Details for: MATCAP2

Gene ID: 23366

Symbol: MATCAP2

Ensembl ID: ENSG00000164542

Description: microtubule associated tyrosine carboxypeptidase 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.46
    Marker Score: 2,759
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.35
    Marker Score: 20,252
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.3
    Marker Score: 12,377
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.29
    Marker Score: 4,970
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.2
    Marker Score: 1,855
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.2
    Marker Score: 10,307
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.2
    Marker Score: 45,385
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.14
    Marker Score: 11,789
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.13
    Marker Score: 8,665
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.11
    Marker Score: 68,547
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.07
    Marker Score: 10,025
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.05
    Marker Score: 16,436
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.04
    Marker Score: 20,588
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,808
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,032
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.99
    Marker Score: 36,453
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.97
    Marker Score: 4,016
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.96
    Marker Score: 1,669
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.95
    Marker Score: 3,887
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.94
    Marker Score: 1,912
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,735
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,197
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.89
    Marker Score: 2,095
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.88
    Marker Score: 367
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,280
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.81
    Marker Score: 3,134
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,263
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.77
    Marker Score: 3,239
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 389
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 573
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 678
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 292
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.71
    Marker Score: 229
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.66
    Marker Score: 5,744
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.65
    Marker Score: 1,501
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.62
    Marker Score: 195
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.61
    Marker Score: 364
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.57
    Marker Score: 824
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.57
    Marker Score: 1,943
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.56
    Marker Score: 2,598
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 437
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.54
    Marker Score: 219
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.54
    Marker Score: 258
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.54
    Marker Score: 2,235
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.54
    Marker Score: 1,018
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.53
    Marker Score: 11,398
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.53
    Marker Score: 276
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.53
    Marker Score: 241
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.52
    Marker Score: 245
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.51
    Marker Score: 390
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.49
    Marker Score: 128
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.48
    Marker Score: 108
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.47
    Marker Score: 302
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.46
    Marker Score: 237
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.45
    Marker Score: 698
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.45
    Marker Score: 1,104
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.45
    Marker Score: 231
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.44
    Marker Score: 4,469
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.44
    Marker Score: 128
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.43
    Marker Score: 15,046
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.43
    Marker Score: 468
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.43
    Marker Score: 3,228
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.42
    Marker Score: 121
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.42
    Marker Score: 182
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.41
    Marker Score: 1,021
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.4
    Marker Score: 167
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.4
    Marker Score: 417
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.39
    Marker Score: 208
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.38
    Marker Score: 381
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.38
    Marker Score: 375
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.38
    Marker Score: 89
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.38
    Marker Score: 6,680
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.38
    Marker Score: 398
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.37
    Marker Score: 323
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.37
    Marker Score: 246
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.37
    Marker Score: 413
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.37
    Marker Score: 162
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.36
    Marker Score: 134
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.36
    Marker Score: 178
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.36
    Marker Score: 198
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.36
    Marker Score: 310
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.35
    Marker Score: 112
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.35
    Marker Score: 1,009
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.35
    Marker Score: 775
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.35
    Marker Score: 131
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.35
    Marker Score: 104
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.35
    Marker Score: 1,288
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.34
    Marker Score: 242
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.34
    Marker Score: 1,202
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.34
    Marker Score: 141
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.34
    Marker Score: 915
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.33
    Marker Score: 384
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.33
    Marker Score: 225
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.33
    Marker Score: 105

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MATCAP2 is a type II transmembrane protein that exhibits carboxypeptidase activity, cleaving amino acids from the C-terminus of its substrate proteins. This activity is crucial for regulating the function and localization of various proteins, including neurotransmitters, growth factors, and receptors. The gene's expression is restricted to specific neuronal populations, including cardiac endothelial cells, GABAergic cortical interneurons, and dopaminergic neurons. These cells are involved in regulating various physiological processes, including cardiovascular function, motor control, and neurotransmission. **Pathways and Functions:** MATCAP2 is involved in several signaling pathways, including: 1. **Carboxypeptidase activity**: MATCAP2's carboxypeptidase activity is essential for regulating the function and localization of various proteins, including neurotransmitters and growth factors. 2. **Metal ion binding**: MATCAP2's metal ion binding domain is necessary for its enzymatic activity and its interaction with other proteins. 3. **Metallopeptidase activity**: MATCAP2's metallopeptidase activity is involved in the degradation of protein substrates, regulating protein function and localization. 4. **Proteolysis**: MATCAP2's proteolytic activity is essential for regulating the function and localization of various proteins, including neurotransmitters and growth factors. **Clinical Significance:** The dysregulation of MATCAP2 has been implicated in various neurological disorders, including: 1. **Neurodevelopmental disorders**: MATCAP2's involvement in neurodevelopmental processes makes it a potential target for therapies aimed at treating disorders such as autism spectrum disorder and schizophrenia. 2. **Neurodegenerative disorders**: MATCAP2's role in regulating protein function and localization makes it a potential target for therapies aimed at treating disorders such as Alzheimer's disease and Parkinson's disease. 3. **Cardiovascular disorders**: MATCAP2's expression in cardiac endothelial cells makes it a potential target for therapies aimed at treating cardiovascular disorders, such as hypertension and atherosclerosis. In conclusion, MATCAP2 is a critical component of the neuronal proteome, playing a pivotal role in regulating protein function and localization through its carboxypeptidase activity. Its involvement in neurodevelopmental processes and its potential as a therapeutic target make it an area of significant interest for researchers and clinicians. Further studies are necessary to elucidate the gene's role in various neurological and cardiovascular disorders, ultimately leading to the development of novel therapeutic strategies.

