Details for: FNBP4

Gene ID: 23360

Symbol: FNBP4

Ensembl ID: ENSG00000109920

Description: formin binding protein 4

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.83
    Marker Score: 63,256
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.73
    Marker Score: 11,415
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.61
    Marker Score: 3,517
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.51
    Marker Score: 1,463
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.49
    Marker Score: 3,011
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.43
    Marker Score: 82,650
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.42
    Marker Score: 5,315
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.38
    Marker Score: 2,962
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.3
    Marker Score: 8,194
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.26
    Marker Score: 2,225
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.19
    Marker Score: 38,814
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.12
    Marker Score: 4,085
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.09
    Marker Score: 611
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.05
    Marker Score: 995
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.04
    Marker Score: 2,316
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.04
    Marker Score: 1,920
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.02
    Marker Score: 2,127
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.01
    Marker Score: 40,034
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.99
    Marker Score: 4,862
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.98
    Marker Score: 29,616
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.98
    Marker Score: 73,000
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.98
    Marker Score: 627
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.97
    Marker Score: 74,800
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.96
    Marker Score: 5,493
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.95
    Marker Score: 819
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.95
    Marker Score: 2,693
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.95
    Marker Score: 1,172
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.94
    Marker Score: 41,312
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.93
    Marker Score: 102,287
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.93
    Marker Score: 611
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.93
    Marker Score: 2,094
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.93
    Marker Score: 2,127
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.91
    Marker Score: 676
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.91
    Marker Score: 1,693
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.91
    Marker Score: 2,196
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.9
    Marker Score: 7,862
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.89
    Marker Score: 14,514
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.88
    Marker Score: 1,239
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.88
    Marker Score: 2,773
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.87
    Marker Score: 2,018
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.86
    Marker Score: 3,891
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.85
    Marker Score: 18,741
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.84
    Marker Score: 1,453
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.84
    Marker Score: 17,287
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.84
    Marker Score: 7,877
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.8
    Marker Score: 1,008
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8
    Marker Score: 110,899
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.79
    Marker Score: 428
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.79
    Marker Score: 3,768
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.78
    Marker Score: 723
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.78
    Marker Score: 28,524
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.77
    Marker Score: 6,855
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.77
    Marker Score: 1,036
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.77
    Marker Score: 762
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.76
    Marker Score: 1,549
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.76
    Marker Score: 1,220
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.74
    Marker Score: 969
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.74
    Marker Score: 1,017
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.74
    Marker Score: 1,499
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.73
    Marker Score: 640
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.73
    Marker Score: 7,026
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.72
    Marker Score: 1,494
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.72
    Marker Score: 1,302
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.72
    Marker Score: 1,609
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.72
    Marker Score: 5,419
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.7
    Marker Score: 19,187
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.7
    Marker Score: 7,078
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.69
    Marker Score: 7,815
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.69
    Marker Score: 16,038
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.69
    Marker Score: 2,482
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.69
    Marker Score: 1,228
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.68
    Marker Score: 837
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.67
    Marker Score: 1,364
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.66
    Marker Score: 1,527
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.66
    Marker Score: 477
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.65
    Marker Score: 1,031
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.65
    Marker Score: 14,166
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.65
    Marker Score: 1,293
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.65
    Marker Score: 1,590
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.65
    Marker Score: 812
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.64
    Marker Score: 1,654
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.64
    Marker Score: 1,119
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.63
    Marker Score: 1,181
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.62
    Marker Score: 552
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.62
    Marker Score: 972
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.61
    Marker Score: 2,884
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.61
    Marker Score: 1,221
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.61
    Marker Score: 603
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.61
    Marker Score: 16,596
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 1.61
    Marker Score: 473
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.61
    Marker Score: 7,894
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.6
    Marker Score: 774
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.6
    Marker Score: 1,172
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.6
    Marker Score: 555
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.6
    Marker Score: 2,064
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.6
    Marker Score: 350
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.6
    Marker Score: 1,345
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.59
    Marker Score: 2,772
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.59
    Marker Score: 554
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.59
    Marker Score: 3,973

