Details for: ZNF629

Gene ID: 23361

Symbol: ZNF629

Ensembl ID: ENSG00000102870

Description: zinc finger protein 629

Associated with

  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Metal ion binding
    (GO:0046872)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.2
    Marker Score: 2,445
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.19
    Marker Score: 18,591
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.13
    Marker Score: 2,134
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,802
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,026
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 498
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 452
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,410
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,730
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5,121
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 317
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,276
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.82
    Marker Score: 798
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,268
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 387
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 557
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.7
    Marker Score: 282
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 636
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2,843
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.65
    Marker Score: 312
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.62
    Marker Score: 462
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.62
    Marker Score: 370
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 437
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.52
    Marker Score: 346
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5
    Marker Score: 319
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.49
    Marker Score: 270
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.46
    Marker Score: 285
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.45
    Marker Score: 488
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.44
    Marker Score: 196
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.44
    Marker Score: 211
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.44
    Marker Score: 464
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.43
    Marker Score: 102
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.43
    Marker Score: 1,487
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.43
    Marker Score: 3,209
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.43
    Marker Score: 910
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.42
    Marker Score: 1,154
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.41
    Marker Score: 1,596
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.41
    Marker Score: 426
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.4
    Marker Score: 265
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.39
    Marker Score: 717
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.39
    Marker Score: 360
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.37
    Marker Score: 446
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.37
    Marker Score: 763
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.36
    Marker Score: 242
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.36
    Marker Score: 382
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.35
    Marker Score: 3,563
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.35
    Marker Score: 396
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.35
    Marker Score: 541
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.35
    Marker Score: 174
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.35
    Marker Score: 3,927
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.35
    Marker Score: 2,255
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.34
    Marker Score: 91
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.34
    Marker Score: 137
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.33
    Marker Score: 567
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.33
    Marker Score: 1,972
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.33
    Marker Score: 351
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.32
    Marker Score: 2,780
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.31
    Marker Score: 144
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.3
    Marker Score: 3,112
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.3
    Marker Score: 1,113
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.3
    Marker Score: 124
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.29
    Marker Score: 692
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.29
    Marker Score: 295
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.29
    Marker Score: 10,801
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.29
    Marker Score: 98
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.29
    Marker Score: 101
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.29
    Marker Score: 650
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.28
    Marker Score: 275
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.28
    Marker Score: 149
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.28
    Marker Score: 114
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.28
    Marker Score: 178
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.28
    Marker Score: 160
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.28
    Marker Score: 176
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.28
    Marker Score: 1,156
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.27
    Marker Score: 1,112
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.27
    Marker Score: 419
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.27
    Marker Score: 86
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.27
    Marker Score: 184
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.27
    Marker Score: 297
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.27
    Marker Score: 254
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.27
    Marker Score: 101
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.26
    Marker Score: 59
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.26
    Marker Score: 128
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.26
    Marker Score: 181
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.25
    Marker Score: 599
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.25
    Marker Score: 2,180
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.25
    Marker Score: 135
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.25
    Marker Score: 448
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.25
    Marker Score: 600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.25
    Marker Score: 1,512
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.25
    Marker Score: 236
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.25
    Marker Score: 5,320
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.25
    Marker Score: 1,153
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.25
    Marker Score: 260
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.25
    Marker Score: 116
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.24
    Marker Score: 217
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.24
    Marker Score: 105
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.24
    Marker Score: 644

