Details for: SRGAP2

Gene ID: 23380

Symbol: SRGAP2

Ensembl ID: ENSG00000266028

Description: SLIT-ROBO Rho GTPase activating protein 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 6.45
    Marker Score: 2,330
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 3.3
    Marker Score: 1,641
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 2.73
    Marker Score: 1,410
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 2.56
    Marker Score: 5,299
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.49
    Marker Score: 1,486
  • Cell Name: podocyte (CL0000653)
    Fold Change: 2.48
    Marker Score: 916
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.36
    Marker Score: 2,612
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.11
    Marker Score: 1,041
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.07
    Marker Score: 41,201
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.05
    Marker Score: 1,447
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.03
    Marker Score: 74,742
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.02
    Marker Score: 76,754
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.99
    Marker Score: 7,694
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.99
    Marker Score: 29,743
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.97
    Marker Score: 8,154
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.94
    Marker Score: 14,852
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.94
    Marker Score: 3,251
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.88
    Marker Score: 2,165
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.81
    Marker Score: 16,982
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.77
    Marker Score: 1,894
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.77
    Marker Score: 8,168
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.74
    Marker Score: 14,945
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.72
    Marker Score: 16,345
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.66
    Marker Score: 102,157
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.64
    Marker Score: 955
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 1.6
    Marker Score: 973
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.57
    Marker Score: 878
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.54
    Marker Score: 2,370
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.51
    Marker Score: 2,904
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.46
    Marker Score: 848
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.43
    Marker Score: 5,951
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.41
    Marker Score: 1,259
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.39
    Marker Score: 912
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.38
    Marker Score: 1,719
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.27
    Marker Score: 408
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.25
    Marker Score: 1,253
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.24
    Marker Score: 2,524
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.23
    Marker Score: 1,328
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.23
    Marker Score: 384
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.21
    Marker Score: 3,445
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.18
    Marker Score: 2,977
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 1.15
    Marker Score: 3,252
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.07
    Marker Score: 59,577
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.04
    Marker Score: 1,101
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.03
    Marker Score: 826
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.03
    Marker Score: 6,817
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.99
    Marker Score: 381
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,397
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.97
    Marker Score: 352
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.96
    Marker Score: 467
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.96
    Marker Score: 462
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 486
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.94
    Marker Score: 1,068
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 442
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.93
    Marker Score: 378
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.93
    Marker Score: 1,816
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.93
    Marker Score: 944
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.93
    Marker Score: 975
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.91
    Marker Score: 2,208
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,710
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.87
    Marker Score: 357
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.87
    Marker Score: 581
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 312
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.86
    Marker Score: 3,519
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.86
    Marker Score: 1,219
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4,875
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.85
    Marker Score: 458
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.83
    Marker Score: 13,027
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.8
    Marker Score: 739
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 322
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 611
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.78
    Marker Score: 603
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,254
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.77
    Marker Score: 931
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.77
    Marker Score: 722
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.76
    Marker Score: 264
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.76
    Marker Score: 286
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.75
    Marker Score: 517
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 683
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.74
    Marker Score: 421
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.74
    Marker Score: 1,630
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.73
    Marker Score: 371
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.73
    Marker Score: 176
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.73
    Marker Score: 428
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.73
    Marker Score: 781
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.73
    Marker Score: 201
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.73
    Marker Score: 781
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.72
    Marker Score: 1,801
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.72
    Marker Score: 1,440
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3,013
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.72
    Marker Score: 820
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.72
    Marker Score: 1,148
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.72
    Marker Score: 384
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.71
    Marker Score: 1,699
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.71
    Marker Score: 1,793
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.7
    Marker Score: 182
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.69
    Marker Score: 329
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.68
    Marker Score: 1,237

