Details for: PUM2

Gene ID: 23369

Symbol: PUM2

Ensembl ID: ENSG00000055917

Description: pumilio RNA binding family member 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 3.31
    Marker Score: 2,490
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 3.01
    Marker Score: 2,671
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.99
    Marker Score: 12,525
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.93
    Marker Score: 2,530
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.9
    Marker Score: 12,106
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.9
    Marker Score: 51,541
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.85
    Marker Score: 6,253
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.8
    Marker Score: 1,945
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 2.78
    Marker Score: 2,284
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.71
    Marker Score: 3,650
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.68
    Marker Score: 90,468
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.64
    Marker Score: 3,190
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.55
    Marker Score: 2,930
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.53
    Marker Score: 2,864
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.47
    Marker Score: 12,980
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.45
    Marker Score: 4,704
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.41
    Marker Score: 703
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.39
    Marker Score: 5,726
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.39
    Marker Score: 2,974
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.38
    Marker Score: 1,386
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.34
    Marker Score: 10,821
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.32
    Marker Score: 88,076
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.3
    Marker Score: 1,144
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.28
    Marker Score: 45,421
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 2.28
    Marker Score: 7,632
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.27
    Marker Score: 17,426
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.26
    Marker Score: 33,749
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.22
    Marker Score: 1,709
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.21
    Marker Score: 47,165
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.2
    Marker Score: 2,428
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 2.19
    Marker Score: 2,356
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.15
    Marker Score: 683
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.15
    Marker Score: 8,915
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.13
    Marker Score: 78,415
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.1
    Marker Score: 11,299
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.1
    Marker Score: 1,227
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.09
    Marker Score: 1,249
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.08
    Marker Score: 1,168
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.08
    Marker Score: 1,980
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.07
    Marker Score: 7,989
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.06
    Marker Score: 652
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.05
    Marker Score: 45,758
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.98
    Marker Score: 1,041
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.97
    Marker Score: 14,863
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.97
    Marker Score: 2,377
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.97
    Marker Score: 121,028
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.96
    Marker Score: 2,753
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.95
    Marker Score: 563
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.94
    Marker Score: 18,243
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.93
    Marker Score: 3,380
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.88
    Marker Score: 1,049
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.87
    Marker Score: 29,997
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.86
    Marker Score: 6,109
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.83
    Marker Score: 1,016
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.82
    Marker Score: 660
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.82
    Marker Score: 17,309
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.81
    Marker Score: 4,156
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.79
    Marker Score: 972
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.76
    Marker Score: 7,184
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.75
    Marker Score: 447
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.75
    Marker Score: 15,060
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.75
    Marker Score: 18,032
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.72
    Marker Score: 624
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.71
    Marker Score: 640
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.71
    Marker Score: 2,112
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.7
    Marker Score: 578
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.69
    Marker Score: 822
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.67
    Marker Score: 2,425
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.67
    Marker Score: 967
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.66
    Marker Score: 697
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.62
    Marker Score: 4,335
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.6
    Marker Score: 1,619
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.59
    Marker Score: 1,673
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.59
    Marker Score: 586
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.57
    Marker Score: 1,036
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.57
    Marker Score: 2,221
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.56
    Marker Score: 752
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.56
    Marker Score: 1,670
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.56
    Marker Score: 814
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.54
    Marker Score: 1,333
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.53
    Marker Score: 9,833
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.52
    Marker Score: 572
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.51
    Marker Score: 1,955
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.51
    Marker Score: 2,332
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.5
    Marker Score: 3,758
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.49
    Marker Score: 738
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.48
    Marker Score: 4,226
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.48
    Marker Score: 7,958
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.44
    Marker Score: 6,204
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.43
    Marker Score: 580
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.43
    Marker Score: 4,901
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.39
    Marker Score: 1,476
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.39
    Marker Score: 4,941
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.38
    Marker Score: 939
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.38
    Marker Score: 2,310
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.36
    Marker Score: 1,592
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.36
    Marker Score: 961
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.36
    Marker Score: 1,247
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.36
    Marker Score: 274
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.35
    Marker Score: 4,792

