Details for: SRGAP2

Gene ID: 23380

Symbol: SRGAP2

Ensembl ID: ENSG00000266028

Description: SLIT-ROBO Rho GTPase activating protein 2

Associated with

Other Information

Genular Protein ID: 1389780114

Symbol: SRGP2_HUMAN

Name: Formin-binding protein 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9455484

Title: Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.

PubMed ID: 9455484

DOI: 10.1093/dnares/4.5.345

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11672528

Title: Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway.

PubMed ID: 11672528

DOI: 10.1016/s0092-8674(01)00530-x

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19807924

Title: Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

PubMed ID: 19807924

DOI: 10.1186/1471-2172-10-53

PubMed ID: 20810653

Title: srGAP2 arginine methylation regulates cell migration and cell spreading through promoting dimerization.

PubMed ID: 20810653

DOI: 10.1074/jbc.m110.153429

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22106086

Title: Early infantile epileptic encephalopathy associated with the disrupted gene encoding Slit-Robo Rho GTPase activating protein 2 (SRGAP2).

PubMed ID: 22106086

DOI: 10.1002/ajmg.a.34363

PubMed ID: 21148482

Title: Bi-modal regulation of a formin by srGAP2.

PubMed ID: 21148482

DOI: 10.1074/jbc.m110.190397

PubMed ID: 22559944

Title: Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation.

PubMed ID: 22559944

DOI: 10.1016/j.cell.2012.03.034

PubMed ID: 22467852

Title: The F-BAR domains from srGAP1, srGAP2, and srGAP3 differentially regulate membrane deformation.

PubMed ID: 22467852

DOI: 10.1242/jcs.098962

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27373832

Title: SRGAP2 and its human-specific paralog co-regulate the development of excitatory and inhibitory synapses.

PubMed ID: 27373832

DOI: 10.1016/j.neuron.2016.06.013

PubMed ID: 24419634

Title: Purification, crystallization and preliminary X-ray analysis of the inverse F-BAR domain of the human srGAP2 protein.

PubMed ID: 24419634

DOI: 10.1107/s2053230x13033712

PubMed ID: 27917825

Title: Molecular symmetry-constrained systematic search approach to structure solution of the coiled-coil SRGAP2 F-BARx domain.

PubMed ID: 27917825

DOI: 10.1107/s2059798316016697

PubMed ID: 26365803

Title: The neuronal migration factor srGAP2 achieves specificity in ligand binding through a two-component molecular mechanism.

PubMed ID: 26365803

DOI: 10.1016/j.str.2015.08.009

PubMed ID: 28333212

Title: Structural history of human SRGAP2 proteins.

PubMed ID: 28333212

DOI: 10.1093/molbev/msx094

Sequence Information:

  • Length: 1071
  • Mass: 120871
  • Checksum: 5693E6AF33A03E97
  • Sequence:
  • MTSPAKFKKD KEIIAEYDTQ VKEIRAQLTE QMKCLDQQCE LRVQLLQDLQ DFFRKKAEIE 
    MDYSRNLEKL AERFLAKTRS TKDQQFKKDQ NVLSPVNCWN LLLNQVKRES RDHTTLSDIY 
    LNNIIPRFVQ VSEDSGRLFK KSKEVGQQLQ DDLMKVLNEL YSVMKTYHMY NADSISAQSK 
    LKEAEKQEEK QIGKSVKQED RQTPRSPDST ANVRIEEKHV RRSSVKKIEK MKEKRQAKYT 
    ENKLKAIKAR NEYLLALEAT NASVFKYYIH DLSDLIDQCC DLGYHASLNR ALRTFLSAEL 
    NLEQSKHEGL DAIENAVENL DATSDKQRLM EMYNNVFCPP MKFEFQPHMG DMASQLCAQQ 
    PVQSELVQRC QQLQSRLSTL KIENEEVKKT MEATLQTIQD IVTVEDFDVS DCFQYSNSME 
    SVKSTVSETF MSKPSIAKRR ANQQETEQFY FTKMKEYLEG RNLITKLQAK HDLLQKTLGE 
    SQRTDCSLAR RSSTVRKQDS SQAIPLVVES CIRFISRHGL QHEGIFRVSG SQVEVNDIKN 
    AFERGEDPLA GDQNDHDMDS IAGVLKLYFR GLEHPLFPKD IFHDLMACVT MDNLQERALH 
    IRKVLLVLPK TTLIIMRYLF AFLNHLSQFS EENMMDPYNL AICFGPSLMS VPEGHDQVSC 
    QAHVNELIKT IIIQHENIFP SPRELEGPVY SRGGSMEDYC DSPHGETTSV EDSTQDVTAE 
    HHTSDDECEP IEAIAKFDYV GRTARELSFK KGASLLLYQR ASDDWWEGRH NGIDGLIPHQ 
    YIVVQDTEDG VVERSSPKSE IEVISEPPEE KVTARAGASC PSGGHVADIY LANINKQRKR 
    PESGSIRKTF RSDSHGLSSS LTDSSSPGVG ASCRPSSQPI MSQSLPKEGP DKCSISGHGS 
    LNSISRHSSL KNRLDSPQIR KTATAGRSKS FNNHRPMDPE VIAQDIEATM NSALNELREL 
    ERQSSVKHTP DVVLDTLEPL KTSPVVAPTS EPSSPLHTQL LKDPEPAFQR SASTAGDIAC 
    AFRPVKSVKM AAPVKPPATR PKPTVFPKTN ATSPGVNSST SPQSTDKSCT V

