Details for: TNS2

Gene ID: 23371

Symbol: TNS2

Ensembl ID: ENSG00000111077

Description: tensin 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 3.85
    Marker Score: 1,867
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 2.71
    Marker Score: 36,068
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.66
    Marker Score: 3,063
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.25
    Marker Score: 1,256
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.91
    Marker Score: 1,823
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.69
    Marker Score: 388
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.62
    Marker Score: 377
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.57
    Marker Score: 853
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.56
    Marker Score: 3,970
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.54
    Marker Score: 920
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.53
    Marker Score: 13,471
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.53
    Marker Score: 1,910
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.53
    Marker Score: 479
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.51
    Marker Score: 1,611
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.5
    Marker Score: 2,894
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.43
    Marker Score: 3,376
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.42
    Marker Score: 935
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.38
    Marker Score: 505
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.38
    Marker Score: 982
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.34
    Marker Score: 2,685
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.3
    Marker Score: 2,450
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.3
    Marker Score: 313
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.29
    Marker Score: 1,872
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.28
    Marker Score: 316
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.22
    Marker Score: 19,088
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.21
    Marker Score: 1,040
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.15
    Marker Score: 651
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.08
    Marker Score: 316
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.07
    Marker Score: 314
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.06
    Marker Score: 2,764
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.05
    Marker Score: 13,888
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.03
    Marker Score: 1,103
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.03
    Marker Score: 929
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 785
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.02
    Marker Score: 22,898
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.01
    Marker Score: 21,662
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1
    Marker Score: 940
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,774
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,998
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.99
    Marker Score: 211
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.98
    Marker Score: 1,318
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.98
    Marker Score: 361
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.97
    Marker Score: 641
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.97
    Marker Score: 246
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.97
    Marker Score: 636
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.96
    Marker Score: 4,024
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,410
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.94
    Marker Score: 10,643
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.93
    Marker Score: 5,617
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.93
    Marker Score: 1,887
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,730
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.9
    Marker Score: 965
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.89
    Marker Score: 5,791
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.89
    Marker Score: 1,368
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.88
    Marker Score: 1,670
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5,011
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.87
    Marker Score: 417
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,273
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.86
    Marker Score: 326
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.86
    Marker Score: 5,551
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.84
    Marker Score: 239
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.83
    Marker Score: 3,587
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.83
    Marker Score: 1,199
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.82
    Marker Score: 1,020
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.82
    Marker Score: 481
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.8
    Marker Score: 4,320
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.8
    Marker Score: 774
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 318
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.78
    Marker Score: 216
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.78
    Marker Score: 252
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.78
    Marker Score: 1,871
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,264
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.78
    Marker Score: 204
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.76
    Marker Score: 685
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.75
    Marker Score: 195
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.75
    Marker Score: 2,665
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.74
    Marker Score: 1,259
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 675
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.73
    Marker Score: 439
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.73
    Marker Score: 406
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.73
    Marker Score: 4,739
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.72
    Marker Score: 1,153
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.72
    Marker Score: 1,760
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.71
    Marker Score: 224
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2,966
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.7
    Marker Score: 3,011
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.7
    Marker Score: 178
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.69
    Marker Score: 23,646
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.68
    Marker Score: 180
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.68
    Marker Score: 149
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.68
    Marker Score: 1,599
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.68
    Marker Score: 234
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.67
    Marker Score: 669
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.67
    Marker Score: 810