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SRGAP2 is a Rho GTPase activating protein (RhoGAP) that specifically regulates the activity of Rho GTPases, including Cdc42, Rac1, and RhoA. These GTPases are essential for various cellular processes, including cell migration, cytoskeleton organization, and cell signaling. SRGAP2's ability to activate or inhibit Rho GTPases, depending on the context, allows for the fine-tuning of cellular responses to specific signals. Additionally, SRGAP2 interacts with other proteins, such as formins, to regulate cytoskeletal dynamics and cell migration. **Pathways and Functions** SRGAP2 is involved in several key signaling pathways, including: 1. **Axon guidance**: SRGAP2 regulates the activity of Rho GTPases to control the extension and retraction of axons during neuronal development. 2. **Dendritic spine development**: SRGAP2 is essential for the formation and maintenance of dendritic spines, which are critical for synaptic plasticity and learning. 3. **Cytoskeletal regulation**: SRGAP2 regulates the activity of Rho GTPases to control cytoskeletal dynamics, including actin filament severing and lamellipodium assembly. 4. **Cell migration**: SRGAP2 inhibits cell migration by regulating the activity of Rho GTPases, which are essential for cell movement and invasion. 5. **Neuron projection morphogenesis**: SRGAP2 is involved in the regulation of neuronal projection morphogenesis, including axon outgrowth and branching. **Clinical Significance** Dysregulation of SRGAP2 has been implicated in various neurological disorders, including: 1. **Neurodevelopmental disorders**: Mutations in SRGAP2 have been associated with neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 2. **Neurodegenerative diseases**: SRGAP2 has been implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 3. **Cerebral palsy**: SRGAP2 has been associated with cerebral palsy, a disorder characterized by impaired motor function and development. In conclusion, SRGAP2 is a critical gene involved in the regulation of neuronal development, axon guidance, and cytoskeletal dynamics. Its dysregulation has been implicated in various neurological disorders, highlighting the importance of this gene in maintaining normal brain function and development.

Genular Protein ID: 1389780114

Symbol: SRGP2_HUMAN

Name: Formin-binding protein 2

UniProtKB Accession Codes:

O75044 A2RUF3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 27 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 6 PIR 1 PRO 1 PROSITE 3 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 8 RefSeq 3 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9455484

Title: Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.

PubMed ID: 9455484

DOI: 10.1093/dnares/4.5.345

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11672528

Title: Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway.

PubMed ID: 11672528

DOI: 10.1016/s0092-8674(01)00530-x

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19807924

Title: Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

PubMed ID: 19807924

DOI: 10.1186/1471-2172-10-53

PubMed ID: 20810653

Title: srGAP2 arginine methylation regulates cell migration and cell spreading through promoting dimerization.

PubMed ID: 20810653

DOI: 10.1074/jbc.m110.153429

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22106086

Title: Early infantile epileptic encephalopathy associated with the disrupted gene encoding Slit-Robo Rho GTPase activating protein 2 (SRGAP2).

PubMed ID: 22106086

DOI: 10.1002/ajmg.a.34363

PubMed ID: 21148482

Title: Bi-modal regulation of a formin by srGAP2.

PubMed ID: 21148482

DOI: 10.1074/jbc.m110.190397

PubMed ID: 22559944

Title: Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation.

PubMed ID: 22559944

DOI: 10.1016/j.cell.2012.03.034

PubMed ID: 22467852

Title: The F-BAR domains from srGAP1, srGAP2, and srGAP3 differentially regulate membrane deformation.

PubMed ID: 22467852

DOI: 10.1242/jcs.098962

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27373832

Title: SRGAP2 and its human-specific paralog co-regulate the development of excitatory and inhibitory synapses.

PubMed ID: 27373832

DOI: 10.1016/j.neuron.2016.06.013

PubMed ID: 24419634

Title: Purification, crystallization and preliminary X-ray analysis of the inverse F-BAR domain of the human srGAP2 protein.

PubMed ID: 24419634

DOI: 10.1107/s2053230x13033712

PubMed ID: 27917825

Title: Molecular symmetry-constrained systematic search approach to structure solution of the coiled-coil SRGAP2 F-BARx domain.

PubMed ID: 27917825

DOI: 10.1107/s2059798316016697

PubMed ID: 26365803

Title: The neuronal migration factor srGAP2 achieves specificity in ligand binding through a two-component molecular mechanism.