Genular Protein ID: 2542966220

Symbol: MACA2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8NCT3 B4DF35 B7ZLT4 B9EGB9 O94969 Q0VGC1 Q7Z4L2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 EMBL 9 Ensembl 6 ExpressionAtlas 1 GO 4 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 RNAct 1 RefSeq 5 SAM 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 520
  • Mass: 60525
  • Checksum: 1803AA8CB1D8FC44
  • Sequence:
    • MAGCTRKLTH LRKRIHRPRR RTTRRWKRWF KFRKRKGEKR PRPNHKAVAR RAKLKFSTSE 
KLHWPEQELA KKSILNAEDS LIIDNKRSIS HLSSGVLKDI FTTGTSSYNV LLQSKEEKKY 
HSQKQSSSTY SKRCRKPSKS PNTSRSKDPR RMKALVPVTS SGTWYCLERR PAVFVTSSVS 
SPVKFTHDIS VTGNGIVLPP KPKSKVKWCH FSTLPKPKPQ LSRSFEKGDD FSGKKFCILT 
AIKPTNLEKE KLRFFKSDYT YNPQFEYANP ALPSVLAKHS HASDRFLKQI VVHLTEDLLS 
RASMTVVNGC PTLTINVSTA REHWLEGMLR HEIGTHYFRG INNLQQPWNS WTGRKKHELK 
PNNPTEEGLA SIHSVLFRKD PFLWRAALLY YTVYQASQMS FCELFKDIGR FVKDPNTRWD 
YCVRAKRGWT DTSQPGCFSK DQVYLDGILQ ILRYRDTIDF HLLTALGKVS YEDVDRLKGL 
AVTENMRVPH FLQDHGRYME HLEKIMEVNE LTDRELKDLI

Genular Protein ID: 1862440675

Symbol: E9PE22_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PE22

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 2 SMART 1 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

Sequence Information:

  • Length: 275
  • Mass: 32141
  • Checksum: 1D1DF5319C699547
  • Sequence:
    • MELTLQKYGS YEKFEQATGG SLLSKTRIWS HVRKYMMKEG CLGEIVVHLT EDLLSRASMT 
VVNGCPTLTI NVSTAREHWL EGMLRHEIGT HYFRGINNLQ QPWNSWTGRK KHELKPNNPT 
EEGLASIHSV LFRKDPFLWR AALLYYTVYQ ASQMSFCELF KDIGRFVKDP NTRWDYCVRA 
KRGWTDTSQP GCFSKDQVYL DGILQILRYR DTIDFHLLTA LGKVSYEDVD RLKGLAVTEN 
MRVPHFLQDH GRYMEHLEKI MEVNELTDRE LKDLI

Genular Protein ID: 3606627734

Symbol: B4DYW2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DYW2

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 1 DNASU 1 EMBL 2 GO 1 Genevisible 1 GenomeRNAi 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 1 RefSeq 1 SMART 1

Sequence Information:

  • Length: 240
  • Mass: 28022
  • Checksum: 50956E1B86E5DBED
  • Sequence:
    • MMKEGCLGEI VVHLTEDLLS RASMTVVNGC PTLTINVSTA REHWLEGMLR HEIGTHYFRG 
INNLQQPWNS WTGRKKHELK PNNPTEEGLA SIHSVLFRKD PFLWRAALLY YTVYQASQMS 
FCELFKDIGR FVKDPNTRWD YCVRAKRGWT DTSQPGCFSK DQVYLDGILQ ILRYRDTIDF 
HLLTALGKVS YEDVDRLKGL AVTENMRVPH FLQDHGRYME HLEKIMEVNE LTDRELKDLI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.