Details for: ARHGEF12

Gene ID: 23365

Symbol: ARHGEF12

Ensembl ID: ENSG00000196914

Description: Rho guanine nucleotide exchange factor 12

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 4
    Marker Score: 5,377
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.86
    Marker Score: 4,677
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 3.23
    Marker Score: 13,518
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.13
    Marker Score: 6,864
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 3.04
    Marker Score: 3,785
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.98
    Marker Score: 63,641
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.97
    Marker Score: 3,414
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.85
    Marker Score: 25,024
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.8
    Marker Score: 62,460
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.75
    Marker Score: 92,988
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.74
    Marker Score: 5,280
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.68
    Marker Score: 9,544
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.68
    Marker Score: 782
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.63
    Marker Score: 1,570
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.6
    Marker Score: 2,006
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2.59
    Marker Score: 1,352
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.54
    Marker Score: 2,425
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.54
    Marker Score: 19,442
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.49
    Marker Score: 49,530
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.48
    Marker Score: 1,382
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.48
    Marker Score: 37,149
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.48
    Marker Score: 3,605
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.48
    Marker Score: 11,477
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.46
    Marker Score: 1,621
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.43
    Marker Score: 1,688
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.41
    Marker Score: 91,355
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.37
    Marker Score: 2,106
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.35
    Marker Score: 1,272
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.34
    Marker Score: 1,366
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.29
    Marker Score: 1,130
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 2.27
    Marker Score: 5,574
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.26
    Marker Score: 2,296
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.26
    Marker Score: 1,323
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.22
    Marker Score: 39,386
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 2.21
    Marker Score: 7,424
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.21
    Marker Score: 2,330
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.21
    Marker Score: 81,591
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.18
    Marker Score: 8,444
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.17
    Marker Score: 11,668
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.17
    Marker Score: 685
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.16
    Marker Score: 8,950
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.16
    Marker Score: 2,443
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.12
    Marker Score: 887
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.11
    Marker Score: 2,329
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.09
    Marker Score: 19,680
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.09
    Marker Score: 1,806
  • Cell Name: podocyte (CL0000653)
    Fold Change: 2.08
    Marker Score: 770
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.08
    Marker Score: 659
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.07
    Marker Score: 1,092
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.07
    Marker Score: 5,185
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.04
    Marker Score: 125,315
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.02
    Marker Score: 32,509
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.98
    Marker Score: 2,116
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.97
    Marker Score: 567
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.97
    Marker Score: 8,007
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.96
    Marker Score: 4,505
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.94
    Marker Score: 706
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.94
    Marker Score: 6,876
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.93
    Marker Score: 2,086
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.93
    Marker Score: 741
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.9
    Marker Score: 6,229
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.89
    Marker Score: 19,478
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.88
    Marker Score: 17,889
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.88
    Marker Score: 1,627
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.87
    Marker Score: 14,078
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.83
    Marker Score: 877
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.82
    Marker Score: 4,878
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.82
    Marker Score: 15,633
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.8
    Marker Score: 1,048
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.79
    Marker Score: 5,094
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.78
    Marker Score: 1,211
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.78
    Marker Score: 9,544
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.77
    Marker Score: 7,380
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.76
    Marker Score: 2,596
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.7
    Marker Score: 10,948
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.7
    Marker Score: 2,849
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.66
    Marker Score: 2,139
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.62
    Marker Score: 7,000
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.62
    Marker Score: 442
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.61
    Marker Score: 1,717
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.6
    Marker Score: 1,070
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.58
    Marker Score: 537
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.58
    Marker Score: 2,435
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.56
    Marker Score: 585
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.56
    Marker Score: 1,887
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.52
    Marker Score: 3,096
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.51
    Marker Score: 3,806
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.51
    Marker Score: 568
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.49
    Marker Score: 1,340
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.49
    Marker Score: 651
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.49
    Marker Score: 751
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.48
    Marker Score: 832
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.48
    Marker Score: 298
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.45
    Marker Score: 2,565
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.43
    Marker Score: 835
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.43
    Marker Score: 1,515
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.43
    Marker Score: 1,480
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.42
    Marker Score: 2,839
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.42
    Marker Score: 450
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.4
    Marker Score: 363

