Details for: ARHGEF18
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 3.4
Marker Score: 28,765 - Cell Name: retinal cone cell (CL0000573)
Fold Change: 2.26
Marker Score: 6,486 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: 2.15
Marker Score: 8,956 - Cell Name: erythroblast (CL0000765)
Fold Change: 2.14
Marker Score: 1,339 - Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 1.72
Marker Score: 7,177 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.72
Marker Score: 1,032 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.59
Marker Score: 1,158 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.23
Marker Score: 1,903 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.19
Marker Score: 11,266 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.14
Marker Score: 70,229 - Cell Name: neuron (CL0000540)
Fold Change: 1.13
Marker Score: 4,616 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.12
Marker Score: 9,601 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.06
Marker Score: 486 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,803 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,027 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.99
Marker Score: 9,318 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,407 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 501 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.96
Marker Score: 36,625 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 454 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.96
Marker Score: 830 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,411 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.94
Marker Score: 3,632 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.94
Marker Score: 34,499 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5,314 - Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 0.92
Marker Score: 2,585 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,740 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.91
Marker Score: 618 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.9
Marker Score: 6,893 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.89
Marker Score: 1,450 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.89
Marker Score: 321 - Cell Name: mesangial cell (CL0000650)
Fold Change: 0.89
Marker Score: 1,075 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.88
Marker Score: 13,146 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,292 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.84
Marker Score: 16,800 - Cell Name: acinar cell (CL0000622)
Fold Change: 0.84
Marker Score: 590 - Cell Name: renal principal cell (CL0005009)
Fold Change: 0.83
Marker Score: 639 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.82
Marker Score: 17,585 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 0.78
Marker Score: 3,631 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.78
Marker Score: 387 - Cell Name: lung goblet cell (CL1000143)
Fold Change: 0.78
Marker Score: 224 - Cell Name: goblet cell (CL0000160)
Fold Change: 0.77
Marker Score: 5,132 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.77
Marker Score: 586 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.76
Marker Score: 401 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.75
Marker Score: 316 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.75
Marker Score: 302 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.75
Marker Score: 390 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 0.72
Marker Score: 830 - Cell Name: brush cell (CL0002204)
Fold Change: 0.71
Marker Score: 651 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.71
Marker Score: 2,981 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 176 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.68
Marker Score: 2,800 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.64
Marker Score: 11,430 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 0.64
Marker Score: 248 - Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.63
Marker Score: 583 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.62
Marker Score: 199 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.61
Marker Score: 1,461 - Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 0.6
Marker Score: 191 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.6
Marker Score: 422 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.57
Marker Score: 367 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.57
Marker Score: 155 - Cell Name: astrocyte (CL0000127)
Fold Change: 0.56
Marker Score: 485 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.55
Marker Score: 1,296 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.51
Marker Score: 211 - Cell Name: hepatoblast (CL0005026)
Fold Change: 0.5
Marker Score: 1,647 - Cell Name: IgG plasma cell (CL0000985)
Fold Change: 0.5
Marker Score: 219 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.49
Marker Score: 294 - Cell Name: podocyte (CL0000653)
Fold Change: 0.49
Marker Score: 180 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.48
Marker Score: 149 - Cell Name: thymocyte (CL0000893)
Fold Change: 0.47
Marker Score: 489 - Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 0.46
Marker Score: 483 - Cell Name: lung ciliated cell (CL1000271)
Fold Change: 0.46
Marker Score: 218 - Cell Name: T-helper 17 cell (CL0000899)
Fold Change: 0.46
Marker Score: 300 - Cell Name: endocrine cell (CL0000163)
Fold Change: 0.45
Marker Score: 234 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.44
Marker Score: 441 - Cell Name: mucus secreting cell (CL0000319)
Fold Change: 0.44
Marker Score: 112 - Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.42
Marker Score: 154 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.42
Marker Score: 421 - Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.41
Marker Score: 204 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.41
Marker Score: 13,802 - Cell Name: enterocyte of colon (CL1000347)
Fold Change: 0.4
Marker Score: 613 - Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.4
Marker Score: 140 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.39
Marker Score: 1,117 - Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 0.39
Marker Score: 569 - Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.39
Marker Score: 302 - Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.38
Marker Score: 120 - Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 0.38
Marker Score: 1,973 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.36
Marker Score: 156 - Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 0.36
Marker Score: 1,005 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.36
Marker Score: 891 - Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.36
Marker Score: 293 - Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.35
Marker Score: 92 - Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 0.35
Marker Score: 93 - Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 0.35
Marker Score: 307 - Cell Name: stellate neuron (CL0000122)
Fold Change: 0.34
Marker Score: 1,850 - Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: 0.34
Marker Score: 207 - Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.34
Marker Score: 151 - Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.34
Marker Score: 116 - Cell Name: B cell (CL0000236)
Fold Change: 0.34
Marker Score: 320
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2623255305
Symbol: ARHGI_HUMAN
Name: Rho guanine nucleotide exchange factor 18
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9628581
Title: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
PubMed ID: 9628581
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11085924
Title: Identification and characterization of a novel Rho-specific guanine nucleotide exchange factor.