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular localization:** TNS2 is a cytoplasmic protein, primarily localized to the focal adhesion complex, where it interacts with various proteins to regulate cell adhesion and signaling. 2. **Protein binding:** TNS2 interacts with multiple proteins, including integrins, p120 catenin, and Src family kinases, to regulate cell adhesion, migration, and signaling. 3. **Signaling pathways:** TNS2 modulates signaling pathways involved in cellular growth, differentiation, and apoptosis, including the insulin receptor signaling pathway and the negative regulation of cell population proliferation. 4. **Expression patterns:** TNS2 is significantly expressed in various cell types, including cardiac muscle cells, vascular endothelial cells, and adipocytes, highlighting its importance in maintaining tissue homeostasis and organ function. **Pathways and Functions:** 1. **Focal adhesion:** TNS2 regulates cell adhesion and migration through its interaction with focal adhesion proteins, such as integrins and p120 catenin. 2. **Cellular growth and differentiation:** TNS2 modulates signaling pathways involved in cellular growth, differentiation, and apoptosis, including the insulin receptor signaling pathway. 3. **Cellular survival:** TNS2 regulates cell survival by modulating the activity of pro-survival and pro-apoptotic proteins. 4. **Organ function:** TNS2 plays a crucial role in maintaining organ function, particularly in the cardiovascular system, where it regulates cardiac muscle cell function and vascular endothelial cell function. **Clinical Significance:** 1. **Cardiovascular disease:** Abnormal expression of TNS2 has been linked to cardiovascular disease, including hypertension, atherosclerosis, and cardiac arrhythmias. 2. **Cancer:** TNS2 has been implicated in cancer development and progression, particularly in epithelial cancers, where it regulates cell adhesion, migration, and invasion. 3. **Metabolic disorders:** TNS2 has been linked to metabolic disorders, including type 2 diabetes, where it regulates insulin receptor signaling and glucose metabolism. 4. **Neurological disorders:** TNS2 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease, where it regulates cellular adhesion and signaling. In conclusion, TNS2 is a multifaceted protein that plays a crucial role in maintaining cellular homeostasis and organ function. Its dysregulation has been linked to various diseases, including cardiovascular disease, cancer, metabolic disorders, and neurological disorders. Further research is needed to fully elucidate the mechanisms by which TNS2 regulates cellular function and to identify potential therapeutic targets for the treatment of these diseases.

Genular Protein ID: 1842464913

Symbol: TENS2_HUMAN

Name: Tensin-2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 12470648

Title: Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin.

PubMed ID: 12470648

DOI: 10.1016/s0006-291x(02)02718-3

PubMed ID: 11792844

Title: Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration.

PubMed ID: 11792844

DOI: 10.1073/pnas.022518699

PubMed ID: 10470851

Title: Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10470851

DOI: 10.1093/dnares/6.3.197

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15817639

Title: C1-TEN is a negative regulator of the Akt/PKB signal transduction pathway and inhibits cell survival, proliferation, and migration.

PubMed ID: 15817639

DOI: 10.1096/fj.04-2532fje

PubMed ID: 20069572

Title: Tensin 2 modulates cell contractility in 3D collagen gels through the RhoGAP DLC1.

PubMed ID: 20069572

DOI: 10.1002/jcb.22460

PubMed ID: 22019427

Title: The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2.

PubMed ID: 22019427

DOI: 10.1016/j.bbamcr.2011.10.001

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23401856

Title: C1-Ten is a protein tyrosine phosphatase of insulin receptor substrate 1 (IRS-1), regulating IRS-1 stability and muscle atrophy.

PubMed ID: 23401856

DOI: 10.1128/mcb.01447-12

PubMed ID: 25101860

Title: Regulation of C1-Ten protein tyrosine phosphatase by p62/SQSTM1-mediated sequestration and degradation.

PubMed ID: 25101860

DOI: 10.1016/j.cellsig.2014.07.033

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26427649

Title: Tensin1 positively regulates RhoA activity through its interaction with DLC1.

PubMed ID: 26427649

DOI: 10.1016/j.bbamcr.2015.09.028

PubMed ID: 29866430

Title:

PubMed ID: 29866430

DOI: 10.1016/j.bbamcr.2018.05.016

PubMed ID: 28955049

Title: C1-Ten is a PTPase of nephrin, regulating podocyte hypertrophy through mTORC1 activation.

