Details for: OBSL1
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: Sertoli cell (CL0000216)
Fold Change: 2.6
Marker Score: 15,446 - Cell Name: germ cell (CL0000586)
Fold Change: 2.37
Marker Score: 4,143 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 2.1
Marker Score: 5,617 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 2.07
Marker Score: 36,728 - Cell Name: Leydig cell (CL0000178)
Fold Change: 1.89
Marker Score: 2,041 - Cell Name: Unknown (CL0002371)
Fold Change: 1.85
Marker Score: 1,962 - Cell Name: granulosa cell (CL0000501)
Fold Change: 1.84
Marker Score: 18,487 - Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.58
Marker Score: 4,295 - Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.36
Marker Score: 3,426 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.33
Marker Score: 1,425 - Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 1.33
Marker Score: 426 - Cell Name: male germ cell (CL0000015)
Fold Change: 1.31
Marker Score: 379 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.31
Marker Score: 5,156 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.3
Marker Score: 8,460 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.28
Marker Score: 1,555 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.28
Marker Score: 1,724 - Cell Name: neural cell (CL0002319)
Fold Change: 1.22
Marker Score: 590 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.15
Marker Score: 43,606 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.14
Marker Score: 41,994 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 1.13
Marker Score: 25,351 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 1.13
Marker Score: 1,197 - Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 1.11
Marker Score: 612 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.09
Marker Score: 2,215 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.06
Marker Score: 16,584 - Cell Name: oogonial cell (CL0000024)
Fold Change: 1.06
Marker Score: 1,517 - Cell Name: decidual cell (CL2000002)
Fold Change: 1.03
Marker Score: 4,463 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.03
Marker Score: 1,070 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.03
Marker Score: 4,290 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.02
Marker Score: 4,239 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.02
Marker Score: 10,547 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1
Marker Score: 585 - Cell Name: theca cell (CL0000503)
Fold Change: 1
Marker Score: 716 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,765 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47,990 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.99
Marker Score: 1,408 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,403 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 498 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.96
Marker Score: 1,481 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 452 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.96
Marker Score: 7,324 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,409 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.94
Marker Score: 815 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.94
Marker Score: 18,699 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.91
Marker Score: 1,101 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,727 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.91
Marker Score: 13,586 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.91
Marker Score: 10,234 - Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 0.9
Marker Score: 335 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.9
Marker Score: 5,116 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.88
Marker Score: 370 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.88
Marker Score: 317 - Cell Name: endocrine cell (CL0000163)
Fold Change: 0.88
Marker Score: 454 - Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.87
Marker Score: 981 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,295 - Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.87
Marker Score: 1,095 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 0.87
Marker Score: 3,086 - Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 0.86
Marker Score: 3,593 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.86
Marker Score: 3,307 - Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 0.85
Marker Score: 806 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.84
Marker Score: 51,567 - Cell Name: neuron (CL0000540)
Fold Change: 0.83
Marker Score: 3,383 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.82
Marker Score: 2,921 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.82
Marker Score: 834 - Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.82
Marker Score: 1,352 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.8
Marker Score: 17,171 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.8
Marker Score: 27,673 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,269 - Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 0.78
Marker Score: 593 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.78
Marker Score: 593 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.78
Marker Score: 311 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.77
Marker Score: 1,696 - Cell Name: chromaffin cell (CL0000166)
Fold Change: 0.76
Marker Score: 1,074 - Cell Name: keratocyte (CL0002363)
Fold Change: 0.76
Marker Score: 175 - Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.76
Marker Score: 538 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.75
Marker Score: 387 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.74
Marker Score: 3,095 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.73
Marker Score: 697 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.73
Marker Score: 1,540 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.73
Marker Score: 6,251 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.73
Marker Score: 769 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.73
Marker Score: 212 - Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.71
Marker Score: 167 - Cell Name: acinar cell (CL0000622)
Fold Change: 0.71
Marker Score: 499 - Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.7
Marker Score: 577 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.7
Marker Score: 446 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.7
Marker Score: 6,551 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.7
Marker Score: 6,616 - Cell Name: brush cell (CL0002204)
Fold Change: 0.69
Marker Score: 629 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.69
Marker Score: 1,688 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 175 - Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.68
Marker Score: 2,528 - Cell Name: Mueller cell (CL0000636)
Fold Change: 0.68
Marker Score: 940 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.67
Marker Score: 184 - Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 0.67
Marker Score: 5,001 - Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.67
Marker Score: 1,575 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.66
Marker Score: 1,512 - Cell Name: oocyte (CL0000023)
Fold Change: 0.66
Marker Score: 164 - Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 0.66
Marker Score: 264 - Cell Name: astrocyte (CL0000127)
Fold Change: 0.64
Marker Score: 556 - Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 0.64
Marker Score: 241
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3651927063
Symbol: OBSL1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 17289344
Title: Obscurin-like 1, OBSL1, is a novel cytoskeletal protein related to obscurin.