PubMed ID: 11085924
DOI: 10.1042/bj3520319
PubMed ID: 11318610
Title: A physical and transcript map of the MCOLN1 gene region on human chromosome 19p13.3-p13.2.
PubMed ID: 11318610
PubMed ID: 14512443
Title: G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production.
PubMed ID: 14512443
PubMed ID: 15558029
Title: Cytoskeletal modification of Rho guanine nucleotide exchange factor activity: identification of a Rho guanine nucleotide exchange factor as a binding partner for Sept9b, a mammalian septin.
PubMed ID: 15558029
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22006950
Title: Lulu2 regulates the circumferential actomyosin tensile system in epithelial cells through p114RhoGEF.
PubMed ID: 22006950
PubMed ID: 29601110
Title: Expression of novel 'LOCGEF' isoforms of ARHGEF18 in eosinophils.
PubMed ID: 29601110
PubMed ID: 28132693
Title: Biallelic mutation of ARHGEF18, involved in the determination of epithelial apicobasal polarity, causes adult-onset retinal degeneration.
PubMed ID: 28132693
Sequence Information:
- Length: 1361
- Mass: 151642
- Checksum: 3028B14BC119FBDC
- Sequence:
MGDDQEDDFP RRLSESMEDL SLDLGALQGS EYLQDLGLGA PSHSQPGETP DSRPTGEEPG RDSLFSSLAG SQDLSRRRSW ERSRSCSESW RRLSLDASAV DEEPCLPRTL ASLALNLPGG GLKTWTQGCL SGGGTPAESP GKECDSPKKR GRSRSVPVSF YEIRSPEISP GLEVPTPPVQ GLEPPVLECM EKDHVEPDHV LIVQQVLQEL RQYHGARQRA CMSASPGGAH SNLTWFEFLS ESEDGAGKNE KSDKSTSVKR RLSCLRSRVT RQKEKGKSPA HLKDKGQDAR ERRECVNGHQ LLQGTFSGPS SCPLCGKPFL SSASLKEHPR GTLLSDGSPA LSRNVGMTVS QKGGPQPTPS PAGPGTQLGP ITGEMDEADS AFLKFKQTAD DSLSLTSPNT ESIFVEDPYT ASLRSEIESD GHEFEAESWS LAVDAAYAKK QKREVVKRQD VLYELMQTEV HHVRTLKIML KVYSRALQEE LQFSSKAIGR LFPCADDLLE THSHFLARLK ERRQESLEEG SDRNYVIQKI GDLLVQQFSG ENGERMKEKY GVFCSGHNEA VSHYKLLLQQ NKKFQNLIKK IGNFSIVRRL GVQECILLVT QRITKYPVLV ERIIQNTEAG TEDYEDLTQA LNLIKDIISQ VDAKVSECEK GQRLREIAGK MDLKSSSKLK NGLTFRKEDM LQRQLHLEGM LCWKTTSGRL KDILAILLTD VLLLLQEKDQ KYVFASVDSK PPVISLQKLI VREVANEEKA MFLISASLQG PEMYEIYTSS KEDRNAWMAH IQRAVESCPD EEEGPFSLPE EERKVVEARA TRLRDFQERL SMKDQLIAQS LLEKQQIYLE MAEMGGLEDL PQPRGLFRGG DPSETLQGEL ILKSAMSEIE