PubMed ID: 28955049

DOI: 10.1038/s41598-017-12382-8

PubMed ID: 30092354

Title: Cellular phosphatase activity of C1-Ten/Tensin2 is controlled by Phosphatidylinositol-3,4,5-triphosphate binding through the C1-Ten/Tensin2 SH2 domain.

PubMed ID: 30092354

DOI: 10.1016/j.cellsig.2018.07.009

Sequence Information:

  • Length: 1409
  • Mass: 152580
  • Checksum: 67824299A1382140
  • Sequence:
  • MKSSGPVERL LRALGRRDSS RAASRPRKAE PHSFREKVFR KKPPVCAVCK VTIDGTGVSC 
    RVCKVATHRK CEAKVTSACQ ALPPVELRRN TAPVRRIEHL GSTKSLNHSK QRSTLPRSFS 
    LDPLMERRWD LDLTYVTERI LAAAFPARPD EQRHRGHLRE LAHVLQSKHR DKYLLFNLSE 
    KRHDLTRLNP KVQDFGWPEL HAPPLDKLCS ICKAMETWLS ADPQHVVVLY CKGNKGKLGV 
    IVSAYMHYSK ISAGADQALA TLTMRKFCED KVATELQPSQ RRYISYFSGL LSGSIRMNSS 
    PLFLHYVLIP MLPAFEPGTG FQPFLKIYQS MQLVYTSGVY HIAGPGPQQL CISLEPALLL 
    KGDVMVTCYH KGGRGTDRTL VFRVQFHTCT IHGPQLTFPK DQLDEAWTDE RFPFQASVEF 
    VFSSSPEKIK GSTPRNDPSV SVDYNTTEPA VRWDSYENFN QHHEDSVDGS LTHTRGPLDG 
    SPYAQVQRPP RQTPPAPSPE PPPPPMLSVS SDSGHSSTLT TEPAAESPGR PPPTAAERQE 
    LDRLLGGCGV ASGGRGAGRE TAILDDEEQP TVGGGPHLGV YPGHRPGLSR HCSCRQGYRE 
    PCGVPNGGYY RPEGTLERRR LAYGGYEGSP QGYAEASMEK RRLCRSLSEG LYPYPPEMGK 
    PATGDFGYRA PGYREVVILE DPGLPALYPC PACEEKLALP TAALYGLRLE REAGEGWASE 
    AGKPLLHPVR PGHPLPLLLP ACGHHHAPMP DYSCLKPPKA GEEGHEGCSY TMCPEGRYGH 
    PGYPALVTYS YGGAVPSYCP AYGRVPHSCG SPGEGRGYPS PGAHSPRAGS ISPGSPPYPQ 
    SRKLSYEIPT EEGGDRYPLP GHLASAGPLA SAESLEPVSW REGPSGHSTL PRSPRDAPCS 
    ASSELSGPST PLHTSSPVQG KESTRRQDTR SPTSAPTQRL SPGEALPPVS QAGTGKAPEL 
    PSGSGPEPLA PSPVSPTFPP SSPSDWPQER SPGGHSDGAS PRSPVPTTLP GLRHAPWQGP 
    RGPPDSPDGS PLTPVPSQMP WLVASPEPPQ SSPTPAFPLA ASYDTNGLSQ PPLPEKRHLP 
    GPGQQPGPWG PEQASSPARG ISHHVTFAPL LSDNVPQTPE PPTQESQSNV KFVQDTSKFW 
    YKPHLSRDQA IALLKDKDPG AFLIRDSHSF QGAYGLALKV ATPPPSAQPW KGDPVEQLVR 
    HFLIETGPKG VKIKGCPSEP YFGSLSALVS QHSISPISLP CCLRIPSKDP LEETPEAPVP 
    TNMSTAADLL RQGAACSVLY LTSVETESLT GPQAVARASS AALSCSPRPT PAVVHFKVSA 
    QGITLTDNQR KLFFRRHYPV NSITFSSTDP QDRRWTNPDG TTSKIFGFVA KKPGSPWENV 
    CHLFAELDPD QPAGAIVTFI TKVLLGQRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.