Details for: ARHGEF18

Gene ID: 23370

Symbol: ARHGEF18

Ensembl ID: ENSG00000104880

Description: Rho/Rac guanine nucleotide exchange factor 18

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.4
    Marker Score: 28,765
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.26
    Marker Score: 6,486
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 2.15
    Marker Score: 8,956
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 2.14
    Marker Score: 1,339
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.72
    Marker Score: 7,177
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.72
    Marker Score: 1,032
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1,158
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.23
    Marker Score: 1,903
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.19
    Marker Score: 11,266
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.14
    Marker Score: 70,229
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.13
    Marker Score: 4,616
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.12
    Marker Score: 9,601
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.06
    Marker Score: 486
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,803
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,027
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.99
    Marker Score: 9,318
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.96
    Marker Score: 36,625
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.96
    Marker Score: 830
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.94
    Marker Score: 3,632
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.94
    Marker Score: 34,499
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,314
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.92
    Marker Score: 2,585
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,740
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.91
    Marker Score: 618
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.9
    Marker Score: 6,893
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.89
    Marker Score: 1,450
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.89
    Marker Score: 1,075
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.88
    Marker Score: 13,146
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,292
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.84
    Marker Score: 16,800
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.84
    Marker Score: 590
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.83
    Marker Score: 639
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.82
    Marker Score: 17,585
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.78
    Marker Score: 3,631
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.78
    Marker Score: 387
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.78
    Marker Score: 224
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.77
    Marker Score: 5,132
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 586
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.76
    Marker Score: 401
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.75
    Marker Score: 316
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 302
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.72
    Marker Score: 830
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 651
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2,981
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.68
    Marker Score: 2,800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.64
    Marker Score: 11,430
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.64
    Marker Score: 248
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.63
    Marker Score: 583
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.62
    Marker Score: 199
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.61
    Marker Score: 1,461
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.6
    Marker Score: 191
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.6
    Marker Score: 422
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.57
    Marker Score: 367
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.57
    Marker Score: 155
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.56
    Marker Score: 485
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.55
    Marker Score: 1,296
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.51
    Marker Score: 211
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.5
    Marker Score: 1,647
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.5
    Marker Score: 219
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.49
    Marker Score: 294
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.49
    Marker Score: 180
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.48
    Marker Score: 149
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.47
    Marker Score: 489
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.46
    Marker Score: 483
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.46
    Marker Score: 218
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.46
    Marker Score: 300
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.45
    Marker Score: 234
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.44
    Marker Score: 441
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.44
    Marker Score: 112
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.42
    Marker Score: 154
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.42
    Marker Score: 421
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.41
    Marker Score: 204
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.41
    Marker Score: 13,802
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.4
    Marker Score: 613
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.4
    Marker Score: 140
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.39
    Marker Score: 1,117
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.39
    Marker Score: 569
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.39
    Marker Score: 302
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.38
    Marker Score: 120
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.38
    Marker Score: 1,973
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.36
    Marker Score: 156
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.36
    Marker Score: 1,005
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.36
    Marker Score: 891
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.36
    Marker Score: 293
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.35
    Marker Score: 92
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.35
    Marker Score: 93
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.35
    Marker Score: 307
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.34
    Marker Score: 1,850
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.34
    Marker Score: 207
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.34
    Marker Score: 151
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.34
    Marker Score: 116
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.34
    Marker Score: 320

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The ARHGEF18 gene exhibits the following key characteristics: 1. **Guanine nucleotide exchange factor activity**: ARHGEF18 possesses the ability to exchange GDP for GTP on Rho and Rac GTPases, thereby activating these GTPases and regulating their downstream signaling pathways. 2. **Rho/Rac GTPase cycle regulation**: ARHGEF18 plays a critical role in regulating the Rho/Rac GTPase cycle, which is essential for various cellular processes, including actin cytoskeleton organization, cell shape regulation, and signaling pathways involved in cell death and EMT. 3. **Cell death signaling**: ARHGEF18 is involved in cell death signaling pathways, including those mediated by the N-ratione (nrage) and N-raf (nrif) proteins. 4. **Epithelial to mesenchymal transition (EMT)**: ARHGEF18 is also involved in EMT, a process by which epithelial cells undergo a phenotypic change to become mesenchymal cells. **Pathways and Functions** The ARHGEF18 gene is involved in various signaling pathways, including: 1. **Actin cytoskeleton organization**: ARHGEF18 regulates the organization of the actin cytoskeleton, which is essential for cell shape, motility, and intracellular transport. 2. **Apical part of cell**: ARHGEF18 is involved in the regulation of the apical part of the cell, including the organization of the apical plasma membrane and the cytoskeleton. 3. **Cell death signaling**: ARHGEF18 is involved in cell death signaling pathways, including those mediated by the N-ratione (nrage) and N-raf (nrif) proteins. 4. **Epithelial to mesenchymal transition (EMT)**: ARHGEF18 is involved in EMT, a process by which epithelial cells undergo a phenotypic change to become mesenchymal cells. 5. **G alpha (12/13) signaling events**: ARHGEF18 is involved in G alpha (12/13) signaling events, which are essential for various cellular processes, including cell growth and differentiation. 6. **Gpcr downstream signaling**: ARHGEF18 is involved in G protein-coupled receptor (Gpcr) downstream signaling, which is essential for various cellular processes, including cell growth and differentiation. 7. **Rac1 GTPase cycle**: ARHGEF18 regulates the Rac1 GTPase cycle, which is essential for various cellular processes, including actin cytoskeleton organization and cell shape regulation. **Clinical Significance** The ARHGEF18 gene has been implicated in various diseases and disorders, including: 1. **Neurological disorders**: ARHGEF18 has been implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Cancer**: ARHGEF18 has been implicated in cancer, including breast cancer, lung cancer, and colon cancer. 3. **Neurodevelopmental disorders**: ARHGEF18 has been implicated in neurodevelopmental disorders, including autism spectrum disorder and schizophrenia. 4. **Eye diseases**: ARHGEF18 has been implicated in eye diseases, including age-related macular degeneration and retinitis pigmentosa. In conclusion, the ARHGEF18 gene plays a crucial role in various cellular processes, including actin cytoskeleton organization, cell shape regulation, and signaling pathways involved in cell death, stress fiber assembly, and EMT. The clinical significance of ARHGEF18 has been implicated in various diseases and disorders, highlighting the importance of further research into the function and regulation of this gene.

