Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 3.85
Marker Score: 1,867 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 2.71
Marker Score: 36,068 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 2.66
Marker Score: 3,063 - Cell Name: fat cell (CL0000136)
Fold Change: 2.25
Marker Score: 1,256 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.91
Marker Score: 1,823 - Cell Name: keratocyte (CL0002363)
Fold Change: 1.69
Marker Score: 388 - Cell Name: peritubular capillary endothelial cell (CL1001033)
Fold Change: 1.62
Marker Score: 377 - Cell Name: contractile cell (CL0000183)
Fold Change: 1.57
Marker Score: 853 - Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 1.56
Marker Score: 3,970 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.54
Marker Score: 920 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.53
Marker Score: 13,471 - Cell Name: cardiac neuron (CL0010022)
Fold Change: 1.53
Marker Score: 1,910 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.53
Marker Score: 479 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.51
Marker Score: 1,611 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 1.5
Marker Score: 2,894 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.43
Marker Score: 3,376 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 1.42
Marker Score: 935 - Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 1.38
Marker Score: 505 - Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 1.38
Marker Score: 982 - Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.34
Marker Score: 2,685 - Cell Name: supporting cell (CL0000630)
Fold Change: 1.3
Marker Score: 2,450 - Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 1.3
Marker Score: 313 - Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 1.29
Marker Score: 1,872 - Cell Name: adventitial cell (CL0002503)
Fold Change: 1.28
Marker Score: 316 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.22
Marker Score: 19,088 - Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 1.21
Marker Score: 1,040 - Cell Name: endocardial cell (CL0002350)
Fold Change: 1.15
Marker Score: 651 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.08
Marker Score: 316 - Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 1.07
Marker Score: 314 - Cell Name: fibroblast of lung (CL0002553)
Fold Change: 1.06
Marker Score: 2,764 - Cell Name: mesodermal cell (CL0000222)
Fold Change: 1.05
Marker Score: 13,888 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.03
Marker Score: 1,103 - Cell Name: vein endothelial cell (CL0002543)
Fold Change: 1.03
Marker Score: 929 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.03
Marker Score: 785 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 1.02
Marker Score: 22,898 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.01
Marker Score: 21,662 - Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 1
Marker Score: 940 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,774 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47,998 - Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 0.99
Marker Score: 211 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,406 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.98
Marker Score: 1,318 - Cell Name: podocyte (CL0000653)
Fold Change: 0.98
Marker Score: 361 - Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.97
Marker Score: 641 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 501 - Cell Name: glomerular endothelial cell (CL0002188)
Fold Change: 0.97
Marker Score: 246 - Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.97
Marker Score: 636 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 456 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.96
Marker Score: 4,024 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,410 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.94
Marker Score: 10,643 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.93
Marker Score: 5,617 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.93
Marker Score: 1,887 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,730 - Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 0.9
Marker Score: 965 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 322 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.89
Marker Score: 5,791 - Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.89
Marker Score: 1,368 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.88
Marker Score: 1,670 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.88
Marker Score: 5,011 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.87
Marker Score: 417 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,273 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.86
Marker Score: 326 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.86
Marker Score: 5,551 - Cell Name: preosteoblast (CL0007010)
Fold Change: 0.84
Marker Score: 239 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.83
Marker Score: 3,587 - Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 0.83
Marker Score: 1,199 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.82
Marker Score: 1,020 - Cell Name: pericyte (CL0000669)
Fold Change: 0.82
Marker Score: 481 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.8
Marker Score: 4,320 - Cell Name: fibroblast (CL0000057)
Fold Change: 0.8
Marker Score: 774 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.79
Marker Score: 318 - Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.78
Marker Score: 216 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.78
Marker Score: 252 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.78
Marker Score: 1,871 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,264 - Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 0.78
Marker Score: 204 - Cell Name: endothelial cell (CL0000115)
Fold Change: 0.76
Marker Score: 685 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 391 - Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.75
Marker Score: 195 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 0.75
Marker Score: 2,665 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.74
Marker Score: 1,259 - Cell Name: brush cell (CL0002204)
Fold Change: 0.74
Marker Score: 675 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.73
Marker Score: 439 - Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 0.73
Marker Score: 406 - Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.73
Marker Score: 4,739 - Cell Name: pneumocyte (CL0000322)
Fold Change: 0.72
Marker Score: 1,153 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.72
Marker Score: 1,760 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.71
Marker Score: 224 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.71
Marker Score: 2,966 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 179 - Cell Name: decidual cell (CL2000002)
Fold Change: 0.7
Marker Score: 3,011 - Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 0.7
Marker Score: 178 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.69
Marker Score: 23,646 - Cell Name: vasa recta ascending limb cell (CL1001131)
Fold Change: 0.68
Marker Score: 180 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.68
Marker Score: 149 - Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.68
Marker Score: 1,599 - Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 0.68
Marker Score: 234 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.67
Marker Score: 669 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.67
Marker Score: 810
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1842464913
Symbol: TENS2_HUMAN
Name: Tensin-2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 12470648
Title: Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin.
PubMed ID: 12470648
PubMed ID: 11792844
Title: Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration.
