Details for: CRTC1
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.78
Marker Score: 67,656 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.74
Marker Score: 107,011 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.73
Marker Score: 25,878 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.72
Marker Score: 13,162 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.7
Marker Score: 16,109 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.66
Marker Score: 6,401 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.64
Marker Score: 1,813 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.63
Marker Score: 15,306 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.6
Marker Score: 13,718 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.59
Marker Score: 58,814 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.59
Marker Score: 33,880 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.57
Marker Score: 31,169 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.51
Marker Score: 6,279 - Cell Name: neuron (CL0000540)
Fold Change: 1.5
Marker Score: 6,112 - Cell Name: mesangial cell (CL0000650)
Fold Change: 1.5
Marker Score: 1,809 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 1.5
Marker Score: 4,275 - Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168,606 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.42
Marker Score: 14,714 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.37
Marker Score: 2,122 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: 1.29
Marker Score: 2,165 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.24
Marker Score: 2,522 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.2
Marker Score: 2,832 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 1.15
Marker Score: 604 - Cell Name: renal principal cell (CL0005009)
Fold Change: 1.12
Marker Score: 863 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 1.11
Marker Score: 958 - Cell Name: endocrine cell (CL0000163)
Fold Change: 1.1
Marker Score: 570 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.09
Marker Score: 17,087 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 1.06
Marker Score: 4,889 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 1.03
Marker Score: 34,836 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1
Marker Score: 1,214 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,761 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47,986 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,401 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.98
Marker Score: 285 - Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 0.97
Marker Score: 543 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.97
Marker Score: 1,864 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 0.96
Marker Score: 559 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,407 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.95
Marker Score: 488 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.94
Marker Score: 443 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.94
Marker Score: 2,058 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.93
Marker Score: 1,256 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.92
Marker Score: 1,501 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.92
Marker Score: 3,858 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,723 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.9
Marker Score: 975 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.88
Marker Score: 5,022 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,295 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.87
Marker Score: 884 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.87
Marker Score: 313 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.85
Marker Score: 5,119 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.84
Marker Score: 271 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 0.84
Marker Score: 964 - Cell Name: germ cell (CL0000586)
Fold Change: 0.82
Marker Score: 1,430 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.82
Marker Score: 342 - Cell Name: stellate neuron (CL0000122)
Fold Change: 0.81
Marker Score: 4,373 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.81
Marker Score: 486 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.8
Marker Score: 14,223 - Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.78
Marker Score: 516 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.77
Marker Score: 591 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.77
Marker Score: 242 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.75
Marker Score: 300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.74
Marker Score: 3,090 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.73
Marker Score: 283 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.73
Marker Score: 379 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.73
Marker Score: 715 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 0.73
Marker Score: 2,584 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.72
Marker Score: 7,293 - Cell Name: astrocyte (CL0000127)
Fold Change: 0.72
Marker Score: 620 - Cell Name: Unknown (CL0002371)
Fold Change: 0.72
Marker Score: 760 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.71
Marker Score: 1,895 - Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 0.7
Marker Score: 389 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.69
Marker Score: 978 - Cell Name: neuronal brush cell (CL0000555)
Fold Change: 0.69
Marker Score: 2,314 - Cell Name: brush cell (CL0002204)
Fold Change: 0.69
Marker Score: 627 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.68
Marker Score: 216 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.68
Marker Score: 395 - Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 0.67
Marker Score: 2,812 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.67
Marker Score: 172 - Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 0.66
Marker Score: 1,673 - Cell Name: male germ cell (CL0000015)
Fold Change: 0.66
Marker Score: 191 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.66
Marker Score: 324 - Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.64
Marker Score: 130 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.64
Marker Score: 614 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.64
Marker Score: 1,305 - Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.64
Marker Score: 202 - Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 0.64
Marker Score: 369 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.63
Marker Score: 301 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.62
Marker Score: 302 - Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.62
Marker Score: 1,029 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.62
Marker Score: 169 - Cell Name: granule cell (CL0000120)
Fold Change: 0.61
Marker Score: 4,596 - Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 0.6
Marker Score: 190 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.6
Marker Score: 2,579 - Cell Name: cardiac neuron (CL0010022)
Fold Change: 0.6
Marker Score: 744 - Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 0.59
Marker Score: 217 - Cell Name: acinar cell (CL0000622)
Fold Change: 0.59
Marker Score: 418 - Cell Name: photoreceptor cell (CL0000210)
Fold Change: 0.59
Marker Score: 444 - Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 0.59
Marker Score: 236 - Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.57
Marker Score: 148
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3150678057
Symbol: CRTC1_HUMAN
Name: CREB-regulated transcription coactivator 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14506290
Title: Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells.
PubMed ID: 14506290
PubMed ID: 12539049
Title: t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway.
PubMed ID: 12539049
DOI: 10.1038/ng1083
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 14720503
Title: Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors.
PubMed ID: 14720503
PubMed ID: 9734811
Title: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
PubMed ID: 9734811
PubMed ID: 14536081
Title: TORCs: transducers of regulated CREB activity.
PubMed ID: 14536081
PubMed ID: 15589160
Title: Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins.
PubMed ID: 15589160
PubMed ID: 15729701
Title: Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)-associated TORC1-MAML2 gene fusion.
PubMed ID: 15729701
DOI: 10.1002/gcc.20168
PubMed ID: 16817901
Title: Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascade.
PubMed ID: 16817901
PubMed ID: 16809310
Title: TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats.
PubMed ID: 16809310
DOI: 10.1128/jvi.00103-06
PubMed ID: 16980408
Title: Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells.
PubMed ID: 16980408
PubMed ID: 17210223
Title: Dephosphorylation of TORC initiates expression of the StAR gene.
PubMed ID: 17210223
PubMed ID: 17525332
Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
PubMed ID: 17525332
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 23699513
Title: Clock and light regulation of the CREB coactivator CRTC1 in the suprachiasmatic circadian clock.
PubMed ID: 23699513
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 30611118
Title: Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment.
PubMed ID: 30611118
Sequence Information:
- Length: 634
- Mass: 67300
- Checksum: ECDC427FF9D6920B
- Sequence:
MATSNNPRKF SEKIALHNQK QAEETAAFEE VMKDLSLTRA ARLQLQKSQY LQLGPSRGQY YGGSLPNVNQ IGSGTMDLPF QTPFQSSGLD TSRTTRHHGL VDRVYRERGR LGSPHRRPLS VDKHGRQADS CPYGTMYLSP PADTSWRRTN SDSALHQSTM TPTQPESFSS GSQDVHQKRV LLLTVPGMEE TTSEADKNLS KQAWDTKKTG SRPKSCEVPG INIFPSADQE NTTALIPATH NTGGSLPDLT NIHFPSPLPT PLDPEEPTFP ALSSSSSTGN LAANLTHLGI GGAGQGMSTP GSSPQHRPAG VSPLSLSTEA RRQQASPTLS PLSPITQAVA MDALSLEQQL PYAFFTQAGS QQPPPQPQPP PPPPPASQQP PPPPPPQAPV RLPPGGPLLP SASLTRGPQP PPLAVTVPSS LPQSPPENPG QPSMGIDIAS APALQQYRTS AGSPANQSPT SPVSNQGFSP GSSPQHTSTL GSVFGDAYYE QQMAARQANA LSHQLEQFNM MENAISSSSL YSPGSTLNYS QAAMMGLTGS HGSLPDSQQL GYASHSGIPN IILTVTGESP PSLSKELTSS LAGVGDVSFD SDSQFPLDEL KIDPLTLDGL HMLNDPDMVL ADPATEDTFR MDRL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.