Genular: Defining Cellular Identity and Function

Details for: PPP1R13B

Gene ID: 23368

Symbol: PPP1R13B

Ensembl ID: ENSG00000088808

Description: protein phosphatase 1 regulatory subunit 13B

Associated with

Activation of bh3-only proteins
(R-HSA-114452)
Activation of puma and translocation to mitochondria
(R-HSA-139915)
Apoptosis
(R-HSA-109581)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Intrinsic pathway for apoptosis
(R-HSA-109606)
Programmed cell death
(R-HSA-5357801)
Regulation of tp53 activity
(R-HSA-5633007)
Regulation of tp53 activity through association with co-factors
(R-HSA-6804759)
Rna polymerase ii transcription
(R-HSA-73857)
Tp53 regulates transcription of cell death genes
(R-HSA-5633008)
Tp53 regulates transcription of death receptors and ligands
(R-HSA-6803211)
Tp53 regulates transcription of genes involved in cytochrome c release
(R-HSA-6803204)
Tp53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
(R-HSA-6803205)
Transcriptional regulation by tp53
(R-HSA-3700989)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Intrinsic apoptotic signaling pathway by p53 class mediator
(GO:0072332)
Negative regulation of cell cycle
(GO:0045786)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
P53 binding
(GO:0002039)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Regulation of apoptotic process
(GO:0042981)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 3.8
Marker Score: 84,861
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 2.87
Marker Score: 12,009
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 2.75
Marker Score: 11,446
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 2.5
Marker Score: 2,828
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 2.45
Marker Score: 8,728
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 2.39
Marker Score: 2,640
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 2.33
Marker Score: 41,318
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 2.32
Marker Score: 87,973
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 2.26
Marker Score: 45,000
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 2.23
Marker Score: 17,082
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 2.18
Marker Score: 32,643
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 2.17
Marker Score: 79,896
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 2.15
Marker Score: 8,909
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 2.03
Marker Score: 9,409
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 2.03
Marker Score: 1,214
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 2.01
Marker Score: 1,174
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.98
Marker Score: 7,665
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 1.98
Marker Score: 5,656
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.96
Marker Score: 2,367
Cell Name: neuron (CL0000540)
Fold Change: 1.93
Marker Score: 7,876
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.92
Marker Score: 806
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.91
Marker Score: 117,642
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.9
Marker Score: 17,859
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.86
Marker Score: 19,165
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.8
Marker Score: 1,050
Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.77
Marker Score: 2,387
Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 1.77
Marker Score: 563
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 1.75
Marker Score: 2,936
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.71
Marker Score: 16,231
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 1.69
Marker Score: 1,499
Cell Name: germ cell (CL0000586)
Fold Change: 1.63
Marker Score: 2,855
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.63
Marker Score: 13,987
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 1.61
Marker Score: 1,117
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.59
Marker Score: 2,456
Cell Name: lactocyte (CL0002325)
Fold Change: 1.59
Marker Score: 25,493
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 1.57
Marker Score: 9,405
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.54
Marker Score: 449
Cell Name: Purkinje cell (CL0000121)
Fold Change: 1.52
Marker Score: 51,446
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.52
Marker Score: 3,328
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 1.51
Marker Score: 795
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.47
Marker Score: 31,470
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1.47
Marker Score: 2,139
Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 168,009
Cell Name: lung goblet cell (CL1000143)
Fold Change: 1.45
Marker Score: 419
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.45
Marker Score: 397
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.36
Marker Score: 1,470
Cell Name: taste receptor cell (CL0000209)
Fold Change: 1.36
Marker Score: 1,176
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.32
Marker Score: 1,386
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.29
Marker Score: 3,050
Cell Name: interneuron (CL0000099)
Fold Change: 1.26
Marker Score: 577
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.26
Marker Score: 19,661
Cell Name: stellate neuron (CL0000122)
Fold Change: 1.24
Marker Score: 6,650
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.22
Marker Score: 1,306
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.15
Marker Score: 10,068
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.13
Marker Score: 2,579
Cell Name: macroglial cell (CL0000126)
Fold Change: 1.13
Marker Score: 2,588
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.12
Marker Score: 7,192
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 1.11
Marker Score: 378
Cell Name: lymphocyte (CL0000542)
Fold Change: 1.1
Marker Score: 557
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 1.1
Marker Score: 399
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.09
Marker Score: 4,686
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.08
Marker Score: 416
Cell Name: hepatoblast (CL0005026)
Fold Change: 1.06
Marker Score: 3,468
Cell Name: cholangiocyte (CL1000488)
Fold Change: 1.03
Marker Score: 386
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 1.03
Marker Score: 2,524
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.02
Marker Score: 320
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.01
Marker Score: 5,413
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 1
Marker Score: 318
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1
Marker Score: 584
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1
Marker Score: 3,549
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,762
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47,987
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.99
Marker Score: 1,465
Cell Name: granule cell (CL0000120)
Fold Change: 0.99
Marker Score: 7,470
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.98
Marker Score: 310
Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.98
Marker Score: 198
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,400
Cell Name: Leydig cell (CL0000178)
Fold Change: 0.98
Marker Score: 1,054
Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.97
Marker Score: 266
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.96
Marker Score: 6,285
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.96
Marker Score: 493
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.95
Marker Score: 1,829
Cell Name: basal cell (CL0000646)
Fold Change: 0.95
Marker Score: 1,225
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,407
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.95
Marker Score: 447
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.94
Marker Score: 886
Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.93
Marker Score: 613
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.93
Marker Score: 1,508
Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.92
Marker Score: 5,478
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.92
Marker Score: 456
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,724
Cell Name: acinar cell (CL0000622)
Fold Change: 0.88
Marker Score: 624
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.88
Marker Score: 316
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,296
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.87
Marker Score: 4,981
Cell Name: Unknown (CL0002371)
Fold Change: 0.86
Marker Score: 916
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.85
Marker Score: 8,587
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.84
Marker Score: 640
Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 0.84
Marker Score: 486
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.83
Marker Score: 866