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ARHGEF12 is a member of the Rho GEF family, which is characterized by their ability to exchange GDP for GTP in Rho GTPases, thereby activating them. The protein ARHGEF12 is highly specific for Rho GTPases, particularly RhoA, Rhob, and Rhoc, and is involved in regulating their activity. The gene is also involved in various signaling pathways, including the cdc42 GTPase cycle, cell death signaling via NRAGE, and semaphorin interactions. The protein ARHGEF12 is characterized by its ability to bind to the G-protein coupled receptor (GPCR) and regulate its signaling pathway. **Pathways and Functions** ARHGEF12 is involved in various signaling pathways, including: 1. **Axon guidance**: ARHGEF12 regulates axon guidance by activating Rho GTPases, which play a crucial role in regulating cytoskeletal dynamics and cell migration. 2. **Cell death signaling**: ARHGEF12 is involved in cell death signaling via NRAGE, a receptor that mediates death signals through JNK activation. 3. **Regulation of small GTPase-mediated signal transduction**: ARHGEF12 regulates the activity of small GTPases, including RhoA, Rhob, and Rhoc, which play a crucial role in regulating cytoskeletal dynamics and cell migration. 4. **G-protein coupled receptor signaling pathway**: ARHGEF12 binds to GPCRs and regulates their signaling pathway, which is involved in various physiological processes, including development and cell migration. 5. **Semaphorin interactions**: ARHGEF12 is involved in semaphorin interactions, which play a crucial role in regulating axon guidance and cell migration. **Clinical Significance** Dysregulation of ARHGEF12 has been implicated in various diseases, including: 1. **Neurological disorders**: Dysregulation of ARHGEF12 has been implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and stroke. 2. **Cancer**: ARHGEF12 is overexpressed in several types of cancer, including breast cancer, lung cancer, and colon cancer. 3. **Cardiovascular disease**: Dysregulation of ARHGEF12 has been implicated in cardiovascular disease, including atherosclerosis and cardiac arrhythmias. In summary, ARHGEF12 is a gene that encodes a protein involved in various cellular processes, including axon guidance, cell death signaling, and regulation of small GTPase-mediated signal transduction. The protein ARHGEF12 is a guanine nucleotide exchange factor that activates Rho GTPases, which play a crucial role in regulating cytoskeletal dynamics, cell migration, and cell death. Dysregulation of ARHGEF12 has been implicated in various diseases, including neurological disorders, cancer, and cardiovascular disease.

Genular Protein ID: 2402678750

Symbol: ARHGC_HUMAN

Name: Rho guanine nucleotide exchange factor 12

UniProtKB Accession Codes:

Q9NZN5 O15086 Q6P526

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 4 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 4 PRO 1 PROSITE 4 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 7 RefSeq 5 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10681437

Title: Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia.

PubMed ID: 10681437

DOI: 10.1073/pnas.040569197

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9205841

Title: Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9205841

DOI: 10.1093/dnares/4.2.141

PubMed ID: 11094164

Title: Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho.

PubMed ID: 11094164

DOI: 10.1016/s0014-5793(00)02224-9

PubMed ID: 11724822

Title: Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF.

PubMed ID: 11724822

DOI: 10.1083/jcb.200106139

PubMed ID: 12372594

Title: B plexins activate Rho through PDZ-RhoGEF.

PubMed ID: 12372594

DOI: 10.1016/s0014-5793(02)03323-9

PubMed ID: 12183458

Title: Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF.

PubMed ID: 12183458

DOI: 10.1074/jbc.m206005200

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20844236

Title: HGAL, a germinal center specific protein, decreases lymphoma cell motility by modulation of the RhoA signaling pathway.

PubMed ID: 20844236

DOI: 10.1182/blood-2010-04-281568

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 15331592

Title: Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor.