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FNBP4 is a cytoplasmic protein that interacts with formin proteins, which are essential components of the actin cytoskeleton. This interaction regulates the dynamics of actin filament assembly and disassembly, influencing cell shape, motility, and signaling. FNBP4 is highly expressed in various tissues, including the heart, lens, cornea, and mammary gland, where it plays a crucial role in maintaining tissue homeostasis. Notably, FNBP4 is also expressed in immune cells, such as B cells and cardiac neurons, suggesting its involvement in immune responses and neuronal function. **Pathways and Functions:** FNBP4's involvement in immune responses is mediated through its interaction with immune receptors and signaling pathways. In B cells, FNBP4 regulates class switching and antibody production by modulating the activity of signaling molecules, such as CD40 and CD80. In cardiac myocytes, FNBP4 regulates cell signaling and cytoskeleton dynamics, influencing heart function and maintaining cardiac homeostasis. The protein also interacts with neuronal signaling pathways, modulating neuronal function and synaptic plasticity. Additionally, FNBP4's role in regulating cytoskeleton dynamics has been implicated in the progression of various diseases, including cancer and neurodegenerative disorders. **Clinical Significance:** FNBP4's involvement in immune-mediated diseases makes it an attractive target for therapeutic intervention. In the context of autoimmune diseases, such as rheumatoid arthritis and lupus, FNBP4's role in regulating immune cell function and signaling pathways has been implicated in disease pathogenesis. Moreover, FNBP4's expression in cardiac and neuronal tissues has led to its consideration as a potential therapeutic target for cardiovascular and neurological disorders. Furthermore, FNBP4's involvement in cancer progression and metastasis has sparked interest in its potential as a biomarker for disease diagnosis and prognosis. In conclusion, FNBP4 is a multifunctional protein that plays a crucial role in regulating immune responses, cell signaling, and cytoskeleton dynamics. Its involvement in various diseases makes it an attractive target for therapeutic intervention, and further research is necessary to elucidate its complex mechanisms and clinical significance. **Research Directions:** To further elucidate FNBP4's functions and clinical significance, the following research directions are proposed: 1. Investigate the molecular mechanisms underlying FNBP4's interaction with immune receptors and signaling pathways. 2. Explore the role of FNBP4 in regulating cytoskeleton dynamics and its implications in disease progression. 3. Investigate FNBP4's expression and function in various diseases, including autoimmune, cardiovascular, and neurological disorders. 4. Develop therapeutic strategies targeting FNBP4 to modulate immune responses and disease progression. By advancing our understanding of FNBP4's functions and clinical significance, we can uncover new therapeutic targets and develop effective treatments for a range of immune-mediated diseases.

Genular Protein ID: 737974157

Symbol: FNBP4_HUMAN

Name: Formin-binding protein 4

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10231032

Title: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10231032

DOI: 10.1093/dnares/6.1.63

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10748127

Title: Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains.

PubMed ID: 10748127

DOI: 10.1074/jbc.m909368199

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23703728

Title: Whole-exome sequencing identified a homozygous FNBP4 mutation in a family with a condition similar to microphthalmia with limb anomalies.

PubMed ID: 23703728

DOI: 10.1002/ajmg.a.35983

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 1017
  • Mass: 110266
  • Checksum: 510DC8011B5973AD
  • Sequence:
  • MGKKSRAVPG RRPILQLSPP GPRGSTPGRD PEPEPDTEPD STAAVPSQPA PSAATTTTTA 
    VTAAAASDDS PSEDEQEAVQ EVPRVVQNPP KPVMTTRPTA VKATGGLCLL GAYADSDDDD 
    NDVSEKLAQS KETNGNQSTD IDSTLANFLA EIDAITAPQP AAPVGASAPP PTPPRPEPKE 
    AATSTLSSST SNGTDSTQTS GWQYDTQCSL AGVGIEMGDW QEVWDENTGC YYYWNTQTNE 
    VTWELPQYLA TQVQGLQHYQ PSSVPGAETS FVVNTDIYSK EKTISVSSSK SGPVIAKREV 
    KKEVNEGIQA LSNSEEEKKG VAASLLAPLL PEGIKEEEER WRRKVICKEE PVSEVKETST 
    TVEEATTIVK PQEIMLDNIE DPSQEDLCSV VQSGESEEEE EQDTLELELV LERKKAELRA 
    LEEGDGSVSG SSPRSDISQP ASQDGMRRLM SKRGKWKMFV RATSPESTSR SSSKTGRDTP 
    ENGETAIGAE NSEKIDENSD KEMEVEESPE KIKVQTTPKV EEEQDLKFQI GELANTLTSK 
    FEFLGINRQS ISNFHVLLLQ TETRIADWRE GALNGNYLKR KLQDAAEQLK QYEINATPKG 
    WSCHWDRDHR RYFYVNEQSG ESQWEFPDGE EEEEESQAQE NRDETLAKQT LKDKTGTDSN 
    STESSETSTG SLCKESFSGQ VSSSSLMPLT PFWTLLQSNV PVLQPPLPLE MPPPPPPPPE 
    SPPPPPPPPP PAEDGEIQEV EMEDEGSEEP PAPGTEEDTP LKPSAQTTVV TSQSSVDSTI 
    SSSSSTKGIK RKATEISTAV VQRSATIGSS PVLYSQSAIA TGHQAAGIGN QATGIGHQTI 
    PVSLPAAGMG HQARGMSLQS NYLGLAAAPA IMSYAECSVP IGVTAPSLQP VQARGAVPTA 
    TIIEPPPPPP PPPPPPPPAP KMPPPEKTKK GRKDKAKKSK TKMPSLVKKW QSIQRELDEE 
    DNSSSSEEDR ESTAQKRIEE WKQQQLVSGM AERNANFEAL PEDWRARLKR RKMAPNT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.