Details for: ENTREP2

Gene ID: 23359

Symbol: ENTREP2

Ensembl ID: ENSG00000104059

Description: endosomal transmembrane epsin interactor 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: interneuron (CL0000099)
    Fold Change: 4.26
    Marker Score: 1,944
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 3.77
    Marker Score: 10,830
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.68
    Marker Score: 31,083
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 3.2
    Marker Score: 1,435
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.62
    Marker Score: 6,017
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.58
    Marker Score: 7,375
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.5
    Marker Score: 13,410
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.36
    Marker Score: 46,981
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.3
    Marker Score: 3,855
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.26
    Marker Score: 83,217
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.22
    Marker Score: 84,326
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.17
    Marker Score: 32,506
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.04
    Marker Score: 125,258
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.03
    Marker Score: 849
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.02
    Marker Score: 19,046
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.01
    Marker Score: 8,341
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.95
    Marker Score: 14,962
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.91
    Marker Score: 19,759
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.9
    Marker Score: 5,419
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.84
    Marker Score: 15,846
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.82
    Marker Score: 6,116
  • Cell Name: T cell (CL0000084)
    Fold Change: 1.82
    Marker Score: 3,132
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.81
    Marker Score: 7,353
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.8
    Marker Score: 654
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.64
    Marker Score: 2,538
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.62
    Marker Score: 1,863
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.54
    Marker Score: 14,623
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.54
    Marker Score: 7,112
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.5
    Marker Score: 5,780
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,533
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.38
    Marker Score: 377
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.29
    Marker Score: 3,049
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 850
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.25
    Marker Score: 603
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.23
    Marker Score: 474
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.23
    Marker Score: 390
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.21
    Marker Score: 9,161
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.15
    Marker Score: 1,223
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.15
    Marker Score: 667
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 792
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.01
    Marker Score: 326
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.01
    Marker Score: 315
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,779
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,003
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.97
    Marker Score: 320
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.93
    Marker Score: 804
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.93
    Marker Score: 3,302
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5,164
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.9
    Marker Score: 527
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.9
    Marker Score: 3,193
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.9
    Marker Score: 614
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.88
    Marker Score: 981
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.87
    Marker Score: 1,082
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,279
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.82
    Marker Score: 1,166
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.81
    Marker Score: 1,049
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.8
    Marker Score: 3,369
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.79
    Marker Score: 3,298
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.78
    Marker Score: 202
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,258
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.77
    Marker Score: 731
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 698
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.75
    Marker Score: 310
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.74
    Marker Score: 1,353
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 461
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 181
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.69
    Marker Score: 3,639
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.66
    Marker Score: 436
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.66
    Marker Score: 369
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.64
    Marker Score: 203
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.62
    Marker Score: 2,585
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.62
    Marker Score: 391
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.61
    Marker Score: 528
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.6
    Marker Score: 460
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.59
    Marker Score: 543
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 453
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.57
    Marker Score: 1,092
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.56
    Marker Score: 727
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.56
    Marker Score: 386
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.55
    Marker Score: 156
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 146
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.54
    Marker Score: 190
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.54
    Marker Score: 787
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.53
    Marker Score: 221
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.53
    Marker Score: 347
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.5
    Marker Score: 159
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.48
    Marker Score: 179
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.47
    Marker Score: 510
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.47
    Marker Score: 10,079
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.44
    Marker Score: 428
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.44
    Marker Score: 1,517
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.44
    Marker Score: 527

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ENTREP2 is a transmembrane protein, characterized by its unique structure and localization to endosomal compartments. Its expression is significantly elevated in interneuron, retinal cone cell, and retinal bipolar neurons, highlighting its potential involvement in neuronal function and development. Moreover, ENTREP2 is also expressed in epithelial cells of the alveoli, macroglial cells, and other cell types, suggesting its broad functional scope. **Pathways and Functions:** The molecular mechanisms underlying ENTREP2's functions are not yet fully elucidated, but several key pathways have been implicated: 1. **Endosomal trafficking:** ENTREP2 is believed to interact with endosomal proteins, influencing the sorting and trafficking of endosomal cargo. This process is crucial for maintaining cellular homeostasis, regulating protein degradation, and modulating immune responses. 2. **Immune regulation:** ENTREP2 has been shown to interact with various immune-related proteins, including those involved in antigen presentation, cytokine signaling, and immune cell activation. These interactions may regulate immune responses, influencing inflammation, tolerance, and immune homeostasis. 3. **Neuronal function:** ENTREP2's expression in neurons suggests its involvement in neuronal development, synaptic plasticity, and neurotransmission. Its role in regulating endosomal trafficking and immune responses may also contribute to neuronal function and disease susceptibility. **Clinical Significance:** The clinical significance of ENTREP2 is an area of active research, with potential implications for various diseases: 1. **Neurological disorders:** ENTREP2's expression in neurons and its involvement in neuronal function suggest its potential role in neurological disorders, such as neurodegenerative diseases (e.g., Alzheimer's, Parkinson's) and psychiatric conditions (e.g., schizophrenia, bipolar disorder). 2. **Immunological disorders:** ENTREP2's interaction with immune-related proteins and its influence on immune responses may contribute to the pathogenesis of immunological disorders, such as autoimmune diseases (e.g., multiple sclerosis, rheumatoid arthritis) and inflammatory conditions. 3. **Cancer:** ENTREP2's expression in epithelial cells and its involvement in endosomal trafficking and immune regulation may also contribute to cancer development and progression. In conclusion, ENTREP2 is a multifunctional protein that plays a critical role in immune regulation, cellular homeostasis, and neuronal function. Further research is necessary to elucidate the molecular mechanisms underlying ENTREP2's functions and to explore its clinical significance in various diseases.

Genular Protein ID: 821218482

Symbol: EREP2_HUMAN

Name: Transmembrane protein 228

UniProtKB Accession Codes:

O60320 A0PK09

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 STRING 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16344560

Title: Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.

PubMed ID: 16344560

DOI: 10.1101/gr.4039406

PubMed ID: 9628581

Title: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9628581

DOI: 10.1093/dnares/5.1.31

Sequence Information:

  • Length: 539
  • Mass: 56544
  • Checksum: 43B9F5A654985E91
  • Sequence:
    • MPPAGGPRAP RPAALPRSLS RLRECPGRSR IVLALGATQM ALGCLIVAVS FAALALTTSA 
RVRHSCPFWA GFSVLLSGLI GVVSWKRPLS LVITFFMLLS AVCVMLNLAG SILSCQNAQL 
VNSLEGCQLI KFDSVEVCVC CELQHQSSGC SNLGETLKLN PLQENCNAVR LTLKDLLFSV 
CALNVLSTIV CALATAMCCM QMVSSDVLQM FLPQRSHPAN PTCVTPHGTV LHQTLDFDEF 
IPPLPPPPYY PPEYTCTPST EAQRGLHLDF APSPFGTLYD VAINSPGLLY PAELPPPYEA 
VVGQPPASQV TSIGQQVAES SSGDPNTSAG FSTPVPADST SLLVSEGTAT PGSSPSPDGP 
VGAPAPSEPA LPPGHVSPED PGMGSQVQPG PGRVSRSTSD PTLCTSSMAG DASSHRPSCS 
QDLEAGLSEA VPGSASMSRS ATAACRAQLS PAGDPDTWKT DQRPTPEPFP ATSKERPRSL 
VDSKAYADAR VLVAKFLEHS HCALPTEAQH MVGAMRLAVT NEERLEEEAV FGADVLDQV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.