PubMed ID: 15331592

DOI: 10.1074/jbc.m406056200

PubMed ID: 18411422

Title: Conformational change upon ligand binding and dynamics of the PDZ domain from leukemia-associated Rho guanine nucleotide exchange factor.

PubMed ID: 18411422

DOI: 10.1110/ps.073416508

Sequence Information:

  • Length: 1544
  • Mass: 173232
  • Checksum: 0B7E319CF7C7A224
  • Sequence:
    • MSGTQSTITD RFPLKKPIRH GSILNRESPT DKKQKVERIA SHDFDPTDSS SKKTKSSSEE 
SRSEIYGLVQ RCVIIQKDDN GFGLTVSGDN PVFVQSVKED GAAMRAGVQT GDRIIKVNGT 
LVTHSNHLEV VKLIKSGSYV ALTVQGRPPG SPQIPLADSE VEPSVIGHMS PIMTSPHSPG 
ASGNMERITS PVLMGEENNV VHNQKVEILR KMLQKEQERL QLLQEDYNRT PAQRLLKEIQ 
EAKKHIPQLQ EQLSKATGSA QDGAVVTPSR PLGDTLTVSE AETDPGDVLG RTDCSSGDAS 
RPSSDNADSP KSGPKERIYL EENPEKSETI QDTDTQSLVG SPSTRIAPHI IGAEDDDFGT 
EHEQINGQCS CFQSIELLKS RPAHLAVFLH HVVSQFDPAT LLCYLYSDLY KHTNSKETRR 
IFLEFHQFFL DRSAHLKVSV PDEMSADLEK RRPELIPEDL HRHYIQTMQE RVHPEVQRHL 
EDFRQKRSMG LTLAESELTK LDAERDKDRL TLEKERTCAE QIVAKIEEVL MTAQAVEEDK 
SSTMQYVILM YMKHLGVKVK EPRNLEHKRG RIGFLPKIKQ SMKKDKEGEE KGKRRGFPSI 
LGPPRRPSRH DNSAIGRAME LQKARHPKHL STPSSVSPEP QDSAKLRQSG LANEGTDAGY 
LPANSMSSVA SGASFSQEGG KENDTGSKQV GETSAPGDTL DGTPRTLNTV FDFPPPPLDQ 
VQEEECEVER VTEHGTPKPF RKFDSVAFGE SQSEDEQFEN DLETDPPNWQ QLVSREVLLG 
LKPCEIKRQE VINELFYTER AHVRTLKVLD QVFYQRVSRE GILSPSELRK IFSNLEDILQ 
LHIGLNEQMK AVRKRNETSV IDQIGEDLLT WFSGPGEEKL KHAAATFCSN QPFALEMIKS 
RQKKDSRFQT FVQDAESNPL CRRLQLKDII PTQMQRLTKY PLLLDNIAKY TEWPTEREKV 
KKAADHCRQI LNYVNQAVKE AENKQRLEDY QRRLDTSSLK LSEYPNVEEL RNLDLTKRKM 
IHEGPLVWKV NRDKTIDLYT LLLEDILVLL QKQDDRLVLR CHSKILASTA DSKHTFSPVI 
KLSTVLVRQV ATDNKALFVI SMSDNGAQIY ELVAQTVSEK TVWQDLICRM AASVKEQSTK 
PIPLPQSTPG EGDNDEEDPS KLKEEQHGIS VTGLQSPDRD LGLESTLISS KPQSHSLSTS 
GKSEVRDLFV AERQFAKEQH TDGTLKEVGE DYQIAIPDSH LPVSEERWAL DALRNLGLLK 
QLLVQQLGLT EKSVQEDWQH FPRYRTASQG PQTDSVIQNS ENIKAYHSGE GHMPFRTGTG 
DIATCYSPRT STESFAPRDS VGLAPQDSQA SNILVMDHMI MTPEMPTMEP EGGLDDSGEH 
FFDAREAHSD ENPSEGDGAV NKEEKDVNLR ISGNYLILDG YDPVQESSTD EEVASSLTLQ 
PMTGIPAVES THQQQHSPQN THSDGAISPF TPEFLVQQRW GAMEYSCFEI QSPSSCADSQ 
SQIMEYIHKI EADLEHLKKV EESYTILCQR LAGSALTDKH SDKS