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

**Key Characteristics** 1. **Regulation of Apoptosis**: PPP1R13B interacts with p53, a key regulator of apoptosis, influencing its activity and transcriptional regulation of cell death genes. 2. **Cell Cycle Regulation**: PPP1R13B is involved in negative regulation of the cell cycle, suggesting its role in preventing excessive cell proliferation. 3. **Protein Phosphatase 1 (PP1)**: PPP1R13B is a regulatory subunit of PP1, a serine/threonine phosphatase involved in various cellular processes, including signal transduction and gene expression. 4. **Transcriptional Regulation**: PPP1R13B influences the transcriptional regulation of p53-dependent genes, highlighting its role in modulating cellular responses to DNA damage and stress. **Pathways and Functions** 1. **Intrinsic Apoptotic Signaling Pathway**: PPP1R13B interacts with p53, leading to the activation of the intrinsic apoptotic signaling pathway, which ultimately results in the induction of apoptosis. 2. **Transcriptional Regulation by p53**: PPP1R13B regulates p53-dependent transcription, influencing the expression of cell death genes, death receptors, and ligands involved in apoptosis. 3. **Activation of Bcl-2 Family Proteins**: PPP1R13B interacts with Bcl-2 family proteins, influencing their activity and promoting apoptosis. 4. **Regulation of Cytochrome c Release**: PPP1R13B regulates the release of cytochrome c from mitochondria, a critical step in the intrinsic apoptotic pathway. **Clinical Significance** 1. **Cancer**: Alterations in PPP1R13B expression have been implicated in various cancers, including breast, lung, and colon cancer. Understanding its role in cancer development and progression is essential for developing novel therapeutic strategies. 2. **Neurodegenerative Diseases**: PPP1R13B has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. Its role in regulating apoptosis and transcriptional regulation of cell death genes may provide insights into disease mechanisms and potential therapeutic targets. 3. **Cardiovascular Diseases**: PPP1R13B expression is altered in various cardiovascular diseases, including heart failure and atherosclerosis. Its role in regulating cell cycle progression and apoptosis may be critical in understanding disease pathogenesis and developing novel therapeutic strategies. In conclusion, PPP1R13B is a multifunctional gene that plays a critical role in regulating various cellular processes, including apoptosis, cell cycle progression, and gene expression. Its interaction with p53 and influence on transcriptional regulation of cell death genes make it an essential component of the intrinsic apoptotic signaling pathway. Understanding its clinical significance and potential therapeutic applications is crucial for elucidating its role in disease and developing novel treatments.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Apoptosis-stimulating of p53 protein 1

