UFL1 | ENSG00000014123 | NCBI 23376

Details for: UFL1

Gene ID: 23376

Symbol: UFL1

Ensembl ID: ENSG00000014123

Description: UFM1 specific ligase 1

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Immune system
(R-HSA-168256)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna damage checkpoint signaling
(GO:0000077)
Dna repair
(GO:0006281)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Erythrocyte differentiation
(GO:0030218)
Hematopoietic stem cell differentiation
(GO:0060218)
Membrane
(GO:0016020)
Mitochondrial outer membrane
(GO:0005741)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of ire1-mediated unfolded protein response
(GO:1903895)
Negative regulation of nf-kappab transcription factor activity
(GO:0032088)
Negative regulation of protein ubiquitination
(GO:0031397)
Neuron projection
(GO:0043005)
Nucleus
(GO:0005634)
Osteoblast differentiation
(GO:0001649)
Positive regulation of autophagy
(GO:0010508)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of glial cell proliferation
(GO:0060252)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein k69-linked ufmylation
(GO:1990592)
Protein kinase binding
(GO:0019901)
Protein ufmylation
(GO:0071569)
Regulation of canonical nf-kappab signal transduction
(GO:0043122)
Regulation of inflammatory response
(GO:0050727)
Regulation of intracellular estrogen receptor signaling pathway
(GO:0033146)
Regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032434)
Regulation of protein localization
(GO:0032880)
Response to endoplasmic reticulum stress
(GO:0034976)
Response to l-glutamate
(GO:1902065)
Reticulophagy
(GO:0061709)
Site of double-strand break
(GO:0035861)
Ufm1 ligase activity
(GO:0061666)
Ufm1 transferase activity
(GO:0071568)

Other Information

Proteins

UFL1_HUMAN

Genular Protein ID: 3968101754

Symbol: UFL1_HUMAN

Name: N/A

UniProtKB Accession Codes:

O94874 A0PJ53 B4DJ57 C0H5X5 Q8N765 Q9NTQ0

Database IDs:

Citations:

PubMed ID: 9872452

Title: Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9872452

DOI: 10.1093/dnares/5.5.277

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 20531390

Title: Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity.

PubMed ID: 20531390

DOI: 10.1038/emboj.2010.116

PubMed ID: 20018847

Title: A novel type of E3 ligase for the Ufm1 conjugation system.

PubMed ID: 20018847

DOI: 10.1074/jbc.m109.036814

PubMed ID: 20164180

Title: A novel LZAP-binding protein, NLBP, inhibits cell invasion.

PubMed ID: 20164180

DOI: 10.1074/jbc.m109.065920

PubMed ID: 20228063

Title: A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling.

PubMed ID: 20228063

DOI: 10.1074/jbc.m110.110619

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23152784

Title: Transcriptional regulation of the Ufm1 conjugation system in response to disturbance of the endoplasmic reticulum homeostasis and inhibition of vesicle trafficking.

PubMed ID: 23152784

DOI: 10.1371/journal.pone.0048587

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25219498

Title: Modification of ASC1 by UFM1 is crucial for ERalpha transactivation and breast cancer development.

PubMed ID: 25219498

DOI: 10.1016/j.molcel.2014.08.007

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30354401

Title: Ufm1-specific ligase Ufl1 regulates endoplasmic reticulum homeostasis and protects against heart failure.

PubMed ID: 30354401

DOI: 10.1161/circheartfailure.118.004917

PubMed ID: 30886146

Title: UFL1 promotes histone H4 ufmylation and ATM activation.

PubMed ID: 30886146

DOI: 10.1038/s41467-019-09175-0

PubMed ID: 32160526

Title: A genome-wide ER-phagy screen highlights key roles of mitochondrial metabolism and ER-Resident UFMylation.

PubMed ID: 32160526

DOI: 10.1016/j.cell.2020.02.017

PubMed ID: 32050156

Title: UFL1 attenuates IL-1beta-induced inflammatory response in human osteoarthritis chondrocytes.

PubMed ID: 32050156

DOI: 10.1016/j.intimp.2020.106278

PubMed ID: 37311461

Title: An Epstein-Barr virus protein interaction map reveals NLRP3 inflammasome evasion via MAVS UFMylation.

PubMed ID: 37311461

DOI: 10.1016/j.molcel.2023.05.018

Sequence Information:

Length: 794
Mass: 89595
Checksum: C6C1777455551991
Sequence:

MADAWEEIRR LAADFQRAQF AEATQRLSER NCIEIVNKLI AQKQLEVVHT LDGKEYITPA 
QISKEMRDEL HVRGGRVNIV DLQQVINVDL IHIENRIGDI IKSEKHVQLV LGQLIDENYL 
DRLAEEVNDK LQESGQVTIS ELCKTYDLPG NFLTQALTQR LGRIISGHID LDNRGVIFTE 
AFVARHKARI RGLFSAITRP TAVNSLISKY GFQEQLLYSV LEELVNSGRL RGTVVGGRQD 
KAVFVPDIYS RTQSTWVDSF FRQNGYLEFD ALSRLGIPDA VSYIKKRYKT TQLLFLKAAC 
VGQGLVDQVE ASVEEAISSG TWVDIAPLLP TSLSVEDAAI LLQQVMRAFS KQASTVVFSD 
TVVVSEKFIN DCTELFRELM HQKAEKEMKN NPVHLITEED LKQISTLESV STSKKDKKDE 
RRRKATEGSG SMRGGGGGNA REYKIKKVKK KGRKDDDSDD ESQSSHTGKK KPEISFMFQD 
EIEDFLRKHI QDAPEEFISE LAEYLIKPLN KTYLEVVRSV FMSSTTSASG TGRKRTIKDL 
QEEVSNLYNN IRLFEKGMKF FADDTQAALT KHLLKSVCTD ITNLIFNFLA SDLMMAVDDP 
AAITSEIRKK ILSKLSEETK VALTKLHNSL NEKSIEDFIS CLDSAAEACD IMVKRGDKKR 
ERQILFQHRQ ALAEQLKVTE DPALILHLTS VLLFQFSTHS MLHAPGRCVP QIIAFLNSKI 
PEDQHALLVK YQGLVVKQLV SQSKKTGQGD YPLNNELDKE QEDVASTTRK ELQELSSSIK 
DLVLKSRKSS VTEE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: UFL1

Associated with

Other Information

Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 9872452

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography. PubMed ID: 18318008

Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity. PubMed ID: 20531390

A novel type of E3 ligase for the Ufm1 conjugation system. PubMed ID: 20018847

A novel LZAP-binding protein, NLBP, inhibits cell invasion. PubMed ID: 20164180

A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling. PubMed ID: 20228063

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

Transcriptional regulation of the Ufm1 conjugation system in response to disturbance of the endoplasmic reticulum homeostasis and inhibition of vesicle trafficking. PubMed ID: 23152784

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Modification of ASC1 by UFM1 is crucial for ERalpha transactivation and breast cancer development. PubMed ID: 25219498

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Ufm1-specific ligase Ufl1 regulates endoplasmic reticulum homeostasis and protects against heart failure. PubMed ID: 30354401

UFL1 promotes histone H4 ufmylation and ATM activation. PubMed ID: 30886146

A genome-wide ER-phagy screen highlights key roles of mitochondrial metabolism and ER-Resident UFMylation. PubMed ID: 32160526

UFL1 attenuates IL-1beta-induced inflammatory response in human osteoarthritis chondrocytes. PubMed ID: 32050156

An Epstein-Barr virus protein interaction map reveals NLRP3 inflammasome evasion via MAVS UFMylation. PubMed ID: 37311461