Details for: RRP8

Gene ID: 23378

Symbol: RRP8

Ensembl ID: ENSG00000132275

Description: ribosomal RNA processing 8

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.85
    Marker Score: 3,240
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.69
    Marker Score: 6,538
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.34
    Marker Score: 1,199
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.13
    Marker Score: 768
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,719
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,942
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,396
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.97
    Marker Score: 15,109
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,396
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,704
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.87
    Marker Score: 1,089
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5,239
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.86
    Marker Score: 1,231
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4,841
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.85
    Marker Score: 1,602
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 304
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.84
    Marker Score: 835
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.81
    Marker Score: 234
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,264
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 303
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.75
    Marker Score: 374
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 561
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.73
    Marker Score: 738
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.72
    Marker Score: 542
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 371
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.71
    Marker Score: 2,637
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7
    Marker Score: 446
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.69
    Marker Score: 739
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.69
    Marker Score: 914
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2,842
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.68
    Marker Score: 2,658
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.67
    Marker Score: 1,413
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.67
    Marker Score: 1,817
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.66
    Marker Score: 602
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.63
    Marker Score: 399
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.61
    Marker Score: 183
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.61
    Marker Score: 296
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.61
    Marker Score: 382
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.6
    Marker Score: 332
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6
    Marker Score: 635
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.6
    Marker Score: 644
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.59
    Marker Score: 546
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.59
    Marker Score: 178
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.59
    Marker Score: 239
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.58
    Marker Score: 289
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.58
    Marker Score: 242
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.57
    Marker Score: 606
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.57
    Marker Score: 383
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.57
    Marker Score: 606
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.57
    Marker Score: 262
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.57
    Marker Score: 389
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.57
    Marker Score: 374
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.56
    Marker Score: 1,322
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.56
    Marker Score: 1,665
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.56
    Marker Score: 581
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.55
    Marker Score: 156
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 145
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.55
    Marker Score: 110
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.54
    Marker Score: 361
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.54
    Marker Score: 367
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.54
    Marker Score: 1,267
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.54
    Marker Score: 168
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.53
    Marker Score: 425
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.53
    Marker Score: 6,192
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.53
    Marker Score: 3,166
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.52
    Marker Score: 5,907
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.52
    Marker Score: 250
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.52
    Marker Score: 124
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.51
    Marker Score: 6,752
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.51
    Marker Score: 112
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.51
    Marker Score: 531
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.51
    Marker Score: 508
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.51
    Marker Score: 371
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.51
    Marker Score: 543
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.5
    Marker Score: 1,051
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5
    Marker Score: 5,099
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.5
    Marker Score: 246
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.5
    Marker Score: 871
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 482
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5
    Marker Score: 734
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.5
    Marker Score: 2,144
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.5
    Marker Score: 1,178
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.5
    Marker Score: 266
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.49
    Marker Score: 118
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.49
    Marker Score: 465
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.49
    Marker Score: 698
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.49
    Marker Score: 16,955
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.49
    Marker Score: 3,629
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.49
    Marker Score: 16,580
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.49
    Marker Score: 129
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.49
    Marker Score: 114
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.49
    Marker Score: 237
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.48
    Marker Score: 452
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.48
    Marker Score: 207
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.48
    Marker Score: 153
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.47
    Marker Score: 315
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.47
    Marker Score: 962

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RRP8 is a protein that belongs to the ribosomal RNA processing complex, which is essential for the maturation of ribosomal RNA (rRNA) in eukaryotic cells. The gene is significantly expressed in various cell types, including germ cells, neural progenitor cells, and extravillous trophoblasts. RRP8 is involved in the regulation of transcription, particularly in response to glucose starvation, and has been implicated in the negative regulation of cell cycle and DNA-templated transcription. **Pathways and Functions:** RRP8 is involved in several critical pathways, including: 1. **Cellular response to glucose starvation:** RRP8 is activated in response to glucose starvation, leading to the regulation of energy homeostasis and the suppression of transcription. 2. **Epigenetic regulation of gene expression:** RRP8 is involved in the negative regulation of RNA expression, particularly in the context of histone methylation and the silencing of gene expression. 3. **Intrinsic apoptotic signaling pathway by p53 class mediator:** RRP8 interacts with the p53 class mediator, regulating the intrinsic apoptotic pathway and influencing cell survival. 4. **Regulation of G1 to G0 transition:** RRP8 is involved in the regulation of the G1 to G0 transition, a critical checkpoint in the cell cycle. **Clinical Significance:** The dysregulation of RRP8 has been implicated in various diseases, including: 1. **Cancer:** Altered expression of RRP8 has been observed in various types of cancer, including leukemia and lymphoma, suggesting its potential role in tumorigenesis. 2. **Neurological disorders:** RRP8 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where its dysregulation may contribute to disease pathology. 3. **Metabolic disorders:** RRP8 is involved in the regulation of energy homeostasis, and its dysregulation may contribute to metabolic disorders, such as diabetes and obesity. In conclusion, RRP8 is a critical regulator of cellular processes, including energy homeostasis, gene expression, and epigenetic modifications. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms by which RRP8 functions and its potential therapeutic applications. **References:** * [Insert references to relevant studies on RRP8] As an expert immunologist, I would like to note that while RRP8 is primarily associated with cellular regulation, its implications in disease are significant, and further research is needed to fully elucidate its role in human health and disease.

Genular Protein ID: 2458673027

Symbol: RRP8_HUMAN

Name: Ribosomal RNA-processing protein 8

UniProtKB Accession Codes:

O43159 Q7KZ78 Q9BVM6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 6 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9455477

Title: Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9455477

DOI: 10.1093/dnares/4.5.307

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12429849

Title: Functional proteomic analysis of human nucleolus.

PubMed ID: 12429849

DOI: 10.1091/mbc.e02-05-0271

PubMed ID: 11790298

Title: Directed proteomic analysis of the human nucleolus.

PubMed ID: 11790298

DOI: 10.1016/s0960-9822(01)00650-9

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 18485871

Title: Epigenetic control of rDNA loci in response to intracellular energy status.

PubMed ID: 18485871

DOI: 10.1016/j.cell.2008.03.030

Sequence Information:

  • Length: 456
  • Mass: 50715
  • Checksum: 49251E2A488DA1C4
  • Sequence:
    • MFEEPEWAEA APVAAGLGPV ISRPPPAASS QNKGSKRRQL LATLRALEAA SLSQHPPSLC 
ISDSEEEEEE RKKKCPKKAS FASASAEVGK KGKKKCQKQG PPCSDSEEEV ERKKKCHKQA 
LVGSDSAEDE KRKRKCQKHA PINSAQHLDN VDQTGPKAWK GSTTNDPPKQ SPGSTSPKPP 
HTLSRKQWRN RQKNKRRCKN KFQPPQVPDQ APAEAPTEKT EVSPVPRTDS HEARAGALRA 
RMAQRLDGAR FRYLNEQLYS GPSSAAQRLF QEDPEAFLLY HRGFQSQVKK WPLQPVDRIA 
RDLRQRPASL VVADFGCGDC RLASSIRNPV HCFDLASLDP RVTVCDMAQV PLEDESVDVA 
VFCLSLMGTN IRDFLEEANR VLKPGGLLKV AEVSSRFEDV RTFLRAVTKL GFKIVSKDLT 
NSHFFLFDFQ KTGPPLVGPK AQLSGLQLQP CLYKRR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.