Details for: UFL1

Gene ID: 23376

Symbol: UFL1

Ensembl ID: ENSG00000014123

Description: UFM1 specific ligase 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.55
    Marker Score: 2,284
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.51
    Marker Score: 3,434
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.46
    Marker Score: 50,706
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.46
    Marker Score: 761
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.42
    Marker Score: 3,404
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.42
    Marker Score: 423
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.41
    Marker Score: 407
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.39
    Marker Score: 5,819
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.32
    Marker Score: 11,376
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.32
    Marker Score: 385
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.31
    Marker Score: 1,889
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.31
    Marker Score: 762
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.31
    Marker Score: 2,871
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.29
    Marker Score: 5,077
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.29
    Marker Score: 1,714
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.28
    Marker Score: 27,297
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.25
    Marker Score: 2,644
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.22
    Marker Score: 1,266
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.22
    Marker Score: 2,157
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.21
    Marker Score: 1,565
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.18
    Marker Score: 10,239
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.14
    Marker Score: 3,062
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.14
    Marker Score: 12,829
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.12
    Marker Score: 9,659
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.12
    Marker Score: 317
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.11
    Marker Score: 1,170
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.11
    Marker Score: 4,502
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.1
    Marker Score: 4,075
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.1
    Marker Score: 271
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.1
    Marker Score: 950
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 1.1
    Marker Score: 329
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.09
    Marker Score: 635
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.08
    Marker Score: 3,082
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.07
    Marker Score: 10,209
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.07
    Marker Score: 7,997
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.07
    Marker Score: 435
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.07
    Marker Score: 1,657
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.07
    Marker Score: 728
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.07
    Marker Score: 527
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.06
    Marker Score: 620
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.06
    Marker Score: 494
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.05
    Marker Score: 393
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.05
    Marker Score: 1,136
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.05
    Marker Score: 500
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.05
    Marker Score: 438
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.05
    Marker Score: 12,158
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.04
    Marker Score: 872
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.04
    Marker Score: 248
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.04
    Marker Score: 693
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.04
    Marker Score: 422
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.03
    Marker Score: 359
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.03
    Marker Score: 566
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.02
    Marker Score: 15,265
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 1.02
    Marker Score: 548
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.02
    Marker Score: 354
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.02
    Marker Score: 62,673
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.01
    Marker Score: 677
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.01
    Marker Score: 578
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.01
    Marker Score: 1,013
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.01
    Marker Score: 1,157
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1
    Marker Score: 1,910
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1
    Marker Score: 231
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1
    Marker Score: 685
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1
    Marker Score: 918
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1
    Marker Score: 484
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,590
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,815
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.99
    Marker Score: 3,413
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.99
    Marker Score: 367
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.99
    Marker Score: 2,493
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.98
    Marker Score: 17,428
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.98
    Marker Score: 714
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,368
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.98
    Marker Score: 1,053
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.97
    Marker Score: 685
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.97
    Marker Score: 1,372
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.97
    Marker Score: 2,635
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.97
    Marker Score: 6,290
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.97
    Marker Score: 1,192
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.96
    Marker Score: 480
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.96
    Marker Score: 440
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.96
    Marker Score: 3,699
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.95
    Marker Score: 1,728
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.94
    Marker Score: 4,070
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.94
    Marker Score: 21,065
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.94
    Marker Score: 34,600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,380
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.93
    Marker Score: 946
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.93
    Marker Score: 274
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.93
    Marker Score: 35,298
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.93
    Marker Score: 8,742
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.93
    Marker Score: 2,104
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.93
    Marker Score: 645
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.92
    Marker Score: 926
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 434
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.92
    Marker Score: 1,726
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.92
    Marker Score: 4,399
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.92
    Marker Score: 817
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.92
    Marker Score: 1,011

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** UFL1 is a type II ubiquitin-conjugating enzyme that specifically recognizes and conjugates UFM1 (ubiquitin-like protein modifier 1) to target proteins. This modification plays a critical role in the regulation of protein stability, localization, and function. UFL1 has been shown to interact with various proteins, including transcription factors, kinases, and chaperones, suggesting its involvement in multiple cellular pathways. **Pathways and Functions:** UFL1 is involved in several key pathways, including: 1. **Adaptive Immune System:** UFL1 plays a crucial role in the regulation of antigen presentation and immune responses. It is involved in the processing and presentation of antigens by MHC class I molecules, which is essential for the activation of cytotoxic T cells. 2. **Antigen Processing:** UFL1 is involved in the ubiquitination and proteasomal degradation of proteins, which is a critical step in the processing of antigens for presentation to the immune system. 3. **DNA Repair:** UFL1 has been shown to interact with proteins involved in DNA repair, suggesting its role in maintaining genome stability. 4. **Inflammatory Response:** UFL1 is involved in the regulation of inflammatory responses, and its dysregulation has been implicated in various inflammatory diseases. 5. **Autophagy:** UFL1 has been shown to regulate autophagy, a process by which cells recycle damaged or dysfunctional proteins and organelles. **Clinical Significance:** Dysregulation of UFL1 has been implicated in various human diseases, including: 1. **Autoimmune Diseases:** UFL1 dysregulation has been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, which are characterized by immune system dysregulation. 2. **Cancer:** UFL1 has been shown to be overexpressed in various types of cancer, suggesting its role in tumorigenesis and cancer progression. 3. **Neurological Disorders:** UFL1 dysregulation has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, which are characterized by protein misfolding and aggregation. 4. **Inflammatory Diseases:** UFL1 dysregulation has been linked to inflammatory diseases, such as atherosclerosis and inflammatory bowel disease. In conclusion, UFL1 is a critical enzyme involved in various cellular processes, including immune regulation, DNA repair, and the regulation of inflammatory responses. Its dysregulation has been implicated in various human diseases, highlighting the importance of understanding its role in maintaining cellular homeostasis.

