Details for: CRTC1

Gene ID: 23373

Symbol: CRTC1

Ensembl ID: ENSG00000105662

Description: CREB regulated transcription coactivator 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.78
    Marker Score: 67,656
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.74
    Marker Score: 107,011
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.73
    Marker Score: 25,878
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.72
    Marker Score: 13,162
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.7
    Marker Score: 16,109
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.66
    Marker Score: 6,401
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.64
    Marker Score: 1,813
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.63
    Marker Score: 15,306
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.6
    Marker Score: 13,718
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.59
    Marker Score: 58,814
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.59
    Marker Score: 33,880
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.57
    Marker Score: 31,169
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.51
    Marker Score: 6,279
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.5
    Marker Score: 6,112
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.5
    Marker Score: 1,809
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.5
    Marker Score: 4,275
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,606
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.42
    Marker Score: 14,714
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.37
    Marker Score: 2,122
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.29
    Marker Score: 2,165
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.24
    Marker Score: 2,522
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.2
    Marker Score: 2,832
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.15
    Marker Score: 604
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.12
    Marker Score: 863
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.11
    Marker Score: 958
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.1
    Marker Score: 570
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.09
    Marker Score: 17,087
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.06
    Marker Score: 4,889
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.03
    Marker Score: 34,836
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1
    Marker Score: 1,214
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,761
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,986
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,401
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.98
    Marker Score: 285
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.97
    Marker Score: 543
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.97
    Marker Score: 1,864
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.96
    Marker Score: 559
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 488
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 443
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.94
    Marker Score: 2,058
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.93
    Marker Score: 1,256
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.92
    Marker Score: 1,501
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.92
    Marker Score: 3,858
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,723
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.9
    Marker Score: 975
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5,022
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.87
    Marker Score: 884
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 313
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.85
    Marker Score: 5,119
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.84
    Marker Score: 271
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.84
    Marker Score: 964
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.82
    Marker Score: 1,430
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.82
    Marker Score: 342
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.81
    Marker Score: 4,373
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.81
    Marker Score: 486
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.8
    Marker Score: 14,223
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.78
    Marker Score: 516
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 591
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.77
    Marker Score: 242
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.74
    Marker Score: 3,090
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.73
    Marker Score: 283
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 379
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.73
    Marker Score: 715
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.73
    Marker Score: 2,584
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.72
    Marker Score: 7,293
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.72
    Marker Score: 620
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.72
    Marker Score: 760
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.71
    Marker Score: 1,895
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.7
    Marker Score: 389
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.69
    Marker Score: 978
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.69
    Marker Score: 2,314
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 627
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.68
    Marker Score: 216
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.68
    Marker Score: 395
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.67
    Marker Score: 2,812
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.66
    Marker Score: 1,673
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.66
    Marker Score: 191
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.66
    Marker Score: 324
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.64
    Marker Score: 130
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.64
    Marker Score: 614
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.64
    Marker Score: 1,305
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.64
    Marker Score: 202
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.64
    Marker Score: 369
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.63
    Marker Score: 301
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.62
    Marker Score: 302
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.62
    Marker Score: 1,029
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.62
    Marker Score: 169
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.61
    Marker Score: 4,596
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.6
    Marker Score: 190
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.6
    Marker Score: 2,579
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.6
    Marker Score: 744
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.59
    Marker Score: 217
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.59
    Marker Score: 418
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.59
    Marker Score: 444
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.59
    Marker Score: 236
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.57
    Marker Score: 148

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CRTC1 is a coactivator protein that interacts with the transcription factor CREB (cAMP response element-binding protein) to regulate gene expression. This interaction enhances the transcriptional activity of CREB, leading to the activation of various target genes involved in cellular processes such as metabolism, energy homeostasis, and circadian rhythm entrainment. CRTC1 is also involved in the regulation of mitochondrial biogenesis, a critical process for maintaining energy homeostasis in cells. **Pathways and Functions:** CRTC1 is implicated in several key pathways, including: 1. **Camp response element binding protein (CREB) signaling pathway**: CRTC1 interacts with CREB to regulate gene expression, promoting the transcription of target genes involved in cellular processes such as metabolism and energy homeostasis. 2. **Circadian clock regulation**: CRTC1 is involved in the entrainment of the circadian clock by photoperiod, ensuring that cellular processes are synchronized with the 24-hour day-night cycle. 3. **Mitochondrial biogenesis**: CRTC1 regulates the transcription of genes involved in mitochondrial biogenesis, a critical process for maintaining energy homeostasis in cells. 4. **Energy homeostasis**: CRTC1 is involved in the regulation of energy homeostasis, ensuring that cells maintain a stable energy balance. **Clinical Significance:** CRTC1 dysregulation has been implicated in various neurological and metabolic disorders, including: 1. **Neurological disorders**: CRTC1 dysregulation has been linked to neurological disorders such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, where disruptions in energy homeostasis and circadian rhythm entrainment contribute to disease pathology. 2. **Metabolic disorders**: CRTC1 dysregulation has also been implicated in metabolic disorders such as type 2 diabetes, where disruptions in energy homeostasis and mitochondrial biogenesis contribute to disease pathology. 3. **Circadian rhythm disorders**: CRTC1 dysregulation has been linked to circadian rhythm disorders, including delayed sleep phase syndrome and non-24-hour sleep-wake disorder, where disruptions in circadian rhythm entrainment contribute to disease pathology. In conclusion, CRTC1 is a critical gene that regulates various cellular processes, including transcriptional regulation, energy homeostasis, and circadian rhythm entrainment. Its dysregulation has been implicated in various neurological and metabolic disorders, highlighting the importance of CRTC1 in maintaining cellular homeostasis and overall health.