Genular Protein ID: 206032439

Symbol: B4E2K6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E2K6

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 4 CTD 1 DNASU 1 EMBL 2 GO 8 Gene3D 4 Genevisible 1 GenomeRNAi 1 InterPro 13 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 7 PeptideAtlas 1 Pfam 4 RefSeq 2 SAM 1 SMART 3 SUPFAM 4

Sequence Information:

  • Length: 1278
  • Mass: 143947
  • Checksum: A6279845201B370A
  • Sequence:
    • MSGTQSTITD RFPLKKPIRH GSILNRESPT DKKQKVERIA SHDFDPTGLV QRCVIIQKDD 
NGFGLTVSGD NPVFVQSVKE DGAAMRAGVQ TGDRIIKVNG TLVTHSNHLE VVKLIKSGSY 
VALTVQGRPP GSPQIPLADS EVEPSVIGHM SPIMTSPHSP GASGNMERIT SPVLMGEENN 
VVHNQKVEIL RKMLQKEQER LQLLQEDYNR TPAQRLLKEI QEAKKHIPQL QEQLSKATGS 
AQDGAVVTPS RPLGDTLTVS EAETDPGDVL GRTDCSSGDA SRPSSDNADS PKSGPKERIY 
LEENPEKSET IQDTDTQSLV GSPSTRIAPH IIGAEDDDFG TEHEQINGQC SCFQSIELLK 
SRPAHLAVFL HHVVSQFDPA TLLCYLYSDL YKHTNSKETR RIFLEFHQFF LDRSAHLKVS 
VPDEMSADLE KRRPELIPED LHRHYIQTMQ ERVHPEVQRH LEDFRQKRSM GLTLAESELT 
KLDAERDKDR LTLEKERTCA EQIVAKIEEV LMTAQAVEED KSSTMQYVIL MYMKHLGVKV 
KEPRNLEHKR GRIGFLPKIK QSMKKDKEGE EKGKRRGFPS ILGPPRRPSR HDNSAIGRAM 
ELQKARHPKH LSTPSSVSPE PQDSAKLRQS GLANEGTDAG YLPANSMSSV ASGASFSQEG 
GKENDTGSKQ VGETSAPGDT LDGTPRTLNT VFDFPPPPLD QVQEEECEVE RVTEHGTPKP 
FRKFDSVAFG ESQSEDEQFE NDLETDPPNW QQLVSREVLL GLKPCEIKRQ EVINELFYTE 
RAHVRTLKVL DQVFYQRVSR EGILSPSELR KIFSNLEDIL QLHIGLNEQM KAVRKRNETS 
VIDQIGEDLL TWFSGPGEEK LKHAAATFCS NQPFALEMIK SRQKKDSRFQ TFVQDAESNP 
LCRRLQLKDI IPTQMQRLTK YPLLLDNIAK YTEWPTEREK VKKAADHCRQ ILNYVNQAVK 
EAENKQRLED YQRRLDTSSL KLSEYPNVEE LRNLDLTKRK MIHEGPLVWK VNRDKTIDLY 
TLLLEDILVL LQKQDDRLVL RCHSKILAST ADSKHTFSPV IKLSTVLVRQ VATDNKALFV 
ISMSDNGAQI YELVAQTVSE KTVWQDLICR MAASVKEQST KPIPLPQSTP GEGDNDEEDP 
SKLKEEQHGI SVTGLQSPDR DLGLESTLIS SKPQSHSLST SGKSEVRDLF VAERQFAKEQ 
HTDGTLKEVG EDYQIAIPDS HLPVSEERWA LDALRNLGLL KQLLVQQLGL TEKSVQEDWQ 
HFPRYRTASQ GPQTDSVI