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The PUM2 gene is characterized by its ability to bind to specific RNA sequences, known as PUMilio-response elements (PREs), which are present in the 3'-untranslated regions (3'-UTRs) of target mRNAs. This binding event triggers a series of downstream effects, including mRNA destabilization, localization, and translation inhibition. The PUM2 protein is also involved in the regulation of microRNA (miRNA)-mediated gene silencing, where it acts as a positive regulator of miRNA-dependent repression. **Pathways and Functions** PUM2 is involved in a wide range of cellular processes, including: 1. **3'-UTR-mediated mRNA destabilization**: PUM2 binds to target mRNAs, leading to their degradation and reducing their translation. 2. **Regulation of miRNA-mediated gene silencing**: PUM2 acts as a positive regulator of miRNA-dependent repression, enhancing the silencing of target genes. 3. **Post-transcriptional regulation of gene expression**: PUM2 regulates the stability, localization, and translation of target mRNAs, thereby controlling gene expression. 4. **Regulation of translation**: PUM2 inhibits translation of target mRNAs, which is essential for controlling protein synthesis. 5. **Stress granule assembly**: PUM2 is involved in the assembly of stress granules, which are cytoplasmic structures that regulate mRNA translation during stress conditions. **Clinical Significance** Dysregulation of PUM2 has been implicated in various diseases, including: 1. **Cancer**: PUM2 is often downregulated in cancer cells, leading to the overexpression of oncogenic mRNAs and the promotion of tumorigenesis. 2. **Neurological disorders**: PUM2 has been implicated in the regulation of neuronal function and plasticity, and its dysregulation has been linked to neurological disorders such as Alzheimer's disease and Parkinson's disease. 3. **Metabolic disorders**: PUM2 regulates glucose metabolism and insulin signaling, and its dysregulation has been linked to metabolic disorders such as diabetes and obesity. In conclusion, PUM2 is a critical regulator of post-transcriptional gene expression, and its dysregulation has significant implications for various diseases. Further research is needed to fully understand the mechanisms by which PUM2 regulates gene expression and to develop therapeutic strategies for targeting PUM2 in disease prevention and treatment.

Genular Protein ID: 76696549

Symbol: PUM2_HUMAN

Name: Pumilio homolog 2

UniProtKB Accession Codes:

Q8TB72 B3KSL0 B4E2B6 D6W527 O00234 Q53TV7 Q8WY43 Q9HAN2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 28 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 3 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 13 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12459267

Title: Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins.

PubMed ID: 12459267

DOI: 10.1016/s0378-1119(02)01060-0

PubMed ID: 9039502

Title: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.

PubMed ID: 9039502

DOI: 10.1093/dnares/3.5.321

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12511597

Title: Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins.

PubMed ID: 12511597

DOI: 10.1073/pnas.0234478100

PubMed ID: 12771951

Title: Genome-wide comparison of human keratinocyte and squamous cell carcinoma responses to UVB irradiation: implications for skin and epithelial cancer.

PubMed ID: 12771951

DOI: 10.1038/sj.onc.1206537

PubMed ID: 12690449

Title: Conservation of a Pumilio-Nanos complex from Drosophila germ plasm to human germ cells.

PubMed ID: 12690449

DOI: 10.1007/s00427-003-0303-2

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18776931

Title: Comparative analysis of mRNA targets for human PUF-family proteins suggests extensive interaction with the miRNA regulatory system.

PubMed ID: 18776931

DOI: 10.1371/journal.pone.0003164

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19168546

Title: The SNARE-associated component SNAPIN binds PUMILIO2 and NANOS1 proteins in human male germ cells.

PubMed ID: 19168546

DOI: 10.1093/molehr/gap004

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21800163

Title: NANOS1 and PUMILIO2 bind microRNA biogenesis factor GEMIN3, within chromatoid body in human germ cells.

PubMed ID: 21800163

DOI: 10.1007/s00418-011-0842-y

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22345517

Title: Pumilio facilitates miRNA regulation of the E2F3 oncogene.

PubMed ID: 22345517

DOI: 10.1101/gad.182568.111

PubMed ID: 22955276

Title: Human Pumilio proteins recruit multiple deadenylases to efficiently repress messenger RNAs.

PubMed ID: 22955276

DOI: 10.1074/jbc.m112.373522

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23125361

Title: The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function.

PubMed ID: 23125361

DOI: 10.1093/nar/gks1032

PubMed ID: 25349211

Title: SCCRO3 (DCUN1D3) antagonizes the neddylation and oncogenic activity of SCCRO (DCUN1D1).

PubMed ID: 25349211

DOI: 10.1074/jbc.m114.585505

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25340845

Title: A novel function of human Pumilio proteins in cytoplasmic sensing of viral infection.

PubMed ID: 25340845

DOI: 10.1371/journal.ppat.1004417

PubMed ID: 26724866

Title: Noncoding RNA NORAD regulates genomic stability by sequestering PUMILIO proteins.

PubMed ID: 26724866

DOI: 10.1016/j.cell.2015.12.017

PubMed ID: 28431233

Title: A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis.

PubMed ID: 28431233

DOI: 10.1016/j.molcel.2017.03.014

PubMed ID: 21397187

Title: Alternate modes of cognate RNA recognition by human PUMILIO proteins.