Genular Protein ID: 4019851001

Symbol: ASPP1_HUMAN

Name: Apoptosis-stimulating of p53 protein 1

UniProtKB Accession Codes:

Q96KQ4 B2RMX5 O94870

Database IDs:

Citations:

PubMed ID: 11684014

Title: ASPP proteins specifically stimulate the apoptotic function of p53.

PubMed ID: 11684014

DOI: 10.1016/s1097-2765(01)00367-7

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9872452

Title: Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9872452

DOI: 10.1093/dnares/5.5.277

PubMed ID: 12524540

Title: iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human.

PubMed ID: 12524540

DOI: 10.1038/ng1070

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

Length: 1090
Mass: 119565
Checksum: 0026F07D7AB33295
Sequence:

MMPMILTVFL SNNEQILTEV PITPETTCRD VVEFCKEPGE GSCHLAEVWR GNERPIPFDH 
MMYEHLQKWG PRREEVKFFL RHEDSPTENS EQGGRQTQEQ RTQRNVINVP GEKRTENGVG 
NPRVELTLSE LQDMAARQQQ QIENQQQMLV AKEQRLHFLK QQERRQQQSI SENEKLQKLK 
ERVEAQENKL KKIRAMRGQV DYSKIMNGNL SAEIERFSAM FQEKKQEVQT AILRVDQLSQ 
QLEDLKKGKL NGFQSYNGKL TGPAAVELKR LYQELQIRNQ LNQEQNSKLQ QQKELLNKRN 
MEVAMMDKRI SELRERLYGK KIQLNRVNGT SSPQSPLSTS GRVAAVGPYI QVPSAGSFPV 
LGDPIKPQSL SIASNAAHGR SKSANDGNWP TLKQNSSSSV KPVQVAGADW KDPSVEGSVK 
QGTVSSQPVP FSALGPTEKP GIEIGKVPPP IPGVGKQLPP SYGTYPSPTP LGPGSTSSLE 
RRKEGSLPRP SAGLPSRQRP TLLPATGSTP QPGSSQQIQQ RISVPPSPTY PPAGPPAFPA 
GDSKPELPLT VAIRPFLADK GSRPQSPRKG PQTVNSSSIY SMYLQQATPP KNYQPAAHSA 
LNKSVKAVYG KPVLPSGSTS PSPLPFLHGS LSTGTPQPQP PSESTEKEPE QDGPAAPADG 
STVESLPRPL SPTKLTPIVH SPLRYQSDAD LEALRRKLAN APRPLKKRSS ITEPEGPGGP 
NIQKLLYQRF NTLAGGMEGT PFYQPSPSQD FMGTLADVDN GNTNANGNLE ELPPAQPTAP 
LPAEPAPSSD ANDNELPSPE PEELICPQTT HQTAEPAEDN NNNVATVPTT EQIPSPVAEA 
PSPGEEQVPP APLPPASHPP ATSTNKRTNL KKPNSERTGH GLRVRFNPLA LLLDASLEGE 
FDLVQRIIYE VEDPSKPNDE GITPLHNAVC AGHHHIVKFL LDFGVNVNAA DSDGWTPLHC 
AASCNSVHLC KQLVESGAAI FASTISDIET AADKCEEMEE GYIQCSQFLY GVQEKLGVMN 
KGVAYALWDY EAQNSDELSF HEGDALTILR RKDESETEWW WARLGDREGY VPKNLLGLYP 
RIKPRQRTLA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PPP1R13B

Associated with

Cells (max top 100)

Other Information

ASPP proteins specifically stimulate the apoptotic function of p53. PubMed ID: 11684014

The DNA sequence and analysis of human chromosome 14. PubMed ID: 12508121

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 9872452

iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human. PubMed ID: 12524540

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569