Genular Protein ID: 1276948125

Symbol: E9PMR6_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PMR6

Database IDs:

ARBA 4 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 4 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 EPD 2 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 4 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 13 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 7 PeptideAtlas 1 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 3 SAM 1 SMART 2 SMR 1 SUPFAM 4 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 1441
  • Mass: 161909
  • Checksum: 7343555DCD901EDD
  • Sequence:
    • MRAGVQTGDR IIKVNGTLVT HSNHLEVVKL IKSGSYVALT VQGRPPGSPQ IPLADSEVEP 
SVIGHMSPIM TSPHSPGASG NMERITSPVL MGEENNVVHN QKVEILRKML QKEQERLQLL 
QEDYNRTPAQ RLLKEIQEAK KHIPQLQEQL SKATGSAQDG AVVTPSRPLG DTLTVSEAET 
DPGDVLGRTD CSSGDASRPS SDNADSPKSG PKERIYLEEN PEKSETIQDT DTQSLVGSPS 
TRIAPHIIGA EDDDFGTEHE QINGQCSCFQ SIELLKSRPA HLAVFLHHVV SQFDPATLLC 
YLYSDLYKHT NSKETRRIFL EFHQFFLDRS AHLKVSVPDE MSADLEKRRP ELIPEDLHRH 
YIQTMQERVH PEVQRHLEDF RQKRSMGLTL AESELTKLDA ERDKDRLTLE KERTCAEQIV 
AKIEEVLMTA QAVEEDKSST MQYVILMYMK HLGVKVKEPR NLEHKRGRIG FLPKIKQSMK 
KDKEGEEKGK RRGFPSILGP PRRPSRHDNS AIGRAMELQK ARHPKHLSTP SSVSPEPQDS 
AKLRQSGLAN EGTDAGYLPA NSMSSVASGA SFSQEGGKEN DTGSKQVGET SAPGDTLDGT 
PRTLNTVFDF PPPPLDQVQE EECEVERVTE HGTPKPFRKF DSVAFGESQS EDEQFENDLE 
TDPPNWQQLV SREVLLGLKP CEIKRQEVIN ELFYTERAHV RTLKVLDQVF YQRVSREGIL 
SPSELRKIFS NLEDILQLHI GLNEQMKAVR KRNETSVIDQ IGEDLLTWFS GPGEEKLKHA 
AATFCSNQPF ALEMIKSRQK KDSRFQTFVQ DAESNPLCRR LQLKDIIPTQ MQRLTKYPLL 
LDNIAKYTEW PTEREKVKKA ADHCRQILNY VNQAVKEAEN KQRLEDYQRR LDTSSLKLSE 
YPNVEELRNL DLTKRKMIHE GPLVWKVNRD KTIDLYTLLL EDILVLLQKQ DDRLVLRCHS 
KILASTADSK HTFSPVIKLS TVLVRQVATD NKALFVISMS DNGAQIYELV AQTVSEKTVW 
QDLICRMAAS VKEQSTKPIP LPQSTPGEGD NDEEDPSKLK EEQHGISVTG LQSPDRDLGL 
ESTLISSKPQ SHSLSTSGKS EVRDLFVAER QFAKEQHTDG TLKEVGEDYQ IAIPDSHLPV 
SEERWALDAL RNLGLLKQLL VQQLGLTEKS VQEDWQHFPR YRTASQGPQT DSVIQNSENI 
KAYHSGEGHM PFRTGTGDIA TCYSPRTSTE SFAPRDSVGL APQDSQASNI LVMDHMIMTP 
EMPTMEPEGG LDDSGEHFFD AREAHSDENP SEGDGAVNKE EKDVNLRISG NYLILDGYDP 
VQESSTDEEV ASSLTLQPMT GIPAVESTHQ QQHSPQNTHS DGAISPFTPE FLVQQRWGAM 
EYSCFEIQSP SSCADSQSQI MEYIHKIEAD LEHLKKVEES YTILCQRLAG SALTDKHSDK 
S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.