73
    Marker Score: 6,313
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3,060
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.73
    Marker Score: 26,869
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.72
    Marker Score: 290
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.71
    Marker Score: 2,907
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.7
    Marker Score: 7,277
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 629
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.68
    Marker Score: 10,652
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.67
    Marker Score: 193
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.66
    Marker Score: 1,892
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.66
    Marker Score: 14,099
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.66
    Marker Score: 823
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.64
    Marker Score: 1,357
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.64
    Marker Score: 3,845
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.61
    Marker Score: 247
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.61
    Marker Score: 3,625
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.6
    Marker Score: 522
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.6
    Marker Score: 637
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.6
    Marker Score: 1,003
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.59
    Marker Score: 5,199
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.59
    Marker Score: 2,442
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.59
    Marker Score: 1,410
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.59
    Marker Score: 2,271
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.58
    Marker Score: 639
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.58
    Marker Score: 4,432
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.58
    Marker Score: 564
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.57
    Marker Score: 343
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.57
    Marker Score: 616
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.56
    Marker Score: 1,317
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.56
    Marker Score: 2,398
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 436
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.54
    Marker Score: 771
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.52
    Marker Score: 166
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.51
    Marker Score: 327
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.51
    Marker Score: 5,096
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.5
    Marker Score: 180
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.5
    Marker Score: 291
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.49
    Marker Score: 7,335
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.49
    Marker Score: 345
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.49
    Marker Score: 390
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.48
    Marker Score: 3,111
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.48
    Marker Score: 228
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.47
    Marker Score: 147
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.46
    Marker Score: 1,508
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.46
    Marker Score: 237
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.45
    Marker Score: 2,393
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.43
    Marker Score: 261
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.43
    Marker Score: 195
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.43
    Marker Score: 212
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.41
    Marker Score: 471
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.4
    Marker Score: 1,664
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.4
    Marker Score: 232
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4
    Marker Score: 7,018
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.38
    Marker Score: 379
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.38
    Marker Score: 355
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.36
    Marker Score: 1,683
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.36
    Marker Score: 374
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.36
    Marker Score: 134
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.36
    Marker Score: 196
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.35
    Marker Score: 152
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.35
    Marker Score: 507
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.34
    Marker Score: 367
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.34
    Marker Score: 224
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.33
    Marker Score: 1,191
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.33
    Marker Score: 411
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.33
    Marker Score: 295
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.33
    Marker Score: 113
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.33
    Marker Score: 215
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.33
    Marker Score: 158
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.32
    Marker Score: 101
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.31
    Marker Score: 116
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.31
    Marker Score: 130
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.31
    Marker Score: 137

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ANGEL1 is a protein-coding gene with an Ensembl ID of ENSG00000013523. It is significantly expressed in various cell types, including mural cells, choroid plexus epithelial cells, germ cells, and neural cells. The gene's expression profile suggests its involvement in regulating cellular processes such as RNA degradation, protein synthesis, and cell signaling. ANGEL1's protein domain-specific binding capabilities indicate its ability to interact with other proteins and modulate their activities. **Pathways and Functions:** ANGEL1's involvement in immunological processes is mediated through its interaction with 3'-5'-RNA exonuclease activity, which is essential for RNA degradation and quality control. This function is critical for maintaining genome stability and preventing the accumulation of aberrant RNA molecules. In addition to its role in RNA degradation, ANGEL1 has been implicated in regulating protein synthesis, cytoskeletal organization, and cell signaling pathways. Its expression in neural cells suggests a potential role in neuronal development, function, and maintenance. **Clinical Significance:** Recent studies have highlighted ANGEL1's involvement in various neurological and immunological disorders. Mutations in the ANGEL1 gene have been associated with an increased risk of developing certain types of cancer, including breast cancer and ovarian cancer. Furthermore, ANGEL1's expression in immune cells has been linked to the regulation of immune responses and the development of autoimmune diseases. In the context of neurological disorders, ANGEL1's involvement in neuronal development and function suggests its potential as a therapeutic target for conditions such as autism spectrum disorder and schizophrenia. In conclusion, ANGEL1 is a gene of critical importance in regulating various cellular and physiological processes. Its involvement in immunological and neurological phenomena has significant implications for our understanding of disease mechanisms and the development of novel therapeutic strategies. Further research is necessary to fully elucidate the functions and clinical significance of ANGEL1, but the existing evidence highlights its importance as a key player in maintaining genome stability and regulating cellular processes. **Recommendations for Future Research:** 1. Investigate the mechanisms by which ANGEL1 regulates RNA degradation and protein synthesis. 2. Explore the role of ANGEL1 in regulating cytoskeletal organization and cell signaling pathways. 3. Conduct further studies on the clinical significance of ANGEL1 mutations in cancer and autoimmune diseases. 4. Investigate the potential therapeutic applications of ANGEL1 in neurological disorders. By advancing our understanding of ANGEL1's functions and clinical significance, we can unlock new avenues for the treatment and prevention of various diseases, ultimately improving human health and well-being.

Genular Protein ID: 1915001901

Symbol: ANGE1_HUMAN

Name: Protein angel homolog 1

UniProtKB Accession Codes:

Q9UNK9 B4DWL7 O94859 Q8NCS9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 5 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9872452

Title: Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9872452

DOI: 10.1093/dnares/5.5.277

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 670
  • Mass: 75276
  • Checksum: 3D40E26813E27D83
  • Sequence:
    • MIASCLCYLL LPATRLFRAL SDAFFTCRKN VLLANSSSPQ VEGDFAMAPR GPEQEECEGL 
LQQWREEGLS QVLSTASEGP LIDKGLAQSS LALLMDNPGE ENAASEDRWS SRQLSDLRAA 
ENLDEPFPEM LGEEPLLEVE GVEGSMWAAI PMQSEPQYAD CAALPVGALA TEQWEEDPAV 
LAWSIAPEPV PQEEASIWPF EGLGQLQPPA VEIPYHEILW REWEDFSTQP DAQGLKAGDG 
PQFQFTLMSY NILAQDLMQQ SSELYLHCHP DILNWNYRFV NLMQEFQHWD PDILCLQEVQ 
EDHYWEQLEP SLRMMGFTCF YKRRTGCKTD GCAVCYKPTR FRLLCASPVE YFRPGLELLN 
RDNVGLVLLL QPLVPEGLGQ VSVAPLCVAN THILYNPRRG DVKLAQMAIL LAEVDKVARL 
SDGSHCPIIL CGDLNSVPDS PLYNFIRDGE LQYHGMPAWK VSGQEDFSHQ LYQRKLQAPL 
WPSSLGITDC CQYVTSCHPK RSERRKYGRD FLLRFRFCSI ACQRPVGLVL MEGVTDTKPE 
RPAGWAESVL EEDASELEPA FSRTVGTIQH CLHLTSVYTH FLPQRGRPEV TTMPLGLGMT 
VDYIFFSAES CENGNRTDHR LYRDGTLKLL GRLSLLSEEI LWAANGLPNP FCSSDHLCLL 
ASFGMEVTAP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.