Genular Protein ID: 2623255305

Symbol: ARHGI_HUMAN

Name: Rho guanine nucleotide exchange factor 18

UniProtKB Accession Codes:

Q6ZSZ5 A8MV62 B5ME81 I3L1I5 O60274 Q6DD92

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 2 CCDS 2 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 8 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 2 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9628581

Title: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9628581

DOI: 10.1093/dnares/5.1.31

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11085924

Title: Identification and characterization of a novel Rho-specific guanine nucleotide exchange factor.

PubMed ID: 11085924

DOI: 10.1042/bj3520319

PubMed ID: 11318610

Title: A physical and transcript map of the MCOLN1 gene region on human chromosome 19p13.3-p13.2.

PubMed ID: 11318610

DOI: 10.1006/geno.2001.6526

PubMed ID: 14512443

Title: G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production.

PubMed ID: 14512443

DOI: 10.1161/01.res.0000097607.14733.0c

PubMed ID: 15558029

Title: Cytoskeletal modification of Rho guanine nucleotide exchange factor activity: identification of a Rho guanine nucleotide exchange factor as a binding partner for Sept9b, a mammalian septin.

PubMed ID: 15558029

DOI: 10.1038/sj.onc.1208101

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22006950

Title: Lulu2 regulates the circumferential actomyosin tensile system in epithelial cells through p114RhoGEF.

PubMed ID: 22006950

DOI: 10.1083/jcb.201104118

PubMed ID: 29601110

Title: Expression of novel 'LOCGEF' isoforms of ARHGEF18 in eosinophils.

PubMed ID: 29601110

DOI: 10.1002/jlb.2ma1017-418rr

PubMed ID: 28132693

Title: Biallelic mutation of ARHGEF18, involved in the determination of epithelial apicobasal polarity, causes adult-onset retinal degeneration.

PubMed ID: 28132693

DOI: 10.1016/j.ajhg.2016.12.014

Sequence Information:

  • Length: 1361
  • Mass: 151642
  • Checksum: 3028B14BC119FBDC
  • Sequence:
    • MGDDQEDDFP RRLSESMEDL SLDLGALQGS EYLQDLGLGA PSHSQPGETP DSRPTGEEPG 
RDSLFSSLAG SQDLSRRRSW ERSRSCSESW RRLSLDASAV DEEPCLPRTL ASLALNLPGG 
GLKTWTQGCL SGGGTPAESP GKECDSPKKR GRSRSVPVSF YEIRSPEISP GLEVPTPPVQ 
GLEPPVLECM EKDHVEPDHV LIVQQVLQEL RQYHGARQRA CMSASPGGAH SNLTWFEFLS 
ESEDGAGKNE KSDKSTSVKR RLSCLRSRVT RQKEKGKSPA HLKDKGQDAR ERRECVNGHQ 
LLQGTFSGPS SCPLCGKPFL SSASLKEHPR GTLLSDGSPA LSRNVGMTVS QKGGPQPTPS 
PAGPGTQLGP ITGEMDEADS AFLKFKQTAD DSLSLTSPNT ESIFVEDPYT ASLRSEIESD 
GHEFEAESWS LAVDAAYAKK QKREVVKRQD VLYELMQTEV HHVRTLKIML KVYSRALQEE 
LQFSSKAIGR LFPCADDLLE THSHFLARLK ERRQESLEEG SDRNYVIQKI GDLLVQQFSG 
ENGERMKEKY GVFCSGHNEA VSHYKLLLQQ NKKFQNLIKK IGNFSIVRRL GVQECILLVT 
QRITKYPVLV ERIIQNTEAG TEDYEDLTQA LNLIKDIISQ VDAKVSECEK GQRLREIAGK 
MDLKSSSKLK NGLTFRKEDM LQRQLHLEGM LCWKTTSGRL KDILAILLTD VLLLLQEKDQ 
KYVFASVDSK PPVISLQKLI VREVANEEKA MFLISASLQG PEMYEIYTSS KEDRNAWMAH 
IQRAVESCPD EEEGPFSLPE EERKVVEARA TRLRDFQERL SMKDQLIAQS LLEKQQIYLE 
MAEMGGLEDL PQPRGLFRGG DPSETLQGEL ILKSAMSEIE GIQSLICRQL GSANGQAEDG 
GSSTGPPRRA ETFAGYDCTN SPTKNGSFKK KVSSTDPRPR DWRGPPNSPD LKLSDSDIPG 
SSEESPQVVE APGTESDPRL PTVLESELVQ RIQTLSQLLL NLQAVIAHQD SYVETQRAAI 
QEREKQFRLQ STRGNLLLEQ ERQRNFEKQR EERAALEKLQ SQLRHEQQRW ERERQWQHQE 
LERAGARLQE REGEARQLRE RLEQERAELE RQRQAYQHDL ERLREAQRAV ERERERLELL 
RRLKKQNTAP GALPPDTLAE AQPPSHPPSF NGEGLEGPRV SMLPSGVGPE YAERPEVARR 
DSAPTENRLA KSDVPIQLLS ATNQFQRQAA VQQQIPTKLA ASTKGGKDKG GKSRGSQRWE 
SSASFDLKQQ LLLNKLMGKD ESTSRNRRSL SPILPGRHSP APPPDPGFPA PSPPPADSPS 
EGFSLKAGGT ALLPGPPAPS PLPATPLSAK EDASKEDVIF F

