Details for: PSD3

Gene ID: 23362

Symbol: PSD3

Ensembl ID: ENSG00000156011

Description: pleckstrin and Sec7 domain containing 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 8.71
    Marker Score: 154,594
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 4.97
    Marker Score: 11,431
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 4.85
    Marker Score: 108,414
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 4.48
    Marker Score: 15,027
  • Cell Name: granule cell (CL0000120)
    Fold Change: 4.25
    Marker Score: 32,068
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 4.11
    Marker Score: 17,156
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 4.09
    Marker Score: 138,202
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 3.96
    Marker Score: 2,605
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 3.78
    Marker Score: 12,377
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 3.7
    Marker Score: 8,847
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.54
    Marker Score: 4,282
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 3.45
    Marker Score: 12,283
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 3.16
    Marker Score: 67,538
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 3.16
    Marker Score: 924
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 3.09
    Marker Score: 1,626
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 3.08
    Marker Score: 4,137
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 3.04
    Marker Score: 963
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.95
    Marker Score: 1,715
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.9
    Marker Score: 5,585
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.88
    Marker Score: 1,675
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.84
    Marker Score: 819
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.64
    Marker Score: 2,985
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.63
    Marker Score: 4,418
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.63
    Marker Score: 11,009
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.6
    Marker Score: 13,990
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.56
    Marker Score: 2,208
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.54
    Marker Score: 13,316
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.51
    Marker Score: 1,469
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 2.51
    Marker Score: 1,298
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.48
    Marker Score: 1,038
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.45
    Marker Score: 1,365
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.4
    Marker Score: 6,853
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.4
    Marker Score: 2,988
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 2.33
    Marker Score: 1,121
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.18
    Marker Score: 2,699
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.17
    Marker Score: 1,073
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.14
    Marker Score: 2,465
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.14
    Marker Score: 20,105
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.11
    Marker Score: 1,185
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.01
    Marker Score: 1,783
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2
    Marker Score: 123,269
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.99
    Marker Score: 20,517
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.99
    Marker Score: 749
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.97
    Marker Score: 2,766
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.93
    Marker Score: 2,326
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.92
    Marker Score: 1,330
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.91
    Marker Score: 651
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.91
    Marker Score: 14,660
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.9
    Marker Score: 7,731
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.9
    Marker Score: 518
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.89
    Marker Score: 17,948
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.87
    Marker Score: 1,012
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.86
    Marker Score: 15,983
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.86
    Marker Score: 70,537
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.84
    Marker Score: 36,510
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.83
    Marker Score: 8,488
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.83
    Marker Score: 1,374
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.78
    Marker Score: 65,613
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.78
    Marker Score: 3,614
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.77
    Marker Score: 882
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.77
    Marker Score: 6,855
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.77
    Marker Score: 1,666
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.73
    Marker Score: 9,292
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.72
    Marker Score: 1,409
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.69
    Marker Score: 1,468
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.69
    Marker Score: 625
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.65
    Marker Score: 10,600
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.63
    Marker Score: 516
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.63
    Marker Score: 2,514
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.6
    Marker Score: 615
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.58
    Marker Score: 23,660
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.53
    Marker Score: 6,592
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.53
    Marker Score: 2,665
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.49
    Marker Score: 5,127
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 166,967
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.45
    Marker Score: 1,751
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.43
    Marker Score: 371
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.42
    Marker Score: 5,874
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.41
    Marker Score: 712
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.39
    Marker Score: 18,499
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.39
    Marker Score: 280
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.38
    Marker Score: 3,020
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.37
    Marker Score: 5,923
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.37
    Marker Score: 21,380
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.34
    Marker Score: 1,583
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.32
    Marker Score: 1,426
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.32
    Marker Score: 738
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.31
    Marker Score: 410
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.3
    Marker Score: 331
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.28
    Marker Score: 859
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.27
    Marker Score: 868
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.25
    Marker Score: 1,194
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.21
    Marker Score: 2,302
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.21
    Marker Score: 727
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.18
    Marker Score: 10,253
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.18
    Marker Score: 13,235
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.17
    Marker Score: 512
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.15
    Marker Score: 759
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.15
    Marker Score: 1,266
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.14
    Marker Score: 1,329