Genular Protein ID: 3150678057

Symbol: CRTC1_HUMAN

Name: CREB-regulated transcription coactivator 1

UniProtKB Accession Codes:

Q6UUV9 A6NMG5 O75114 Q6Y3A3 Q7LDZ2 Q8IUL3 Q8IZ34 Q8IZL1 Q8N6W3 Q96AI8 Q9H801

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 22 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 15 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 3 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14506290

Title: Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells.

PubMed ID: 14506290

DOI: 10.1073/pnas.1932773100

PubMed ID: 12539049

Title: t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway.

PubMed ID: 12539049

DOI: 10.1038/ng1083

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14720503

Title: Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors.

PubMed ID: 14720503

DOI: 10.1016/j.yexcr.2003.09.007

PubMed ID: 9734811

Title: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9734811

DOI: 10.1093/dnares/5.3.169

PubMed ID: 14536081

Title: TORCs: transducers of regulated CREB activity.

PubMed ID: 14536081

DOI: 10.1016/j.molcel.2003.08.013

PubMed ID: 15589160

Title: Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins.

PubMed ID: 15589160

DOI: 10.1016/j.cub.2004.11.002

PubMed ID: 15729701

Title: Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)-associated TORC1-MAML2 gene fusion.

PubMed ID: 15729701

DOI: 10.1002/gcc.20168

PubMed ID: 16817901

Title: Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascade.

PubMed ID: 16817901

DOI: 10.1111/j.1742-4658.2006.05291.x

PubMed ID: 16809310

Title: TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats.

PubMed ID: 16809310

DOI: 10.1128/jvi.00103-06

PubMed ID: 16980408

Title: Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells.

PubMed ID: 16980408

DOI: 10.1073/pnas.0606714103

PubMed ID: 17210223

Title: Dephosphorylation of TORC initiates expression of the StAR gene.

PubMed ID: 17210223

DOI: 10.1016/j.mce.2006.12.020

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23699513

Title: Clock and light regulation of the CREB coactivator CRTC1 in the suprachiasmatic circadian clock.

PubMed ID: 23699513

DOI: 10.1523/jneurosci.4202-12.2013

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 30611118

Title: Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment.

PubMed ID: 30611118

DOI: 10.1016/j.isci.2018.12.012

Sequence Information:

  • Length: 634
  • Mass: 67300
  • Checksum: ECDC427FF9D6920B
  • Sequence:
    • MATSNNPRKF SEKIALHNQK QAEETAAFEE VMKDLSLTRA ARLQLQKSQY LQLGPSRGQY 
YGGSLPNVNQ IGSGTMDLPF QTPFQSSGLD TSRTTRHHGL VDRVYRERGR LGSPHRRPLS 
VDKHGRQADS CPYGTMYLSP PADTSWRRTN SDSALHQSTM TPTQPESFSS GSQDVHQKRV 
LLLTVPGMEE TTSEADKNLS KQAWDTKKTG SRPKSCEVPG INIFPSADQE NTTALIPATH 
NTGGSLPDLT NIHFPSPLPT PLDPEEPTFP ALSSSSSTGN LAANLTHLGI GGAGQGMSTP 
GSSPQHRPAG VSPLSLSTEA RRQQASPTLS PLSPITQAVA MDALSLEQQL PYAFFTQAGS 
QQPPPQPQPP PPPPPASQQP PPPPPPQAPV RLPPGGPLLP SASLTRGPQP PPLAVTVPSS 
LPQSPPENPG QPSMGIDIAS APALQQYRTS AGSPANQSPT SPVSNQGFSP GSSPQHTSTL 
GSVFGDAYYE QQMAARQANA LSHQLEQFNM MENAISSSSL YSPGSTLNYS QAAMMGLTGS 
HGSLPDSQQL GYASHSGIPN IILTVTGESP PSLSKELTSS LAGVGDVSFD SDSQFPLDEL 
KIDPLTLDGL HMLNDPDMVL ADPATEDTFR MDRL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.