Genular Protein ID: 1467145282

Symbol: A0A087WZG4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WZG4

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioMuta 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 2 HGNC 1 HOGENOM 1 InterPro 6 KEGG 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PROSITE 4 PaxDb 1 PeptideAtlas 1 Pfam 2 Proteomes 2 RNAct 1 RefSeq 1 SAM 2 SMART 2 SMR 1 STRING 1 SUPFAM 2 UCSC 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

Sequence Information:

  • Length: 1173
  • Mass: 130780
  • Checksum: D986A1F85D48EE24
  • Sequence:
    • MVTVGTNILP SRPAASANTA REDAALFSRR IPPRHKNGAA QPGAAPGPGA PGANMGNAHS 
KSGDRHSALP GRPELSFYGS FPRKWSENVF LDNELLTSKI LSVLRPQSER GFRAGDLRYP 
THFLSTNSVL ASVTASLKEH PRGTLLSDGS PALSRNVGMT VSQKGGPQPT PSPAGPGTQL 
GPITGEMDEA DSAFLKFKQT ADDSLSLTSP NTESIFVEDP YTASLRSEIE SDGHEFEAES 
WSLAVDAAYA KKQKREVVKR QDVLYELMQT EVHHVRTLKI MLKVYSRALQ EELQFSSKAI 
GRLFPCADDL LETHSHFLAR LKERRQESLE EGSDRNYVIQ KIGDLLVQQF SGENGERMKE 
KYGVFCSGHN EAVSHYKLLL QQNKKFQNLI KKIGNFSIVR RLGVQECILL VTQRITKYPV 
LVERIIQNTE AGTEDYEDLT QALNLIKDII SQVDAKVSEC EKGQRLREIA GKMDLKSSSK 
LKNGLTFRKE DMLQRQLHLE GMLCWKTTSG RLKDILAILL TDVLLLLQEK DQKYVFASVD 
SKPPVISLQK LIVREVANEE KAMFLISASL QGPEMYEIYT SSKEDRNAWM AHIQRAVESC 
PDEEEGPFSL PEEERKVVEA RATRLRDFQE RLSMKDQLIA QSLLEKQQIY LEMAEMGGLE 
DLPQPRGLFR GGDPSETLQG ELILKSAMSE IEGIQSLICR QLGSANGQAE DGGSSTGPPR 
RAETFAGYDC TNSPTKNGSF KKKVSSTDPR PRDWRGPPNS PDLKLSDSDI PGSSEESPQV 
VEAPGTESDP RLPTVLESEL VQRIQTLSQL LLNLQAVIAH QDSYVETQRA AIQEREKQFR 
LQSTRGNLLL EQERQRNFEK QREERAALEK LQSQLRHEQQ RWERERQWQH QELERAGARL 
QEREGEARQL RERLEQERAE LERQRQAYQH DLERLREAQR AVERERERLE LLRRLKKQNT 
APGALPPDTL AEAQPPSHPP SFNGEGLEGP RVSMLPSGVG PEYAERPEVA RRDSAPTENR 
LAKSDVPIQL LSATNQFQRQ AAVQQQIPTK LAASTKGGKD KGGKSRGSQR WESSASFDLK 
QQLLLNKLMG KDESTSRNRR SLSPILPGRH SPAPPPDPGF PAPSPPPADS PSEGFSLKAG 
GTALLPGPPA PSPLPATPLS AKEDASKEDV IFF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.