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Dual-domain structure**: PSD3 contains a pleckstrin domain, which is characterized by a phosphoinositide-binding motif, and a Sec7 domain, which is involved in guanyl-nucleotide exchange factor activity. 2. **Regulation of membrane dynamics**: The pleckstrin domain of PSD3 allows it to bind to phosphoinositides, influencing membrane trafficking and organization. 3. **Interactions with signaling pathways**: PSD3 interacts with various signaling pathways, including guanyl-nucleotide exchange factor activity, postsynaptic density, regulation of arf protein signal transduction, and ruffle membrane formation. **Pathways and Functions** 1. **Guanyl-nucleotide exchange factor activity**: PSD3's Sec7 domain enables it to activate guanine nucleotide exchange factors (GEFs), which play a crucial role in regulating small GTPases involved in membrane trafficking and signaling. 2. **Postsynaptic density formation**: PSD3's interaction with the postsynaptic density protein PSD-95 (postsynaptic density protein, 95 kDa) is essential for the formation and maintenance of postsynaptic density structures in neurons. 3. **Regulation of arf protein signal transduction**: PSD3's pleckstrin domain regulates the activity of the ADP-ribosylation factor (ARF) protein, which is involved in membrane trafficking and signaling. 4. **Ruffle membrane formation**: PSD3's interaction with the actin cytoskeleton and other proteins is essential for the formation and maintenance of ruffle membranes, which are involved in cell migration and signaling. **Clinical Significance** 1. **Neurodegenerative diseases**: Dysregulation of PSD3 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where postsynaptic density formation and membrane trafficking are impaired. 2. **Cancer**: Alterations in PSD3 expression and function have been observed in various types of cancer, including breast cancer and lung cancer, where membrane trafficking and signaling are dysregulated. 3. **Neurological disorders**: PSD3's role in regulating membrane dynamics and signaling pathways makes it an attractive target for the treatment of neurological disorders, such as epilepsy and multiple sclerosis. In conclusion, PSD3 is a complex gene that plays a multifaceted role in regulating membrane dynamics and signaling pathways. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms underlying PSD3's functions and its potential as a therapeutic target.

Genular Protein ID: 2749714032

Symbol: PSD3_HUMAN

Name: PH and SEC7 domain-containing protein 3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10231032

Title: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10231032

DOI: 10.1093/dnares/6.1.63

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 20736409

Title: Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins.

PubMed ID: 20736409

DOI: 10.1074/mcp.m110.001719

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 12097419

Title: Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies.

PubMed ID: 12097419

DOI: 10.4049/jimmunol.169.2.1102

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 1048
  • Mass: 116034
  • Checksum: BE879B65AB390162
  • Sequence:
  • MEGRSAAAET FVWVNNASAH SQSVAKAKYE FLFGRSEGKA PDTSDHGGST LLPPNVTNEF 
    PEYGTMEEGG EGLRASLEFD GEALPCHPQE QQGVQPLTGC HSGLDSVTEG PKDVREAPSQ 
    SHLKEQSLQP IDSLISALKA TEARIISGTL QATKVLDQDA VSSFSVQQVE KELDTASRKT 
    QRVNKTLPAG QKNLPEIPLS AEVTTEESFY LSIQKDLTAL LTGDTQAEIS QIMNNGRKGA 
    VCVQEPSCPL ASLGSSAVTC HSAGSVGFLK EQRSALGREH PGGCDRSSSM GRPGRVKHVE 
    FQGVEILWTG GDKRETQHPI DFETSLQRTA SPDSKESSKV PRHLISSAGL CNSSSLTENV 
    WDESWKAPSE RPGTSSGTFS PVRLDESGED EVFLQENKQH LEKTPKPERD RERISEQEEH 
    VKGEDEDILG PGYTEDSTDV YSSQFETILD NTSLYYSAES LETLYSEPDS YFSFEMPLTP 
    MIQQRIKEGG QFLERTSGGG HQDILSVSAD GGIVMGYSSG VTNGLNDASD SIYTKGTPEI 
    AFWGSNAGVK TTRLEAHSEM GSTEILEKET PENLSNGTSS NVEAAKRLAK RLYQLDRFKR 
    SDVAKHLGKN NEFSKLVAEE YLKFFDFTGM TLDQSLRYFF KAFSLVGETQ ERERVLIHFS 
    NRYFYCNPDT IASQDGVHCL TCAIMLLNTD LHGHVNIGKK MTCQEFIANL QGVNEGVDFS 
    KDLLKALYNS IKNEKLEWAV DDEEKKKSPS ESTEEKANGT HPKTISRIGS TTNPFLDIPH 
    DPNAAVYKSG FLARKIHADM DGKKTPRGKR GWKTFYAVLK GTVLYLQKDE YKPEKALSEE 
    DLKNAVSVHH ALASKATDYE KKPNVFKLKT ADWRVLLFQT QSPEEMQGWI NKINCVAAVF 
    SAPPFPAAIG SQKKFSRPLL PATTTKLSQE EQLKSHESKL KQITTELAEH RSYPPDKKVK 
    AKDVDEYKLK DHYLEFEKTR YEMYVSILKE GGKELLSNDE SEAAGLKKSH SSPSLNPDTS 
    PITAKVKRNV SERKDHRPET PSIKQKVT