PubMed ID: 26365803

DOI: 10.1016/j.str.2015.08.009

PubMed ID: 28333212

Title: Structural history of human SRGAP2 proteins.

PubMed ID: 28333212

DOI: 10.1093/molbev/msx094

Sequence Information:

  • Length: 1071
  • Mass: 120871
  • Checksum: 5693E6AF33A03E97
  • Sequence:
    • MTSPAKFKKD KEIIAEYDTQ VKEIRAQLTE QMKCLDQQCE LRVQLLQDLQ DFFRKKAEIE 
MDYSRNLEKL AERFLAKTRS TKDQQFKKDQ NVLSPVNCWN LLLNQVKRES RDHTTLSDIY 
LNNIIPRFVQ VSEDSGRLFK KSKEVGQQLQ DDLMKVLNEL YSVMKTYHMY NADSISAQSK 
LKEAEKQEEK QIGKSVKQED RQTPRSPDST ANVRIEEKHV RRSSVKKIEK MKEKRQAKYT 
ENKLKAIKAR NEYLLALEAT NASVFKYYIH DLSDLIDQCC DLGYHASLNR ALRTFLSAEL 
NLEQSKHEGL DAIENAVENL DATSDKQRLM EMYNNVFCPP MKFEFQPHMG DMASQLCAQQ 
PVQSELVQRC QQLQSRLSTL KIENEEVKKT MEATLQTIQD IVTVEDFDVS DCFQYSNSME 
SVKSTVSETF MSKPSIAKRR ANQQETEQFY FTKMKEYLEG RNLITKLQAK HDLLQKTLGE 
SQRTDCSLAR RSSTVRKQDS SQAIPLVVES CIRFISRHGL QHEGIFRVSG SQVEVNDIKN 
AFERGEDPLA GDQNDHDMDS IAGVLKLYFR GLEHPLFPKD IFHDLMACVT MDNLQERALH 
IRKVLLVLPK TTLIIMRYLF AFLNHLSQFS EENMMDPYNL AICFGPSLMS VPEGHDQVSC 
QAHVNELIKT IIIQHENIFP SPRELEGPVY SRGGSMEDYC DSPHGETTSV EDSTQDVTAE 
HHTSDDECEP IEAIAKFDYV GRTARELSFK KGASLLLYQR ASDDWWEGRH NGIDGLIPHQ 
YIVVQDTEDG VVERSSPKSE IEVISEPPEE KVTARAGASC PSGGHVADIY LANINKQRKR 
PESGSIRKTF RSDSHGLSSS LTDSSSPGVG ASCRPSSQPI MSQSLPKEGP DKCSISGHGS 
LNSISRHSSL KNRLDSPQIR KTATAGRSKS FNNHRPMDPE VIAQDIEATM NSALNELREL 
ERQSSVKHTP DVVLDTLEPL KTSPVVAPTS EPSSPLHTQL LKDPEPAFQR SASTAGDIAC 
AFRPVKSVKM AAPVKPPATR PKPTVFPKTN ATSPGVNSST SPQSTDKSCT V