Genular Protein ID: 2903538804

Symbol: A0A075B7B5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 789
  • Mass: 90909
  • Checksum: 5E84AA2D9144D4AD
  • Sequence:
  • MTSPAKFKKD KEIIAEYDTQ VKEIRAQLTE QMKCLDQQCE LRVQLLQDLQ DFFRKKAEIE 
    MDYSRNLEKL AERFLAKTRS TKDQQFKKDQ NVLSPVNCWN LLLNQVKRES RDHTTLSDIY 
    LNNIIPRFVQ VSEDSGRLFK KSKEVGQQLQ DDLMKVLNEL YSVMKTYHMY NADSISAQSK 
    LKEAEKQEEK QIGKSVKQED RQTPRSPDST ANVRIEEKHV RRSSVKKIEK MKEKRQAKYT 
    ENKLKAIKAR NEYLLALEAT NASVFKYYIH DLSDLIDCCD LGYHASLNRA LRTFLSAELN 
    LEQSKHEGLD AIENAVENLD ATSDKQRLME MYNNVFCPPM KFEFQPHMGD MASQLCAQQP 
    VQSELVQRCQ QLQSRLSTLK IENEEVKKTM EATLQTIQDI VTVEDFDVSD CFQYSNSMES 
    VKSTVSETFM SKPSIAKRRA NQQETEQFYF TKMKEYLEGR NLITKLQAKH DLLQKTLGES 
    QRTDCSLARR SSTVRKQDSS QAIPLVVESC IRFISRHGLQ HEGIFRVSGS QVEVNDIKNA 
    FERGEDPLAG DQNDHDMDSI AGVLKLYFRG LEHPLFPKDI FHDLMACVTM DNLQERALHI 
    RKVLLVLPKT TLIIMRYLFA FLNHLSQFSE ENMMDPYNLA ICFGPSLMSV PEGHDQVSCQ 
    AHVNELIKTI IIQHENIFPS PRELEGPVYS RGGSMEDYCD SPHGETTSVE DSTQDVTAEH 
    HTSDDECEPI EAIAKFDYVG RTARELSFKK GASLLLYQRA SDDWWEGRHN GIDGLIPHQY 
    IVVQDTLIS

Genular Protein ID: 2854232949

Symbol: B7Z3G4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 789
  • Mass: 90990
  • Checksum: EAE58E3F6B64FBBF
  • Sequence:
  • MTSPAKFKKD KEIIAEYDTQ VKEIRAQLTE QMKCLDQQRE LRVQLLQDLQ DFFRKKAEIE 
    MDYSRNLEKL AERFLAKTRS TKDQQFKKDQ NVLSPVNCWN LLLNQVKRES RDHTTLSDIY 
    LNNIIPRFVQ VSEDSGRLFK KSKEVGQQLQ DDLMKVLNEL YSVMKTYHMY NADSISAQSK 
    LKEAEKQEEK QIGKSVKQED RQTPRSPDST ANVRIEEKHV RRSSVKKIEK MKEKRQAKYT 
    ENKLKAIKAR NEYLLALEAT NASVFKYYIH DLSDLIDCCD LGYHASLNRA LRTFLSAELN 
    LEQSKHEGLD AIENAVENLD ATSDKQRLME MYNNVFCPPM KFEFQPHMGD MASQLCAQQP 
    VQSELVQRCQ QLQSRLSTLK IENEEVKKTM EATLQTIQDI VTVEDFDVSD CFQYSNSMES 
    VKSTVSETFM SKPSIAKRRA NQQETEQFYF TKMREYLEGR NLITKLQAKH DLLQKTLGES 
    QRTDCSLARR SSTVRKQDSS QAIPLVVESC IRFISRHGLQ HEGIFRVSGS QVEVNDIKNA 
    FERGEDPLAG DQNDHDMDSI AGVLKLYFRG LEHPLFPKDI FHDLMACVTM DNLQERALHI 
    RKVLLVLPKT TLIIMRYLFA FLNHLSQFSE ENMMDPYNLA ICFGPSLMSV PEGHDQVSCQ 
    AHVNELIKTI IIQHENIFPS PRELEGPVYS RGGSMEDYCD SPHGETTSVE DSTQDVTAEH 
    HTSDDECEPI EAIAKFDYVG RTARELSFKK GASLLLYQRA SDDWWEGRHN GIDGLIPHQY 
    IVVQDTLIS