Genular Protein ID: 797212733

Symbol: B3KRC4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 1047
  • Mass: 116019
  • Checksum: BB99AE449C70CF20
  • Sequence:
  • MEGRSAAAET FVWVNNASAH SQSVAKAKYE FLFGRSEGKA PDTSDHGGST LLPPNVTNEF 
    PEYGTMEEGG EGLRASLEFD GEALPCHPQE QQGVQPLTGC HSGLDSVTEG PKDVREAPSQ 
    SHLKEQSLQP IDSLISALKA TEARIISGTL QATKVLDQDA VSSFSVQQVE KELDTASRKT 
    QRVNKLLPAG QKNLPEIPLS AEVTTEESFY LSIQKDLTAL LTGDTQAEIS QIMNNGRKGA 
    VCVQEPSCPL ASLGSSAVTC HSAGSVGFLK EQRSALGREH PGGCDRSSSM GRPGRVKHVE 
    FQGVEILWTG GDKRETQHPI DFETSLQRTA SPDSKESSKV PRHLISSAGL CNSSSLTENV 
    WDESWKAPSE RPGTSSGTFS PVRLDESGED EVFLQENKQH LEKTPKPERD RERISEQEEH 
    VKGEDEDILG PGYTEDSTDV YSSQFETILD NTSLYYSAES LETLYSEPDS YFSFEMPLTP 
    MIQQRIKEGG QFLERTSGGE HQDILSVSAD GGIVMGYSSG VTNGLNDASD SIYTKGTPEI 
    AFWGSNAGVK TTRLEAHSEM GSTEILEKET PENLSNGTSS NVEAAKRLAK RLYQLDRFKR 
    SDVAKHLGKN NEFSKLVAEE YLKFFDFTGM TLDQSLRYFF KAFSLVGETQ ERERVLIHFS 
    NRYFYCNPDT IASQDGVHCL TCAIMLLNTD LHGHNIGKKM TCQEFIANLQ GVNEGVDFSK 
    DLLKALYNSI KNEKLEWAVD DEEKKKSPSE STEEKANGTH PKTISRIGST TNPFLDIPHD 
    PNAAVYKSGF LARKIHADMD GKKTPRGKRG WKTFYAVLKG TVLYLQKDEY KPEKALSEED 
    LKNAVSVHHA LASKATDYEK KPNVFKLKTA DWRVLLFQTQ SPEEMQGWIN KINCVAAVFS 
    APPFPAAIGS QKKFSRPLLP ATTTKLSQEE QLKSHESKLK QITTELAEHR SYPPDKKVKA 
    KDVDEYKLKD HYLEFEKTRY EMYVSILKEG GKELLSNDES EAAGLKKSHS SPSLNPDTSP 
    ITAKVKRNVS ERKDHRPETP SIKQKVT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.