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Zinc finger domain:** ZNF629 possesses a zinc finger domain, which is a conserved motif involved in DNA binding and recognition. 2. **RNA polymerase II specificity:** ZNF629 exhibits specificity for RNA polymerase II (RNAPII), a key enzyme responsible for transcribing genes in eukaryotic cells. 3. **Transcriptional activation:** ZNF629 acts as a transcriptional activator, promoting the expression of target genes. 4. **Cell-type specificity:** ZNF629 is expressed in a variety of cell types, including immune cells, cardiac muscle cells, and intestinal epithelial cells. **Pathways and Functions:** 1. **DNA-binding transcription activator activity:** ZNF629 interacts with specific DNA sequences, facilitating the recruitment of RNAPII and the activation of transcription. 2. **Metal ion binding:** The zinc finger domain of ZNF629 is responsible for binding metal ions, which is essential for its DNA-binding activity. 3. **Regulation of transcription by RNAPII:** ZNF629 modulates the activity of RNAPII, influencing the expression of genes involved in immune response, cell development, and tissue homeostasis. 4. **Cell-type-specific functions:** ZNF629 plays distinct roles in different cell types, including the regulation of immune response in innate lymphoid cells and the maintenance of cardiac muscle cell function. **Clinical Significance:** 1. **Immune disorders:** Abnormal expression or function of ZNF629 may contribute to immune disorders, such as autoimmune diseases or immunodeficiency syndromes. 2. **Cardiac diseases:** ZNF629 may play a role in the regulation of cardiac muscle cell function, making it a potential target for the treatment of cardiac diseases. 3. **Intestinal diseases:** The expression of ZNF629 in intestinal epithelial cells suggests its involvement in the regulation of intestinal homeostasis, which may be relevant to the pathogenesis of intestinal diseases, such as inflammatory bowel disease. 4. **Cancer:** ZNF629 may act as a tumor suppressor or oncogene, depending on the context, and its dysregulation may contribute to cancer development. In conclusion, ZNF629 is a multifunctional protein that plays a critical role in the regulation of transcription in various cell types. Its dysregulation may contribute to immune disorders, cardiac diseases, and intestinal diseases, highlighting the need for further research into the clinical significance of ZNF629.

Genular Protein ID: 529727341

Symbol: ZN629_HUMAN

Name: Zinc finger protein 629

UniProtKB Accession Codes:

Q9UEG4 Q15938

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 EPD 1 Ensembl 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9205841

Title: Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9205841

DOI: 10.1093/dnares/4.2.141

PubMed ID: 1946370

Title: Characterization and mapping of human genes encoding zinc finger proteins.

PubMed ID: 1946370

DOI: 10.1073/pnas.88.21.9563

PubMed ID: 1505991

Title: Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes.

PubMed ID: 1505991

DOI: 10.1016/0888-7543(92)90013-i

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 869
  • Mass: 96620
  • Checksum: A3C1B86589BD57F5
  • Sequence:
    • MEPETALWGP DLQGPEQSPN DAHRGAESEN EEESPRQESS GEEIIMGDPA QSPESKDSTE 
MSLERSSQDP SVPQNPPTPL GHSNPLDHQI PLDPPAPEVV PTPSDWTKAC EASWQWGALT 
TWNSPPVVPA NEPSLRELVQ GRPAGAEKPY ICNECGKSFS QWSKLLRHQR IHTGERPNTC 
SECGKSFTQS SHLVQHQRTH TGEKPYKCPD CGKCFSWSSN LVQHQRTHTG EKPYKCTECE 
KAFTQSTNLI KHQRSHTGEK PYKCGECRRA FYRSSDLIQH QATHTGEKPY KCPECGKRFG 
QNHNLLKHQK IHAGEKPYRC TECGKSFIQS SELTQHQRTH TGEKPYECLE CGKSFGHSST 
LIKHQRTHLR EDPFKCPVCG KTFTLSATLL RHQRTHTGER PYKCPECGKS FSVSSNLINH 
QRIHRGERPY ICADCGKSFI MSSTLIRHQR IHTGEKPYKC SDCGKSFIRS SHLIQHRRTH 
TGEKPYKCPE CGKSFSQSSN LITHVRTHMD ENLFVCSDCG KAFLEAHELE QHRVIHERGK 
TPARRAQGDS LLGLGDPSLL TPPPGAKPHK CLVCGKGFND EGIFMQHQRI HIGENPYKNA 
DGLIAHAAPK PPQLRSPRLP FRGNSYPGAA EGRAEAPGQP LKPPEGQEGF SQRRGLLSSK 
TYICSHCGES FLDRSVLLQH QLTHGNEKPF LFPDYRIGLG EGAGPSPFLS GKPFKCPECK 
QSFGLSSELL LHQKVHAGGK SSQKSPELGK SSSVLLEHLR SPLGARPYRC SDCRASFLDR 
VALTRHQETH TQEKPPNPED PPPEAVTLST DQEGEGETPT PTESSSHGEG QNPKTLVEEK 
PYLCPECGAG FTEVAALLLH RSCHPGVSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.