Genular Protein ID: 2362601635

Symbol: B7ZM87_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 1070
  • Mass: 120742
  • Checksum: 3476DEAC3AC3DF8C
  • Sequence:
  • MTSPAKFKKD KEIIAEYDTQ VKEIRAQLTE QMKCLDQQCE LRVQLLQDLQ DFFRKKAEIE 
    MDYSRNLEKL AERFLAKTRS TKDQQFKKDQ NVLSPVNCWN LLLNQVKRES RDHTTLSDIY 
    LNNIIPRFVQ VSEDSGRLFK KSKEVGQQLQ DDLMKVLNEL YSVMKTYHMY NADSISAQSK 
    LKEAEKQEEK QIGKSVKQED RQTPRSPDST ANVRIEEKHV RRSSVKKIEK MKEKRQAKYT 
    ENKLKAIKAR NEYLLALEAT NASVFKYYIH DLSDLIDCCD LGYHASLNRA LRTFLSAELN 
    LEQSKHEGLD AIENAVENLD ATSDKQRLME MYNNVFCPPM KFEFQPHMGD MASQLCAQQP 
    VQSELVQRCQ QLQSRLSTLK IENEEVKKTM EATLQTIQDI VTVEDFDVSD CFQYSNSMES 
    VKSTVSETFM SKPSIAKRRA NQQETEQFYF TKMKEYLEGR NLITKLQAKH DLLQKTLGES 
    QRTDCSLARR SSTVRKQDSS QAIPLVVESC IRFISRHGLQ HEGIFRVSGS QVEVNDIKNA 
    FERGEDPLAG DQNDHDMDSI AGVLKLYFRG LEHPLFPKDI FHDLMACVTM DNLQERALHI 
    RKVLLVLPKT TLIIMRYLFA FLNHLSQFSE ENMMDPYNLA ICFGPSLMSV PEGHDQVSCQ 
    AHVNELIKTI IIQHENIFPS PRELEGPVYS RGGSMEDYCD SPHGETTSVE DSTQDVTAEH 
    HTSDDECEPI EAIAKFDYVG RTARELSFKK GASLLLYQRA SDDWWEGRHN GIDGLIPHQY 
    IVVQDTEDGV VERSSPKSEI EVISEPPEEK VTARAGASCP SGGHVADIYL ANINKQRKRP 
    ESGSIRKTFR SDSHGLSSSL TDSSSPGVGA SCRPSSQPIM SQSLPKEGPD KCSISGHGSL 
    NSISRHSSLK NRLDSPQIRK TATAGRSKSF NNHRPMDPEV IAQDIEATMN SALNELRELE 
    RQSSVKHTPD VVLDTLEPLK TSPVVAPTSE PSSPLHTQLL KDPEPAFQRS ASTAGDIACA 
    FRPVKSVKMA APVKPPATRP KPTVFPKTNA TSPGVNSSTS PQSTDKSCTV

Genular Protein ID: 741577766

Symbol: B4DFE5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 438
  • Mass: 47413
  • Checksum: CAF04159C1B45E9F
  • Sequence:
  • MMDPYNLAIC FGPSLMSVPE GHDQVSCQAH VNELIKTIII QHENIFPSPR ELEGPVYSRG 
    GSMEDYCDSP HGETTSVEDS TQDVTAEHHT SDDECEPIEA IAKFDYVGRT ARELSFKKGA 
    SLLLYQRASD DWWEGRHNGI DGLIPHQYIV VQDTEDGVVE RSSPKSEIEV ISEPPEEKVT 
    ARAGASCPSG GHVADIYLAN INKQRKRPES GSIRKTFRSD SHGLSSSLTD SSSPGVGASC 
    RPSSQPIMSQ SLPKEGPDKC SISGHGSLNS ISRHSSLKNR LDSPQIRKTA TAGRSKSFNN 
    HRPMDPEVIA QDIEATMNSA LNELRELERQ SSVKHTPDVV LDTLEPLKTS PVVAPTSEPS 
    SPLHTQLLKD PEPAFQRSAS TAGDIACAFR PVKSVKMAAP VKPPATRPKP TVFPKTNATS 
    PGVNSSTSPQ STDKSCTV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.