Genular Protein ID: 3968101754

Symbol: UFL1_HUMAN

Name: N/A

UniProtKB Accession Codes:

O94874 A0PJ53 B4DJ57 C0H5X5 Q8N765 Q9NTQ0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 1 GO 35 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SIGNOR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9872452

Title: Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9872452

DOI: 10.1093/dnares/5.5.277

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 20531390

Title: Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity.

PubMed ID: 20531390

DOI: 10.1038/emboj.2010.116

PubMed ID: 20018847

Title: A novel type of E3 ligase for the Ufm1 conjugation system.

PubMed ID: 20018847

DOI: 10.1074/jbc.m109.036814

PubMed ID: 20164180

Title: A novel LZAP-binding protein, NLBP, inhibits cell invasion.

PubMed ID: 20164180

DOI: 10.1074/jbc.m109.065920

PubMed ID: 20228063

Title: A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling.

PubMed ID: 20228063

DOI: 10.1074/jbc.m110.110619

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23152784

Title: Transcriptional regulation of the Ufm1 conjugation system in response to disturbance of the endoplasmic reticulum homeostasis and inhibition of vesicle trafficking.

PubMed ID: 23152784

DOI: 10.1371/journal.pone.0048587

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25219498

Title: Modification of ASC1 by UFM1 is crucial for ERalpha transactivation and breast cancer development.

PubMed ID: 25219498

DOI: 10.1016/j.molcel.2014.08.007

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30354401

Title: Ufm1-specific ligase Ufl1 regulates endoplasmic reticulum homeostasis and protects against heart failure.

PubMed ID: 30354401

DOI: 10.1161/circheartfailure.118.004917

PubMed ID: 30886146

Title: UFL1 promotes histone H4 ufmylation and ATM activation.

PubMed ID: 30886146

DOI: 10.1038/s41467-019-09175-0

PubMed ID: 32160526

Title: A genome-wide ER-phagy screen highlights key roles of mitochondrial metabolism and ER-Resident UFMylation.

PubMed ID: 32160526

DOI: 10.1016/j.cell.2020.02.017

PubMed ID: 32050156

Title: UFL1 attenuates IL-1beta-induced inflammatory response in human osteoarthritis chondrocytes.

PubMed ID: 32050156

DOI: 10.1016/j.intimp.2020.106278

PubMed ID: 37311461

Title: An Epstein-Barr virus protein interaction map reveals NLRP3 inflammasome evasion via MAVS UFMylation.

PubMed ID: 37311461

DOI: 10.1016/j.molcel.2023.05.018

Sequence Information:

  • Length: 794
  • Mass: 89595
  • Checksum: C6C1777455551991
  • Sequence:
    • MADAWEEIRR LAADFQRAQF AEATQRLSER NCIEIVNKLI AQKQLEVVHT LDGKEYITPA 
QISKEMRDEL HVRGGRVNIV DLQQVINVDL IHIENRIGDI IKSEKHVQLV LGQLIDENYL 
DRLAEEVNDK LQESGQVTIS ELCKTYDLPG NFLTQALTQR LGRIISGHID LDNRGVIFTE 
AFVARHKARI RGLFSAITRP TAVNSLISKY GFQEQLLYSV LEELVNSGRL RGTVVGGRQD 
KAVFVPDIYS RTQSTWVDSF FRQNGYLEFD ALSRLGIPDA VSYIKKRYKT TQLLFLKAAC 
VGQGLVDQVE ASVEEAISSG TWVDIAPLLP TSLSVEDAAI LLQQVMRAFS KQASTVVFSD 
TVVVSEKFIN DCTELFRELM HQKAEKEMKN NPVHLITEED LKQISTLESV STSKKDKKDE 
RRRKATEGSG SMRGGGGGNA REYKIKKVKK KGRKDDDSDD ESQSSHTGKK KPEISFMFQD 
EIEDFLRKHI QDAPEEFISE LAEYLIKPLN KTYLEVVRSV FMSSTTSASG TGRKRTIKDL 
QEEVSNLYNN IRLFEKGMKF FADDTQAALT KHLLKSVCTD ITNLIFNFLA SDLMMAVDDP 
AAITSEIRKK ILSKLSEETK VALTKLHNSL NEKSIEDFIS CLDSAAEACD IMVKRGDKKR 
ERQILFQHRQ ALAEQLKVTE DPALILHLTS VLLFQFSTHS MLHAPGRCVP QIIAFLNSKI 
PEDQHALLVK YQGLVVKQLV SQSKKTGQGD YPLNNELDKE QEDVASTTRK ELQELSSSIK 
DLVLKSRKSS VTEE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.