Genular Protein ID: 2903538804

Symbol: A0A075B7B5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A075B7B5

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 3 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 8 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 6 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 3 Proteomes 2 RefSeq 2 SAM 2 SMART 3 SMR 1 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 789
  • Mass: 90909
  • Checksum: 5E84AA2D9144D4AD
  • Sequence:
    • MTSPAKFKKD KEIIAEYDTQ VKEIRAQLTE QMKCLDQQCE LRVQLLQDLQ DFFRKKAEIE 
MDYSRNLEKL AERFLAKTRS TKDQQFKKDQ NVLSPVNCWN LLLNQVKRES RDHTTLSDIY 
LNNIIPRFVQ VSEDSGRLFK KSKEVGQQLQ DDLMKVLNEL YSVMKTYHMY NADSISAQSK 
LKEAEKQEEK QIGKSVKQED RQTPRSPDST ANVRIEEKHV RRSSVKKIEK MKEKRQAKYT 
ENKLKAIKAR NEYLLALEAT NASVFKYYIH DLSDLIDCCD LGYHASLNRA LRTFLSAELN 
LEQSKHEGLD AIENAVENLD ATSDKQRLME MYNNVFCPPM KFEFQPHMGD MASQLCAQQP 
VQSELVQRCQ QLQSRLSTLK IENEEVKKTM EATLQTIQDI VTVEDFDVSD CFQYSNSMES 
VKSTVSETFM SKPSIAKRRA NQQETEQFYF TKMKEYLEGR NLITKLQAKH DLLQKTLGES 
QRTDCSLARR SSTVRKQDSS QAIPLVVESC IRFISRHGLQ HEGIFRVSGS QVEVNDIKNA 
FERGEDPLAG DQNDHDMDSI AGVLKLYFRG LEHPLFPKDI FHDLMACVTM DNLQERALHI 
RKVLLVLPKT TLIIMRYLFA FLNHLSQFSE ENMMDPYNLA ICFGPSLMSV PEGHDQVSCQ 
AHVNELIKTI IIQHENIFPS PRELEGPVYS RGGSMEDYCD SPHGETTSVE DSTQDVTAEH 
HTSDDECEPI EAIAKFDYVG RTARELSFKK GASLLLYQRA SDDWWEGRHN GIDGLIPHQY 
IVVQDTLIS

Genular Protein ID: 2854232949

Symbol: B7Z3G4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z3G4

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 3 GenomeRNAi 1 InterPro 8 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 6 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 3 RefSeq 1 SAM 2 SMART 3 SUPFAM 3

Sequence Information:

  • Length: 789
  • Mass: 90990
  • Checksum: EAE58E3F6B64FBBF
  • Sequence:
    • MTSPAKFKKD KEIIAEYDTQ VKEIRAQLTE QMKCLDQQRE LRVQLLQDLQ DFFRKKAEIE 
MDYSRNLEKL AERFLAKTRS TKDQQFKKDQ NVLSPVNCWN LLLNQVKRES RDHTTLSDIY 
LNNIIPRFVQ VSEDSGRLFK KSKEVGQQLQ DDLMKVLNEL YSVMKTYHMY NADSISAQSK 
LKEAEKQEEK QIGKSVKQED RQTPRSPDST ANVRIEEKHV RRSSVKKIEK MKEKRQAKYT 
ENKLKAIKAR NEYLLALEAT NASVFKYYIH DLSDLIDCCD LGYHASLNRA LRTFLSAELN 
LEQSKHEGLD AIENAVENLD ATSDKQRLME MYNNVFCPPM KFEFQPHMGD MASQLCAQQP 
VQSELVQRCQ QLQSRLSTLK IENEEVKKTM EATLQTIQDI VTVEDFDVSD CFQYSNSMES 
VKSTVSETFM SKPSIAKRRA NQQETEQFYF TKMREYLEGR NLITKLQAKH DLLQKTLGES 
QRTDCSLARR SSTVRKQDSS QAIPLVVESC IRFISRHGLQ HEGIFRVSGS QVEVNDIKNA 
FERGEDPLAG DQNDHDMDSI AGVLKLYFRG LEHPLFPKDI FHDLMACVTM DNLQERALHI 
RKVLLVLPKT TLIIMRYLFA FLNHLSQFSE ENMMDPYNLA ICFGPSLMSV PEGHDQVSCQ 
AHVNELIKTI IIQHENIFPS PRELEGPVYS RGGSMEDYCD SPHGETTSVE DSTQDVTAEH 
HTSDDECEPI EAIAKFDYVG RTARELSFKK GASLLLYQRA SDDWWEGRHN GIDGLIPHQY 
IVVQDTLIS

Genular Protein ID: 2362601635

Symbol: B7ZM87_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7ZM87

Database IDs:

ARBA 2 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 EMBL 6 EPD 1 Ensembl 2 GO 1 Gene3D 3 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 8 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 6 PROSITE-ProRule 2 Pfam 3 PharmGKB 1 Proteomes 2 RefSeq 2 SAM 2 SMART 3 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 1070
  • Mass: 120742
  • Checksum: 3476DEAC3AC3DF8C
  • Sequence:
    • MTSPAKFKKD KEIIAEYDTQ VKEIRAQLTE QMKCLDQQCE LRVQLLQDLQ DFFRKKAEIE 
MDYSRNLEKL AERFLAKTRS TKDQQFKKDQ NVLSPVNCWN LLLNQVKRES RDHTTLSDIY 
LNNIIPRFVQ VSEDSGRLFK KSKEVGQQLQ DDLMKVLNEL YSVMKTYHMY NADSISAQSK 
LKEAEKQEEK QIGKSVKQED RQTPRSPDST ANVRIEEKHV RRSSVKKIEK MKEKRQAKYT 
ENKLKAIKAR NEYLLALEAT NASVFKYYIH DLSDLIDCCD LGYHASLNRA LRTFLSAELN 
LEQSKHEGLD AIENAVENLD ATSDKQRLME MYNNVFCPPM KFEFQPHMGD MASQLCAQQP 
VQSELVQRCQ QLQSRLSTLK IENEEVKKTM EATLQTIQDI VTVEDFDVSD CFQYSNSMES 
VKSTVSETFM SKPSIAKRRA NQQETEQFYF TKMKEYLEGR NLITKLQAKH DLLQKTLGES 
QRTDCSLARR SSTVRKQDSS QAIPLVVESC IRFISRHGLQ HEGIFRVSGS QVEVNDIKNA 
FERGEDPLAG DQNDHDMDSI AGVLKLYFRG LEHPLFPKDI FHDLMACVTM DNLQERALHI 
RKVLLVLPKT TLIIMRYLFA FLNHLSQFSE ENMMDPYNLA ICFGPSLMSV PEGHDQVSCQ 
AHVNELIKTI IIQHENIFPS PRELEGPVYS RGGSMEDYCD SPHGETTSVE DSTQDVTAEH 
HTSDDECEPI EAIAKFDYVG RTARELSFKK GASLLLYQRA SDDWWEGRHN GIDGLIPHQY 
IVVQDTEDGV VERSSPKSEI EVISEPPEEK VTARAGASCP SGGHVADIYL ANINKQRKRP 
ESGSIRKTFR SDSHGLSSSL TDSSSPGVGA SCRPSSQPIM SQSLPKEGPD KCSISGHGSL 
NSISRHSSLK NRLDSPQIRK TATAGRSKSF NNHRPMDPEV IAQDIEATMN SALNELRELE 
RQSSVKHTPD VVLDTLEPLK TSPVVAPTSE PSSPLHTQLL KDPEPAFQRS ASTAGDIACA 
FRPVKSVKMA APVKPPATRP KPTVFPKTNA TSPGVNSSTS PQSTDKSCTV

Genular Protein ID: 741577766

Symbol: B4DFE5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DFE5

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 2 GenomeRNAi 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 2 SAM 1 SMART 1 SUPFAM 2

Sequence Information:

  • Length: 438
  • Mass: 47413
  • Checksum: CAF04159C1B45E9F
  • Sequence:
    • MMDPYNLAIC FGPSLMSVPE GHDQVSCQAH VNELIKTIII QHENIFPSPR ELEGPVYSRG 
GSMEDYCDSP HGETTSVEDS TQDVTAEHHT SDDECEPIEA IAKFDYVGRT ARELSFKKGA 
SLLLYQRASD DWWEGRHNGI DGLIPHQYIV VQDTEDGVVE RSSPKSEIEV ISEPPEEKVT 
ARAGASCPSG GHVADIYLAN INKQRKRPES GSIRKTFRSD SHGLSSSLTD SSSPGVGASC 
RPSSQPIMSQ SLPKEGPDKC SISGHGSLNS ISRHSSLKNR LDSPQIRKTA TAGRSKSFNN 
HRPMDPEVIA QDIEATMNSA LNELRELERQ SSVKHTPDVV LDTLEPLKTS PVVAPTSEPS 
SPLHTQLLKD PEPAFQRSAS TAGDIACAFR PVKSVKMAAP VKPPATRPKP TVFPKTNATS 
PGVNSSTSPQ STDKSCTV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.