PubMed ID: 21397187

DOI: 10.1016/j.str.2010.12.019

Sequence Information:

  • Length: 1066
  • Mass: 114216
  • Checksum: CF6F9D7998CD5D9E
  • Sequence:
    • MNHDFQALAL ESRGMGELLP TKKFWEPDDS TKDGQKGIFL GDDEWRETAW GASHHSMSQP 
IMVQRRSGQG FHGNSEVNAI LSPRSESGGL GVSMVEYVLS SSPADKLDSR FRKGNFGTRD 
AETDGPEKGD QKGKASPFEE DQNRDLKQGD DDDSKINGRG LPNGMDADCK DFNRTPGSRQ 
ASPTEVVERL GPNTNPSEGL GPLPNPTANK PLVEEFSNPE TQNLDAMEQV GLESLQFDYP 
GNQVPMDSSG ATVGLFDYNS QQQLFQRTNA LTVQQLTAAQ QQQYALAAAQ QPHIAGVFSA 
GLAPAAFVPN PYIISAAPPG TDPYTAAGLA AAATLAGPAV VPPQYYGVPW GVYPANLFQQ 
QAAAAANNTA SQQAASQAQP GQQQVLRAGA GQRPLTPNQG QQGQQAESLA AAAAANPTLA 
FGQGLATGMP GYQVLAPTAY YDQTGALVVG PGARTGLGAP VRLMAPTPVL ISSAAAQAAA 
AAAAGGTASS LTGSTNGLFR PIGTQPPQQQ QQQPSTNLQS NSFYGSSSLT NSSQSSSLFS 
HGPGQPGSTS LGFGSGNSLG AAIGSALSGF GSSVGSSASS SATRRESLST SSDLYKRSSS 
SLAPIGQPFY NSLGFSSSPS PIGMPLPSQT PGHSLTPPPS LSSHGSSSSL HLGGLTNGSG 
RYISAAPGAE AKYRSASSTS SLFSSSSQLF PPSRLRYNRS DIMPSGRSRL LEDFRNNRFP 
NLQLRDLIGH IVEFSQDQHG SRFIQQKLER ATPAERQMVF NEILQAAYQL MTDVFGNYVI 
QKFFEFGSLD QKLALATRIR GHVLPLALQM YGCRVIQKAL ESISSDQQVI SEMVKELDGH 
VLKCVKDQNG NHVVQKCIEC VQPQSLQFII DAFKGQVFVL STHPYGCRVI QRILEHCTAE 
QTLPILEELH QHTEQLVQDQ YGNYVIQHVL EHGRPEDKSK IVSEIRGKVL ALSQHKFASN 
VVEKCVTHAS RAERALLIDE VCCQNDGPHS ALYTMMKDQY ANYVVQKMID MAEPAQRKII 
MHKIRPHITT LRKYTYGKHI LAKLEKYYLK NSPDLGPIGG PPNGML

Genular Protein ID: 3449825584

Symbol: B7ZL34_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7ZL34

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 GO 1 Gene3D 1 GenomeRNAi 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 6 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 985
  • Mass: 106003
  • Checksum: AD305125806106C9
  • Sequence:
    • MNHDFQALAL ESRGMGELLP TKKFWEPDDS TKDGQKGIFL GDDEWRETAW GASHHSMSQP 
IMVQRRSGQG FHGNSEVNAI LSPRSESGGL GVSMVEYVLS SSPADKLDSR FRKGNFGTRD 
AETDGPEKGD QKGKASPFEE DQNRDLKQGD DDDSKINGRG LPNGMDADCK DFNRTPGSRQ 
ASPTEVVERL GPNTNPSEGL GPLPNPTANK PLVEEFSNPE TQNLDAMEQV GLESLQFDYP 
GNQVPMDSSG ATVGLFDYNS QQQLFQRTNA LTVQQLTAAQ QQQYALAAAQ QPHIAGVFSA 
GLAPAAFVPN PYIISAAPPG TDPYTAAGLA AAATLAGPAV VPPQYYGVPW GVYPANLFQQ 
QAAAAANNTA SQQAASQAQP GQQQVLRAGA GQRPLTPNQG QQGQQAESLA AAAAANPTLA 
FGQGLATGMP GYQVLAPTAY YDQTGALVVG PGARTGLGAP VRLMAPTPVL ISSAAAQAAA 
AAAAGGTASS LTGSTNGLFR PIGTQPPQQQ QQQPSTNLQS NSFYGSSSLT NSSQSSSLFS 
HGPGQPGSTS LGFGSGNSLG AAIGSALSGF GSSGGLTNGS GRYISAAPGA EAKYRSASST 
SSLFSSSSQL FPPSRLRYNR SDIMPSGRSR LLEDFRNNRF PNLQLRDLIG HIVEFSQDQH 
GSRFIQQKLE RATPAERQMV FNEILQAAYQ LMTDVFGNYV IQKFFEFGSL DQKLALATRI 
RGHVLPLALQ MYGCRVIQKA LESISSDQQS EMVKELDGHV LKCVKDQNGN HVVQKCIECV 
QPQSLQFIID AFKGQVFVLS THPYGCRVIQ RILEHCTAEQ TLPILEELHQ HTEQLVQDQY 
GNYVIQHVLE HGRPEDKSKI VSEIRGKVLA LSQHKFASNV VEKCVTHASR AERALLIDEV 
CCQNDGPHSA LYTMMKDQYA NYVVQKMIDM AEPAQRKIIM HKIRPHITTL RKYTYGKHIL 
AKLEKYYLKN SPDLGPIGGP PNGML

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.