PubMed ID: 17289344
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9734811
Title: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
PubMed ID: 9734811
PubMed ID: 12168954
Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
PubMed ID: 12168954
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19481195
Title: The primordial growth disorder 3-M syndrome connects ubiquitination to the cytoskeletal adaptor OBSL1.
PubMed ID: 19481195
PubMed ID: 21737058
Title: Exome sequencing identifies CCDC8 mutations in 3-M syndrome, Suggesting that CCDC8 Contributes in a Pathway with CUL7 and OBSL1 to Control Human Growth.
PubMed ID: 21737058
PubMed ID: 21572988
Title: An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterning.
PubMed ID: 21572988
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24793695
Title: The 3M complex maintains microtubule and genome integrity.
PubMed ID: 24793695
PubMed ID: 24793696
Title: CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity.
PubMed ID: 24793696
PubMed ID: 23018678
Title: Mutations in CUL7, OBSL1 and CCDC8 in 3-M syndrome lead to disordered growth factor signalling.
PubMed ID: 23018678
DOI: 10.1530/jme-12-0034
PubMed ID: 20489725
Title: Molecular basis of the head-to-tail assembly of giant muscle proteins obscurin-like 1 and titin.
PubMed ID: 20489725
PubMed ID: 20133654
Title: Structural insight into M-band assembly and mechanics from the titin-obscurin-like-1 complex.
PubMed ID: 20133654
Sequence Information:
- Length: 1896
- Mass: 206947
- Checksum: 6D592AC3E30E9ACA
- Sequence:
MKASSGDQGS PPCFLRFPRP VRVVSGAEAE LKCVVLGEPP PVVVWEKGGQ QLAASERLSF PADGAEHGLL LTAALPTDAG VYVCRARNAA GEAYAAAAVT VLEPPASDPE LQPAERPLPS PGSGEGAPVF LTGPRSQWVL RGAEVVLTCR AGGLPEPTLY WEKDGMALDE VWDSSHFALQ PGRAEDGPGA SLALRILAAR LPDSGVYVCH ARNAHGHAQA GALLQVHQPP ESPPADPDEA PAPVVEPLKC APKTFWVNEG KHAKFRCYVM GKPEPEIEWH WEGRPLLPDR RRLMYRDRDG GFVLKVLYCQ AKDRGLYVCA ARNSAGQTLS AVQLHVKEPR LRFTRPLQDV EGREHGIAVL ECKVPNSRIP TAWFREDQRL LPCRKYEQIE EGTVRRLIIH RLKADDDGIY LCEMRGRVRT VANVTVKGPI LKRLPRKLDV LEGENAVLLV ETLEAGVEGR WSRDGEELPV ICQSSSGHMH ALVLPGVTRE DAGEVTFSLG NSRTTTLLRV KCVKHSPPGP PILAEMFKGH KNTVLLTWKP PEPAPETPFI YRLERQEVGS EDWIQCFSIE