PubMed ID: 11792844
PubMed ID: 10470851
Title: Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 10470851
PubMed ID: 12168954
Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
PubMed ID: 12168954
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15817639
Title: C1-TEN is a negative regulator of the Akt/PKB signal transduction pathway and inhibits cell survival, proliferation, and migration.
PubMed ID: 15817639
PubMed ID: 20069572
Title: Tensin 2 modulates cell contractility in 3D collagen gels through the RhoGAP DLC1.
PubMed ID: 20069572
DOI: 10.1002/jcb.22460
PubMed ID: 22019427
Title: The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2.
PubMed ID: 22019427
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23401856
Title: C1-Ten is a protein tyrosine phosphatase of insulin receptor substrate 1 (IRS-1), regulating IRS-1 stability and muscle atrophy.
PubMed ID: 23401856
DOI: 10.1128/mcb.01447-12
PubMed ID: 25101860
Title: Regulation of C1-Ten protein tyrosine phosphatase by p62/SQSTM1-mediated sequestration and degradation.
PubMed ID: 25101860
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 26427649
Title: Tensin1 positively regulates RhoA activity through its interaction with DLC1.
PubMed ID: 26427649
PubMed ID: 29866430
PubMed ID: 28955049
Title: C1-Ten is a PTPase of nephrin, regulating podocyte hypertrophy through mTORC1 activation.
PubMed ID: 28955049
PubMed ID: 30092354
Title: Cellular phosphatase activity of C1-Ten/Tensin2 is controlled by Phosphatidylinositol-3,4,5-triphosphate binding through the C1-Ten/Tensin2 SH2 domain.
PubMed ID: 30092354
Sequence Information:
- Length: 1409
- Mass: 152580
- Checksum: 67824299A1382140
- Sequence:
MKSSGPVERL LRALGRRDSS RAASRPRKAE PHSFREKVFR KKPPVCAVCK VTIDGTGVSC RVCKVATHRK CEAKVTSACQ ALPPVELRRN TAPVRRIEHL GSTKSLNHSK QRSTLPRSFS LDPLMERRWD LDLTYVTERI LAAAFPARPD EQRHRGHLRE LAHVLQSKHR DKYLLFNLSE KRHDLTRLNP KVQDFGWPEL HAPPLDKLCS ICKAMETWLS ADPQHVVVLY CKGNKGKLGV IVSAYMHYSK ISAGADQALA TLTMRKFCED KVATELQPSQ RRYISYFSGL LSGSIRMNSS PLFLHYVLIP MLPAFEPGTG FQPFLKIYQS MQLVYTSGVY HIAGPGPQQL CISLEPALLL KGDVMVTCYH KGGRGTDRTL VFRVQFHTCT IHGPQLTFPK DQLDEAWTDE RFPFQASVEF VFSSSPEKIK GSTPRNDPSV SVDYNTTEPA VRWDSYENFN QHHEDSVDGS LTHTRGPLDG SPYAQVQRPP RQTPPAPSPE PPPPPMLSVS SDSGHSSTLT TEPAAESPGR PPPTAAERQE LDRLLGGCGV ASGGRGAGRE TAILDDEEQP TVGGGPHLGV YPGHRPGLSR HCSCRQGYRE PCGVPNGGYY RPEGTLERRR LAYGGYEGSP QGYAEASMEK RRLCRSLSEG LYPYPPEMGK PATGDFGYRA PGYREVVILE DPGLPALYPC PACEEKLALP TAALYGLRLE REAGEGWASE AGKPLLHPVR PGHPLPLLLP ACGHHHAPMP DYSCLKPPKA GEEGHEGCSY TMCPEGRYGH PGYPALVTYS YGGAVPSYCP AYGRVPHSCG SPGEGRGYPS PGAHSPRAGS ISPGSPPYPQ SRKLSYEIPT EEGGDRYPLP GHLASAGPLA SAESLEPVSW REGPSGHSTL PRSPRDAPCS ASSELSGPST PLHTSSPVQG KESTRRQDTR SPTSAPTQRL SPGEALPPVS QAGTGKAPEL PSGSGPEPLA PSPVSPTFPP SSPSDWPQER SPGGHSDGAS PRSPVPTTLP GLRHAPWQGP RGPPDSPDGS PLTPVPSQMP WLVASPEPPQ SSPTPAFPLA ASYDTNGLSQ PPLPEKRHLP GPGQQPGPWG PEQASSPARG ISHHVTFAPL LSDNVPQTPE PPTQESQSNV KFVQDTSKFW YKPHLSRDQA IALLKDKDPG AFLIRDSHSF QGAYGLALKV ATPPPSAQPW KGDPVEQLVR HFLIETGPKG VKIKGCPSEP YFGSLSALVS QHSISPISLP CCLRIPSKDP LEETPEAPVP TNMSTAADLL RQGAACSVLY LTSVETESLT GPQAVARASS AALSCSPRPT PAVVHFKVSA QGITLTDNQR KLFFRRHYPV NSITFSSTDP QDRRWTNPDG TTSKIFGFVA KKPGSPWENV CHLFAELDPD QPAGAIVTFI TKVLLGQRK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.