GIQSLICRQL GSANGQAEDG GSSTGPPRRA ETFAGYDCTN SPTKNGSFKK KVSSTDPRPR DWRGPPNSPD LKLSDSDIPG SSEESPQVVE APGTESDPRL PTVLESELVQ RIQTLSQLLL NLQAVIAHQD SYVETQRAAI QEREKQFRLQ STRGNLLLEQ ERQRNFEKQR EERAALEKLQ SQLRHEQQRW ERERQWQHQE LERAGARLQE REGEARQLRE RLEQERAELE RQRQAYQHDL ERLREAQRAV ERERERLELL RRLKKQNTAP GALPPDTLAE AQPPSHPPSF NGEGLEGPRV SMLPSGVGPE YAERPEVARR DSAPTENRLA KSDVPIQLLS ATNQFQRQAA VQQQIPTKLA ASTKGGKDKG GKSRGSQRWE SSASFDLKQQ LLLNKLMGKD ESTSRNRRSL SPILPGRHSP APPPDPGFPA PSPPPADSPS EGFSLKAGGT ALLPGPPAPS PLPATPLSAK EDASKEDVIF F
Genular Protein ID: 1467145282
Symbol: A0A087WZG4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
Sequence Information:
- Length: 1173
- Mass: 130780
- Checksum: D986A1F85D48EE24
- Sequence:
MVTVGTNILP SRPAASANTA REDAALFSRR IPPRHKNGAA QPGAAPGPGA PGANMGNAHS KSGDRHSALP GRPELSFYGS FPRKWSENVF LDNELLTSKI LSVLRPQSER GFRAGDLRYP THFLSTNSVL ASVTASLKEH PRGTLLSDGS PALSRNVGMT VSQKGGPQPT PSPAGPGTQL GPITGEMDEA DSAFLKFKQT ADDSLSLTSP NTESIFVEDP YTASLRSEIE SDGHEFEAES WSLAVDAAYA KKQKREVVKR QDVLYELMQT EVHHVRTLKI MLKVYSRALQ EELQFSSKAI GRLFPCADDL LETHSHFLAR LKERRQESLE EGSDRNYVIQ KIGDLLVQQF SGENGERMKE KYGVFCSGHN EAVSHYKLLL QQNKKFQNLI KKIGNFSIVR RLGVQECILL VTQRITKYPV LVERIIQNTE AGTEDYEDLT QALNLIKDII SQVDAKVSEC EKGQRLREIA GKMDLKSSSK LKNGLTFRKE DMLQRQLHLE GMLCWKTTSG RLKDILAILL TDVLLLLQEK DQKYVFASVD SKPPVISLQK LIVREVANEE KAMFLISASL QGPEMYEIYT SSKEDRNAWM AHIQRAVESC PDEEEGPFSL PEEERKVVEA RATRLRDFQE RLSMKDQLIA QSLLEKQQIY LEMAEMGGLE DLPQPRGLFR GGDPSETLQG ELILKSAMSE IEGIQSLICR QLGSANGQAE DGGSSTGPPR RAETFAGYDC TNSPTKNGSF KKKVSSTDPR PRDWRGPPNS PDLKLSDSDI PGSSEESPQV VEAPGTESDP RLPTVLESEL VQRIQTLSQL LLNLQAVIAH QDSYVETQRA AIQEREKQFR LQSTRGNLLL EQERQRNFEK QREERAALEK LQSQLRHEQQ RWERERQWQH QELERAGARL QEREGEARQL RERLEQERAE LERQRQAYQH DLERLREAQR AVERERERLE LLRRLKKQNT APGALPPDTL AEAQPPSHPP SFNGEGLEGP RVSMLPSGVG PEYAERPEVA RRDSAPTENR LAKSDVPIQL LSATNQFQRQ AAVQQQIPTK LAASTKGGKD KGGKSRGSQR WESSASFDLK QQLLLNKLMG KDESTSRNRR SLSPILPGRH SPAPPPDPGF PAPSPPPADS PSEGFSLKAG GTALLPGPPA PSPLPATPLS AKEDASKEDV IFF
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.