KAGAVEVPGD CVPSEGDYRF RICTVSGHGR SPHVVFHGSA HLVPTARLVA GLEDVQVYDG EDAVFSLDLS TIIQGTWFLN GEELKSNEPE GQVEPGALRY RIEQKGLQHR LILHAVKHQD SGALVGFSCP GVQDSAALTI QESPVHILSP QDRVSLTFTT SERVVLTCEL SRVDFPATWY KDGQKVEESE LLVVKMDGRK HRLILPEAKV QDSGEFECRT EGVSAFFGVT VQDPPVHIVD PREHVFVHAI TSECVMLACE VDREDAPVRW YKDGQEVEES DFVVLENEGP HRRLVLPATQ PSDGGEFQCV AGDECAYFTV TITDVSSWIV YPSGKVYVAA VRLERVVLTC ELCRPWAEVR WTKDGEEVVE SPALLLQKED TVRRLVLPAV QLEDSGEYLC EIDDESASFT VTVTEPPVRI IYPRDEVTLI AVTLECVVLM CELSREDAPV RWYKDGLEVE ESEALVLERD GPRCRLVLPA AQPEDGGEFV CDAGDDSAFF TVTVTAPPER IVHPAARSLD LHFGAPGRVE LRCEVAPAGS QVRWYKDGLE VEASDALQLG AEGPTRTLTL PHAQPEDAGE YVCETRHEAI TFNVILAEPP VQFLALETTP SPLCVAPGEP VVLSCELSRA GAPVVWSHNG RPVQEGEGLE LHAEGPRRVL CIQAAGPAHA GLYTCQSGAA PGAPSLSFTV QVAEPPVRVV APEAAQTRVR STPGGDLELV VHLSGPGGPV RWYKDGERLA SQGRVQLEQA GARQVLRVQG ARSGDAGEYL CDAPQDSRIF LVSVEEPLLV KLVSELTPLT VHEGDDATFR CEVSPPDADV TWLRNGAVVT PGPQVEMAQN GSSRILTLRG CQLGDAGTVT LRAGSTATSA RLHVRETELL FLRRLQDVRA EEGQDVCLEV ETGRVGAAGA VRWVRGGQPL PHDSRLSMAQ DGHIHRLFIH GVILADQGTY GCESHHDRTL ARLSVRPRQL RVLRPLEDVT ISEGGSATFQ LELSQEGVTG EWARGGVQLY PGPKCHIHSD GHRHRLVLNG LGLADSGCVS FTADSLRCAA RLIVREVPVT IVRGPHDLEV TEGDTATFEC ELSQALADVT WEKDGNALTP SPRLRLQALG TRRLLQLRRC GPSDAGTYSC AVGTARAGPV RLTVRERTVA VLSELRSVSA REGDGATFEC TVSEVETTGR WELGGRPLRP GARVRIRQEG KKHILVLSEL RAEDAGEVRF QAGPAQSLAL LEVEALPLQM CRHPPREKTV LVGRRAVLEV TVSRSGGHVC WLREGAELCP GDKYEMRSHG PTHSLVIHDV RPEDQGTYCC QAGQDSTHTR LLVEGN
Genular Protein ID: 3632765343
Symbol: Q9H8B3_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
Sequence Information:
- Length: 442
- Mass: 47378
- Checksum: DEC475AE8B964195
- Sequence:
MCELSREDAP VRWYKDGLEV EESEALVLER DGPRCRLVLP AAQPEDGGEF VCDAGDDSAF FTVTVTAPPE RIVHPAARSL DLHFGAPGRV ELRCEVAPAG SQVRWYKDGL EVEASDALQL GAEGPTRTLT LPHAQPEDAG EYVCETRHEA ITFNVILAEP PVQFLALETT PSPLCVAPGE PVVLSCELSR AGAPVVWSHN GGPVQEGEGL ELHAEGPRRV LCIQAAGPAH AGLYTCQSGA APGAPSLSFT VQVAEPLLVK LVSDLTPLTV HEGDDATFRC EVSPPDADVT WLRNGAVVTP GPQVEMAQNG SSRILTLRGC QLGDAGTVTL RAGSTATSAR LHVRETELLF LRRLQDVRAE EGQDVCLEME TGRVGAAGAV RWVRGGQPLP HDSRLSMAQD GHIHRLFIHG VILADQGTYG CESHHDRTLA RLSVRRECPV LS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.